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Gene: Il5 (interleukin 5) Rattus norvegicus
Symbol: Il5
Name: interleukin 5
Description: Exhibits cytokine activity and interleukin-5 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of eosinophil differentiation; and positive regulation of receptor signaling pathway via JAK-STAT. Localizes to extracellular space. Used to study asthma. Biomarker of several diseases, including allergic rhinitis; esophageal cancer; middle cerebral artery infarction; peptic esophagitis; and prostatic hypertrophy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5 (interleukin 5); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-4 signaling pathway; interleukin-5 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; ammonium chloride.
Type: protein-coding
Also known as: B-cell growth factor II; BCGF-II; cytotoxic T-lymphocyte inducer; eosinophil differentiation factor; IL-5; Interleukin 5 (colony-stimulating factor eosinophil); Interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5; T-cell replacing factor; TRF
Homo sapiens (human) : IL5 (interleukin 5)  HGNC  Alliance
Mus musculus (house mouse) : Il5 (interleukin 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il5 (interleukin 5)
Pan paniscus (bonobo/pygmy chimpanzee) : IL5 (interleukin 5)
Canis lupus familiaris (dog) : IL5 (interleukin 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il5 (interleukin 5)
Sus scrofa (pig) : IL5 (interleukin 5)
Chlorocebus sabaeus (African green monkey) : IL5 (interleukin 5)
Heterocephalus glaber (naked mole-rat) : Il5 (interleukin 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01039,066,716 - 39,069,587 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,066,716 - 39,069,587 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,848,654 - 38,851,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,177,786 - 39,180,657 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,187,032 - 39,189,904 (+)NCBI
Celera1037,217,913 - 37,220,782 (+)NCBICelera
Cytogenetic Map10q22NCBI
RH 3.4 Map10405.8RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Il5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2900
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.