IL12B (interleukin 12B) - Rat Genome Database
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Gene: IL12B (interleukin 12B) Homo sapiens
Analyze
Symbol: IL12B
Name: interleukin 12B
RGD ID: 1353629
HGNC Page HGNC
Description: Exhibits identical protein binding activity; interleukin-12 alpha subunit binding activity; and protein heterodimerization activity. Contributes to cytokine activity; growth factor activity; and interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of lymphocyte proliferation; positive regulation of peptidyl-tyrosine phosphorylation; and regulation of cytokine production. Localizes to interleukin-12 complex and interleukin-23 complex. Implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Biomarker of anogenital venereal wart.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CLMF; CLMF p40; CLMF2; cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; IL-12B; IL12, subunit p40; IMD28; IMD29; interleukin 12, p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; interleukin-12 subunit beta; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5159,314,783 - 159,330,887 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl5159,314,780 - 159,330,487 (-)EnsemblGRCh38hg38GRCh38
GRCh385159,314,780 - 159,330,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375158,741,788 - 158,757,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365158,674,369 - 158,690,059 (-)NCBINCBI36hg18NCBI36
Build 345158,674,368 - 158,690,059NCBI
Celera5154,772,647 - 154,788,337 (-)NCBI
Cytogenetic Map5q33.3NCBI
HuRef5153,836,180 - 153,851,870 (-)NCBIHuRef
CHM1_15158,174,226 - 158,189,916 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(R)-mevalonic acid  (ISO)
(S)-nicotine  (ISO)
1,3,5-trinitrobenzene  (ISO)
1,4-benzoquinone  (EXP)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-tert-butylhydroquinone  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-methylhistamine  (EXP)
4-nitroquinoline N-oxide  (ISO)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
8-OH-DPAT  (EXP)
9-cis-retinoic acid  (EXP,ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
adenosine  (ISO)
adenosine 5'-[gamma-thio]triphosphate  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
Aflatoxin G1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alloxan  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiloride  (ISO)
ammonium chloride  (ISO)
anandamide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthranilic acid  (EXP)
antimony(0)  (ISO)
arachidonic acid  (EXP)
arsenite(3-)  (EXP,ISO)
ATP  (EXP)
azathioprine  (EXP)
Benzamil  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucan  (EXP)
betulin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
Brevetoxin B  (EXP)
bromosulfophthalein  (ISO)
bryostatin 1  (EXP)
bucladesine  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (EXP)
carbamate ester  (EXP)
carbon monoxide  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
carvedilol  (EXP)
choline  (ISO)
ciprofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diazinon  (ISO)
dichlorine  (ISO)
diltiazem  (EXP)
Dimaprit  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
Erionite  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
ethylisopropylamiloride  (ISO)
eugenol  (ISO)
famotidine  (EXP)
farnesyl diphosphate  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
ferulic acid  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (EXP)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (ISO)
glucuronoxylomannan  (EXP)
glyburide  (ISO)
glycyrrhizinic acid  (ISO)
helenalin  (EXP)
histamine  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
Ibudilast  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isocyanates  (EXP)
isoniazide  (EXP)
isoprenaline  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lenalidomide  (ISO)
leukotriene B4  (ISO)
leukotriene D4  (EXP)
lipid As  (EXP)
lipoarabinomannan  (ISO)
lipophosphoglycan  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lupane  (EXP)
luteolin  (ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (EXP)
mercury dichloride  (ISO)
metam  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methyl 3,4,5-trihydroxybenzoate  (ISO)
methyl isothiocyanate  (ISO)
methylprednisolone aceponate  (EXP)
mifepristone  (EXP,ISO)
mometasone furoate  (EXP)
monodansylcadaverine  (ISO)
montelukast  (EXP)
morphine  (ISO)
muramyl dipeptide  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nadolol  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nicotine  (ISO)
nitric oxide  (EXP)
nonanoic acid  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
parathion  (ISO)
parthenolide  (EXP)
peptidoglycan  (EXP)
perfluorooctanoic acid  (ISO)
phenanthridone  (EXP)
phenethyl caffeate  (ISO)
phenylarsine oxide  (ISO)
phorbol 12,13-dibutanoate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phthalaldehyde  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP,ISO)
polymyxin B2  (ISO)
prednisolone  (ISO)
prednisone  (EXP)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
prostaglandin E2  (EXP,ISO)
protein kinase inhibitor  (EXP,ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
ranitidine  (EXP)
resiquimod  (EXP,ISO)
resveratrol  (EXP,ISO)
ribavirin  (EXP)
Ro 41-5253  (EXP)
rotenone  (EXP)
rottlerin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (EXP)
SB 203580  (EXP,ISO)
serotonin  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP)
sodium stibogluconate  (ISO)
soybean oil  (ISO)
SR 144528  (ISO)
streptozocin  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP)
suramin  (EXP)
thalidomide  (EXP,ISO)
theophylline  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
trichostatin A  (EXP)
trifluoperazine  (ISO)
trimellitic acid  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP)
tunicamycin  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
warfarin  (ISO)
wortmannin  (EXP)
zileuton  (EXP)
zinc dichloride  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell cycle arrest  (IDA)
cell migration  (IDA)
cell population proliferation  (IEA,ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to interferon-gamma  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cytokine-mediated signaling pathway  (IBA,TAS)
defense response to Gram-negative bacterium  (IDA)
defense response to protozoan  (IEA,ISO)
defense response to virus  (IEA,ISO)
interleukin-12-mediated signaling pathway  (TAS)
interleukin-23-mediated signaling pathway  (TAS)
natural killer cell activation  (IDA)
natural killer cell activation involved in immune response  (IEA,ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IGI)
negative regulation of inflammatory response to antigenic stimulus  (IEA,ISO)
negative regulation of interleukin-10 production  (IMP)
negative regulation of interleukin-17 production  (IDA)
negative regulation of protein secretion  (IGI)
negative regulation of smooth muscle cell proliferation  (IDA)
negative regulation of vascular endothelial growth factor signaling pathway  (IGI)
positive regulation of activated T cell proliferation  (IDA)
positive regulation of activation of Janus kinase activity  (IDA)
positive regulation of cell adhesion  (IDA)
positive regulation of defense response to virus by host  (IDA,ISO,ISS)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IDA)
positive regulation of inflammatory response  (IC)
positive regulation of interferon-gamma production  (IDA,ISO,TAS)
positive regulation of interleukin-10 production  (IDA,TAS)
positive regulation of interleukin-12 production  (IDA)
positive regulation of interleukin-17 production  (IDA)
positive regulation of lymphocyte proliferation  (IDA)
positive regulation of memory T cell differentiation  (ISS)
positive regulation of mononuclear cell proliferation  (IMP)
positive regulation of natural killer cell activation  (IC,IDA)
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target  (IDA)
positive regulation of natural killer cell proliferation  (IDA)
positive regulation of NIK/NF-kappaB signaling  (TAS)
positive regulation of NK T cell activation  (IC,IDA)
positive regulation of NK T cell proliferation  (IDA)
positive regulation of osteoclast differentiation  (IDA)
positive regulation of smooth muscle cell apoptotic process  (IDA)
positive regulation of T cell mediated cytotoxicity  (ISO,ISS)
positive regulation of T cell proliferation  (IDA,ISO)
positive regulation of T-helper 1 type immune response  (IDA,ISO,ISS)
positive regulation of T-helper 17 cell lineage commitment  (ISS)
positive regulation of T-helper 17 type immune response  (ISS)
positive regulation of tissue remodeling  (IC)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
regulation of cytokine production  (TAS)
regulation of tyrosine phosphorylation of STAT protein  (IDA)
response to organic substance  (ISO)
response to UV-B  (IDA)
sensory perception of pain  (IEA,ISO)
sexual reproduction  (TAS)
T-helper 1 type immune response  (TAS)
T-helper cell differentiation  (IDA)

Cellular Component

References

References - curated
1. Altare F, etal., J Clin Invest. 1998 Dec 15;102(12):2035-40.
2. GOA_HUMAN data from the GO Consortium
3. He D, etal., Liver Int. 2015 Aug;35(8):1941-9. doi: 10.1111/liv.12756. Epub 2015 Jan 21.
4. Hirota T, etal., J Allergy Clin Immunol. 2005 Oct;116(4):789-95. Epub 2005 Aug 8.
5. Houldsworth A, etal., J Interferon Cytokine Res. 2005 May;25(5):271-6. doi: 10.1089/jir.2005.25.271.
6. Markovic M, etal., Mol Immunol. 2009 Nov;47(1):141-6. Epub 2009 Feb 23.
7. Morahan G, etal., Lancet. 2002 Aug 10;360(9331):455-9.
8. Mukherjee T, etal., J Infect Dis. 2019 May 5;219(11):1841-1851. doi: 10.1093/infdis/jiz009.
9. Oku H, etal., Eur J Pharmacol. 2008 Aug 20;590(1-3):400-8. Epub 2008 Jun 16.
10. OMIM Disease Annotation Pipeline
11. Orson FM, etal., J Gene Med. 2006 Apr;8(4):488-97.
12. Pipeline to import KEGG annotations from KEGG into RGD
13. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Randolph AG, etal., Am J Hum Genet. 2004 Oct;75(4):709-15. Epub 2004 Aug 20.
15. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. RGD automated import pipeline for gene-chemical interactions
17. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
18. Rice L, etal., J Infect Dis. 2005 Apr 15;191(8):1368-76. Epub 2005 Mar 3.
19. Schuyler M, etal., Int J Exp Pathol. 2002 Apr;83(2):87-98.
20. Shi YJ, etal., Mol Med Rep. 2013 Aug;8(2):480-6. doi: 10.3892/mmr.2013.1511. Epub 2013 Jun 6.
21. Trajkov D, etal., Iran J Allergy Asthma Immunol. 2009 Mar;8(1):31-42.
22. Wilson MS, etal., J Exp Med. 2010 Mar 15;207(3):535-52. Epub 2010 Feb 22.
23. Zhang R and DeGroot LJ, Clin Endocrinol (Oxf). 2000 Jun;52(6):687-94.
24. Zuo CX, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Dec;29(6):690-2.
Additional References at PubMed
PMID:1358798   PMID:1673147   PMID:1674604   PMID:2070420   PMID:2204066   PMID:7527439   PMID:7527811   PMID:7565674   PMID:7695626   PMID:7698768   PMID:7836910   PMID:7843232  
PMID:7867080   PMID:7903063   PMID:8551218   PMID:8627017   PMID:8648753   PMID:8760829   PMID:8799158   PMID:8992506   PMID:9108403   PMID:9158092   PMID:9225992   PMID:9516412  
PMID:9603732   PMID:9603733   PMID:9671213   PMID:9700192   PMID:9712080   PMID:9789052   PMID:10207176   PMID:10320373   PMID:10352291   PMID:10419056   PMID:10890924   PMID:10899108  
PMID:11023671   PMID:11087201   PMID:11110796   PMID:11114383   PMID:11196715   PMID:11197695   PMID:11751963   PMID:11753820   PMID:11813133   PMID:11820460   PMID:11940489   PMID:11972887  
PMID:11978670   PMID:12023369   PMID:12065887   PMID:12086971   PMID:12100467   PMID:12117904   PMID:12117918   PMID:12202149   PMID:12207325   PMID:12270766   PMID:12297341   PMID:12370346  
PMID:12413772   PMID:12421946   PMID:12424624   PMID:12424627   PMID:12472178   PMID:12477932   PMID:12542496   PMID:12672403   PMID:12719551   PMID:12857749   PMID:12876411   PMID:12914676  
PMID:14551880   PMID:14597672   PMID:14675396   PMID:14679201   PMID:14746806   PMID:14764743   PMID:14962816   PMID:14976188   PMID:15004750   PMID:15007350   PMID:15057902   PMID:15102082  
PMID:15114670   PMID:15265908   PMID:15285014   PMID:15295696   PMID:15331709   PMID:15356557   PMID:15448160   PMID:15464247   PMID:15482860   PMID:15483662   PMID:15489334   PMID:15523691  
PMID:15603869   PMID:15620465   PMID:15644581   PMID:15837792   PMID:15858599   PMID:15869883   PMID:15937086   PMID:15941730   PMID:15988104   PMID:15993716   PMID:16005098   PMID:16039994  
PMID:16100774   PMID:16216674   PMID:16467190   PMID:16482511   PMID:16514412   PMID:16574246   PMID:16600026   PMID:16637265   PMID:16681592   PMID:16712658   PMID:16750991   PMID:16751425  
PMID:16772281   PMID:16789008   PMID:16942485   PMID:16948912   PMID:16966828   PMID:17077296   PMID:17148969   PMID:17152005   PMID:17172248   PMID:17207965   PMID:17236132   PMID:17327408  
PMID:17388919   PMID:17392024   PMID:17403771   PMID:17431094   PMID:17445208   PMID:17477815   PMID:17504509   PMID:17509455   PMID:17513774   PMID:17554261   PMID:17564777   PMID:17567674  
PMID:17579859   PMID:17587057   PMID:17644387   PMID:17653830   PMID:17703412   PMID:17846855   PMID:17881511   PMID:17888176   PMID:17889143   PMID:17901940   PMID:17932439   PMID:17945537  
PMID:17993580   PMID:17994425   PMID:18034172   PMID:18048021   PMID:18075513   PMID:18082575   PMID:18086266   PMID:18092318   PMID:18163209   PMID:18190588   PMID:18192685   PMID:18219280  
PMID:18240960   PMID:18300039   PMID:18319400   PMID:18341612   PMID:18367309   PMID:18369459   PMID:18383521   PMID:18389618   PMID:18413324   PMID:18422730   PMID:18438406   PMID:18449199  
PMID:18485489   PMID:18497679   PMID:18512797   PMID:18522869   PMID:18557702   PMID:18563338   PMID:18587394   PMID:18588591   PMID:18606709   PMID:18619507   PMID:18628242   PMID:18631256  
PMID:18632587   PMID:18633131   PMID:18675459   PMID:18676680   PMID:18680750   PMID:18703108   PMID:18717726   PMID:18800148   PMID:18821674   PMID:18827961   PMID:18834321   PMID:19012493  
PMID:19013323   PMID:19035472   PMID:19088061   PMID:19118071   PMID:19134014   PMID:19169254   PMID:19169255   PMID:19170196   PMID:19174780   PMID:19185507   PMID:19210338   PMID:19234184  
PMID:19247692   PMID:19249008   PMID:19258635   PMID:19258923   PMID:19262574   PMID:19264456   PMID:19274925   PMID:19328947   PMID:19342681   PMID:19419334   PMID:19422935   PMID:19435421  
PMID:19487916   PMID:19495883   PMID:19505916   PMID:19516896   PMID:19525409   PMID:19554267   PMID:19573080   PMID:19625176   PMID:19646340   PMID:19683555   PMID:19692168   PMID:19705136  
PMID:19733878   PMID:19760754   PMID:19773279   PMID:19773451   PMID:19782084   PMID:19819209   PMID:19832040   PMID:19838195   PMID:19860911   PMID:19861958   PMID:19913121   PMID:19956104  
PMID:20003322   PMID:20012528   PMID:20014019   PMID:20016509   PMID:20027291   PMID:20027321   PMID:20054003   PMID:20060272   PMID:20061784   PMID:20105444   PMID:20145925   PMID:20217072  
PMID:20236616   PMID:20237496   PMID:20331378   PMID:20349123   PMID:20350312   PMID:20371868   PMID:20372811   PMID:20387064   PMID:20395963   PMID:20399512   PMID:20416077   PMID:20428758  
PMID:20452482   PMID:20453000   PMID:20483637   PMID:20485444   PMID:20503287   PMID:20521253   PMID:20525402   PMID:20530519   PMID:20544370   PMID:20551083   PMID:20568250   PMID:20570966  
PMID:20621951   PMID:20628086   PMID:20653817   PMID:20653995   PMID:20658240   PMID:20673868   PMID:20705102   PMID:20711808   PMID:20714168   PMID:20716621   PMID:20802378   PMID:20811626  
PMID:20875078   PMID:20875477   PMID:20953186   PMID:20953188   PMID:20953190   PMID:21055733   PMID:21072187   PMID:21102463   PMID:21145044   PMID:21196650   PMID:21198744   PMID:21208785  
PMID:21278068   PMID:21297633   PMID:21310195   PMID:21321105   PMID:21339808   PMID:21351215   PMID:21397857   PMID:21443923   PMID:21470215   PMID:21513752   PMID:21567173   PMID:21623733  
PMID:21637332   PMID:21641076   PMID:21689404   PMID:21733366   PMID:21743469   PMID:21747388   PMID:21753150   PMID:21796650   PMID:21819616   PMID:21833088   PMID:21873635   PMID:21878338  
PMID:21972680   PMID:22005588   PMID:22011063   PMID:22045842   PMID:22070668   PMID:22144535   PMID:22190364   PMID:22194214   PMID:22296201   PMID:22327783   PMID:22383962   PMID:22384203  
PMID:22479607   PMID:22503230   PMID:22581790   PMID:22614250   PMID:22621617   PMID:22655069   PMID:22656398   PMID:22702905   PMID:22739501   PMID:22740240   PMID:22819329   PMID:22863216  
PMID:22897389   PMID:22930279   PMID:22940148   PMID:23006423   PMID:23028907   PMID:23053983   PMID:23065198   PMID:23065210   PMID:23071313   PMID:23093722   PMID:23099807   PMID:23103228  
PMID:23128233   PMID:23137633   PMID:23154183   PMID:23240095   PMID:23285955   PMID:23297015   PMID:23297419   PMID:23376980   PMID:23403235   PMID:23429356   PMID:23441821   PMID:23527200  
PMID:23573954   PMID:23575353   PMID:23578145   PMID:23600862   PMID:23621408   PMID:23665963   PMID:23679818   PMID:23717436   PMID:23722323   PMID:23734222   PMID:23755218   PMID:23817431  
PMID:23830516   PMID:23844553   PMID:23901045   PMID:23955419   PMID:23991654   PMID:24051922   PMID:24073214   PMID:24127073   PMID:24139871   PMID:24140476   PMID:24158609   PMID:24161121  
PMID:24365584   PMID:24418364   PMID:24522266   PMID:24529168   PMID:24547735   PMID:24568095   PMID:24654313   PMID:24748538   PMID:24782489   PMID:24796719   PMID:24808365   PMID:24859272  
PMID:24876666   PMID:24909386   PMID:24957500   PMID:25008917   PMID:25015728   PMID:25024369   PMID:25037175   PMID:25131111   PMID:25177683   PMID:25200154   PMID:25201764   PMID:25202013  
PMID:25234720   PMID:25292079   PMID:25406098   PMID:25445750   PMID:25447399   PMID:25456886   PMID:25469793   PMID:25548252   PMID:25550844   PMID:25563480   PMID:25613737   PMID:25614889  
PMID:25642632   PMID:25710036   PMID:25761185   PMID:25783557   PMID:25848976   PMID:25877925   PMID:25908236   PMID:25924204   PMID:25931203   PMID:25943894   PMID:25966091   PMID:25985710  
PMID:26000455   PMID:26062743   PMID:26103568   PMID:26104769   PMID:26116899   PMID:26239551   PMID:26302971   PMID:26375522   PMID:26387630   PMID:26430781   PMID:26472011   PMID:26516307  
PMID:26631030   PMID:26663019   PMID:26667304   PMID:26667837   PMID:26697414   PMID:26800664   PMID:26850223   PMID:26874795   PMID:26915668   PMID:26956584   PMID:26987707   PMID:27002606  
PMID:27058587   PMID:27059274   PMID:27068848   PMID:27081760   PMID:27108964   PMID:27111145   PMID:27119521   PMID:27148908   PMID:27155343   PMID:27191929   PMID:27211553   PMID:27223631  
PMID:27240992   PMID:27282560   PMID:27312970   PMID:27426943   PMID:27491770   PMID:27751764   PMID:27774749   PMID:27819525   PMID:27829679   PMID:27873456   PMID:27892456   PMID:27896842  
PMID:28051794   PMID:28127111   PMID:28160070   PMID:28219892   PMID:28229296   PMID:28276258   PMID:28287286   PMID:28325840   PMID:28595541   PMID:28596683   PMID:28697396   PMID:28697498  
PMID:28738472   PMID:28874185   PMID:28980933   PMID:29070909   PMID:29155516   PMID:29200018   PMID:29283074   PMID:29454820   PMID:29589181   PMID:29675399   PMID:29731755   PMID:29738836  
PMID:29754746   PMID:29763989   PMID:29997244   PMID:30069682   PMID:30106099   PMID:30443744   PMID:30554348   PMID:30584776   PMID:30865360   PMID:30889422   PMID:30917537   PMID:31131048  
PMID:31161840   PMID:31277552   PMID:31465608   PMID:31567936   PMID:31670094   PMID:31810916   PMID:31818255   PMID:32149085   PMID:32209656   PMID:32352837   PMID:32421725   PMID:32458622  
PMID:32464244   PMID:32620160   PMID:33180384  


Genomics

Comparative Map Data
IL12B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5159,314,783 - 159,330,887 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl5159,314,780 - 159,330,487 (-)EnsemblGRCh38hg38GRCh38
GRCh385159,314,780 - 159,330,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375158,741,788 - 158,757,495 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365158,674,369 - 158,690,059 (-)NCBINCBI36hg18NCBI36
Build 345158,674,368 - 158,690,059NCBI
Celera5154,772,647 - 154,788,337 (-)NCBI
Cytogenetic Map5q33.3NCBI
HuRef5153,836,180 - 153,851,870 (-)NCBIHuRef
CHM1_15158,174,226 - 158,189,916 (-)NCBICHM1_1
Il12b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391144,290,890 - 44,305,504 (+)NCBIGRCm39mm39
GRCm39 Ensembl1144,290,890 - 44,304,860 (+)Ensembl
GRCm381144,400,063 - 44,414,677 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1144,400,063 - 44,414,033 (+)EnsemblGRCm38mm10GRCm38
MGSCv371144,213,565 - 44,227,519 (+)NCBIGRCm37mm9NCBIm37
MGSCv361144,243,486 - 44,257,440 (+)NCBImm8
Celera1149,032,464 - 49,046,411 (+)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1125.94NCBI
Il12b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21028,888,832 - 28,903,796 (+)NCBI
Rnor_6.0 Ensembl1030,038,709 - 30,048,085 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01030,034,447 - 30,048,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01029,868,367 - 29,882,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41029,558,955 - 29,568,331 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11029,560,003 - 29,569,378 (+)NCBI
Celera1028,372,232 - 28,381,601 (+)NCBICelera
Cytogenetic Map10q21NCBI
Il12b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540813,304,219 - 13,312,620 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540813,302,506 - 13,316,300 (-)NCBIChiLan1.0ChiLan1.0
IL12B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15161,323,402 - 161,339,051 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5161,325,303 - 161,335,381 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05154,706,467 - 154,722,231 (-)NCBIMhudiblu_PPA_v0panPan3
IL12B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl451,183,568 - 51,193,228 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1451,178,637 - 51,194,606 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Il12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365154,056,214 - 4,066,121 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL12B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1664,147,247 - 64,158,952 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11664,143,268 - 64,158,929 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21669,952,428 - 69,964,218 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL12B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12361,714,293 - 61,731,835 (-)NCBI
Il12b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473330,146,050 - 30,156,144 (+)NCBI

Position Markers
D5S1480  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375144,143,718 - 144,143,948UniSTSGRCh37
Build 365144,123,911 - 144,124,141RGDNCBI36
Celera5140,225,129 - 140,225,359RGD
Cytogenetic Map5q31-q33UniSTS
Cytogenetic Map5q31.1-q33.1UniSTS
HuRef5139,291,236 - 139,291,451UniSTS
Marshfield Genetic Map5147.49UniSTS
Marshfield Genetic Map5147.49RGD
deCODE Assembly Map5146.55UniSTS
Whitehead-RH Map5462.6UniSTS
Whitehead-YAC Contig Map5 UniSTS
NCBI RH Map5891.6UniSTS
PMC321570P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375158,749,455 - 158,750,151UniSTSGRCh37
Build 365158,682,033 - 158,682,729RGDNCBI36
Celera5154,780,311 - 154,781,007RGD
Cytogenetic Map5q31.1-q33.1UniSTS
HuRef5153,843,843 - 153,844,539UniSTS
IL12B_146  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375158,741,766 - 158,742,416UniSTSGRCh37
Build 365158,674,344 - 158,674,994RGDNCBI36
Celera5154,772,622 - 154,773,272RGD
HuRef5153,836,155 - 153,836,804UniSTS
RH17728  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375158,741,943 - 158,742,123UniSTSGRCh37
Build 365158,674,521 - 158,674,701RGDNCBI36
Celera5154,772,799 - 154,772,979RGD
Cytogenetic Map5q31.1-q33.1UniSTS
HuRef5153,836,332 - 153,836,512UniSTS
GeneMap99-GB4 RH Map5594.37UniSTS
SGC35786  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375158,742,866 - 158,743,085UniSTSGRCh37
Build 365158,675,444 - 158,675,663RGDNCBI36
Celera5154,773,722 - 154,773,941RGD
Cytogenetic Map5q31.1-q33.1UniSTS
HuRef5153,837,254 - 153,837,473UniSTS
GeneMap99-GB4 RH Map5591.55UniSTS
Whitehead-RH Map5509.7UniSTS
NCBI RH Map5891.6UniSTS
G10637  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375158,741,814 - 158,742,022UniSTSGRCh37
Build 365158,674,392 - 158,674,600RGDNCBI36
Celera5154,772,670 - 154,772,878RGD
Cytogenetic Map5q31.1-q33.1UniSTS
HuRef5153,836,203 - 153,836,411UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:443
Count of miRNA genes:359
Interacting mature miRNAs:388
Transcripts:ENST00000231228
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1 23 2
Low 10 216 14 421 6 2 1 198 47 61 67 8 1
Below cutoff 945 878 791 299 921 157 1366 499 1964 237 782 1133 147 487 715

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_009618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC011418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF180563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF512686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY008847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY046592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY046593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY064126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF173865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA104591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP140700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M65272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M65290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U89323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000231228   ⟹   ENSP00000231228
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl5159,314,780 - 159,330,487 (-)Ensembl
RefSeq Acc Id: NM_002187   ⟹   NP_002178
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385159,314,780 - 159,330,487 (-)NCBI
GRCh375158,741,791 - 158,757,481 (-)ENTREZGENE
Build 365158,674,369 - 158,690,059 (-)NCBI Archive
HuRef5153,836,180 - 153,851,870 (-)ENTREZGENE
CHM1_15158,174,226 - 158,189,916 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002178   ⟸   NM_002187
- Peptide Label: precursor
- UniProtKB: P29460 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000231228   ⟸   ENST00000231228
Promoters
RGD ID:6803264
Promoter ID:HG_KWN:51669
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:NM_002187
Position:
Human AssemblyChrPosition (strand)Source
Build 365158,690,746 - 158,691,246 (-)MPROMDB
RGD ID:6871434
Promoter ID:EPDNEW_H8882
Type:multiple initiation site
Name:IL12B_1
Description:interleukin 12B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385159,330,487 - 159,330,547EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002187.2(IL12B):c.97G>A (p.Val33Ile) single nucleotide variant Immunodeficiency 29 [RCV000545923] Chr5:159323321 [GRCh38]
Chr5:158750329 [GRCh37]
Chr5:5q33.3
benign
NC_000005.10:g.(159317671_159317673)_(159322312_159322314)del deletion Immunodeficiency 29 [RCV000015097] Chr5:159317673..159322312 [GRCh38]
Chr5:5q31.1-q33.1
pathogenic
NM_002187.2(IL12B):c.320dup (p.Glu108fs) duplication Immunodeficiency 29 [RCV000015098] Chr5:159323097..159323098 [GRCh38]
Chr5:158750105..158750106 [GRCh37]
Chr5:5q33.3
pathogenic|conflicting interpretations of pathogenicity
IL12B, 4237G-A single nucleotide variant Asthma, severe, susceptibility to [RCV000015099] Chr5:5q31.1-q33.1 risk factor|uncertain significance
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3
pathogenic
GRCh38/hg38 5q33.1-34(chr5:152761187-167248053)x1 copy number loss See cases [RCV000052144] Chr5:152761187..167248053 [GRCh38]
Chr5:152140747..166675058 [GRCh37]
Chr5:152120940..166607636 [NCBI36]
Chr5:5q33.1-34
pathogenic
GRCh38/hg38 5q33.1-34(chr5:153195314-164014005)x1 copy number loss See cases [RCV000052145] Chr5:153195314..164014005 [GRCh38]
Chr5:152574874..163441011 [GRCh37]
Chr5:152555067..163373589 [NCBI36]
Chr5:5q33.1-34
pathogenic
NM_002187.2(IL12B):c.278G>A (p.Gly93Glu) single nucleotide variant Malignant melanoma [RCV000066812] Chr5:159323140 [GRCh38]
Chr5:158750148 [GRCh37]
Chr5:158682726 [NCBI36]
Chr5:5q33.3
not provided
GRCh38/hg38 5q33.3-35.3(chr5:156825512-181269805)x3 copy number gain See cases [RCV000133847] Chr5:156825512..181269805 [GRCh38]
Chr5:156252523..180696806 [GRCh37]
Chr5:156185101..180629412 [NCBI36]
Chr5:5q33.3-35.3
pathogenic
GRCh38/hg38 5q33.1-34(chr5:152443869-166104392)x1 copy number loss See cases [RCV000138282] Chr5:152443869..166104392 [GRCh38]
Chr5:151823430..165531397 [GRCh37]
Chr5:151803623..165463975 [NCBI36]
Chr5:5q33.1-34
pathogenic
GRCh38/hg38 5q33.3-34(chr5:158941354-164386760)x1 copy number loss See cases [RCV000138895] Chr5:158941354..164386760 [GRCh38]
Chr5:158368362..163813766 [GRCh37]
Chr5:158300940..163746344 [NCBI36]
Chr5:5q33.3-34
pathogenic
NM_002187.2(IL12B):c.298_305del (p.Ser100fs) deletion Immunodeficiency 29 [RCV000162204] Chr5:159323113..159323120 [GRCh38]
Chr5:158750121..158750128 [GRCh37]
Chr5:5q33.3
pathogenic
NM_002187.2(IL12B):c.*991del deletion Familial Atypical Mycobacteriosis, Autosomal Recessive [RCV000264186] Chr5:159315110 [GRCh38]
Chr5:158742118 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.738A>G (p.Leu246=) single nucleotide variant Immunodeficiency 29 [RCV000263626] Chr5:159318853 [GRCh38]
Chr5:158745861 [GRCh37]
Chr5:5q33.3
uncertain significance
GRCh37/hg19 5q33.2-35.1(chr5:154886174-169757448)x1 copy number loss See cases [RCV000240059] Chr5:154886174..169757448 [GRCh37]
Chr5:5q33.2-35.1
pathogenic
NM_002187.2(IL12B):c.*1095C>A single nucleotide variant Immunodeficiency 29 [RCV000267660] Chr5:159315006 [GRCh38]
Chr5:158742014 [GRCh37]
Chr5:5q33.3
benign
NM_002187.2(IL12B):c.*883C>A single nucleotide variant Immunodeficiency 29 [RCV000279408] Chr5:159315218 [GRCh38]
Chr5:158742226 [GRCh37]
Chr5:5q33.3
benign|likely benign
NM_002187.2(IL12B):c.300G>A (p.Ser100=) single nucleotide variant Immunodeficiency 29 [RCV000277010] Chr5:159323118 [GRCh38]
Chr5:158750126 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*901del deletion Familial Atypical Mycobacteriosis, Autosomal Recessive [RCV000373911] Chr5:159315200 [GRCh38]
Chr5:158742208 [GRCh37]
Chr5:5q33.3
benign
NM_002187.2(IL12B):c.536G>C (p.Arg179Thr) single nucleotide variant Immunodeficiency 29 [RCV000300179] Chr5:159320467 [GRCh38]
Chr5:158747475 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*225A>C single nucleotide variant Immunodeficiency 29 [RCV000398443] Chr5:159315876 [GRCh38]
Chr5:158742884 [GRCh37]
Chr5:5q33.3
benign|likely benign
NM_002187.2(IL12B):c.960C>T (p.Ser320=) single nucleotide variant Immunodeficiency 29 [RCV000399314] Chr5:159316712 [GRCh38]
Chr5:158743720 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.483-8G>C single nucleotide variant Immunodeficiency 29 [RCV000540689] Chr5:159320528 [GRCh38]
Chr5:158747536 [GRCh37]
Chr5:5q33.3
benign|likely benign
NM_002187.2(IL12B):c.*780G>A single nucleotide variant Immunodeficiency 29 [RCV000316557] Chr5:159315321 [GRCh38]
Chr5:158742329 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.892G>T (p.Val298Phe) single nucleotide variant Immunodeficiency 29 [RCV000531175] Chr5:159316780 [GRCh38]
Chr5:158743788 [GRCh37]
Chr5:5q33.3
benign|likely benign
NM_002187.2(IL12B):c.863G>C (p.Arg288Thr) single nucleotide variant Immunodeficiency 29 [RCV000970450] Chr5:159316809 [GRCh38]
Chr5:158743817 [GRCh37]
Chr5:5q33.3
benign|likely benign|uncertain significance
NM_002187.2(IL12B):c.*1016T>A single nucleotide variant Immunodeficiency 29 [RCV000358948] Chr5:159315085 [GRCh38]
Chr5:158742093 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*486A>G single nucleotide variant Immunodeficiency 29 [RCV000386364] Chr5:159315615 [GRCh38]
Chr5:158742623 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*408C>T single nucleotide variant Immunodeficiency 29 [RCV000292106] Chr5:159315693 [GRCh38]
Chr5:158742701 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*159A>C single nucleotide variant Immunodeficiency 29 [RCV000307367] Chr5:159315942 [GRCh38]
Chr5:158742950 [GRCh37]
Chr5:5q33.3
benign
NM_002187.2(IL12B):c.*746C>T single nucleotide variant Immunodeficiency 29 [RCV000389807] Chr5:159315355 [GRCh38]
Chr5:158742363 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*520C>T single nucleotide variant Immunodeficiency 29 [RCV000295529] Chr5:159315581 [GRCh38]
Chr5:158742589 [GRCh37]
Chr5:5q33.3
likely benign|uncertain significance
NM_002187.2(IL12B):c.*230C>T single nucleotide variant Immunodeficiency 29 [RCV000347000] Chr5:159315871 [GRCh38]
Chr5:158742879 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*497C>T single nucleotide variant Immunodeficiency 29 [RCV000350398] Chr5:159315604 [GRCh38]
Chr5:158742612 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*121dup duplication Familial Atypical Mycobacteriosis, Autosomal Recessive [RCV000343502] Chr5:159315979..159315980 [GRCh38]
Chr5:158742987..158742988 [GRCh37]
Chr5:5q33.3
uncertain significance
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
NM_002187.2(IL12B):c.*1232A>G single nucleotide variant Immunodeficiency 29 [RCV000362307] Chr5:159314869 [GRCh38]
Chr5:158741877 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.-29A>G single nucleotide variant Immunodeficiency 29 [RCV000332099] Chr5:159330460 [GRCh38]
Chr5:158757468 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*901dup duplication Familial Atypical Mycobacteriosis, Autosomal Recessive [RCV000319287] Chr5:159315199..159315200 [GRCh38]
Chr5:158742207..158742208 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*1272_*1275delATTT microsatellite Familial Atypical Mycobacteriosis, Autosomal Recessive [RCV000307793] Chr5:159314826..159314829 [GRCh38]
Chr5:158741834..158741837 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.*1082del deletion Familial Atypical Mycobacteriosis, Autosomal Recessive [RCV000322801] Chr5:159315019 [GRCh38]
Chr5:158742027 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.506C>T (p.Thr169Met) single nucleotide variant Immunodeficiency 29 [RCV000555413] Chr5:159320497 [GRCh38]
Chr5:158747505 [GRCh37]
Chr5:5q33.3
likely benign
NM_002187.3(IL12B):c.902G>A (p.Arg301His) single nucleotide variant Immunodeficiency 29 [RCV001151840] Chr5:159316770 [GRCh38]
Chr5:158743778 [GRCh37]
Chr5:5q33.3
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NM_002187.2(IL12B):c.925C>A (p.Arg309=) single nucleotide variant Immunodeficiency 29 [RCV000652135] Chr5:159316747 [GRCh38]
Chr5:158743755 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.973G>A (p.Val325Met) single nucleotide variant Immunodeficiency 29 [RCV000652136] Chr5:159316699 [GRCh38]
Chr5:158743707 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.247G>A (p.Gly83Arg) single nucleotide variant Immunodeficiency 29 [RCV000652137] Chr5:159323171 [GRCh38]
Chr5:158750179 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.612G>C (p.Glu204Asp) single nucleotide variant Immunodeficiency 29 [RCV000652138] Chr5:159320391 [GRCh38]
Chr5:158747399 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.227C>T (p.Thr76Ile) single nucleotide variant Immunodeficiency 29 [RCV000652139] Chr5:159323191 [GRCh38]
Chr5:158750199 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.620C>T (p.Pro207Leu) single nucleotide variant Immunodeficiency 29 [RCV000652140] Chr5:159320383 [GRCh38]
Chr5:158747391 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.327T>C (p.Asp109=) single nucleotide variant Immunodeficiency 29 [RCV000652141] Chr5:159323091 [GRCh38]
Chr5:158750099 [GRCh37]
Chr5:5q33.3
likely benign
NM_002187.2(IL12B):c.544G>A (p.Gly182Arg) single nucleotide variant Immunodeficiency 29 [RCV000652142] Chr5:159320459 [GRCh38]
Chr5:158747467 [GRCh37]
Chr5:5q33.3
likely benign
NM_002187.2(IL12B):c.283G>A (p.Glu95Lys) single nucleotide variant Immunodeficiency 29 [RCV000652143] Chr5:159323135 [GRCh38]
Chr5:158750143 [GRCh37]
Chr5:5q33.3
likely benign|conflicting interpretations of pathogenicity
NM_002187.2(IL12B):c.749G>A (p.Arg250Gln) single nucleotide variant Immunodeficiency 29 [RCV000652144]|not provided [RCV001091687] Chr5:159318842 [GRCh38]
Chr5:158745850 [GRCh37]
Chr5:5q33.3
likely benign|conflicting interpretations of pathogenicity|uncertain significance
NM_002187.2(IL12B):c.88+4A>G single nucleotide variant Immunodeficiency 29 [RCV000689179] Chr5:159326691 [GRCh38]
Chr5:158753699 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.703C>T (p.Pro235Ser) single nucleotide variant Immunodeficiency 29 [RCV000691948] Chr5:159318888 [GRCh38]
Chr5:158745896 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.259C>T (p.Gln87Ter) single nucleotide variant Immunodeficiency 29 [RCV000692446] Chr5:159323159 [GRCh38]
Chr5:158750167 [GRCh37]
Chr5:5q33.3
pathogenic
NM_002187.2(IL12B):c.961G>A (p.Glu321Lys) single nucleotide variant Immunodeficiency 29 [RCV000706739] Chr5:159316711 [GRCh38]
Chr5:158743719 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.585_587delGGA microsatellite Immunodeficiency 29 [RCV000704860] Chr5:159320416..159320418 [GRCh38]
Chr5:158747424..158747426 [GRCh37]
Chr5:5q33.3
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q33.2-35.3(chr5:155344802-180693344)x3 copy number gain not provided [RCV000745284] Chr5:155344802..180693344 [GRCh37]
Chr5:5q33.2-35.3
pathogenic
NM_002187.3(IL12B):c.282C>A (p.Gly94=) single nucleotide variant not provided [RCV000943723] Chr5:159323136 [GRCh38]
Chr5:158750144 [GRCh37]
Chr5:5q33.3
likely benign
NM_002187.3(IL12B):c.922G>A (p.Val308Met) single nucleotide variant Immunodeficiency 29 [RCV001035273] Chr5:159316750 [GRCh38]
Chr5:158743758 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.134T>C (p.Met45Thr) single nucleotide variant Immunodeficiency 29 [RCV001068636] Chr5:159323284 [GRCh38]
Chr5:158750292 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.24C>T (p.Ile8=) single nucleotide variant Immunodeficiency 29 [RCV000897764] Chr5:159326759 [GRCh38]
Chr5:158753767 [GRCh37]
Chr5:5q33.3
likely benign
NM_002187.2(IL12B):c.660T>A (p.Tyr220Ter) single nucleotide variant Immunodeficiency 29 [RCV000779470] Chr5:159320343 [GRCh38]
Chr5:158747351 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.881C>T (p.Thr294Ile) single nucleotide variant Immunodeficiency 29 [RCV000804970] Chr5:159316791 [GRCh38]
Chr5:158743799 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.500G>A (p.Gly167Glu) single nucleotide variant Immunodeficiency 29 [RCV000800087] Chr5:159320503 [GRCh38]
Chr5:158747511 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.301C>T (p.Leu101Phe) single nucleotide variant Immunodeficiency 29 [RCV000821979] Chr5:159323117 [GRCh38]
Chr5:158750125 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.299C>T (p.Ser100Leu) single nucleotide variant Immunodeficiency 29 [RCV000813296] Chr5:159323119 [GRCh38]
Chr5:158750127 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.2(IL12B):c.70T>C (p.Trp24Arg) single nucleotide variant Immunodeficiency 29 [RCV000795785] Chr5:159326713 [GRCh38]
Chr5:158753721 [GRCh37]
Chr5:5q33.3
uncertain significance
GRCh37/hg19 5q33.3(chr5:158423338-159076314)x3 copy number gain not provided [RCV000848661] Chr5:158423338..159076314 [GRCh37]
Chr5:5q33.3
uncertain significance
GRCh37/hg19 5q33.3-35.1(chr5:156597181-171166353)x3 copy number gain not provided [RCV000845588] Chr5:156597181..171166353 [GRCh37]
Chr5:5q33.3-35.1
pathogenic
NM_002187.3(IL12B):c.900C>A (p.Cys300Ter) single nucleotide variant Immunodeficiency 29 [RCV001246117] Chr5:159316772 [GRCh38]
Chr5:158743780 [GRCh37]
Chr5:5q33.3
pathogenic
NM_002187.3(IL12B):c.87T>C (p.Asp29=) single nucleotide variant Immunodeficiency 29 [RCV001225029] Chr5:159326696 [GRCh38]
Chr5:158753704 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.937C>T (p.Arg313Cys) single nucleotide variant Immunodeficiency 29 [RCV001210288] Chr5:159316735 [GRCh38]
Chr5:158743743 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.855G>T (p.Lys285Asn) single nucleotide variant Immunodeficiency 29 [RCV001201429] Chr5:159318736 [GRCh38]
Chr5:158745744 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.*696C>G single nucleotide variant Immunodeficiency 29 [RCV001157285] Chr5:159315405 [GRCh38]
Chr5:158742413 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.*840G>A single nucleotide variant Immunodeficiency 29 [RCV001155620] Chr5:159315261 [GRCh38]
Chr5:158742269 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.522A>G (p.Thr174=) single nucleotide variant not provided [RCV000927641] Chr5:159320481 [GRCh38]
Chr5:158747489 [GRCh37]
Chr5:5q33.3
likely benign
NM_002187.3(IL12B):c.483-6C>T single nucleotide variant Immunodeficiency 29 [RCV000909843] Chr5:159320526 [GRCh38]
Chr5:158747534 [GRCh37]
Chr5:5q33.3
likely benign
NM_002187.3(IL12B):c.642C>T (p.Ala214=) single nucleotide variant Immunodeficiency 29 [RCV000905378] Chr5:159320361 [GRCh38]
Chr5:158747369 [GRCh37]
Chr5:5q33.3
likely benign
NM_002187.3(IL12B):c.677G>A (p.Ser226Asn) single nucleotide variant Immunodeficiency 29 [RCV000973979] Chr5:159320326 [GRCh38]
Chr5:158747334 [GRCh37]
Chr5:5q33.3
benign
NM_002187.3(IL12B):c.555G>A (p.Lys185=) single nucleotide variant not provided [RCV000928755] Chr5:159320448 [GRCh38]
Chr5:158747456 [GRCh37]
Chr5:5q33.3
likely benign
NM_002187.3(IL12B):c.200A>C (p.Glu67Ala) single nucleotide variant Immunodeficiency 29 [RCV001227278] Chr5:159323218 [GRCh38]
Chr5:158750226 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.*1G>A single nucleotide variant Immunodeficiency 29 [RCV001151839] Chr5:159316100 [GRCh38]
Chr5:158743108 [GRCh37]
Chr5:5q33.3
benign
NM_002187.3(IL12B):c.*957C>T single nucleotide variant Immunodeficiency 29 [RCV001155619] Chr5:159315144 [GRCh38]
Chr5:158742152 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.*395A>T single nucleotide variant Immunodeficiency 29 [RCV001157287] Chr5:159315706 [GRCh38]
Chr5:158742714 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.*324T>C single nucleotide variant Immunodeficiency 29 [RCV001157288] Chr5:159315777 [GRCh38]
Chr5:158742785 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.483-6C>G single nucleotide variant Immunodeficiency 29 [RCV001207038] Chr5:159320526 [GRCh38]
Chr5:158747534 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.669C>T (p.Tyr223=) single nucleotide variant Immunodeficiency 29 [RCV000956350] Chr5:159320334 [GRCh38]
Chr5:158747342 [GRCh37]
Chr5:5q33.3
benign
GRCh37/hg19 5q33.3-34(chr5:157801321-162780186)x1 copy number loss not provided [RCV001005747] Chr5:157801321..162780186 [GRCh37]
Chr5:5q33.3-34
pathogenic
NM_002187.3(IL12B):c.415C>T (p.Arg139Cys) single nucleotide variant Immunodeficiency 29 [RCV001155701] Chr5:159322461 [GRCh38]
Chr5:158749469 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.105G>A (p.Leu35=) single nucleotide variant Immunodeficiency 29 [RCV001155702] Chr5:159323313 [GRCh38]
Chr5:158750321 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.872C>T (p.Thr291Met) single nucleotide variant Immunodeficiency 29 [RCV001153083] Chr5:159316800 [GRCh38]
Chr5:158743808 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.643G>A (p.Val215Ile) single nucleotide variant Immunodeficiency 29 [RCV001153085] Chr5:159320360 [GRCh38]
Chr5:158747368 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.822C>T (p.Cys274=) single nucleotide variant Immunodeficiency 29 [RCV001153084] Chr5:159318769 [GRCh38]
Chr5:158745777 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.*984A>T single nucleotide variant Immunodeficiency 29 [RCV001155618] Chr5:159315117 [GRCh38]
Chr5:158742125 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.823G>A (p.Val275Ile) single nucleotide variant Immunodeficiency 29 [RCV001041727] Chr5:159318768 [GRCh38]
Chr5:158745776 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.511G>A (p.Gly171Arg) single nucleotide variant Immunodeficiency 29 [RCV001229593] Chr5:159320492 [GRCh38]
Chr5:158747500 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.*293G>A single nucleotide variant Immunodeficiency 29 [RCV001151838] Chr5:159315808 [GRCh38]
Chr5:158742816 [GRCh37]
Chr5:5q33.3
likely benign
NM_002187.3(IL12B):c.30G>A (p.Trp10Ter) single nucleotide variant Immunodeficiency 29 [RCV001050613] Chr5:159326753 [GRCh38]
Chr5:158753761 [GRCh37]
Chr5:5q33.3
pathogenic
NM_002187.3(IL12B):c.*1036C>T single nucleotide variant Immunodeficiency 29 [RCV001155617] Chr5:159315065 [GRCh38]
Chr5:158742073 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.938G>T (p.Arg313Leu) single nucleotide variant Immunodeficiency 29 [RCV001234314] Chr5:159316734 [GRCh38]
Chr5:158743742 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.*437A>G single nucleotide variant Immunodeficiency 29 [RCV001157286] Chr5:159315664 [GRCh38]
Chr5:158742672 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.890C>T (p.Thr297Met) single nucleotide variant Immunodeficiency 29 [RCV001064141] Chr5:159316782 [GRCh38]
Chr5:158743790 [GRCh37]
Chr5:5q33.3
uncertain significance
GRCh37/hg19 5q33.3-35.1(chr5:156347980-169959880)x1 copy number loss not provided [RCV001005746] Chr5:156347980..169959880 [GRCh37]
Chr5:5q33.3-35.1
pathogenic
NM_002187.3(IL12B):c.*1312T>A single nucleotide variant Immunodeficiency 29 [RCV001152970] Chr5:159314789 [GRCh38]
Chr5:158741797 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.*1069G>T single nucleotide variant Immunodeficiency 29 [RCV001152971] Chr5:159315032 [GRCh38]
Chr5:158742040 [GRCh37]
Chr5:5q33.3
uncertain significance
NM_002187.3(IL12B):c.674G>T (p.Ser225Ile) single nucleotide variant Immunodeficiency 29 [RCV001056375] Chr5:159320329 [GRCh38]
Chr5:158747337 [GRCh37]
Chr5:5q33.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5970 AgrOrtholog
COSMIC IL12B COSMIC
Ensembl Genes ENSG00000113302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000231228 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000231228 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000113302 GTEx
HGNC ID HGNC:5970 ENTREZGENE
Human Proteome Map IL12B Human Proteome Map
InterPro FN3_dom UniProtKB/Swiss-Prot
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hematopoietin_rcpt_L_F3_CS UniProtKB/Swiss-Prot
  Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot
  IL-12_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-12_beta_cen-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3593 UniProtKB/Swiss-Prot
NCBI Gene 3593 ENTREZGENE
OMIM 161561 OMIM
  614890 OMIM
PANTHER PTHR23036:SF156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL12p40_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB IL12B RGD, PharmGKB
PIRSF IL_12_beta UniProtKB/Swiss-Prot
PRINTS INTRLEUKN12B UniProtKB/Swiss-Prot
PROSITE FN3 UniProtKB/Swiss-Prot
  HEMATOPO_REC_L_F3 UniProtKB/Swiss-Prot
  IG_LIKE UniProtKB/Swiss-Prot
SMART IGc2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0C5PF30_HUMAN UniProtKB/TrEMBL
  A0A0C5PF35_HUMAN UniProtKB/TrEMBL
  A0A0C5PMG4_HUMAN UniProtKB/TrEMBL
  A0A0C5PP83_HUMAN UniProtKB/TrEMBL
  A0A0C5PP88_HUMAN UniProtKB/TrEMBL
  A0A0C5PS98_HUMAN UniProtKB/TrEMBL
  A0A0C5PSA9_HUMAN UniProtKB/TrEMBL
  A0A0C5Q0B8_HUMAN UniProtKB/TrEMBL
  A0A0C5Q0C2_HUMAN UniProtKB/TrEMBL
  A0A0C5Q0C7_HUMAN UniProtKB/TrEMBL
  IL12B_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-15 IL12B  interleukin 12B  IL12B  interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)  Symbol and/or name change 5135510 APPROVED