Il12b (interleukin 12B) - Rat Genome Database

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Gene: Il12b (interleukin 12B) Rattus norvegicus
Analyze
Symbol: Il12b
Name: interleukin 12B
RGD ID: 628704
Description: Enables interleukin-12 alpha subunit binding activity. Involved in natural killer cell activation involved in immune response. Located in extracellular space. Part of interleukin-12 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Il12; Interleukin 12; interleukin-12 p40; interleukin-12 p40 precursor; interleukin-12 subunit beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia10 Eau7
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81029,390,300 - 29,405,194 (+)NCBIGRCr8
mRatBN7.21028,888,832 - 28,903,802 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1028,893,008 - 28,902,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1033,646,865 - 33,656,254 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0102,185,271 - 2,194,657 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01028,617,471 - 28,626,860 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01030,034,447 - 30,048,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1030,038,709 - 30,048,085 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01029,868,367 - 29,882,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41029,558,955 - 29,568,331 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11029,560,003 - 29,569,378 (+)NCBI
Celera1028,372,232 - 28,381,601 (+)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Il12bRatanogenital venereal wart treatmentISOIL12B (Homo sapiens)7829774 RGD 
Il12bRatanogenital venereal wart  ISOIL12B (Homo sapiens)40400714protein:decreased expression:peripheral blood mononuclear cells (human)RGD 
Il12bRatasthma susceptibilityISOIL12B (Homo sapiens)4145438DNA:polymorphisms:promoter and 3'utr:RGD 
Il12bRatasthma severityISOIL12B (Homo sapiens)4145428DNA:polymorphism:promoterRGD 
Il12bRatasthma severityISOIL12B (Homo sapiens)1600043DNA:polymorphisms:introns:RGD 
Il12bRatChronic Hepatitis B susceptibilityISOIL12B (Homo sapiens)11074616DNA:SNP:3'utr: (rs3212227)RGD 
Il12bRatChronic Hepatitis C severityISOIL12B (Homo sapiens)14401721DNA:SNP:3' utr:+1188A>C (human)RGD 
Il12bRatchronic obstructive pulmonary disease  ISOIL12B (Homo sapiens)4145423DNA:polymorphism: :RGD 
Il12bRatExperimental Autoimmune Encephalomyelitis  IEP 4831840mRNA and protein:increased expression:lymph nodeRGD 
Il12bRatfarmer's lung  ISOIl12b (Mus musculus)4145430 RGD 
Il12bRatHuman Influenza  ISOIl12b (Mus musculus)4145426 RGD 
Il12bRatKidney Reperfusion Injury amelioratesISOIl12b (Mus musculus)329845564 RGD 
Il12bRatNontuberculous Mycobacterium Infections susceptibilityISOIL12B (Homo sapiens)1600042disseminated BCG and Salmonella enteritidis infection and OMIM:209950RGD 
Il12bRatpulmonary fibrosis  ISOIl12b (Mus musculus)4889581protein:increased expression:lungRGD 
Il12bRatpulmonary fibrosis  ISOIl12b (Mus musculus)4888529 RGD 
Il12bRatsalmonellosis susceptibilityISOIL12B (Homo sapiens)1600042disseminated BCG and Salmonella enteritidis infection and OMIM:209950RGD 
Il12bRatSepsis  IDA 4888507protein:increased expression:peritoneal fluid and plasmaRGD 
Il12bRatshigellosis treatmentISOIl12b (Mus musculus)39938959 RGD 
Il12bRatThyroid Neoplasms  ISOIl12b (Mus musculus)4145421 RGD 
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Original Reference(s)
Il12bRatasthma  ISOIL12B (Homo sapiens)8554872ClinVar Annotator: match by term: Asthma and susceptibility toClinVarPMID:15322986
Il12bRatgenetic disease  ISOIL12B (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
Il12bRatimmunodeficiency 29  ISOIL12B (Homo sapiens)8554872ClinVar Annotator: match by term: Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiencyClinVarPMID:11704807 more ...
Il12bRatNontuberculous Mycobacterium Infections  ISOIL12B (Homo sapiens)8554872ClinVar Annotator: match by term: Familial Atypical Mycobacteriosis and Autosomal RecessiveClinVar 
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Il12bRatankylosing spondylitis  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21743469
Il12bRatChemical and Drug Induced Liver Injury  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:36520315
Il12bRatCrohn's disease  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18438406
Il12bRatExperimental Neoplasms  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:17332360
Il12bRathigh grade glioma  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:18176109
Il12bRatHypothermia  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16369138
Il12bRatLiver Neoplasms  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:17326190
Il12bRatmalignant mesothelioma  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25162674
Il12bRatNeuralgia  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31432094
Il12bRatprimary biliary cholangitis  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20639880
Il12bRatpsoriasis  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19169254 more ...
Il12bRatpsoriatic arthritis  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20953186
Il12bRatpulmonary fibrosis  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12193738
Il12bRatSpontaneous Abortions  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18539642
Il12bRatsystemic lupus erythematosus  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19838195 and PMID:26808113
Il12bRatulcerative colitis  ISOIL12B (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18438406 more ...
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Il12bRatimmunodeficiency 29  ISOIL12B (Homo sapiens)7240710 OMIM 

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Il12bRat(+)-pilocarpine increases expressionISOIl12b (Mus musculus)6480464Pilocarpine results in increased expression of IL12B mRNACTDPMID:15193289
Il12bRat(S)-nicotine multiple interactionsISOIl12b (Mus musculus)6480464Acetylcysteine inhibits the reaction [Nicotine results in increased expression of IL12B mRNA] more ...CTDPMID:21237301
Il12bRat(S)-nicotine increases expressionISOIl12b (Mus musculus)6480464Nicotine results in increased expression of IL12B mRNACTDPMID:21237301
Il12bRat(Z)-ligustilide multiple interactionsISOIl12b (Mus musculus)6480464ligustilide inhibits the reaction [Dextran Sulfate results in increased expression of IL12B mRNA]CTDPMID:33130971
Il12bRat1,3,5-trinitrobenzene multiple interactionsISOIl12b (Mus musculus)6480464Eicosapentaenoic Acid analog inhibits the reaction [sym-trinitrobenzene results in increased expression of IL12B mRNA]CTDPMID:15890784
Il12bRat1,3,5-trinitrobenzene decreases response to substanceISOIl12b (Mus musculus)6480464IL12B protein results in decreased susceptibility to sym-trinitrobenzeneCTDPMID:11782017
Il12bRat1,3,5-trinitrobenzene increases expressionISOIl12b (Mus musculus)6480464sym-trinitrobenzene results in increased expression of IL12B mRNACTDPMID:15890784
Il12bRat1,4-benzoquinone increases secretionISOIL12B (Homo sapiens)6480464quinone results in increased secretion of IL12B proteinCTDPMID:31958493
Il12bRat1-chloro-2,4,6-trinitrobenzene multiple interactionsISOIl12b (Mus musculus)6480464[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL12B protein and PPARA protein affects the reaction [[Picryl Chloride co-treated with pirinixic acid] results in decreased expression of IL12B protein]CTDPMID:17371993
Il12bRat1-chloro-2,4,6-trinitrobenzene increases expressionISOIl12b (Mus musculus)6480464Picryl Chloride results in increased expression of IL12B mRNACTDPMID:11708898
Il12bRat1-chloro-2,4-dinitrobenzene increases expressionISOIl12b (Mus musculus)6480464Dinitrochlorobenzene results in increased expression of IL12B mRNA and Dinitrochlorobenzene results in increased expression of IL12B proteinCTDPMID:10199581 more ...
Il12bRat1-chloro-2,4-dinitrobenzene increases expressionEXP 6480464Dinitrochlorobenzene results in increased expression of IL12B mRNACTDPMID:25449201
Il12bRat1-chloro-2,4-dinitrobenzene increases methylationISOIl12b (Mus musculus)6480464Dinitrochlorobenzene results in increased methylation of IL12B geneCTDPMID:26732893
Il12bRat1-chloro-2,4-dinitrobenzene decreases methylationISOIl12b (Mus musculus)6480464Dinitrochlorobenzene results in decreased methylation of IL12B geneCTDPMID:26732893
Il12bRat1-chloro-2,4-dinitrobenzene affects expressionISOIl12b (Mus musculus)6480464Dinitrochlorobenzene affects the expression of IL12B mRNACTDPMID:22302311
Il12bRat1-chloro-2,4-dinitrobenzene increases secretionISOIl12b (Mus musculus)6480464Dinitrochlorobenzene results in increased secretion of IL12B proteinCTDPMID:10199581
Il12bRat1-fluoro-2,4-dinitrobenzene increases expressionISOIl12b (Mus musculus)6480464Dinitrofluorobenzene results in increased expression of IL12B mRNACTDPMID:11708898
Il12bRat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of IL12B mRNACTDPMID:30723492
Il12bRat1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine increases expressionISOIL12B (Homo sapiens)6480464KRN 7000 results in increased expression of IL12B proteinCTDPMID:15867097
Il12bRat17beta-estradiol multiple interactionsISOIL12B (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of IL12B mRNA more ...CTDPMID:20130130 and PMID:20823114

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Biological Process
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Original Reference(s)
Il12bRatcell migration involved_inISOIL12B (Homo sapiens)1624291 PMID:7903063RGDPMID:7903063
Il12bRatcell migration involved_inIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatcell population proliferation acts_upstream_of_or_withinISOIl12b (Mus musculus)1624291MGI:107936 more ...RGDPMID:15843532
Il12bRatcell surface receptor signaling pathway acts_upstream_of_or_withinISOIl12b (Mus musculus)1624291 PMID:12871593RGDPMID:12871593
Il12bRatcell surface receptor signaling pathway via JAK-STAT involved_inISOIL12B (Homo sapiens)1624291 PMID:12023369RGDPMID:12023369
Il12bRatcell surface receptor signaling pathway via JAK-STAT involved_inIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatcellular response to lipopolysaccharide acts_upstream_of_or_withinISOIl12b (Mus musculus)1624291 PMID:18025219 and PMID:21606371RGDPMID:18025219 and PMID:21606371
Il12bRatcellular response to type II interferon acts_upstream_of_or_withinISOIl12b (Mus musculus)1624291 PMID:18025219RGDPMID:18025219
Il12bRatcytokine-mediated signaling pathway involved_inIEAUniRule:UR0000764581600115GO_REF:0000104UniProtGO_REF:0000104
Il12bRatdefense response to Gram-negative bacterium involved_inISOIL12B (Homo sapiens)1624291 PMID:15114670 and PMID:20027291RGDPMID:15114670 and PMID:20027291
Il12bRatdefense response to Gram-negative bacterium involved_inIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatdefense response to protozoan acts_upstream_of_or_withinISOIl12b (Mus musculus)1624291MGI:1857201 more ...RGDPMID:19050265 and PMID:9348310
Il12bRatdefense response to virus acts_upstream_of_or_withinISOIl12b (Mus musculus)1624291 PMID:17277142RGDPMID:17277142
Il12bRatinterleukin-12-mediated signaling pathway involved_inISOIL12B (Homo sapiens)1624291 PMID:7584494RGDPMID:7584494
Il12bRatinterleukin-12-mediated signaling pathway involved_inIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatinterleukin-12-mediated signaling pathway involved_inIBAPANTHER:PTN009232574 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il12bRatnatural killer cell activation involved_inISOIL12B (Homo sapiens)1624291 PMID:1673147RGDPMID:1673147
Il12bRatnatural killer cell activation involved_inIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatnatural killer cell activation involved in immune response  IMP 1600048 RGD 
Il12bRatnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis acts_upstream_ofISOIL12B (Homo sapiens)1624291UniProtKB:P29459 and PMID:30106099RGDPMID:30106099
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Cellular Component
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Original Reference(s)
Il12bRatcell surface located_inISOIl12b (Mus musculus)1624291 PMID:20818394RGDPMID:20818394
Il12bRatcytoplasm located_inISOIl12b (Mus musculus)1624291 PMID:11737071RGDPMID:11737071
Il12bRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Il12bRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Il12bRatextracellular space  IDA 1600057 RGD 
Il12bRatextracellular space located_inIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Il12bRatextracellular space is_active_inIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatextracellular space located_inISOIl12b (Mus musculus)1624291 PMID:12855817 more ...RGDPMID:12855817 more ...
Il12bRatextracellular space is_active_inISOIL12B (Homo sapiens)1624291 PMID:7584494RGDPMID:7584494
Il12bRatinterleukin-12 complex  IDA 1600058 RGD 
Il12bRatinterleukin-12 complex part_ofIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatinterleukin-12 complex part_ofISOIl12b (Mus musculus)1624291MGI:96539 PMID:15220916 and PMID:7690439RGDPMID:15220916 and PMID:7690439
Il12bRatinterleukin-12 complex part_ofIBAMGI:96539 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il12bRatinterleukin-12 complex part_ofISOIL12B (Homo sapiens)1624291 PMID:11114383 and PMID:1674604RGDPMID:11114383 and PMID:1674604
Il12bRatinterleukin-23 complex part_ofISOIL12B (Homo sapiens)1624291 PMID:11114383RGDPMID:11114383
Il12bRatinterleukin-23 complex part_ofIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatinterleukin-23 complex part_ofISOIl12b (Mus musculus)1624291 PMID:11114383RGDPMID:11114383
Il12bRatmembrane located_inIEAInterPro:IPR0035301600115GO_REF:0000002InterProGO_REF:0000002
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Molecular Function
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Il12bRatcytokine activity contributes_toISOIL12B (Homo sapiens)1624291 PMID:1674604RGDPMID:1674604
Il12bRatcytokine activity enablesIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Il12bRatcytokine activity contributes_toISOIl12b (Mus musculus)1624291 PMID:11057672RGDPMID:11057672
Il12bRatcytokine activity contributes_toIBAMGI:96539 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il12bRatcytokine activity contributes_toIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatcytokine activity enablesISOIL12B (Homo sapiens)1624291 PMID:7584494RGDPMID:7584494
Il12bRatcytokine receptor activity enablesIEAUniRule:UR0000764581600115GO_REF:0000104UniProtGO_REF:0000104
Il12bRatcytokine receptor activity enablesIEAInterPro:IPR0035301600115GO_REF:0000002InterProGO_REF:0000002
Il12bRatcytokine receptor binding contributes_toISOIl12b (Mus musculus)1624291UniProtKB:Q60837 and PMID:11114383RGDPMID:11114383
Il12bRatgrowth factor activity contributes_toISOIL12B (Homo sapiens)1624291 PMID:1674604RGDPMID:1674604
Il12bRatgrowth factor activity contributes_toIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatidentical protein binding enablesISOIL12B (Homo sapiens)1624291UniProtKB:P29460 and PMID:7527811RGDPMID:7527811
Il12bRatidentical protein binding enablesIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatidentical protein binding enablesISOIl12b (Mus musculus)1624291PR:P43432 PMID:12871593RGDPMID:12871593
Il12bRatinterleukin-12 alpha subunit binding  IDA 1600058 RGD 
Il12bRatinterleukin-12 alpha subunit binding enablesIEAUniProtKB:P29460 and ensembl:ENSP000002312281600115GO_REF:0000107EnsemblGO_REF:0000107
Il12bRatinterleukin-12 alpha subunit binding enablesISOIl12b (Mus musculus)1624291PR:P43431 PMID:15220916RGDPMID:15220916
Il12bRatinterleukin-12 alpha subunit binding enablesIBAMGI:96540 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Il12bRatinterleukin-12 alpha subunit binding enablesISOIL12B (Homo sapiens)1624291UniProtKB:E7ENE1 more ...RGDPMID:11023671
Il12bRatinterleukin-12 receptor binding enablesIBAPANTHER:PTN009232574 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Imported Annotations - KEGG (archival)

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Imported Annotations - PID (archival)

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Il12bRatinterleukin-12 signaling pathway  ISOIL12B (Homo sapiens)6484113 PIDPID:200045
Il12bRatinterleukin-23 signaling pathway  ISOIL12B (Homo sapiens)6484113 PIDPID:200154
Il12bRatinterleukin-27 signaling pathway  ISOIL12B (Homo sapiens)6484113 PIDPID:200028

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Reference Title
Reference Citation
1. Interleukin-12 secreted by mature dendritic cells mediates activation of NK cell function. Alli RS and Khar A, FEBS Lett. 2004 Feb 13;559(1-3):71-6.
2. Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection. Altare F, etal., J Clin Invest. 1998 Dec 15;102(12):2035-40.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Mapping autoimmunity genes. Griffiths MM, etal., Curr Opin Immunol. 1999 Dec;11(6):689-700.
5. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
6. Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis. Halpern MD, etal., Pediatr Res 2002 Jun;51(6):733-9.
7. Interaction of TLR-IFN and HLA polymorphisms on susceptibility of chronic HBV infection in Southwest Han Chinese. He D, etal., Liver Int. 2015 Aug;35(8):1941-9. doi: 10.1111/liv.12756. Epub 2015 Jan 21.
8. Functional haplotypes of IL-12B are associated with childhood atopic asthma. Hirota T, etal., J Allergy Clin Immunol. 2005 Oct;116(4):789-95. Epub 2005 Aug 8.
9. Polymorphisms in the IL-12B gene and outcome of HCV infection. Houldsworth A, etal., J Interferon Cytokine Res. 2005 May;25(5):271-6. doi: 10.1089/jir.2005.25.271.
10. Molecular cloning and sequencing of the rat interleukin-12 p40 gene. Khalife J, etal., Eur Cytokine Netw 1998 Mar;9(1):69-73.
11. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Lai CF, etal., Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92. doi: 10.1152/ajprenal.00670.2013. Epub 2014 Jun 11.
12. Strain difference in susceptibility to experimental autoimmune encephalomyelitis in rats correlates with T(H)1 and T(H)17-inducing cytokine profiles. Markovic M, etal., Mol Immunol. 2009 Nov;47(1):141-6. Epub 2009 Feb 23.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Morahan G, etal., Lancet. 2002 Aug 10;360(9331):455-9.
15. Epidermal Growth Factor Receptor-Responsive Indoleamine 2,3-Dioxygenase Confers Immune Homeostasis During Shigella flexneri Infection. Mukherjee T, etal., J Infect Dis. 2019 May 5;219(11):1841-1851. doi: 10.1093/infdis/jiz009.
16. Identification of a rat bone marrow-derived dendritic cell population which secretes both IL-10 and IL-12: evidence against a reciprocal relationship between IL-10 and IL-12 secretion. Muthana M, etal., Immunobiology. 2006;211(5):391-402. Epub 2006 Mar 14.
17. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Oku H, etal., Eur J Pharmacol. 2008 Aug 20;590(1-3):400-8. Epub 2008 Jun 16.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Protection against influenza infection by cytokine-enhanced aerosol genetic immunization. Orson FM, etal., J Gene Med. 2006 Apr;8(4):488-97.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
1 to 20 of 35 rows
PMID:1673147   PMID:1674604   PMID:7527811   PMID:7690439   PMID:7903063   PMID:8992506   PMID:9348310   PMID:11023671   PMID:11057672   PMID:11114383   PMID:11737071   PMID:12023369  
PMID:12421946   PMID:12432235   PMID:12855817   PMID:12871593   PMID:14688363   PMID:15114670   PMID:15220916   PMID:15240714   PMID:15265908   PMID:15371491   PMID:15692051   PMID:15781254  
PMID:15843532   PMID:16236719   PMID:16482511   PMID:16751425   PMID:16942485   PMID:16949315   PMID:17277142   PMID:17475835   PMID:17888176   PMID:18025219   PMID:19050265   PMID:19088061  
PMID:19299163   PMID:19420081   PMID:19710466   PMID:19922500   PMID:20027291   PMID:20818394   PMID:21444916   PMID:21606371   PMID:23892723   PMID:26950239   PMID:30106099  



Il12b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81029,390,300 - 29,405,194 (+)NCBIGRCr8
mRatBN7.21028,888,832 - 28,903,802 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1028,893,008 - 28,902,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1033,646,865 - 33,656,254 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0102,185,271 - 2,194,657 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01028,617,471 - 28,626,860 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01030,034,447 - 30,048,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1030,038,709 - 30,048,085 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01029,868,367 - 29,882,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41029,558,955 - 29,568,331 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11029,560,003 - 29,569,378 (+)NCBI
Celera1028,372,232 - 28,381,601 (+)NCBICelera
Cytogenetic Map10q21NCBI
IL12B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385159,314,780 - 159,330,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5159,314,780 - 159,330,863 (-)EnsemblGRCh38hg38GRCh38
GRCh375158,741,788 - 158,757,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365158,674,369 - 158,690,059 (-)NCBINCBI36Build 36hg18NCBI36
Build 345158,674,368 - 158,690,059NCBI
Celera5154,772,647 - 154,788,337 (-)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5153,836,180 - 153,851,870 (-)NCBIHuRef
CHM1_15158,174,226 - 158,189,916 (-)NCBICHM1_1
T2T-CHM13v2.05159,843,275 - 159,858,983 (-)NCBIT2T-CHM13v2.0
Il12b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391144,290,890 - 44,305,504 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1144,290,890 - 44,304,860 (+)EnsemblGRCm39 Ensembl
GRCm381144,400,063 - 44,414,677 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1144,400,063 - 44,414,033 (+)EnsemblGRCm38mm10GRCm38
MGSCv371144,213,565 - 44,227,519 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361144,243,486 - 44,257,440 (+)NCBIMGSCv36mm8
Celera1149,032,464 - 49,046,411 (+)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1125.94NCBI
Il12b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540813,304,219 - 13,312,620 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540813,302,506 - 13,316,300 (-)NCBIChiLan1.0ChiLan1.0
IL12B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24154,500,951 - 154,516,997 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15152,640,499 - 152,656,293 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05154,706,467 - 154,722,231 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15161,323,402 - 161,339,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5161,325,303 - 161,335,381 (-)Ensemblpanpan1.1panPan2
IL12B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1451,178,637 - 51,194,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl451,183,568 - 51,193,228 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha451,076,678 - 51,086,695 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0451,613,430 - 51,629,329 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl451,613,283 - 51,629,335 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1451,447,354 - 51,457,365 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0451,553,170 - 51,563,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0452,069,793 - 52,079,810 (+)NCBIUU_Cfam_GSD_1.0
Il12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213105,602,399 - 105,617,640 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365154,056,214 - 4,065,076 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365154,056,214 - 4,066,121 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL12B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1664,143,268 - 64,158,929 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11664,143,268 - 64,158,929 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21669,952,428 - 69,964,218 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL12B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12361,714,293 - 61,731,835 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603415,892,244 - 15,902,867 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il12b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473330,146,050 - 30,154,589 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473330,146,050 - 30,156,144 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Il12b
168 total Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 29876824 29876825 T G snv SR/JrHsd (MCW), FHH/EurMcwi (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000005898
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 47 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat

1 to 10 of 47 rows
PMC355839P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21028,896,656 - 28,897,391 (+)MAPPERmRatBN7.2
Rnor_6.01030,042,356 - 30,043,089NCBIRnor6.0
Rnor_5.01029,876,100 - 29,876,833UniSTSRnor5.0
RGSC_v3.41029,562,602 - 29,563,335UniSTSRGSC3.4
Celera1028,375,879 - 28,376,612UniSTS
Cytogenetic Map10q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 3 10 27 54 58 27 25 27 6 97 50 12 9 34 31



Ensembl Acc Id: ENSRNOT00000005898   ⟹   ENSRNOP00000005898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1028,893,008 - 28,902,903 (+)Ensembl
Rnor_6.0 Ensembl1030,038,709 - 30,048,085 (+)Ensembl
RefSeq Acc Id: NM_022611   ⟹   NP_072133
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81029,390,300 - 29,405,194 (+)NCBI
mRatBN7.21028,888,906 - 28,903,802 (+)NCBI
Rnor_6.01030,038,709 - 30,048,085 (+)NCBI
Rnor_5.01029,868,367 - 29,882,535 (+)NCBI
RGSC_v3.41029,558,955 - 29,568,331 (+)RGD
Celera1028,372,232 - 28,381,601 (+)RGD
Sequence:
Protein RefSeqs NP_072133 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA52229 (Get FASTA)   NCBI Sequence Viewer  
  AAD24190 (Get FASTA)   NCBI Sequence Viewer  
  EDM04146 (Get FASTA)   NCBI Sequence Viewer  
  EDM04147 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005898
  ENSRNOP00000005898.5
RefSeq Acc Id: NP_072133   ⟸   NM_022611
- Peptide Label: precursor
- UniProtKB: G3V9Y5 (UniProtKB/TrEMBL),   A6HDP1 (UniProtKB/TrEMBL),   E9PU71 (UniProtKB/TrEMBL),   Q9R278 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005898   ⟸   ENSRNOT00000005898
Fibronectin type-III   Ig-like

Name Modeler Protein Id AA Range Protein Structure
AF-E9PU71-F1-model_v2 AlphaFold E9PU71 1-335 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-25405 BioCyc
Ensembl Genes ENSRNOG00000004380 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005898 ENTREZGENE
  ENSRNOT00000005898.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Hematopoietin_rcpt_L_F3_CS UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  IL-12_family_cytokines UniProtKB/TrEMBL
  IL_12_beta UniProtKB/TrEMBL
  Interleukin-12_bsu_cen-dom UniProtKB/TrEMBL
KEGG Report rno:64546 UniProtKB/TrEMBL
NCBI Gene 64546 ENTREZGENE
PANTHER INTERLEUKIN-12 SUBUNIT BETA UniProtKB/TrEMBL
  INTERLEUKIN-12 SUBUNIT BETA-RELATED UniProtKB/TrEMBL
Pfam IL12p40_C UniProtKB/TrEMBL
PharmGKB IL12B RGD
PhenoGen Il12b PhenoGen
PIRSF IL_12_beta UniProtKB/TrEMBL
PRINTS INTRLEUKN12B UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_L_F3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004380 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A6HDP1 ENTREZGENE, UniProtKB/TrEMBL
  E9PU71 ENTREZGENE, UniProtKB/TrEMBL
  G3V9Y5 ENTREZGENE
  Q62712_RAT UniProtKB/TrEMBL
  Q9R278 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary G3V9Y5 UniProtKB/TrEMBL
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-29 Il12b  interleukin 12B  Il12b  interleukin 12b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Il12b  interleukin 12b      Symbol and Name status set to approved 1299863 APPROVED
2003-04-14 Il12b  interleukin 12b  Il12  Interleukin 12  Data merged from RGD:61304 628472 PENDING
2003-02-27 Il12b  interleukin 12b      Symbol and Name status set to provisional 70820 PROVISIONAL
2001-08-29 Il12  Interleukin 12      Symbol updated 68687 APPROVED

Note Type Note Reference
gene_homology shows 92% and 65% identity to mouse and human homologs 633120
gene_transcript contains six exons and five introns 633120