Mapk9 (mitogen-activated protein kinase 9) - Rat Genome Database
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Gene: Mapk9 (mitogen-activated protein kinase 9) Rattus norvegicus
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Symbol: Mapk9
Name: mitogen-activated protein kinase 9
RGD ID: 628847
Description: Exhibits several functions, including ATP binding activity; JUN kinase activity; and cysteine-type endopeptidase activator activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; mitochondrion organization; and positive regulation of cellular metabolic process. Localizes to several cellular components, including cytosol; mitochondrion; and perikaryon. Used to study type 2 diabetes mellitus. Biomarker of pre-malignant neoplasm. Human ortholog(s) of this gene implicated in colorectal cancer; pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human MAPK9 (mitogen-activated protein kinase 9); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; FasL mediated signaling pathway; glypican signaling pathway; INTERACTS WITH (S)-nicotine; 1,3-dichloropropan-2-ol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-Jun N-terminal kinase 2; MAP kinase 9; MAPK 9; p54-alpha; SAPK; SAPK-alpha; stress activated protein kinase alpha II; stress-activated protein kinase JNK2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01035,333,859 - 35,374,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,333,859 - 35,374,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,105,633 - 35,147,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,353,486 - 35,384,319 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11035,354,534 - 35,385,368 (+)NCBI
Celera1033,525,368 - 33,565,857 (+)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-alpha-viniferin  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,4-phenylenediamine  (ISO)
1,8-cineole  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (EXP,ISO)
acrylamide  (EXP,ISO)
ADP  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Chaconine  (ISO)
alpha-mangostin  (ISO)
amidotrizoic acid  (ISO)
amiloride  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (EXP)
apocynin  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Azaspiracid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-hexachlorocyclohexane  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
Bisphenol A diglycidyl ether  (EXP)
bortezomib  (ISO)
bufalin  (ISO)
buspirone  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP,ISO)
calcidiol  (EXP)
calix[6]arene  (ISO)
camptothecin  (ISO)
cantharidic acid  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (EXP)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chromones  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
DDT  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dichromium trioxide  (ISO)
dicoumarol  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dobutamine  (EXP)
donepezil hydrochloride  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
emetine  (ISO)
enalapril  (EXP)
enzyme inhibitor  (ISO)
esculetin  (ISO)
Estragole  (EXP)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
Evodiamine  (ISO)
ferrosoferric oxide  (ISO)
fluorescein 5-isothiocyanate  (ISO)
folic acid  (ISO)
fomepizole  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (EXP)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Geniposide pentaacetate  (EXP)
ginsenoside Rg1  (ISO)
glucose  (EXP)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
haloperidol  (EXP)
hemin  (EXP)
hesperidin  (ISO)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hypochlorous acid  (ISO)
ICI 118551  (EXP)
indoxyl sulfate  (EXP)
iomeprol  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
Longikaurin A  (ISO)
lovastatin  (EXP)
luteolin  (ISO)
LY294002  (EXP,ISO)
Magnolol  (ISO)
Malonoben  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
Manumycin A  (ISO)
masoprocol  (ISO)
mebendazole  (ISO)
mechlorethamine  (ISO)
melatonin  (ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methotrexate  (EXP,ISO)
Methylazoxymethanol acetate  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mycophenolic acid  (EXP,ISO)
myricetin  (ISO)
N(6),N(6)-dimethyladenine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naringin  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
Niclosamide  (ISO)
nicotine  (EXP)
nimesulide  (EXP)
nitroprusside  (EXP)
nocodazole  (ISO)
notoginsenoside R1  (EXP)
ochratoxin A  (ISO)
olmesartan  (ISO)
osthole  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
phenylephrine  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (ISO)
phosgene  (EXP)
phthalic anhydride  (ISO)
platycodin D  (ISO)
poly(I:C)  (EXP)
potassium chloride  (ISO)
pramipexole  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
prodigiosin  (ISO)
progesterone  (EXP)
prostaglandin F2alpha  (ISO)
protein kinase inhibitor  (EXP,ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
Ro 31-8220  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salubrinal  (EXP,ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sorafenib  (ISO)
SR 144528  (ISO)
stattic  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulfasalazine  (EXP)
sulfates  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
taurine  (EXP)
taurocholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
tetracaine  (EXP)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (ISO)
ursolic acid  (EXP)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
WIN 55212-2  (ISO)
wogonin  (ISO)
wortmannin  (EXP)
zinc acetate  (EXP)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
cellular hyperosmotic response  (IEP)
cellular response to amyloid-beta  (IEP)
cellular response to cadmium ion  (IEA,ISO)
cellular response to growth factor stimulus  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to reactive oxygen species  (IEA,ISO)
cellular response to tumor necrosis factor  (IEP)
cellular response to UV  (IMP)
central nervous system development  (IEP)
intracellular signal transduction  (IBA)
JNK cascade  (IBA,IDA,ISO)
JUN phosphorylation  (IEA,IMP)
MAPK cascade  (IEA)
neuron development  (IEP)
neuron projection development  (IMP)
peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of cell morphogenesis involved in differentiation  (IMP)
positive regulation of chemokine production  (IMP)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IMP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of nitric-oxide synthase biosynthetic process  (IMP)
positive regulation of podosome assembly  (IEA,ISO)
positive regulation of prostaglandin biosynthetic process  (IMP)
positive regulation of prostaglandin secretion  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of protein ubiquitination  (IEA,ISO)
positive regulation of transcription factor catabolic process  (IEA,ISO)
positive regulation of transcription, DNA-templated  (IMP)
protein localization to tricellular tight junction  (IEA,ISO)
protein phosphorylation  (IDA,IEA,ISO)
protein targeting to mitochondrion  (IEP)
regulation of circadian rhythm  (IEA,ISO,ISS)
regulation of gene expression  (IBA)
regulation of JNK cascade  (IMP)
regulation of protein ubiquitination  (IMP)
release of cytochrome c from mitochondria  (IMP)
response to amine  (IEP)
response to cadmium ion  (ISO)
response to drug  (IMP)
response to mechanical stimulus  (IEP)
response to nerve growth factor  (IEP)
response to organic substance  (IEP)
response to toxic substance  (IEP)
response to water deprivation  (IEP)
rhythmic process  (IEA)

Cellular Component
cytoplasm  (IBA,IDA,ISO)
cytosol  (IDA,IEA,ISO)
mitochondrion  (IDA,IEA,ISO)
neuron projection  (IDA)
nucleus  (IBA,IDA)
perikaryon  (IDA)

References

References - curated
1. Bracci PM, etal., Cancer. 2012 Nov 1;118(21):5384-94. doi: 10.1002/cncr.27538. Epub 2012 Apr 19.
2. Butterfield L, etal., Biochem J. 1999 Mar 15;338 ( Pt 3):681-6.
3. Carboni L, etal., Brain Res Mol Brain Res. 1998 Sep 18;60(1):57-68.
4. Chaudhary LR and Avioli LV, J Cell Biochem. 1998 Apr 1;69(1):87-93.
5. Downer EJ, etal., Br J Pharmacol. 2003 Oct;140(3):547-57.
6. Eminel S, etal., J Biol Chem. 2004 Dec 31;279(53):55385-92. Epub 2004 Oct 25.
7. Fan Y, etal., Cancer Sci. 2008 Mar;99(3):497-501. Epub 2007 Dec 15.
8. Fogarty MP, etal., Biochem J. 2003 May 1;371(Pt 3):789-98.
9. Fuchs SY, etal., Oncogene. 1996 Oct 3;13(7):1531-5.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GOA data from the GO Consortium
12. Guan Z, etal., J Biol Chem. 1998 Oct 30;273(44):28670-6.
13. Guan Z, etal., J Biol Chem. 1999 Dec 17;274(51):36200-6.
14. Hreniuk D, etal., Mol Pharmacol. 2001 Apr;59(4):867-74.
15. Jezierski MK, etal., Endocrinology. 2001 Jun;142(6):2401.
16. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
17. KEGG
18. Kurokawa M, etal., EMBO J. 2000 Jun 15;19(12):2958-68.
19. Kyriakis JM, etal., Nature 1994 May 12;369(6476):156-60.
20. Meeker R and Fernandes A, Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E475-86.
21. MGD data from the GO Consortium
22. Miller B, etal., Biochem Biophys Res Commun 2003 Jan 24;300(4):884-8.
23. Papachristou DJ, etal., Histochem Cell Biol. 2005 Sep;124(3-4):215-23. Epub 2005 Oct 28.
24. Park HJ, etal., Hepatology. 2002 Jun;35(6):1360-71.
25. Pipeline to import KEGG annotations from KEGG into RGD
26. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. Rardin MJ, etal., J Biol Chem. 2008 May 30;283(22):15440-50. doi: 10.1074/jbc.M709547200. Epub 2008 Apr 2.
28. RGD automated import pipeline for gene-chemical interactions
29. Ricci R, etal., Science. 2004 Nov 26;306(5701):1558-61.
30. Sabapathy K, etal., Mech Dev 1999 Dec;89(1-2):115-24.
31. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Sui H, etal., Mol Cancer Ther. 2014 Dec;13(12):3137-51. doi: 10.1158/1535-7163.MCT-14-0167. Epub 2014 Sep 9.
33. Syed I, etal., Diabetes. 2011 Nov;60(11):2843-52. doi: 10.2337/db11-0809. Epub 2011 Sep 12.
34. Waetzig V and Herdegen T, Mol Cell Neurosci. 2005 Sep;30(1):67-78.
35. Wang R, etal., J Neurochem. 2006 Dec;99(6):1543-54. Epub 2006 Oct 25.
36. Wang Y, etal., Biochem J. 2007 Jan 1;401(1):65-78.
37. Zhang L, etal., Cell Cycle. 2007 Jun 15;6(12):1479-86. Epub 2007 Apr 18.
38. Zhang P, etal., Neurochem Res. 1998 Feb;23(2):219-25.
39. Zhang QX, etal., Biochemistry. 2007 Apr 3;46(13):4006-16. Epub 2007 Mar 10.
40. Zhu X, etal., J Neurochem. 2001 Jan;76(2):435-41.
Additional References at PubMed
PMID:8654373   PMID:8889548   PMID:9651196   PMID:10376527   PMID:11884367   PMID:12445686   PMID:16458303   PMID:16641100   PMID:17333127   PMID:17555943   PMID:18096574   PMID:18262097  
PMID:18287535   PMID:18625195   PMID:18666320   PMID:18926830   PMID:19362079   PMID:20196785   PMID:20595622   PMID:21856198   PMID:22441692   PMID:22644775   PMID:22661329   PMID:22753708  
PMID:22871113   PMID:23969109   PMID:24127566   PMID:24134609   PMID:24889144   PMID:25285524   PMID:26514923   PMID:29153991  


Genomics

Candidate Gene Status
Mapk9 is a candidate Gene for QTL Eau7
Comparative Map Data
Mapk9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01035,333,859 - 35,374,364 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,333,859 - 35,374,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,105,633 - 35,147,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,353,486 - 35,384,319 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11035,354,534 - 35,385,368 (+)NCBI
Celera1033,525,368 - 33,565,857 (+)NCBICelera
Cytogenetic Map10q21NCBI
MAPK9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5180,233,143 - 180,292,099 (-)EnsemblGRCh38hg38GRCh38
GRCh385180,233,143 - 180,292,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375179,660,594 - 179,719,071 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,595,390 - 179,640,216 (-)NCBINCBI36hg18NCBI36
Build 345179,595,389 - 179,640,216NCBI
Celera5175,286,573 - 175,345,058 (-)NCBI
Cytogenetic Map5q35.3NCBI
HuRef5174,385,878 - 174,444,273 (-)NCBIHuRef
CHM1_15179,092,988 - 179,151,485 (-)NCBICHM1_1
Mapk9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,737,558 - 49,777,248 (+)NCBIGRCm39mm39
GRCm381149,846,728 - 49,886,421 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1149,846,751 - 49,886,421 (+)EnsemblGRCm38mm10GRCm38
MGSCv371149,660,253 - 49,699,923 (+)NCBIGRCm37mm9NCBIm37
MGSCv361149,690,177 - 49,729,521 (+)NCBImm8
Celera1154,408,836 - 54,448,385 (+)NCBICelera
Cytogenetic Map11B1.2NCBI
Mapk9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955408391,094 - 430,981 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955408391,094 - 430,638 (+)NCBIChiLan1.0ChiLan1.0
MAPK9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15182,748,381 - 182,801,464 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5182,748,381 - 182,795,135 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05175,437,167 - 175,495,469 (-)NCBIMhudiblu_PPA_v0panPan3
MAPK9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl111,443,547 - 1,478,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1111,443,528 - 1,480,501 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mapk9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936739551,678 - 602,027 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,338,369 - 78,399,105 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,338,466 - 78,399,108 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2279,823,618 - 79,884,343 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK9
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2381,963,899 - 82,013,659 (-)Ensembl
ChlSab1.12381,965,330 - 82,026,414 (-)NCBI
Mapk9
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473342,998,948 - 43,048,392 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135538813Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138594330Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10622928936185929Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101263951357639513Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101482789492423564Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014827894107857673Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014827894110992275Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101537547462469074Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101646873661468736Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101824639453637634Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101940281464402814Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)1020170031102897474Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102152390683549467Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)12152390690312401Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102152390690312401Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102170776664648311Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum total immunoglobulin E level (CMO:0001542)102240281738204229Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102290149793886300Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102386101566539843Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1023861015112626471Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102488408447487910Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102723753064648311Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)1027237530101482600Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1027237530102427718Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102878928073789280Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)103002135454057745Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)103009990975099909Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)103009990975099909Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)103098380575983805Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103191939778343192Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103317903078179030Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103334319278343192Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103513942480139424Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:543
Count of miRNA genes:217
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000003987, ENSRNOT00000004010
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 55 39 19 39 8 11 74 35 41 11 8
Low 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003987   ⟹   ENSRNOP00000003987
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1035,333,859 - 35,374,355 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000004010   ⟹   ENSRNOP00000004010
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1035,333,859 - 35,374,355 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083688   ⟹   ENSRNOP00000070771
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1035,343,189 - 35,372,401 (+)Ensembl
RefSeq Acc Id: NM_001270544   ⟹   NP_001257473
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,333,859 - 35,374,364 (+)NCBI
Rnor_5.01035,105,633 - 35,147,516 (+)NCBI
Celera1033,525,368 - 33,565,857 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270545   ⟹   NP_001257474
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,333,859 - 35,374,364 (+)NCBI
Rnor_5.01035,105,633 - 35,147,516 (+)NCBI
Celera1033,525,368 - 33,565,857 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017322   ⟹   NP_059018
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,333,859 - 35,374,364 (+)NCBI
Rnor_5.01035,105,633 - 35,147,516 (+)NCBI
RGSC_v3.41035,353,486 - 35,384,319 (+)RGD
Celera1033,525,368 - 33,565,857 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006246318   ⟹   XP_006246380
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,342,751 - 35,374,364 (+)NCBI
Rnor_5.01035,105,633 - 35,147,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597479   ⟹   XP_017452968
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,333,862 - 35,363,499 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_059018   ⟸   NM_017322
- Peptide Label: isoform 1
- UniProtKB: P49186 (UniProtKB/Swiss-Prot),   Q6P727 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257473   ⟸   NM_001270544
- Peptide Label: isoform 2
- UniProtKB: P49186 (UniProtKB/Swiss-Prot),   D4A5V8 (UniProtKB/TrEMBL),   Q6P727 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257474   ⟸   NM_001270545
- Peptide Label: isoform 3
- UniProtKB: Q6P727 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246380   ⟸   XM_006246318
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452968   ⟸   XM_017597479
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000004010   ⟸   ENSRNOT00000004010
RefSeq Acc Id: ENSRNOP00000070771   ⟸   ENSRNOT00000083688
RefSeq Acc Id: ENSRNOP00000003987   ⟸   ENSRNOT00000003987
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697146
Promoter ID:EPDNEW_R7671
Type:initiation region
Name:Mapk9_1
Description:mitogen-activated protein kinase 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01035,333,842 - 35,333,902EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628847 AgrOrtholog
Ensembl Genes ENSRNOG00000002823 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003987 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000004010 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070771 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003987 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000004010 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000083688 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598943 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPK_JNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50658 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72494 IMAGE-MGC_LOAD
NCBI Gene 50658 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mapk9 PhenoGen
PRINTS JNKMAPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MAPK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.177202 ENTREZGENE
  Rn.9910 ENTREZGENE
UniProt A0A0G2JYS4 ENTREZGENE, UniProtKB/TrEMBL
  D4A5V8 ENTREZGENE, UniProtKB/TrEMBL
  MK09_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P727 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Mapk9  mitogen-activated protein kinase 9    stress activated protein kinase alpha II  Name updated 1299863 APPROVED
2003-02-27 Mapk9  stress activated protein kinase alpha II      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process activation has a role in the initiation of PC12 cell death 729126