Mapk9 (mitogen-activated protein kinase 9) - Rat Genome Database

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Gene: Mapk9 (mitogen-activated protein kinase 9) Rattus norvegicus
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Symbol: Mapk9
Name: mitogen-activated protein kinase 9
RGD ID: 628847
Description: Enables several functions, including ATP binding activity; JUN kinase activity; and cysteine-type endopeptidase activator activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; mitochondrion organization; and positive regulation of macromolecule metabolic process. Located in several cellular components, including cytosol; mitochondrion; and perikaryon. Used to study type 2 diabetes mellitus. Biomarker of pre-malignant neoplasm. Human ortholog(s) of this gene implicated in colorectal cancer; pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human MAPK9 (mitogen-activated protein kinase 9); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; FasL mediated signaling pathway; glypican signaling pathway; INTERACTS WITH (S)-nicotine; 1,3-dichloropropan-2-ol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: c-Jun N-terminal kinase 2; MAP kinase 9; MAPK 9; p54-alpha; SAPK; SAPK-alpha; stress activated protein kinase alpha II; stress-activated protein kinase JNK2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eau7
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21034,169,661 - 34,211,138 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,169,675 - 34,210,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1038,845,042 - 38,885,532 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0107,383,457 - 7,423,947 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01033,838,708 - 33,879,198 (+)NCBIRnor_WKY
Rnor_6.01035,333,859 - 35,374,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,333,859 - 35,374,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,105,633 - 35,147,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,353,486 - 35,384,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,354,534 - 35,385,368 (+)NCBI
Celera1033,525,368 - 33,565,857 (+)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,4-phenylenediamine  (ISO)
1,8-cineole  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2''-galloylhyperin  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (EXP,ISO)
acrylamide  (EXP,ISO)
ADP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Chaconine  (ISO)
alpha-mangostin  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
ANTIMYCIN  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP)
apocynin  (ISO)
arecoline  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Azaspiracid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-hexachlorocyclohexane  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
Bisphenol A diglycidyl ether  (EXP)
bortezomib  (ISO)
bufalin  (ISO)
buspirone  (EXP)
C.I. Natural Red 20  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP,ISO)
caffeine  (ISO)
calcidiol  (EXP)
calix[6]arene  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidic acid  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (EXP)
Carnosol  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chromones  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucitol  (ISO)
D-glucose  (EXP)
DDT  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dichromium trioxide  (ISO)
dicoumarol  (ISO)
diethyl maleate  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dobutamine  (EXP)
donepezil hydrochloride  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
emetine  (ISO)
enalapril  (EXP)
enzyme inhibitor  (ISO)
esculetin  (ISO)
Estragole  (EXP)
ethanol  (EXP,ISO)
Ethyl pyruvate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
Evodiamine  (ISO)
ferrosoferric oxide  (ISO)
fluorescein 5-isothiocyanate  (ISO)
folic acid  (ISO)
fomepizole  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (EXP)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Geniposide pentaacetate  (EXP)
ginsenoside Rg1  (ISO)
glucose  (EXP)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
haloperidol  (EXP)
hemin  (EXP)
hesperidin  (ISO)
hexadecanoic acid  (EXP,ISO)
hexamethylene diisocyanate  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hypochlorous acid  (ISO)
ICI 118551  (EXP)
indoxyl sulfate  (EXP)
iomeprol  (ISO)
kaempferol  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-glutamic acid  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
Longikaurin A  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
LY294002  (EXP,ISO)
Maduramicin  (EXP,ISO)
Magnolol  (ISO)
Malonoben  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
manumycin A  (ISO)
masoprocol  (ISO)
mebendazole  (ISO)
mechlorethamine  (ISO)
melamine  (ISO)
melatonin  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP,ISO)
Methylazoxymethanol acetate  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mycophenolic acid  (EXP,ISO)
myricetin  (ISO)
N(6),N(6)-dimethyladenine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naringin  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
nimesulide  (EXP)
nitroprusside  (EXP)
nocodazole  (ISO)
notoginsenoside R1  (EXP)
ochratoxin A  (ISO)
olmesartan  (ISO)
osthole  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
phenylephrine  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (ISO)
phosgene  (EXP)
phthalic anhydride  (ISO)
platycodin D  (ISO)
poly(I:C)  (EXP)
potassium chloride  (ISO)
pramipexole  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
prodigiosin  (ISO)
progesterone  (EXP)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
Ro 31-8220  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salubrinal  (EXP,ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
Shikonin  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
SR 144528  (ISO)
stattic  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulfasalazine  (EXP)
sulfates  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taurine  (EXP)
taurocholic acid  (ISO)
temozolomide  (ISO)
TEMPO  (ISO)
tert-butyl hydroperoxide  (ISO)
tetracaine  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
ursolic acid  (EXP)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP,ISO)
WIN 55212-2  (ISO)
wogonin  (ISO)
wortmannin  (EXP)
zinc acetate  (EXP)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
apoptotic signaling pathway  (ISO)
cellular hyperosmotic response  (IEP)
cellular response to amyloid-beta  (IEP)
cellular response to cadmium ion  (ISO)
cellular response to growth factor stimulus  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to reactive oxygen species  (ISO)
cellular response to tumor necrosis factor  (IEP)
cellular response to UV  (IMP)
central nervous system development  (IEP)
intracellular signal transduction  (IBA)
JNK cascade  (IBA,IDA,ISO)
JUN phosphorylation  (IMP)
MAPK cascade  (IEA)
modulation of chemical synaptic transmission  (ISO)
neuron development  (IEP)
neuron projection development  (IMP)
peptidyl-serine phosphorylation  (ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell morphogenesis involved in differentiation  (IMP)
positive regulation of chemokine production  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of DNA-templated transcription  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of macrophage derived foam cell differentiation  (ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of nitric-oxide synthase biosynthetic process  (IMP)
positive regulation of podosome assembly  (ISO)
positive regulation of prostaglandin biosynthetic process  (IMP)
positive regulation of prostaglandin secretion  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription factor catabolic process  (ISO)
protein localization to tricellular tight junction  (ISO)
protein phosphorylation  (IDA,IEA,ISO)
protein targeting to mitochondrion  (IEP)
regulation of circadian rhythm  (ISO,ISS)
regulation of JNK cascade  (IMP)
regulation of protein ubiquitination  (IMP)
release of cytochrome c from mitochondria  (IMP)
response to amine  (IEP)
response to cadmium ion  (ISO)
response to mechanical stimulus  (IEP)
response to nerve growth factor  (IEP)
response to organic substance  (IEP)
response to toxic substance  (IEP)
response to water deprivation  (IEP)
response to xenobiotic stimulus  (IMP)
rhythmic process  (IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Serum autoantibodies to pancreatic cancer antigens as biomarkers of pancreatic cancer in a San Francisco Bay Area case-control study. Bracci PM, etal., Cancer. 2012 Nov 1;118(21):5384-94. doi: 10.1002/cncr.27538. Epub 2012 Apr 19.
2. Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms. Butterfield L, etal., Biochem J. 1999 Mar 15;338 ( Pt 3):681-6.
3. Differential expression of SAPK isoforms in the rat brain. An in situ hybridisation study in the adult rat brain and during post-natal development. Carboni L, etal., Brain Res Mol Brain Res. 1998 Sep 18;60(1):57-68.
4. Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in normal human osteoblastic and rat UMR-106 cells. Chaudhary LR and Avioli LV, J Cell Biochem. 1998 Apr 1;69(1):87-93.
5. Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury. Cubero FJ, etal., J Hepatol. 2015 Jan;62(1):140-9. doi: 10.1016/j.jhep.2014.08.029. Epub 2014 Aug 27.
6. Tetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neurons. Downer EJ, etal., Br J Pharmacol. 2003 Oct;140(3):547-57.
7. JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine. Eminel S, etal., J Biol Chem. 2004 Dec 31;279(53):55385-92. Epub 2004 Oct 25.
8. Development of glutathione S-transferase-P-negative foci accompanying nuclear factor-erythroid 2-related factor 2 expression during early stage of rat hepatocarcinogenesis. Fan Y, etal., Cancer Sci. 2008 Mar;99(3):497-501. Epub 2007 Dec 15.
9. A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons. Fogarty MP, etal., Biochem J. 2003 May 1;371(Pt 3):789-98.
10. Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase. Fuchs SY, etal., Oncogene. 1996 Oct 3;13(7):1531-5.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. Guan Z, etal., J Biol Chem. 1998 Oct 30;273(44):28670-6.
14. Both p38alpha(MAPK) and JNK/SAPK pathways are important for induction of nitric-oxide synthase by interleukin-1beta in rat glomerular mesangial cells. Guan Z, etal., J Biol Chem. 1999 Dec 17;274(51):36200-6.
15. Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. Hreniuk D, etal., Mol Pharmacol. 2001 Apr;59(4):867-74.
16. NGF stimulation increases JNK2 phosphorylation and reduces caspase-3 activity in the olfactory bulb of estrogen-replaced animals. Jezierski MK, etal., Endocrinology. 2001 Jun;142(6):2401.
17. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
18. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
19. The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death. Kurokawa M, etal., EMBO J. 2000 Jun 15;19(12):2958-68.
20. The stress-activated protein kinase subfamily of c-Jun kinases. Kyriakis JM, etal., Nature 1994 May 12;369(6476):156-60.
21. Osmotic and glutamate receptor regulation of c-Jun NH(2)-terminal protein kinase in neuroendocrine cells. Meeker R and Fernandes A, Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E475-86.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Cyclooxygenase 2 inhibits SAPK activation in neuronal apoptosis. Miller B, etal., Biochem Biophys Res Commun 2003 Jan 24;300(4):884-8.
24. JNK/ERK-AP-1/Runx2 induction "paves the way" to cartilage load-ignited chondroblastic differentiation. Papachristou DJ, etal., Histochem Cell Biol. 2005 Sep;124(3-4):215-23. Epub 2005 Oct 28.
25. Role of MAP kinases and their cross-talk in TGF-beta1-induced apoptosis in FaO rat hepatoma cell line. Park HJ, etal., Hepatology. 2002 Jun;35(6):1360-71.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. Rardin MJ, etal., J Biol Chem. 2008 May 30;283(22):15440-50. doi: 10.1074/jbc.M709547200. Epub 2008 Apr 2.
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Ricci R, etal., Science. 2004 Nov 26;306(5701):1558-61.
31. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Sabapathy K, etal., Mech Dev 1999 Dec;89(1-2):115-24.
32. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
33. miR200c attenuates P-gp-mediated MDR and metastasis by targeting JNK2/c-Jun signaling pathway in colorectal cancer. Sui H, etal., Mol Cancer Ther. 2014 Dec;13(12):3137-51. doi: 10.1158/1535-7163.MCT-14-0167. Epub 2014 Sep 9.
34. Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet. Syed I, etal., Diabetes. 2011 Nov;60(11):2843-52. doi: 10.2337/db11-0809. Epub 2011 Sep 12.
35. MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling. Waetzig V and Herdegen T, Mol Cell Neurosci. 2005 Sep;30(1):67-78.
36. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. Wang R, etal., J Neurochem. 2006 Dec;99(6):1543-54. Epub 2006 Oct 25.
37. Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain. Wang Y, etal., Biochem J. 2007 Jan 1;401(1):65-78.
38. TNFalpha induces apoptosis through JNK/Bax-dependent pathway in differentiated, but not naive PC12 cells. Zhang L, etal., Cell Cycle. 2007 Jun 15;6(12):1479-86. Epub 2007 Apr 18.
39. Activation of JNK/SAPK in primary glial cultures: II. Differential activation of kinase isoforms corresponds to their differential expression. Zhang P, etal., Neurochem Res. 1998 Feb;23(2):219-25.
40. Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia. Zhang QX, etal., Biochemistry. 2007 Apr 3;46(13):4006-16. Epub 2007 Mar 10.
41. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. Zhu X, etal., J Neurochem. 2001 Jan;76(2):435-41.
Additional References at PubMed
PMID:8654373   PMID:8889548   PMID:9651196   PMID:10376527   PMID:11884367   PMID:12445686   PMID:16458303   PMID:16641100   PMID:17333127   PMID:17555943   PMID:18096574   PMID:18262097  
PMID:18287535   PMID:18625195   PMID:18666320   PMID:18926830   PMID:19362079   PMID:20196785   PMID:20595622   PMID:21856198   PMID:22441692   PMID:22644775   PMID:22661329   PMID:22753708  
PMID:22871113   PMID:23969109   PMID:24127566   PMID:24134609   PMID:24889144   PMID:25285524   PMID:26514923   PMID:29153991   PMID:32414595   PMID:33044948  


Genomics

Comparative Map Data
Mapk9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21034,169,661 - 34,211,138 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,169,675 - 34,210,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1038,845,042 - 38,885,532 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0107,383,457 - 7,423,947 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01033,838,708 - 33,879,198 (+)NCBIRnor_WKY
Rnor_6.01035,333,859 - 35,374,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,333,859 - 35,374,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,105,633 - 35,147,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,353,486 - 35,384,319 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,354,534 - 35,385,368 (+)NCBI
Celera1033,525,368 - 33,565,857 (+)NCBICelera
Cytogenetic Map10q21NCBI
MAPK9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385180,233,143 - 180,292,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5180,233,143 - 180,292,099 (-)EnsemblGRCh38hg38GRCh38
GRCh375179,660,143 - 179,719,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,595,390 - 179,640,216 (-)NCBINCBI36Build 36hg18NCBI36
Build 345179,595,389 - 179,640,216NCBI
Celera5175,286,573 - 175,345,058 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5174,385,878 - 174,444,273 (-)NCBIHuRef
CHM1_15179,092,988 - 179,151,485 (-)NCBICHM1_1
T2T-CHM13v2.05180,788,589 - 180,847,539 (-)NCBIT2T-CHM13v2.0
Mapk9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,737,558 - 49,777,248 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,737,578 - 49,777,248 (+)EnsemblGRCm39 Ensembl
GRCm381149,846,728 - 49,886,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,846,751 - 49,886,421 (+)EnsemblGRCm38mm10GRCm38
MGSCv371149,660,253 - 49,699,923 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361149,690,177 - 49,729,521 (+)NCBIMGSCv36mm8
Celera1154,408,836 - 54,448,385 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
Mapk9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408391,094 - 430,981 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955408391,094 - 430,638 (+)NCBIChiLan1.0ChiLan1.0
MAPK9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15182,748,381 - 182,801,464 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5182,748,381 - 182,795,135 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05175,437,167 - 175,495,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAPK9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,443,528 - 1,480,501 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,443,547 - 1,478,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha111,491,213 - 1,542,807 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,400,469 - 1,452,082 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,400,430 - 1,452,077 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,353,353 - 1,404,946 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,451,386 - 1,502,976 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0111,691,426 - 1,743,027 (+)NCBIUU_Cfam_GSD_1.0
Mapk9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,341,905 - 119,392,250 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739551,629 - 602,047 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936739551,678 - 602,027 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,338,376 - 78,399,100 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,338,466 - 78,399,108 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,823,618 - 79,884,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,965,330 - 82,026,414 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2381,963,899 - 82,013,659 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607513,351,365 - 13,412,409 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,999,339 - 43,048,285 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,998,948 - 43,048,392 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mapk9
113 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:543
Count of miRNA genes:217
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000003987, ENSRNOT00000004010
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum total immunoglobulin E level (CMO:0001542)102291826836400810Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)102795762634490668Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 55 39 19 39 8 11 74 35 41 11 8
Low 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003987   ⟹   ENSRNOP00000003987
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,169,683 - 34,210,178 (+)Ensembl
Rnor_6.0 Ensembl1035,333,859 - 35,374,355 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000004010   ⟹   ENSRNOP00000004010
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,169,683 - 34,210,178 (+)Ensembl
Rnor_6.0 Ensembl1035,333,859 - 35,374,355 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083688   ⟹   ENSRNOP00000070771
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,169,683 - 34,208,026 (+)Ensembl
Rnor_6.0 Ensembl1035,343,189 - 35,372,401 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097148   ⟹   ENSRNOP00000097678
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,181,934 - 34,210,178 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107644   ⟹   ENSRNOP00000090510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,169,675 - 34,210,178 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114525   ⟹   ENSRNOP00000085365
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,169,815 - 34,185,884 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116124   ⟹   ENSRNOP00000087042
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1034,186,113 - 34,210,178 (+)Ensembl
RefSeq Acc Id: NM_001270544   ⟹   NP_001257473
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21034,169,683 - 34,210,187 (+)NCBI
Rnor_6.01035,333,859 - 35,374,364 (+)NCBI
Rnor_5.01035,105,633 - 35,147,516 (+)NCBI
Celera1033,525,368 - 33,565,857 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270545   ⟹   NP_001257474
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21034,169,683 - 34,210,187 (+)NCBI
Rnor_6.01035,333,859 - 35,374,364 (+)NCBI
Rnor_5.01035,105,633 - 35,147,516 (+)NCBI
Celera1033,525,368 - 33,565,857 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017322   ⟹   NP_059018
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21034,169,683 - 34,210,187 (+)NCBI
Rnor_6.01035,333,859 - 35,374,364 (+)NCBI
Rnor_5.01035,105,633 - 35,147,516 (+)NCBI
RGSC_v3.41035,353,486 - 35,384,319 (+)RGD
Celera1033,525,368 - 33,565,857 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246318   ⟹   XP_006246380
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21034,178,525 - 34,211,138 (+)NCBI
Rnor_6.01035,342,751 - 35,374,364 (+)NCBI
Rnor_5.01035,105,633 - 35,147,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597479   ⟹   XP_017452968
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21034,169,661 - 34,199,061 (+)NCBI
Rnor_6.01035,333,862 - 35,363,499 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086658   ⟹   XP_038942586
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21034,178,525 - 34,211,138 (+)NCBI
RefSeq Acc Id: XM_039086659   ⟹   XP_038942587
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21034,169,664 - 34,211,138 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_059018   ⟸   NM_017322
- Peptide Label: isoform 1
- UniProtKB: P49186 (UniProtKB/Swiss-Prot),   Q6P727 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257473   ⟸   NM_001270544
- Peptide Label: isoform 2
- UniProtKB: P49186 (UniProtKB/Swiss-Prot),   D4A5V8 (UniProtKB/TrEMBL),   Q6P727 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257474   ⟸   NM_001270545
- Peptide Label: isoform 3
- UniProtKB: Q6P727 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246380   ⟸   XM_006246318
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYS4 (UniProtKB/TrEMBL),   A0A8I6AND2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452968   ⟸   XM_017597479
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000004010   ⟸   ENSRNOT00000004010
RefSeq Acc Id: ENSRNOP00000070771   ⟸   ENSRNOT00000083688
RefSeq Acc Id: ENSRNOP00000003987   ⟸   ENSRNOT00000003987
RefSeq Acc Id: XP_038942587   ⟸   XM_039086659
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038942586   ⟸   XM_039086658
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000085365   ⟸   ENSRNOT00000114525
RefSeq Acc Id: ENSRNOP00000087042   ⟸   ENSRNOT00000116124
RefSeq Acc Id: ENSRNOP00000097678   ⟸   ENSRNOT00000097148
RefSeq Acc Id: ENSRNOP00000090510   ⟸   ENSRNOT00000107644
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49186-F1-model_v2 AlphaFold P49186 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697146
Promoter ID:EPDNEW_R7671
Type:initiation region
Name:Mapk9_1
Description:mitogen-activated protein kinase 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,333,842 - 35,333,902EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628847 AgrOrtholog
BioCyc Gene G2FUF-25265 BioCyc
Ensembl Genes ENSRNOG00000002823 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003987 ENTREZGENE
  ENSRNOP00000003987.3 UniProtKB/TrEMBL
  ENSRNOP00000004010 ENTREZGENE
  ENSRNOP00000004010.4 UniProtKB/TrEMBL
  ENSRNOP00000070771.2 UniProtKB/TrEMBL
  ENSRNOP00000085365.1 UniProtKB/TrEMBL
  ENSRNOP00000087042 ENTREZGENE
  ENSRNOP00000087042.1 UniProtKB/TrEMBL
  ENSRNOP00000090510 ENTREZGENE
  ENSRNOP00000090510.1 UniProtKB/TrEMBL
  ENSRNOP00000097678.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003987 ENTREZGENE
  ENSRNOT00000003987.6 UniProtKB/TrEMBL
  ENSRNOT00000004010 ENTREZGENE
  ENSRNOT00000004010.5 UniProtKB/TrEMBL
  ENSRNOT00000083688.2 UniProtKB/TrEMBL
  ENSRNOT00000097148.1 UniProtKB/TrEMBL
  ENSRNOT00000107644 ENTREZGENE
  ENSRNOT00000107644.1 UniProtKB/TrEMBL
  ENSRNOT00000114525.1 UniProtKB/TrEMBL
  ENSRNOT00000116124 ENTREZGENE
  ENSRNOT00000116124.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598943 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPK_JNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50658 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72494 IMAGE-MGC_LOAD
NCBI Gene 50658 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mapk9 PhenoGen
PRINTS JNKMAPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A503_RAT UniProtKB/TrEMBL
  A0A8I6AND2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANM5_RAT UniProtKB/TrEMBL
  A0A8I6GCT6_RAT UniProtKB/TrEMBL
  D4A5V8 ENTREZGENE, UniProtKB/TrEMBL
  MK09_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P727 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Mapk9  mitogen-activated protein kinase 9    stress activated protein kinase alpha II  Name updated 1299863 APPROVED
2003-02-27 Mapk9  stress activated protein kinase alpha II      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process activation has a role in the initiation of PC12 cell death 729126