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Gene: Il12b (interleukin 12b) Mus musculus
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Symbol: Il12b
Name: interleukin 12b
Description: Exhibits interleukin-12 alpha subunit binding activity and protein homodimerization activity. Contributes to cytokine activity and cytokine receptor binding activity. Involved in several processes, including defense response to other organism; positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and regulation of defense response. Localizes to several cellular components, including the cell surface; interleukin-12 complex; and interleukin-23 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; primary immunodeficiency disease; and salmonellosis. Is expressed in colon. Orthologous to human IL12B (interleukin 12B).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CLMF p40; cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 p40; IL-12 p40 subunit; IL-12 subunit p40; Il-12b; Il-12p40; IL-23 subunit p40; Il12p40; interleukin-12 p40 subunit; interleukin-12 subunit beta; p40
Orthologs:
Homo sapiens (human) : IL12B (interleukin 12B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il12b (interleukin 12B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il12b (interleukin 12B)
Pan paniscus (bonobo/pygmy chimpanzee) : IL12B (interleukin 12B)
Canis lupus familiaris (dog) : IL12B (interleukin 12B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il12b (interleukin 12B)
Sus scrofa (pig) : IL12B (interleukin 12B)
Chlorocebus sabaeus (African green monkey) : IL12B (interleukin 12B)
Heterocephalus glaber (naked mole-rat) : Il12b (interleukin 12B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1144,400,063 - 44,414,033 (+)Ensembl
GRCm381144,400,063 - 44,414,677 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371144,213,565 - 44,227,519 (+)NCBIGRCm37mm9NCBIm37
MGSCv361144,243,486 - 44,257,440 (+)NCBImm8
Celera1149,032,464 - 49,047,071 (+)NCBICelera
Cytogenetic Map11 B1.1NCBI
cM Map1125.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Il12b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732857
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.