Nipal4 (NIPA-like domain containing 4)

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Gene: Nipal4 (NIPA-like domain containing 4) Rattus norvegicus

Analyze

Symbol:

Nipal4

Name:

NIPA-like domain containing 4

RGD ID:

1309452

Description:

Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 6. Orthologous to human NIPAL4 (NIPA like domain containing 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC303070; magnesium transporter NIPA4; RGD1309452; similar to RIKEN cDNA 9530066K23

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NIPAL4 (NIPA like domain containing 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Nipal4 (NIPA-like domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nipal4 (NIPA like domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NIPAL4 (NIPA like domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NIPAL4 (NIPA like domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nipal4 (NIPA like domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NIPAL4 (NIPA like domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NIPAL4 (NIPA like domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nipal4 (NIPA like domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RFNG (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Nipal4 (NIPA-like domain containing 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NIPAL4 (NIPA like domain containing 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nipal4 (NIPA like domain containing 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nipa-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	spict	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nipal4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	30,583,926 - 30,600,640 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	30,583,926 - 30,600,640 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	35,311,174 - 35,327,879 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	3,849,620 - 3,866,325 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	30,285,634 - 30,302,343 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	31,241,394 - 31,258,105 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	31,241,394 - 31,258,105 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	31,060,605 - 31,077,316 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	31,283,585 - 31,300,297 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	31,286,597 - 31,301,325 (-)	NCBI
Celera	10	30,036,962 - 30,053,673 (-)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive congenital ichthyosis (ISO)

autosomal recessive congenital ichthyosis 6 (ISO)

erythrokeratodermia variabilis et progressiva 1 (ISO)

genetic disease (ISO)

lymphoproliferative syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-Hydroxypyrene (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (EXP)

aldrin (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

cisplatin (ISO)

dimethylarsinic acid (ISO)

doxorubicin (ISO)

folic acid (ISO)

genistein (ISO)

gentamycin (EXP)

lipopolysaccharide (ISO)

methotrexate (ISO)

methylarsonic acid (ISO)

nickel atom (ISO)

ozone (EXP)

paracetamol (EXP)

pentanal (ISO)

potassium chromate (ISO)

propanal (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

temozolomide (ISO)

trametinib (ISO)

trichloroethene (EXP)

triclosan (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

magnesium ion transmembrane transport (IEA)

magnesium ion transport (IBA,ISO)

Cellular Component

membrane (IBA)

Molecular Function

magnesium ion transmembrane transporter activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:18667602

Genomics

Comparative Map Data

Nipal4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	30,583,926 - 30,600,640 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	30,583,926 - 30,600,640 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	35,311,174 - 35,327,879 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	3,849,620 - 3,866,325 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	30,285,634 - 30,302,343 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	31,241,394 - 31,258,105 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	31,241,394 - 31,258,105 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	31,060,605 - 31,077,316 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	31,283,585 - 31,300,297 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	31,286,597 - 31,301,325 (-)	NCBI
Celera	10	30,036,962 - 30,053,673 (-)	NCBI		Celera
Cytogenetic Map	10	q21	NCBI

NIPAL4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	157,460,213 - 157,474,722 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	157,460,213 - 157,474,722 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	156,887,027 - 156,901,730 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	156,819,605 - 156,834,308 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	152,913,590 - 152,928,293 (+)	NCBI		Celera
Cytogenetic Map	5	q33.3	NCBI
HuRef	5	151,975,322 - 151,990,026 (+)	NCBI		HuRef
CHM1_1	5	156,319,751 - 156,334,452 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	157,979,233 - 157,993,740 (+)	NCBI		T2T-CHM13v2.0

Nipal4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	46,038,982 - 46,057,186 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	46,038,982 - 46,057,335 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	46,148,155 - 46,166,359 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	46,148,155 - 46,166,508 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	45,961,657 - 45,979,861 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	45,991,578 - 46,009,782 (-)	NCBI		MGSCv36	mm8
Celera	11	50,737,284 - 50,756,134 (-)	NCBI		Celera
Cytogenetic Map	11	B1.1	NCBI
cM Map	11	27.59	NCBI

Nipal4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	11,635,724 - 11,650,942 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	11,635,724 - 11,648,359 (+)	NCBI	ChiLan1.0	ChiLan1.0

NIPAL4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	5	150,790,803 - 150,805,410 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	152,856,602 - 152,871,218 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	159,472,383 - 159,492,182 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	159,472,383 - 159,492,182 (+)	Ensembl	panpan1.1		panPan2

NIPAL4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	52,735,094 - 52,748,168 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	52,736,693 - 52,745,189 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	52,627,190 - 52,640,198 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	53,171,446 - 53,184,445 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	53,171,439 - 53,185,686 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	52,998,113 - 53,011,101 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	53,104,623 - 53,117,611 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	53,621,790 - 53,634,790 (-)	NCBI		UU_Cfam_GSD_1.0

Nipal4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	107,236,398 - 107,250,072 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936515	5,687,523 - 5,695,845 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936515	5,687,364 - 5,699,153 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NIPAL4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	65,815,295 - 65,829,296 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	65,814,588 - 65,831,788 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	71,669,182 - 71,683,851 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NIPAL4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	59,848,827 - 59,865,369 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	59,849,970 - 59,863,601 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	17,765,125 - 17,780,379 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nipal4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	31,948,414 - 31,959,894 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	31,945,996 - 31,960,187 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nipal4
48 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	295
Count of miRNA genes:	203
Interacting mature miRNAs:	248
Transcripts:	ENSRNOT00000008544
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	5801990	62146030	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
1578761	Stresp21	Stress response QTL 21	3.3		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	6375746	51375746	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
9590310	Scort19	Serum corticosterone level QTL 19	6.3	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9590268	Scort13	Serum corticosterone level QTL 13	3.26	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	11474010	56474010	Rat
9589136	Insul27	Insulin level QTL 27	10.46	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	10	11474010	56474010	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15028513	60430477	Rat
631564	Apr3	Acute phase response QTL 3	3.9		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	10	15275955	60275955	Rat
6893350	Bw99	Body weight QTL 99	0.87	0.16	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
6893352	Bw100	Body weight QTL 100	0.33	0.6	body mass (VT:0001259)	body weight (CMO:0000012)	1	15906665	60906665	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	17907113	51786432	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18167841	63167841	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	19606483	64606483	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	19606483	64606483	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21329805	61345413	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
631531	Iresp2	Immunoglobin response QTL2	6.3		blood immunoglobulin E amount (VT:0002492)	serum total immunoglobulin E level (CMO:0001542)	10	22918268	36400810	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	26521957	61345413	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2298480	Eau7	Experimental allergic uveoretinitis QTL 7		0.0049	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	27957626	34490668	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1600371	Mcs21	Mammary carcinoma susceptibility QTL 21	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	28875650	52200160	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29299504	64155584	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat

Markers in Region

RH132820

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	30,584,446 - 30,584,628 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	31,241,915 - 31,242,096	NCBI	Rnor6.0
Rnor_5.0	10	31,061,126 - 31,061,307	UniSTS	Rnor5.0
RGSC_v3.4	10	31,284,106 - 31,284,287	UniSTS	RGSC3.4
Celera	10	30,037,483 - 30,037,664	UniSTS
Cytogenetic Map	10	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									10
Low		20	11	4	14	4	1	1	45	22	28	11	1
Below cutoff	3	16	18	12	5	12	5	5	19	13	11		5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000008544 ⟹ ENSRNOP00000008544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	30,583,926 - 30,600,640 (-)	Ensembl
Rnor_6.0 Ensembl	10	31,241,394 - 31,258,105 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106840 ⟹ ENSRNOP00000082461

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	30,583,926 - 30,596,566 (-)	Ensembl

RefSeq Acc Id:

NM_001106995 ⟹ NP_001100465

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	30,583,926 - 30,600,640 (-)	NCBI
Rnor_6.0	10	31,241,394 - 31,258,105 (-)	NCBI
Rnor_5.0	10	31,060,605 - 31,077,316 (-)	NCBI
RGSC_v3.4	10	31,283,585 - 31,300,297 (-)	RGD
Celera	10	30,036,962 - 30,053,673 (-)	RGD

Sequence:

show sequence

CGTGCCCGAGTCACGCTGGGACAAGTCGCGGCAACCTGTCCAGGAGCCGCGGACCTCGGGCGCC
TTCAGCCCAGGTCCCCATGGAGCTGCGGGTCGCCAACTCCAATGGCAGCTGCGAGAACGGTTCC
ATAGTCAGCCTCTACTGCTCCTCTCAAGAGGTCCTCTGTCAGATTGTGAGAGGCATCGGCCCTG
AAGAGCCCTACAATGCCACTTTGATCACCTGGCAAGAGAGGATCAGGAAGAAGTATGGCTTCTA
CATCGGTGTGGGCCTCGCCTTCCTCTCCTGCTTCCTCATTGGCACCAGTGTCATCCTTAAGAAG
AAAGGCCTCATTCGGCTTGTGGCCACAGGGGCCACAAGGGCAGTGAACGGAGGCTACGGTTACC
TGAAGGACCCAATGTGGTGGGCTGGCTTTGCTACCATGTCTGCTGGAGAAGTTGCCAACTTCGG
GGCCTATGCGTTTGCACCTGCGACAGTTGTCACACCGCTGGGAGCACTGAGCGTCCTCATAAGT
GCGGTCTTCTCCTCCTATTGCCTGGGAGAGAGCCTGAATCTACTAGGGAAGCTGGGCTGTGTGA
TCTGCATGGCTGGCAGCACAGTGATGGTCATACATGCCCCCAAAGAGGAGAAGATCACGACCGT
TGCAGAGATGGCTTCCAAGATGAAAGACACAGGGTTCATCGTATTTGCTGTCCTTCTGGTGGTG
TCTTGCCTCATCCTCATCTTCATTGTGGCCCCACGTTATGGGCAAAGGAATATCCTCATTTACA
TCATCATCTGCTCGGTGATCGGATCCTTCTCTGTGACAGCCGTCAAGGGGCTCGGCGTCACCAT
TAGGAACTTCTTCCAGGGCTTACCAGTTGTGCATCACCCCCTCCCCTATATCCTGTCCCTCATC
CTGGGGCTTTCCATCATCATCCAGGTCAACTTCCTCAACAGGGCACTGGATATTTTTAACACCT
CCTTGGTCTTCCCCATCTACTACGTCTTCTTCACCACAGTGGTGGTGGTCTCCTCCATCGTCCT
CTTCAAGGAGTGGTACACCATGTCTGCTGTGGACATTGTGGGCACCCTGTCTGGCTTTGTCACC
ATCATCCTGGGTGTTTTCATGCTCCATGCTTTCAAGGATTTGGACATCAGCCAAATCAGCTTGC
CCCACACGCACAAAAACACAACTCCAGCCCCTGCCCCAGAGCCCACAGTCATTAAACTAGAAGA
CAAGAATGTCCTTGTGGACAACATAGAACTTGCCAGCACACCATCACCACAACAGAAGCCCAAA
GTATTTATGATCCACTCTTAAAGCCTGGAATACATGAGTAAGAGGAGACATCCAATGGTCCAGC
CTGACCTCTTAAGATCATAACTACCTGGTTACTTTCAGCACATCTGTTGCCGAGGGCTATTTTT
TTTCCTCTGATATACTGATTTATACCTCACTGCTGTTCCTAGAAGAAAACAAATCCCTACCCAA
TAAGGTAGGTGGCAGCACTTCCTGGAGATACAGCCTTGGTGACTAAATGCACAAGTTTCTGTCA
GAGCCAGCAAGCCCTTAGAGCCTCTTCCCTCTGGTTCCCTCAACACCACCATGTTGTTGGTTGA
ATTTGACCTGCTGAATGTAGCCCAGCTCAAGAACTTCCCTCAGATATTGGTCATCAGGAAATCC
TTTCTACCAGTTAGCCTGTCAAGCTGGACTTCTCAGTCCTTAGCCCCAGGAATGGAGCTTGTGA
GGGACTGCAGAGCAATCTGTATGCCTCGTCATGCCACGGTGTATAGCAAGCACATGCCGAGTAG
CCTGGTGTTTCTTGTAGACGGAAGCAAGACCCCAGCTGACTTTCTTACTGTGAATGCCACCTGA
AGTCTCAGGGAAGTTTCAACTGGCCTGTTCTCCAAGCACTCCAGCCTGGAGGTCACCTCTTGTC
TGTGTCTCCAGTGGCAGGCACCACTACCCTTCCCTCCCTGTGTCCATCTGTCATTGACACATGT
AGGCTGTAACCTTAGAACCAACAGCAGAGGATGCCTCCTAGTCCAGCTCTGTTGTTCAAACCCA
CGTTCACTTAGCAGCCTCTGGGACAAGAACAGCAGACTGCTGTCGTGGTGGCGTTTAGCAAAAT
GCATTTTCTTTGCATCGAGAAGTTGACCATAATATGACTTGGAGAGGCAGGGGAGAGTATAAGA
AACAGTGTCATGGTTGTCAGAGTGGAGTCATGGGCTCTCTGGAAACCTGGATGTAATGTTTGAC
CTGATTCAGACCCGAGAAAGGACCAGACCTGAAAAAGTATGGGGGAAATTCCGAGCTGTATCTA
GTGGAATTGGATTCGCATCCCAGTGACCAAGTGGGAGGTCAGGCTTGACATAGCCTTGTTGGCC
CAACTGGAACTGAGTTTATCTCCGTTGACAACTTAGCCGTCCACACAGGAAACAGCATGCTGTA
GCTCCTTCCCCTGCTCTTGGGGCCACCTTTGGTGACCTCACCATTTGGCCAGAAGCAGGCAGAG
AATAGCAGCTGGAGAGAGAAAATGGGGTCCTTTTCTTCCTAGCCTCTTATAGCCATGTAAGTGG
AAGTGTAGGCTTGACACATGGACCATAAGAGAGTGAAGTTAGGAGCCAGTTTGAGGGAAAGGGG
AAACTCGATCTTCAGTTCAGGTAGCACTGCCGAGCTCCCAGCCTACATCCTGTGCCCCCATCTG
ATCCCCACAGCCAGGTCAAACTGTTTCTAGCCTTGGACAAGCTCTTAGGGCAGATCAACACTCT
GGGCCCCTGTACCCTCCCACCTCCAATCCCCAGTATTTTAATGAATGTGGATTTCTGACTGTGA
CTGAAATCAATGCAATACATTGGCTCTTGGGGGTGGTGGCAAACGGAGGGATTTGAGAGTGTGG
GCTCTGGGGTCAGTAATAAAGACTTCGGAGTGTGTTTACTTGACAAATGTCCTGACCTTCCCTG
AACATGGAGTAAATTCACTCTACTGGTCCCTCTCTCATACTGCGATGCCAGCTCCCGATCTCCA
AAGCAAAGCCCTCCTGTGTCTTCCAAGATCTGCCCTCACTCAAGTGGGGAAGGTTGCTGTATTT
CTGAGTACCAGTCACTCAGACAATGGCTACGTCTTTAGTAGGGAGCCAGGCGTGTGGCAAAAAG
CTTATGAAATAAGAAGGATGCTGCTTCCCTAGCATCAGTGTGAGGGTTCAATGAGGTGCCTATC
AGGGTATTATTACTGTGAGAGACACCATGACCGTGGCAACTTCTATAAAGGAAAACATTTCACT
G

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100465	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM04165	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001100465 ⟸ NM_001106995

- UniProtKB:

D3ZA72 (UniProtKB/TrEMBL), A6HDR0 (UniProtKB/TrEMBL), A0A8I5ZU63 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELRVANSNGSCENGSIVSLYCSSQEVLCQIVRGIGPEEPYNATLITWQERIRKKYGFYIGVGL
AFLSCFLIGTSVILKKKGLIRLVATGATRAVNGGYGYLKDPMWWAGFATMSAGEVANFGAYAFA
PATVVTPLGALSVLISAVFSSYCLGESLNLLGKLGCVICMAGSTVMVIHAPKEEKITTVAEMAS
KMKDTGFIVFAVLLVVSCLILIFIVAPRYGQRNILIYIIICSVIGSFSVTAVKGLGVTIRNFFQ
GLPVVHHPLPYILSLILGLSIIIQVNFLNRALDIFNTSLVFPIYYVFFTTVVVVSSIVLFKEWY
TMSAVDIVGTLSGFVTIILGVFMLHAFKDLDISQISLPHTHKNTTPAPAPEPTVIKLEDKNVLV
DNIELASTPSPQQKPKVFMIHS

hide sequence

RefSeq Acc Id:

ENSRNOP00000008544 ⟸ ENSRNOT00000008544

RefSeq Acc Id:

ENSRNOP00000082461 ⟸ ENSRNOT00000106840

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZA72-F1-model_v2	AlphaFold	D3ZA72	1-406	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309452	AgrOrtholog
BioCyc Gene	G2FUF-25372	BioCyc
Ensembl Genes	ENSRNOG00000006255	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000008544	ENTREZGENE
	ENSRNOP00000008544.5	UniProtKB/TrEMBL
	ENSRNOP00000082461.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000008544	ENTREZGENE
	ENSRNOT00000008544.6	UniProtKB/TrEMBL
	ENSRNOT00000106840.1	UniProtKB/TrEMBL
InterPro	DUF803	UniProtKB/TrEMBL
KEGG Report	rno:303070	UniProtKB/TrEMBL
NCBI Gene	303070	ENTREZGENE
PANTHER	DUF803	UniProtKB/TrEMBL
	MAGNESIUM TRANSPORTER NIPA4	UniProtKB/TrEMBL
Pfam	DUF803	UniProtKB/TrEMBL
PhenoGen	Nipal4	PhenoGen
Superfamily-SCOP	Multidrug resistance efflux transporter EmrE	UniProtKB/TrEMBL
UniProt	A0A8I5ZU63	ENTREZGENE, UniProtKB/TrEMBL
	A6HDR0	ENTREZGENE, UniProtKB/TrEMBL
	D3ZA72	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-06-12	Nipal4	NIPA-like domain containing 4	RGD1309452	similar to RIKEN cDNA 9530066K23	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1309452	similar to RIKEN cDNA 9530066K23	RGD1309452_predicted	similar to RIKEN cDNA 9530066K23 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1309452_predicted	similar to RIKEN cDNA 9530066K23 (predicted)	LOC303070_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC303070_predicted	similar to RIKEN cDNA 9530066K23 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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