Adra1b (adrenoceptor alpha 1B) - Rat Genome Database

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Gene: Adra1b (adrenoceptor alpha 1B) Rattus norvegicus
Analyze
Symbol: Adra1b
Name: adrenoceptor alpha 1B
RGD ID: 2054
Description: Enables alpha1-adrenergic receptor activity. Involved in several processes, including positive regulation of cytosolic calcium ion concentration; response to estrogen; and response to steroid hormone. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and intercalated disc. Biomarker of polycystic ovary syndrome. Orthologous to human ADRA1B (adrenoceptor alpha 1B); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adrenergic alpha 1B receptor; Adrenergic alpha 1B- receptor; adrenergic receptor, alpha 1b; adrenergic, alpha 1B, receptor; Adrenergic, alpha 1B-, receptor; adrenergic, alpha-1B-, receptor; alpha 1B-adrenoceptor; alpha 1B-adrenoreceptor; alpha-1B adrenergic receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21028,255,025 - 28,373,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1028,255,025 - 28,312,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1033,014,641 - 33,072,459 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0101,553,026 - 1,610,850 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01027,985,197 - 28,043,019 (-)NCBIRnor_WKY
Rnor_6.01029,392,762 - 29,450,644 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,392,762 - 29,450,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01029,233,972 - 29,291,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41028,889,092 - 28,946,889 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11028,890,140 - 28,947,938 (-)NCBI
Celera1027,744,674 - 27,802,198 (-)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-aminopyridine  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
alfuzosin  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
C60 fullerene  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclazosin  (EXP)
dexamethasone  (ISO)
diazinon  (EXP)
doxazosin  (ISO)
fipronil  (ISO)
folic acid  (ISO)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
kainic acid  (ISO)
ketanserin  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
oxymetazoline  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phentolamine  (ISO)
phenylephrine  (EXP,ISO)
picrotoxin  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prazosin  (EXP,ISO)
propiconazole  (ISO)
quinidine  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
taurine  (ISO)
terazosin  (ISO)
terbutaline  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
verapamil  (ISO)
Xylometazoline  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway  (IBA)
adrenergic receptor signaling pathway  (IEA,ISO)
adult heart development  (ISO)
behavioral response to cocaine  (ISO)
blood vessel remodeling  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell-cell signaling  (IBA)
glucose homeostasis  (ISO)
glycogen catabolic process  (ISO)
locomotory behavior  (ISO)
multicellular organism aging  (ISO)
negative regulation of glycogen catabolic process  (ISO)
negative regulation of Rho protein signal transduction  (IMP)
neuron-glial cell signaling  (ISO)
organ growth  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA)
positive regulation of cytosolic calcium ion concentration  (IBA,IDA)
positive regulation of glycogen catabolic process  (ISO)
positive regulation of heart rate by epinephrine-norepinephrine  (IBA,ISO)
positive regulation of MAPK cascade  (IBA,IEA,ISO,ISS)
positive regulation of the force of heart contraction by epinephrine-norepinephrine  (ISO)
positive regulation of vasoconstriction  (IBA)
regulation of blood pressure  (ISO)
regulation of cardiac muscle contraction  (IEA)
regulation of vasoconstriction  (IEA)
response to amphetamine  (ISO)
response to estrogen  (IEP)
response to hormone  (IMP)
response to morphine  (ISO)
response to steroid hormone  (IMP)
response to xenobiotic stimulus  (IEP)
vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure  (ISO)
visual learning  (ISO)

Cellular Component
caveola  (IEA)
cytoplasm  (IEA,ISO,ISS)
intercalated disc  (IDA)
membrane  (IDA,ISO)
nuclear membrane  (IEA,ISO,ISS)
nucleus  (ISO,ISS)
plasma membrane  (IBA,ISO)
T-tubule  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Impaired glucose homeostasis in mice lacking the alpha1b-adrenergic receptor subtype. Burcelin R, etal., J Biol Chem. 2004 Jan 9;279(2):1108-15. Epub 2003 Oct 27.
2. Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens. Campos M, etal., Eur J Pharmacol. 2003 Jun 20;471(2):149-55.
3. Adrenaline (via alpha(1B)-adrenoceptors) and ethanol stimulate OH* radical production in isolated rat hepatocytes. Castrejon-Sosa M, etal., Life Sci. 2002 Oct 11;71(21):2469-74.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland. González S, etal., PLoS Biol. 2012;10(6):e1001347. doi: 10.1371/journal.pbio.1001347. Epub 2012 Jun 19.
7. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. Hague C, etal., J Biol Chem. 2004 Apr 9;279(15):15541-9. Epub 2004 Jan 21.
8. Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1. Kang SK, etal., Biochem Biophys Res Commun 2002 Apr 26;293(1):383-90.
9. Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells. Lindblom J, etal., Eur J Pharmacol. 2005 Dec 19;527(1-3):157-62. Epub 2005 Nov 23.
10. Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5. Lomasney JW, etal., J Biol Chem 1991 Apr 5;266(10):6365-9.
11. Ovarian expression of alpha (1)- and beta (2)-adrenoceptors and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries. Manni L, etal., Auton Neurosci. 2005 Mar 31;118(1-2):79-87.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. O-Uchi J, etal., Circ Res. 2008 Jun 6;102(11):1378-88. Epub 2008 May 8.
15. MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Ogata T, etal., Mol Cell Biol. 2008 May;28(10):3424-36. doi: 10.1128/MCB.02186-07. Epub 2008 Mar 10.
16. Alpha-1B adrenoceptors mediate neurogenic constriction in mesenteric arteries of normotensive and DOCA-salt hypertensive mice. Perez-Rivera AA, etal., Auton Neurosci. 2005 Aug 31;121(1-2):64-73.
17. Alpha1-adrenergic receptors: new insights and directions. Piascik MT and Perez DM, J Pharmacol Exp Ther. 2001 Aug;298(2):403-10.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Functional interactions between estrogen and insulin-like growth factor-I in the regulation of alpha 1B-adrenoceptors and female reproductive function. Quesada A and Etgen AM, J Neurosci. 2002 Mar 15;22(6):2401-8.
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
25. Sequence of a rat brain cDNA encoding an alpha-1B adrenergic receptor. Voigt MM, etal., Nucleic Acids Res 1990 Feb 25;18(4):1053.
Additional References at PubMed
PMID:7911220   PMID:7989580   PMID:8406017   PMID:9326654   PMID:10409668   PMID:10493741   PMID:11222061   PMID:11923452   PMID:12184796   PMID:12595294   PMID:12782680   PMID:12871582  
PMID:12880866   PMID:15174080   PMID:15231500   PMID:15793568   PMID:16026926   PMID:16308429   PMID:17915215   PMID:17936747   PMID:18204069   PMID:18246093   PMID:18297111   PMID:18336813  
PMID:19120133   PMID:19302553   PMID:20882287   PMID:21958220   PMID:22120526   PMID:22302710   PMID:24567387   PMID:25283507   PMID:25630693   PMID:25775528   PMID:27923787   PMID:29229557  
PMID:29624247   PMID:34062902  


Genomics

Comparative Map Data
Adra1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21028,255,025 - 28,373,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1028,255,025 - 28,312,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1033,014,641 - 33,072,459 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0101,553,026 - 1,610,850 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01027,985,197 - 28,043,019 (-)NCBIRnor_WKY
Rnor_6.01029,392,762 - 29,450,644 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1029,392,762 - 29,450,644 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01029,233,972 - 29,291,344 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41028,889,092 - 28,946,889 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11028,890,140 - 28,947,938 (-)NCBI
Celera1027,744,674 - 27,802,198 (-)NCBICelera
Cytogenetic Map10q21NCBI
ADRA1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385159,865,086 - 159,989,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5159,865,080 - 159,973,012 (+)EnsemblGRCh38hg38GRCh38
GRCh375159,343,489 - 159,400,019 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,276,318 - 159,332,595 (+)NCBINCBI36Build 36hg18NCBI36
Build 345159,276,317 - 159,332,129NCBI
Celera5155,374,535 - 155,430,824 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5154,438,201 - 154,494,477 (+)NCBIHuRef
CHM1_15158,776,756 - 158,833,023 (+)NCBICHM1_1
T2T-CHM13v2.05160,445,048 - 160,501,585 (+)NCBIT2T-CHM13v2.0
Adra1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,665,432 - 43,792,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,665,433 - 43,792,037 (-)EnsemblGRCm39 Ensembl
GRCm381143,774,605 - 43,901,250 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,774,606 - 43,901,210 (-)EnsemblGRCm38mm10GRCm38
MGSCv371143,588,108 - 43,649,834 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361143,618,029 - 43,679,755 (-)NCBIMGSCv36mm8
Celera1148,401,465 - 48,463,919 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1125.81NCBI
Adra1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540813,883,574 - 13,937,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540813,883,574 - 13,937,798 (+)NCBIChiLan1.0ChiLan1.0
ADRA1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15161,923,708 - 161,954,901 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5161,923,895 - 161,979,461 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05155,307,148 - 155,363,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADRA1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1450,676,816 - 50,724,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl450,677,255 - 50,724,999 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha450,570,905 - 50,619,105 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0451,111,625 - 51,159,868 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl451,111,625 - 51,159,868 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1450,919,759 - 50,967,913 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0451,043,059 - 51,091,264 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0451,563,698 - 51,612,138 (-)NCBIUU_Cfam_GSD_1.0
Adra1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213105,074,452 - 105,123,271 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365153,523,797 - 3,572,596 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365153,523,799 - 3,572,467 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADRA1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1663,550,130 - 63,603,034 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11663,550,123 - 64,010,838 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21669,039,634 - 69,092,211 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADRA1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12362,281,500 - 62,338,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603415,270,198 - 15,333,460 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adra1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473329,545,789 - 29,662,028 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473329,545,870 - 29,661,954 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adra1b
656 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum total immunoglobulin E level (CMO:0001542)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)102795762634490668Rat

Markers in Region
D10Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map10298.61UniSTS
RH 3.4 Map10298.61RGD
RH 2.0 Map10367.3RGD
Cytogenetic Map10q21UniSTS
RH133503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21028,255,057 - 28,255,254 (+)MAPPERmRatBN7.2
Rnor_6.01029,392,795 - 29,392,991NCBIRnor6.0
Rnor_5.01029,234,005 - 29,234,201UniSTSRnor5.0
RGSC_v3.41028,889,125 - 28,889,321UniSTSRGSC3.4
Celera1027,744,707 - 27,744,903UniSTS
RH 3.4 Map10296.7UniSTS
Cytogenetic Map10q21UniSTS
PMC150908P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01029,449,417 - 29,450,205NCBIRnor6.0
Rnor_5.01029,290,117 - 29,290,905UniSTSRnor5.0
RGSC_v3.41028,945,662 - 28,946,450UniSTSRGSC3.4
Cytogenetic Map10q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 22 22 22 6
Low 1 23 26 19 12 19 54 35 21 11
Below cutoff 2 8 6 8 11 14 20 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087937   ⟹   ENSRNOP00000073309
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1028,255,025 - 28,312,919 (-)Ensembl
Rnor_6.0 Ensembl1029,392,762 - 29,450,644 (-)Ensembl
RefSeq Acc Id: NM_016991   ⟹   NP_058687
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21028,255,025 - 28,312,919 (-)NCBI
Rnor_6.01029,392,762 - 29,450,644 (-)NCBI
Rnor_5.01029,233,972 - 29,291,344 (-)NCBI
RGSC_v3.41028,889,092 - 28,946,889 (-)RGD
Celera1027,744,674 - 27,802,198 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085165   ⟹   XP_038941093
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21028,255,025 - 28,373,418 (-)NCBI
RefSeq Acc Id: XM_039085167   ⟹   XP_038941095
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21028,256,086 - 28,312,763 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058687   ⟸   NM_016991
- UniProtKB: Q6IRH4 (UniProtKB/TrEMBL),   A0A0G2K564 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073309   ⟸   ENSRNOT00000087937
RefSeq Acc Id: XP_038941093   ⟸   XM_039085165
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K564 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941095   ⟸   XM_039085167
- Peptide Label: isoform X2
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15823-F1-model_v2 AlphaFold P15823 1-515 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697119
Promoter ID:EPDNEW_R7643
Type:single initiation site
Name:Adra1b_1
Description:adrenoceptor alpha 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01029,450,685 - 29,450,745EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2054 AgrOrtholog
BioCyc Gene G2FUF-25438 BioCyc
Ensembl Genes ENSRNOG00000060087 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000073309 ENTREZGENE
  ENSRNOP00000073309.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087937 ENTREZGENE
  ENSRNOT00000087937.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7105608 IMAGE-MGC_LOAD
InterPro ADR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRA1B_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24173 UniProtKB/TrEMBL
MGC_CLONE MGC:91757 IMAGE-MGC_LOAD
NCBI Gene 24173 ENTREZGENE
PANTHER PTHR24248:SF17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adra1b PhenoGen
PRINTS ADRENERGICR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADRENRGCA1BR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K564 ENTREZGENE
  ADA1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6IRH4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2K564 UniProtKB/TrEMBL
  Q63215 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Adra1b  adrenoceptor alpha 1B  Adra1b  adrenergic, alpha-1B-, receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Adra1b  adrenergic, alpha-1B-, receptor  Adra1b  adrenergic receptor, alpha 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Adra1b  adrenergic receptor, alpha 1b    adrenergic, alpha 1B, receptor  Name updated 629478 APPROVED
2002-06-10 Adra1b  adrenergic, alpha 1B, receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction associates with G proteins that activate a phosphatidylinositol- calcium second messenger system 61489
gene_process mediates blood pressure and aorta contractile responses induced by alpha-1 agonists