Adam19 (ADAM metallopeptidase domain 19) - Rat Genome Database

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Gene: Adam19 (ADAM metallopeptidase domain 19) Rattus norvegicus
Analyze
Symbol: Adam19
Name: ADAM metallopeptidase domain 19
RGD ID: 1585017
Description: Predicted to enable SH3 domain binding activity and metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in several processes, including amyloid precursor protein catabolic process; positive regulation of cell-cell adhesion mediated by cadherin; and proteolysis. Predicted to act upstream of or within heart development. Predicted to be located in Golgi apparatus and nucleus. Orthologous to human ADAM19 (ADAM metallopeptidase domain 19); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 19 (meltrin beta); a disintegrin and metalloproteinase domain 19 (meltrin beta); a disintegrin and metalloproteinase domain 19 (meltrin beta) (mapped); Adam19_mapped; disintegrin and metalloproteinase domain-containing protein 19; LOC303068; meltrin beta; Sox30; SRY-box containing gene 30
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21030,491,362 - 30,583,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1030,491,405 - 30,583,105 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,218,634 - 35,310,362 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0103,757,069 - 3,848,808 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01030,193,020 - 30,284,822 (+)NCBIRnor_WKY
Rnor_6.01031,146,107 - 31,240,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,146,107 - 31,240,582 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01030,966,982 - 31,059,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,190,242 - 31,282,773 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11031,117,503 - 31,279,676 (+)NCBI
Celera1029,944,988 - 30,036,150 (+)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methoxyethanol  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
menadione  (ISO)
methyl methanesulfonate  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
PD 0325901  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
potassium chromate  (ISO)
propanal  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
toluene  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. ADAMs: key components in EGFR signalling and development. Blobel CP Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43.
2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Meltrin beta (ADAM19) gene: cloning, mapping, and analysis of the regulatory region. Kurohara K, etal., Biochem Biophys Res Commun 2000 Apr 13;270(2):522-7.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Canonical transforming growth factor-ß signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. Ramdas V, etal., Am J Pathol. 2013 Dec;183(6):1885-1896. doi: 10.1016/j.ajpath.2013.08.027. Epub 2013 Oct 6.
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Roles of Meltrin beta /ADAM19 in the processing of neuregulin. Shirakabe K, etal., J Biol Chem. 2001 Mar 23;276(12):9352-8. Epub 2000 Dec 14.
11. Essential role for ADAM19 in cardiovascular morphogenesis. Zhou HM, etal., Mol Cell Biol. 2004 Jan;24(1):96-104.
Additional References at PubMed
PMID:11162584   PMID:12615925   PMID:14975714   PMID:19727588  


Genomics

Comparative Map Data
Adam19
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21030,491,362 - 30,583,115 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1030,491,405 - 30,583,105 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,218,634 - 35,310,362 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0103,757,069 - 3,848,808 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01030,193,020 - 30,284,822 (+)NCBIRnor_WKY
Rnor_6.01031,146,107 - 31,240,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,146,107 - 31,240,582 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01030,966,982 - 31,059,793 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,190,242 - 31,282,773 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11031,117,503 - 31,279,676 (+)NCBI
Celera1029,944,988 - 30,036,150 (+)NCBICelera
Cytogenetic Map10q21NCBI
ADAM19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385157,477,304 - 157,575,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5157,395,534 - 157,575,775 (-)EnsemblGRCh38hg38GRCh38
GRCh375156,904,312 - 157,002,783 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365156,836,890 - 156,935,346 (-)NCBINCBI36Build 36hg18NCBI36
Build 345156,836,890 - 156,935,346NCBI
Celera5152,930,875 - 153,029,355 (-)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5151,992,608 - 152,091,126 (-)NCBIHuRef
CHM1_15156,337,034 - 156,435,579 (-)NCBICHM1_1
T2T-CHM13v2.05157,996,322 - 158,094,808 (-)NCBIT2T-CHM13v2.0
Adam19
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391145,945,329 - 46,038,174 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1145,946,819 - 46,038,170 (+)EnsemblGRCm39 Ensembl
GRCm381146,054,502 - 46,147,347 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,055,992 - 46,147,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv371145,869,489 - 45,960,845 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361145,899,475 - 45,990,766 (+)NCBIMGSCv36mm8
Celera1150,642,938 - 50,736,472 (+)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1127.54NCBI
Adam19
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540811,654,630 - 11,745,262 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540811,651,298 - 11,746,391 (-)NCBIChiLan1.0ChiLan1.0
ADAM19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15159,494,786 - 159,593,171 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5159,494,786 - 159,593,171 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05152,839,326 - 152,972,741 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADAM19
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1452,650,077 - 52,733,299 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl452,650,162 - 52,729,843 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha452,541,667 - 52,625,395 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0453,085,204 - 53,169,651 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1452,912,670 - 52,996,321 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0453,019,009 - 53,102,828 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0453,536,728 - 53,619,997 (+)NCBIUU_Cfam_GSD_1.0
Adam19
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213107,151,126 - 107,234,001 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365155,603,095 - 5,683,347 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM19
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1665,715,517 - 65,814,758 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11665,715,445 - 65,814,761 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21671,570,083 - 71,669,354 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12359,867,949 - 59,966,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2359,867,596 - 59,966,802 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603417,663,866 - 17,762,545 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam19
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473331,858,450 - 31,944,893 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473331,857,795 - 31,944,252 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam19
335 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:480
Count of miRNA genes:240
Interacting mature miRNAs:319
Transcripts:ENSRNOT00000008184
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum total immunoglobulin E level (CMO:0001542)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)102795762634490668Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat

Markers in Region
D10Got50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21030,493,139 - 30,493,350 (+)MAPPERmRatBN7.2
Rnor_6.01031,147,834 - 31,148,044NCBIRnor6.0
Rnor_5.01030,968,709 - 30,968,919UniSTSRnor5.0
RGSC_v3.41031,191,968 - 31,192,179RGDRGSC3.4
RGSC_v3.41031,191,969 - 31,192,179UniSTSRGSC3.4
RGSC_v3.11031,193,018 - 31,193,228RGD
Celera1029,946,715 - 29,946,939UniSTS
RH 3.4 Map10339.01UniSTS
RH 3.4 Map10339.01RGD
RH 2.0 Map10343.7RGD
Cytogenetic Map10q21UniSTS
RH128156  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21030,582,820 - 30,583,032 (+)MAPPERmRatBN7.2
Rnor_6.01031,240,289 - 31,240,500NCBIRnor6.0
Rnor_5.01031,059,500 - 31,059,711UniSTSRnor5.0
RGSC_v3.41031,282,480 - 31,282,691UniSTSRGSC3.4
Celera1030,035,857 - 30,036,068UniSTS
RH 3.4 Map10318.8UniSTS
Cytogenetic Map10q21UniSTS
RH128894  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21030,577,761 - 30,577,960 (+)MAPPERmRatBN7.2
mRatBN7.21743,538,399 - 43,538,598 (+)MAPPERmRatBN7.2
Rnor_6.01745,613,981 - 45,614,179NCBIRnor6.0
Rnor_6.01031,235,230 - 31,235,428NCBIRnor6.0
Rnor_5.01757,856,187 - 57,856,385UniSTSRnor5.0
Rnor_5.01031,054,441 - 31,054,639UniSTSRnor5.0
RGSC_v3.41031,277,421 - 31,277,619UniSTSRGSC3.4
RGSC_v3.41751,192,709 - 51,192,907UniSTSRGSC3.4
Celera1752,940,820 - 52,941,018UniSTS
Celera1030,030,798 - 30,030,996UniSTS
Cytogenetic Map10q21UniSTS
Cytogenetic Map17q11UniSTS
AI431060  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21030,582,806 - 30,583,032 (+)MAPPERmRatBN7.2
Rnor_6.01031,240,275 - 31,240,500NCBIRnor6.0
Rnor_5.01031,059,486 - 31,059,711UniSTSRnor5.0
RGSC_v3.41031,282,466 - 31,282,691UniSTSRGSC3.4
Celera1030,035,843 - 30,036,068UniSTS
Cytogenetic Map10q21UniSTS
BF410193  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21030,568,386 - 30,568,499 (+)MAPPERmRatBN7.2
Rnor_6.01031,225,855 - 31,225,967NCBIRnor6.0
Rnor_5.01031,045,066 - 31,045,178UniSTSRnor5.0
RGSC_v3.41031,268,046 - 31,268,158UniSTSRGSC3.4
Celera1030,021,422 - 30,021,534UniSTS
Cytogenetic Map10q21UniSTS
AU049292  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21030,546,952 - 30,547,231 (+)MAPPERmRatBN7.2
Rnor_6.01031,204,426 - 31,204,704NCBIRnor6.0
Rnor_5.01031,023,637 - 31,023,915UniSTSRnor5.0
RGSC_v3.41031,246,616 - 31,246,894UniSTSRGSC3.4
Celera1029,999,995 - 30,000,273UniSTS
Cytogenetic Map10q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 14 6 19 6 2 2 64 22 33 11 2
Low 1 43 35 35 6 9 10 13 8 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008184   ⟹   ENSRNOP00000008184
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1030,491,446 - 30,583,105 (+)Ensembl
Rnor_6.0 Ensembl1031,146,107 - 31,240,582 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108861   ⟹   ENSRNOP00000077829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1030,491,405 - 30,582,988 (+)Ensembl
RefSeq Acc Id: NM_001160228   ⟹   NP_001153700
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21030,491,412 - 30,583,114 (+)NCBI
Rnor_6.01031,146,107 - 31,240,582 (+)NCBI
Rnor_5.01030,966,982 - 31,059,793 (+)NCBI
RGSC_v3.41031,190,242 - 31,282,773 (+)RGD
Celera1029,944,988 - 30,036,150 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085915   ⟹   XP_038941843
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21030,521,552 - 30,583,115 (+)NCBI
RefSeq Acc Id: XM_039085916   ⟹   XP_038941844
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21030,491,362 - 30,567,341 (+)NCBI
RefSeq Acc Id: XM_039085917   ⟹   XP_038941845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21030,562,771 - 30,583,115 (+)NCBI
RefSeq Acc Id: XR_005489807
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21030,491,362 - 30,583,115 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001153700 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941843 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941844 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941845 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04164 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001153700   ⟸   NM_001160228
- Peptide Label: precursor
- UniProtKB: D3ZPM7 (UniProtKB/TrEMBL),   A0A8I5Y236 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008184   ⟸   ENSRNOT00000008184
RefSeq Acc Id: XP_038941844   ⟸   XM_039085916
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038941843   ⟸   XM_039085915
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941845   ⟸   XM_039085917
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000077829   ⟸   ENSRNOT00000108861
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZPM7-F1-model_v2 AlphaFold D3ZPM7 1-920 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697123
Promoter ID:EPDNEW_R7648
Type:initiation region
Name:Adam19_1
Description:ADAM metallopeptidase domain 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01031,146,146 - 31,146,206EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585017 AgrOrtholog
BioCyc Gene G2FUF-25376 BioCyc
Ensembl Genes ENSRNOG00000042980 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008184.5 UniProtKB/TrEMBL
  ENSRNOP00000077829 ENTREZGENE
  ENSRNOP00000077829.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008184.7 UniProtKB/TrEMBL
  ENSRNOT00000108861 ENTREZGENE
  ENSRNOT00000108861.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM19 UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report rno:303068 UniProtKB/TrEMBL
NCBI Gene 303068 ENTREZGENE
PANTHER PTHR11905:SF19 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam19 PhenoGen
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
UniProt A0A8I5Y236 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPM7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-01-06 Adam19  ADAM metallopeptidase domain 19  Adam19  a disintegrin and metallopeptidase domain 19 (meltrin beta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-02 Adam19  a disintegrin and metallopeptidase domain 19 (meltrin beta)  Sox30_predicted  SRY-box containing gene 30 (predicted)  Data Merged 737654 APPROVED
2008-02-26 Adam19  a disintegrin and metallopeptidase domain 19 (meltrin beta)  Adam19  a disintegrin and metalloproteinase domain 19 (meltrin beta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-10 Adam19  a disintegrin and metalloproteinase domain 19 (meltrin beta)  Adam19_mapped  a disintegrin and metalloproteinase domain 19 (meltrin beta) (mapped)  Data Merged 737654 APPROVED
2006-11-19 Adam19_mapped  a disintegrin and metalloproteinase domain 19 (meltrin beta)(mapped)  Adam19  a disintegrin and metalloproteinase domain 19 (meltrin beta)  Symbol set to symbol_mapped, name set to name (mapped) 1582166 APPROVED
2006-11-19 Adam19  a disintegrin and metalloproteinase domain 19 (meltrin beta)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Sox30_predicted  SRY-box containing gene 30 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2004-02-26 Adam19  a disintegrin and metalloproteinase domain 19 (meltrin beta)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Adam19  a disintegrin and metalloproteinase domain 19 (meltrin beta)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_homology highly homologous to mouse Adam19 632493