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Mapping autoimmunity genes.

Authors: Griffiths, M M  Encinas, J A  Remmers, E F  Kuchroo, V K  Wilder, R L 
Citation: Griffiths MM, etal., Curr Opin Immunol. 1999 Dec;11(6):689-700.
Pubmed: (View Article at PubMed) PMID:10631556

Rat and mouse models for the major human autoimmune/inflammatory diseases are under intense genetic scrutiny. Genome-wide linkage studies reveal that each model is regulated by multiple genetic loci. Many of these loci colocalize to homologous genomic regions associated with several different autoimmune diseases of mice, rats and humans. Candidate genes are being identified. Polymorphic alleles associated with these chromosomal segments may represent predisposing genetic elements common to a number of human diseases with very different clinical presentations.


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RGD Object Information
RGD ID: 61065
Created: 2000-12-21
Species: All species
Last Modified: 2017-01-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.