Il12b (interleukin 12B) - Rat Genome Database

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Gene: Il12b (interleukin 12B) Rattus norvegicus
Symbol: Il12b
Name: interleukin 12B
RGD ID: 628704
Description: Enables interleukin-12 alpha subunit binding activity. Involved in natural killer cell activation involved in immune response. Located in extracellular space. Part of interleukin-12 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Il12; Interleukin 12; interleukin-12 p40; interleukin-12 p40 precursor; interleukin-12 subunit beta
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Cia10 Eau7
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21028,888,832 - 28,903,802 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1028,893,008 - 28,902,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1033,646,865 - 33,656,254 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0102,185,271 - 2,194,657 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01028,617,471 - 28,626,860 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01030,034,447 - 30,048,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1030,038,709 - 30,048,085 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01029,868,367 - 29,882,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41029,558,955 - 29,568,331 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11029,560,003 - 29,569,378 (+)NCBI
Celera1028,372,232 - 28,381,601 (+)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (ISO)
(Z)-ligustilide  (ISO)
1,3,5-trinitrobenzene  (ISO)
1,4-benzoquinone  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-tert-butylhydroquinone  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-methylhistamine  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acyclovir  (ISO)
adenosine  (ISO)
adenosine 5'-[gamma-thio]triphosphate  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthranilic acid  (ISO)
antimony(0)  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
Benzamil  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzoic acid  (ISO)
beta-D-glucan  (ISO)
betulin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
Brevetoxin B  (ISO)
bromosulfophthalein  (ISO)
bryostatin 1  (ISO)
bucladesine  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbamate ester  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chlorobenzene  (ISO)
choline  (ISO)
ciprofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corn oil  (EXP)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dichlorine  (ISO)
dichloroacetyl chloride  (ISO)
diltiazem  (ISO)
Dimaprit  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Erionite  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethionamide  (EXP)
ethylisopropylamiloride  (ISO)
eugenol  (ISO)
famotidine  (ISO)
farnesyl diphosphate  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
ferulic acid  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
fructose  (ISO)
gemfibrozil  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glucuronoxylomannan  (ISO)
glyburide  (ISO)
glycyrrhizinic acid  (ISO)
GW 7647  (ISO)
helenalin  (ISO)
histamine  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
Ibudilast  (ISO)
imiquimod  (ISO)
indometacin  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isocyanates  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
itraconazole  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
lenalidomide  (ISO)
leukotriene B4  (ISO)
leukotriene D4  (ISO)
lipid As  (ISO)
lipoarabinomannan  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lupane  (ISO)
luteolin  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
mechlorethamine  (EXP)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (ISO)
mesalamine  (ISO)
metam  (ISO)
methapyrilene  (EXP)
methoxychlor  (EXP,ISO)
methyl 3,4,5-trihydroxybenzoate  (ISO)
methyl isothiocyanate  (ISO)
methyl salicylate  (ISO)
methylprednisolone aceponate  (ISO)
mevalonic acid  (ISO)
mifepristone  (ISO)
MK-2206  (ISO)
mometasone furoate  (ISO)
monodansylcadaverine  (ISO)
montelukast  (ISO)
morphine  (ISO)
muramyl dipeptide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nadolol  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
parathion  (ISO)
parthenolide  (ISO)
peptidoglycan  (ISO)
perfluorooctanoic acid  (EXP)
phenanthridone  (ISO)
Phenelzine  (ISO)
phenethyl caffeate  (ISO)
phenylarsine oxide  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
procyanidin B3  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
ranitidine  (ISO)
resiquimod  (ISO)
resveratrol  (ISO)
ribavirin  (ISO)
Ro 41-5253  (ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
salicylic acid  (ISO)
SB 203580  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium stibogluconate  (ISO)
soybean oil  (ISO)
SR 144528  (ISO)
streptozocin  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
suramin  (ISO)
tacrolimus hydrate  (ISO)
terameprocol  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trifluoperazine  (ISO)
trimellitic acid  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanillin  (ISO)
warfarin  (EXP)
wortmannin  (ISO)
zileuton  (ISO)
zinc dichloride  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell migration  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to type II interferon  (ISO)
cytokine-mediated signaling pathway  (IBA)
defense response to Gram-negative bacterium  (ISO)
defense response to protozoan  (ISO)
defense response to virus  (ISO)
interleukin-12-mediated signaling pathway  (ISO)
natural killer cell activation  (ISO)
natural killer cell activation involved in immune response  (IMP)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of interleukin-17 production  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of vascular endothelial growth factor signaling pathway  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of defense response to virus by host  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of mononuclear cell proliferation  (ISO)
positive regulation of natural killer cell activation  (ISO)
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (ISO)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of NK T cell activation  (ISO)
positive regulation of NK T cell proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of smooth muscle cell apoptotic process  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 1 type immune response  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of tyrosine phosphorylation of STAT protein  (ISO)
response to organic substance  (ISO)
response to UV-B  (ISO)
T cell proliferation  (ISO)
T-helper cell differentiation  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Interleukin-12 secreted by mature dendritic cells mediates activation of NK cell function. Alli RS and Khar A, FEBS Lett. 2004 Feb 13;559(1-3):71-6.
2. Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection. Altare F, etal., J Clin Invest. 1998 Dec 15;102(12):2035-40.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Mapping autoimmunity genes. Griffiths MM, etal., Curr Opin Immunol. 1999 Dec;11(6):689-700.
5. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
6. Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis. Halpern MD, etal., Pediatr Res 2002 Jun;51(6):733-9.
7. Interaction of TLR-IFN and HLA polymorphisms on susceptibility of chronic HBV infection in Southwest Han Chinese. He D, etal., Liver Int. 2015 Aug;35(8):1941-9. doi: 10.1111/liv.12756. Epub 2015 Jan 21.
8. Functional haplotypes of IL-12B are associated with childhood atopic asthma. Hirota T, etal., J Allergy Clin Immunol. 2005 Oct;116(4):789-95. Epub 2005 Aug 8.
9. Polymorphisms in the IL-12B gene and outcome of HCV infection. Houldsworth A, etal., J Interferon Cytokine Res. 2005 May;25(5):271-6. doi: 10.1089/jir.2005.25.271.
10. Molecular cloning and sequencing of the rat interleukin-12 p40 gene. Khalife J, etal., Eur Cytokine Netw 1998 Mar;9(1):69-73.
11. Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury. Lai CF, etal., Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92. doi: 10.1152/ajprenal.00670.2013. Epub 2014 Jun 11.
12. Strain difference in susceptibility to experimental autoimmune encephalomyelitis in rats correlates with T(H)1 and T(H)17-inducing cytokine profiles. Markovic M, etal., Mol Immunol. 2009 Nov;47(1):141-6. Epub 2009 Feb 23.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Morahan G, etal., Lancet. 2002 Aug 10;360(9331):455-9.
15. Epidermal Growth Factor Receptor-Responsive Indoleamine 2,3-Dioxygenase Confers Immune Homeostasis During Shigella flexneri Infection. Mukherjee T, etal., J Infect Dis. 2019 May 5;219(11):1841-1851. doi: 10.1093/infdis/jiz009.
16. Identification of a rat bone marrow-derived dendritic cell population which secretes both IL-10 and IL-12: evidence against a reciprocal relationship between IL-10 and IL-12 secretion. Muthana M, etal., Immunobiology. 2006;211(5):391-402. Epub 2006 Mar 14.
17. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Oku H, etal., Eur J Pharmacol. 2008 Aug 20;590(1-3):400-8. Epub 2008 Jun 16.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Protection against influenza infection by cytokine-enhanced aerosol genetic immunization. Orson FM, etal., J Gene Med. 2006 Apr;8(4):488-97.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. The IL12B gene is associated with asthma. Randolph AG, etal., Am J Hum Genet. 2004 Oct;75(4):709-15. Epub 2004 Aug 20.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17. Rice L, etal., J Infect Dis. 2005 Apr 15;191(8):1368-76. Epub 2005 Mar 3.
27. Is IL12 necessary in experimental hypersensitivity pneumonitis? Schuyler M, etal., Int J Exp Pathol. 2002 Apr;83(2):87-98.
28. Mechanistic investigation of immunosuppression in patients with condyloma acuminata. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
29. Association of cytokine gene polymorphisms with chronic obstructive pulmonary disease in Macedonians. Trajkov D, etal., Iran J Allergy Asthma Immunol. 2009 Mar;8(1):31-42.
30. Preliminary data suggesting production of interleukin-12 by rat Leydig cells cultured in vitro. Valenti S, etal., Ann N Y Acad Sci. 1999 Jun 22;876:259-61.
31. Nociceptive effect of subcutaneously injected interleukin-12 is mediated by endothelin (ET) acting on ETB receptors in rats. Verri WA Jr, etal., J Pharmacol Exp Ther. 2005 Nov;315(2):609-15. Epub 2005 Jul 15.
32. Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases. Wilder RL, etal., Transplant Proc 1999 May;31(3):1585-8
33. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. Wilson MS, etal., J Exp Med. 2010 Mar 15;207(3):535-52. Epub 2010 Feb 22.
34. Genetic immunotherapy of established tumours with adenoviral vectors transducing murine interleukin-12 (mIL12) subunits in a rat medullary thyroid carcinoma model. Zhang R and DeGroot LJ, Clin Endocrinol (Oxf). 2000 Jun;52(6):687-94.
35. [Effects of BCG-PSN on serum levels of IL-4 and IL-12 in patients with condyloma acuminatum]. Zuo CX, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Dec;29(6):690-2.
Additional References at PubMed
PMID:1673147   PMID:1674604   PMID:7527811   PMID:7690439   PMID:7903063   PMID:8992506   PMID:9348310   PMID:11023671   PMID:11057672   PMID:11114383   PMID:11737071   PMID:12023369  
PMID:12421946   PMID:12432235   PMID:12855817   PMID:12871593   PMID:14688363   PMID:15114670   PMID:15220916   PMID:15240714   PMID:15265908   PMID:15371491   PMID:15692051   PMID:15781254  
PMID:15843532   PMID:16236719   PMID:16482511   PMID:16751425   PMID:16942485   PMID:16949315   PMID:17277142   PMID:17475835   PMID:17888176   PMID:18025219   PMID:19050265   PMID:19088061  
PMID:19299163   PMID:19420081   PMID:19710466   PMID:19922500   PMID:20027291   PMID:20818394   PMID:21444916   PMID:21606371   PMID:23892723   PMID:26950239   PMID:30106099  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21028,888,832 - 28,903,802 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1028,893,008 - 28,902,903 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1033,646,865 - 33,656,254 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0102,185,271 - 2,194,657 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01028,617,471 - 28,626,860 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01030,034,447 - 30,048,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1030,038,709 - 30,048,085 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01029,868,367 - 29,882,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41029,558,955 - 29,568,331 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11029,560,003 - 29,569,378 (+)NCBI
Celera1028,372,232 - 28,381,601 (+)NCBICelera
Cytogenetic Map10q21NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385159,314,780 - 159,330,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5159,314,780 - 159,330,863 (-)EnsemblGRCh38hg38GRCh38
GRCh375158,741,788 - 158,757,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365158,674,369 - 158,690,059 (-)NCBINCBI36Build 36hg18NCBI36
Build 345158,674,368 - 158,690,059NCBI
Celera5154,772,647 - 154,788,337 (-)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5153,836,180 - 153,851,870 (-)NCBIHuRef
CHM1_15158,174,226 - 158,189,916 (-)NCBICHM1_1
T2T-CHM13v2.05159,843,275 - 159,858,983 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391144,290,890 - 44,305,504 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1144,290,890 - 44,304,860 (+)EnsemblGRCm39 Ensembl
GRCm381144,400,063 - 44,414,677 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1144,400,063 - 44,414,033 (+)EnsemblGRCm38mm10GRCm38
MGSCv371144,213,565 - 44,227,519 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361144,243,486 - 44,257,440 (+)NCBIMGSCv36mm8
Celera1149,032,464 - 49,046,411 (+)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1125.94NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540813,304,219 - 13,312,620 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540813,302,506 - 13,316,300 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan15152,640,499 - 152,656,293 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05154,706,467 - 154,722,231 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15161,323,402 - 161,339,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5161,325,303 - 161,335,381 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1451,178,637 - 51,194,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl451,183,568 - 51,193,228 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha451,076,678 - 51,086,695 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0451,613,430 - 51,629,329 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl451,613,283 - 51,629,335 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1451,447,354 - 51,457,365 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0451,553,170 - 51,563,187 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0452,069,793 - 52,079,810 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213105,602,399 - 105,617,640 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365154,056,214 - 4,065,076 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365154,056,214 - 4,066,121 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1664,143,268 - 64,158,929 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11664,143,268 - 64,158,929 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21669,952,428 - 69,964,218 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12361,714,293 - 61,731,835 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603415,892,244 - 15,902,867 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473330,146,050 - 30,154,589 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473330,146,050 - 30,156,144 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Il12b
164 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:42
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)102795762634490668Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21028,896,656 - 28,897,391 (+)MAPPERmRatBN7.2
Rnor_6.01030,042,356 - 30,043,089NCBIRnor6.0
Rnor_5.01029,876,100 - 29,876,833UniSTSRnor5.0
RGSC_v3.41029,562,602 - 29,563,335UniSTSRGSC3.4
Celera1028,375,879 - 28,376,612UniSTS
Cytogenetic Map10q21UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 1 8 19 6 6
Below cutoff 2 6 18 15 15 2 3 3 6 13 5 2


RefSeq Acc Id: ENSRNOT00000005898   ⟹   ENSRNOP00000005898
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1028,893,008 - 28,902,903 (+)Ensembl
Rnor_6.0 Ensembl1030,038,709 - 30,048,085 (+)Ensembl
RefSeq Acc Id: NM_022611   ⟹   NP_072133
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21028,888,906 - 28,903,802 (+)NCBI
Rnor_6.01030,038,709 - 30,048,085 (+)NCBI
Rnor_5.01029,868,367 - 29,882,535 (+)NCBI
RGSC_v3.41029,558,955 - 29,568,331 (+)RGD
Celera1028,372,232 - 28,381,601 (+)RGD
RefSeq Acc Id: XM_039086799   ⟹   XP_038942727
Rat AssemblyChrPosition (strand)Source
mRatBN7.21028,888,832 - 28,901,804 (+)NCBI
Protein Sequences
Protein RefSeqs NP_072133 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942727 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA52229 (Get FASTA)   NCBI Sequence Viewer  
  AAD24190 (Get FASTA)   NCBI Sequence Viewer  
  EDM04146 (Get FASTA)   NCBI Sequence Viewer  
  EDM04147 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005898
RefSeq Acc Id: NP_072133   ⟸   NM_022611
- Peptide Label: precursor
- UniProtKB: G3V9Y5 (UniProtKB/TrEMBL),   A6HDP1 (UniProtKB/TrEMBL),   E9PU71 (UniProtKB/TrEMBL),   Q9R278 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005898   ⟸   ENSRNOT00000005898
RefSeq Acc Id: XP_038942727   ⟸   XM_039086799
- Peptide Label: isoform X2
- UniProtKB: Q9R278 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PU71-F1-model_v2 AlphaFold E9PU71 1-335 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628704 AgrOrtholog
BioCyc Gene G2FUF-25405 BioCyc
Ensembl Genes ENSRNOG00000004380 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005898 ENTREZGENE
  ENSRNOT00000005898.7 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Hematopoietin_rcpt_L_F3_CS UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  IL_12_beta UniProtKB/TrEMBL
  Interleukin-12_bsu_cen-dom UniProtKB/TrEMBL
KEGG Report rno:64546 UniProtKB/TrEMBL
Pfam IL12p40_C UniProtKB/TrEMBL
PhenoGen Il12b PhenoGen
PIRSF IL_12_beta UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004380 RatGTEx
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  Q62712_RAT UniProtKB/TrEMBL
UniProt Secondary G3V9Y5 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-29 Il12b  interleukin 12B  Il12b  interleukin 12b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Il12b  interleukin 12b      Symbol and Name status set to approved 1299863 APPROVED
2003-04-14 Il12b  interleukin 12b  Il12  Interleukin 12  Data merged from RGD:61304 628472 PENDING
2003-02-27 Il12b  interleukin 12b      Symbol and Name status set to provisional 70820 PROVISIONAL
2001-08-29 Il12  Interleukin 12      Symbol updated 68687 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology shows 92% and 65% identity to mouse and human homologs 633120
gene_transcript contains six exons and five introns 633120