Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: IL12B (interleukin 12B) Homo sapiens
Analyze
Symbol: IL12B
Name: interleukin 12B
Description: Exhibits identical protein binding activity; interleukin-12 alpha subunit binding activity; and protein heterodimerization activity. Contributes to cytokine activity; growth factor activity; and interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of lymphocyte proliferation; and positive regulation of receptor signaling pathway via JAK-STAT. Localizes to the interleukin-12 complex and interleukin-23 complex. Implicated in asthma; chronic obstructive pulmonary disease; primary immunodeficiency disease; and salmonellosis. Biomarker of anogenital venereal wart.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CLMF; CLMF p40; CLMF2; cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; IL-12B; IL12, subunit p40; IMD28; IMD29; interleukin 12, p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; interleukin-12 subunit beta; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF; NKSF2
Orthologs:
Mus musculus (house mouse) : Il12b (interleukin 12b)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il12b (interleukin 12B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il12b (interleukin 12B)
Pan paniscus (bonobo/pygmy chimpanzee) : IL12B (interleukin 12B)
Canis lupus familiaris (dog) : IL12B (interleukin 12B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il12b (interleukin 12B)
Sus scrofa (pig) : IL12B (interleukin 12B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385159,314,780 - 159,330,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375158,741,791 - 158,757,481 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365158,674,369 - 158,690,059 (-)NCBINCBI36hg18NCBI36
Build 345158,674,368 - 158,690,059NCBI
Celera5154,772,647 - 154,788,337 (-)NCBI
Cytogenetic Map5q33.3NCBI
HuRef5153,836,180 - 153,851,870 (-)NCBIHuRef
CHM1_15158,174,226 - 158,189,916 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on IL12B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353629
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.