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Gene: Il12b (interleukin 12B) Rattus norvegicus
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Symbol: Il12b
Name: interleukin 12B
Description: Exhibits interleukin-12 alpha subunit binding activity and protein heterodimerization activity. Predicted to contribute to cytokine activity; growth factor activity; and interleukin-23 receptor binding activity. Involved in natural killer cell activation involved in immune response and sensory perception of pain. Localizes to the interleukin-12 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; primary immunodeficiency disease; and salmonellosis. Orthologous to human IL12B (interleukin 12B); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Il12; Interleukin 12; interleukin-12 p40; interleukin-12 p40 precursor; interleukin-12 subunit beta
Orthologs:
Homo sapiens (human) : IL12B (interleukin 12B)  HGNC  Alliance
Mus musculus (house mouse) : Il12b (interleukin 12b)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il12b (interleukin 12B)
Pan paniscus (bonobo/pygmy chimpanzee) : IL12B (interleukin 12B)
Canis lupus familiaris (dog) : IL12B (interleukin 12B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il12b (interleukin 12B)
Sus scrofa (pig) : IL12B (interleukin 12B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01030,034,447 - 30,048,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01029,868,367 - 29,882,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41029,558,955 - 29,568,331 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11029,560,003 - 29,569,378 (+)NCBI
Celera1028,372,232 - 28,381,601 (+)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Il12b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628704
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.