Il3 (interleukin 3) - Rat Genome Database

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Gene: Il3 (interleukin 3) Rattus norvegicus
Analyze
Symbol: Il3
Name: interleukin 3
RGD ID: 2897
Description: Enables cytokine activity and interleukin-3 receptor binding activity. Involved in several processes, including hemopoiesis; positive regulation of cell population proliferation; and regulation of cell growth. Located in extracellular space. Used to study osteosarcoma. Biomarker of prostatic hypertrophy and pyelonephritis. Human ortholog(s) of this gene implicated in Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-3 signaling pathway; apoptotic cell death pathway; INTERACTS WITH ammonium chloride; bisphenol A; Calcimycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hematopoietic growth factor; IL-3; interleukin-3; mast cell growth factor; MCGF; multipotential colony-stimulating factor; P-cell-stimulating factor
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21038,405,716 - 38,408,066 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1038,405,716 - 38,408,066 (-)Ensembl
Rnor_6.01039,620,535 - 39,622,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,620,563 - 39,622,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,397,782 - 39,400,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,684,691 - 39,687,041 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,698,313 - 39,700,664 (-)NCBI
Celera1037,746,256 - 37,748,606 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
alclometasone dipropionate  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aspartame  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
betamethasone valerate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
chloroquine  (ISO)
ciprofloxacin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
entinostat  (ISO)
ethanol  (ISO)
formaldehyde  (ISO)
hydralazine  (ISO)
ionomycin  (ISO)
lipopolysaccharide  (ISO)
luteolin  (EXP)
methotrexate  (ISO)
microcystin-LR  (ISO)
monodansylcadaverine  (ISO)
mycophenolic acid  (ISO)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
naproxen  (EXP)
neocuproine  (ISO)
nonanoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenylarsine oxide  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
resveratrol  (EXP,ISO)
sirolimus  (ISO)
sterigmatocystin  (ISO)
sumatriptan  (EXP)
tacrolimus hydrate  (ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (ISO)
B cell apoptotic process  (ISO)
B cell proliferation  (ISO)
cell population proliferation  (ISO)
cytokine-mediated signaling pathway  (ISO)
embryonic hemopoiesis  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
hemopoiesis  (IMP)
immune response  (IEA)
interleukin-3-mediated signaling pathway  (ISO)
JNK cascade  (ISO)
mast cell apoptotic process  (ISO)
mast cell proliferation  (ISO)
monocyte differentiation  (ISO)
myeloid cell apoptotic process  (ISO)
myeloid leukocyte differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of autophagy  (ISO)
negative regulation of B cell apoptotic process  (ISO)
negative regulation of mast cell apoptotic process  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell population proliferation  (IDA,IMP,ISO,ISS)
positive regulation of hematopoietic progenitor cell differentiation  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of mast cell proliferation  (ISO)
positive regulation of myeloid leukocyte differentiation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO,ISS)
positive regulation of protein phosphorylation  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
protein phosphorylation  (ISO)
regulation of cell growth  (IMP,ISO)
regulation of gene expression  (ISO)
regulation of glycolytic process  (ISO)
regulation of protein dephosphorylation  (ISO)
response to hormone  (IMP)
response to hypoxia  (ISO)
signal transduction  (IEA,ISO)
T cell proliferation  (ISO)

Cellular Component
extracellular space  (IDA,IEA,ISO,ISS)

Molecular Function
cytokine activity  (IDA,IEA,IMP,ISO,ISS)
growth factor activity  (IEA,ISO)
interleukin-3 receptor binding  (IEA,IMP,ISO)

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of the rat interleukin-3 gene. Cohen DR, etal., Nucleic Acids Res 1986 May 12;14(9):3641-58.
2. Adenovirus-mediated interleukin 3 beta gene transfer by isolated limb perfusion inhibits growth of limb sarcoma in rats. de Wilt JH, etal., Hum Gene Ther. 2001 Mar 20;12(5):489-502.
3. Cloning, biological characterization and high-level expression of rat interleukin-3 using recombinant adenovirus: description of a new splicing variant. del C Esandi M, etal., Gene 1998 Apr 28;211(1):151-8.
4. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
5. A dual role for the immune response in a mouse model of inflammation-associated lung cancer. Dougan M, etal., J Clin Invest. 2011 Jun 1;121(6):2436-46. doi: 10.1172/JCI44796. Epub 2011 May 2.
6. Strongyloides ratti infection induces transient nematode-specific Th2 response and reciprocal suppression of IFN-gamma production in mice. Eschbach ML, etal., Parasite Immunol. 2010 May;32(5):370-83.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Identification of a 5-protein biomarker molecular signature for predicting Alzheimer's disease. Gomez Ravetti M and Moscato P, PLoS One. 2008 Sep 3;3(9):e3111.
9. Rat IL-3 stimulates the growth of rat mucosal mast cells in culture. Haig DM, etal., Immunology. 1988 Oct;65(2):205-11.
10. The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production. Helmy A, etal., J Cereb Blood Flow Metab. 2011 Feb;31(2):658-70. Epub 2010 Aug 18.
11. Rheumatoid arthritis-associated gene-gene interaction network for rheumatoid arthritis candidate genes. Huang CH, etal., BMC Proc. 2009 Dec 15;3 Suppl 7:S75.
12. Global gene expression profiling of renal scarring in a rat model of pyelonephritis. Ichino M, etal., Pediatr Nephrol. 2008 Jul;23(7):1059-71. Epub 2008 Jan 23.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: the Kyushu Okinawa maternal and child health study. Miyake Y, etal., Cytokine. 2013 Oct;64(1):86-9. doi: 10.1016/j.cyto.2013.07.020. Epub 2013 Aug 15.
15. IL3 rs40401 polymorphism and interaction with smoking in risk of asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health study. Miyake Y, etal., Scand J Immunol. 2014 Jun;79(6):410-4. doi: 10.1111/sji.12171.
16. Hematopoietic cytokines in the sera of patients with pancreatic cancer. Mroczko B, etal., Clin Chem Lab Med. 2005;43(2):146-50.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats. Nishihara T, etal., Exp Neurol. 2011 Jun;229(2):507-16. Epub 2011 Apr 16.
19. Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. Park BL, etal., J Hum Genet. 2004;49(10):517-27. doi: 10.1007/s10038-004-0184-x. Epub 2004 Sep 11.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Ray S, etal., Nat Med. 2007 Nov;13(11):1359-62. Epub 2007 Oct 14.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia. Rick FG, etal., Prostate. 2011 May 15;71(7):736-47. doi: 10.1002/pros.21289. Epub 2010 Oct 13.
28. Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection. Shao Y, etal., Acta Virol. 2010;54(4):261-7.
29. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Shelton RC, etal., Mol Psychiatry. 2011 Jul;16(7):751-62. doi: 10.1038/mp.2010.52. Epub 2010 May 18.
30. Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects. van Dijk SJ, etal., PLoS One. 2010 Dec 23;5(12):e14422.
31. Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis. Wauquier N, etal., PLoS Negl Trop Dis. 2010 Oct 5;4(10). pii: e837.
32. Differential cytokine secretion of cultured bone marrow stromal cells from patients with psoriasis and healthy volunteers. Zhang K, etal., Eur J Dermatol. 2010 Jan-Feb;20(1):49-53. Epub 2009 Nov 4.
33. Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease. Zhu W, etal., J Endocrinol Invest. 2010 Nov;33(10):751-5. Epub 2010 Mar 22.
Additional References at PubMed
PMID:1350248   PMID:1375116   PMID:7519779   PMID:7690439   PMID:7736574   PMID:7957045   PMID:8378315   PMID:9202146   PMID:9697835   PMID:9722506   PMID:9747458   PMID:10652277  
PMID:10872802   PMID:11527400   PMID:12124386   PMID:12714518   PMID:12944463   PMID:14967141   PMID:15231831   PMID:15680329   PMID:15947484   PMID:17437992   PMID:19109256   PMID:20696593  
PMID:21149635   PMID:25389122   PMID:34183475  


Genomics

Candidate Gene Status
Il3 is a candidate Gene for QTL Eau7
Comparative Map Data
Il3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21038,405,716 - 38,408,066 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1038,405,716 - 38,408,066 (-)Ensembl
Rnor_6.01039,620,535 - 39,622,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,620,563 - 39,622,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,397,782 - 39,400,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,684,691 - 39,687,041 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,698,313 - 39,700,664 (-)NCBI
Celera1037,746,256 - 37,748,606 (-)NCBICelera
Cytogenetic Map10q22NCBI
IL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,060,655 - 132,063,204 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5132,060,655 - 132,063,204 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,396,348 - 131,398,897 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,424,246 - 131,426,795 (+)NCBINCBI36hg18NCBI36
Build 345131,424,245 - 131,426,795NCBI
Celera5127,526,422 - 127,528,971 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5126,588,706 - 126,591,255 (+)NCBIHuRef
CHM1_15130,829,174 - 130,831,722 (+)NCBICHM1_1
T2T-CHM13v2.05132,580,524 - 132,583,073 (+)NCBI
Il3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,155,911 - 54,158,105 (-)NCBIGRCm39mm39
GRCm39 Ensembl1154,156,129 - 54,158,103 (-)Ensembl
GRCm381154,265,085 - 54,267,279 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,265,303 - 54,267,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv371154,078,587 - 54,080,781 (-)NCBIGRCm37mm9NCBIm37
MGSCv361154,108,726 - 54,110,700 (-)NCBImm8
Celera1158,854,078 - 58,856,272 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
IL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15133,647,667 - 133,650,213 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,647,667 - 133,650,213 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05127,483,843 - 127,486,388 (+)NCBIMhudiblu_PPA_v0panPan3
IL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,330,480 - 20,332,668 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,330,480 - 20,332,668 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,126,033 - 19,128,221 (+)NCBI
UMICH_Zoey_3.11119,835,277 - 19,837,465 (+)NCBI
UNSW_CanFamBas_1.01119,683,253 - 19,685,440 (+)NCBI
UU_Cfam_GSD_1.01120,324,838 - 20,327,026 (+)NCBI
Il3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,100,160 - 116,101,996 (-)NCBI
SpeTri2.0NW_0049366473,102,922 - 3,104,758 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,894,630 - 34,899,105 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603443,059,393 - 43,061,627 (-)NCBIVero_WHO_p1.0

Position Markers
D10Wox10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21038,406,240 - 38,407,090 (+)MAPPERmRatBN7.2
Rnor_6.01039,621,088 - 39,621,997NCBIRnor6.0
Rnor_5.01039,398,307 - 39,399,216UniSTSRnor5.0
RGSC_v3.41039,685,216 - 39,686,065UniSTSRGSC3.4
Celera1037,746,781 - 37,747,630UniSTS
Cytogenetic Map10q22UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000031762
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system renal system reproductive system respiratory system
High
Medium
Low
Below cutoff 5 1 6 1 1 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000031762   ⟹   ENSRNOP00000030704
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1038,405,716 - 38,408,066 (-)Ensembl
Rnor_6.0 Ensembl1039,620,563 - 39,622,973 (-)Ensembl
RefSeq Acc Id: NM_031513   ⟹   NP_113701
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21038,405,716 - 38,408,066 (-)NCBI
Rnor_6.01039,620,563 - 39,622,973 (-)NCBI
Rnor_5.01039,397,782 - 39,400,192 (-)NCBI
RGSC_v3.41039,684,691 - 39,687,041 (-)RGD
Celera1037,746,256 - 37,748,606 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246226   ⟹   XP_006246288
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21038,405,716 - 38,408,060 (-)NCBI
Rnor_6.01039,620,535 - 39,622,956 (-)NCBI
Rnor_5.01039,397,782 - 39,400,192 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_113701   ⟸   NM_031513
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_006246288   ⟸   XM_006246226
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000030704   ⟸   ENSRNOT00000031762

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04823-F1-model_v2 AlphaFold P04823 1-166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6850122
Promoter ID:EP14065
Type:single initiation site
Name:RN_IL3
Description:Interleukin-3, multi-colony stimulating factor, IL3 or IL-3 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 48; Mammalian interleukin-3
Experiment Methods:Sequencing of a full-length cDNA; experiments performed with; closely related gene
Regulation:T (repressed by or weakly expressed in) lymphocytes; (induced by or strongly expressed in) antigen
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41039,687,045 - 39,687,105EPD

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2897 AgrOrtholog
BioCyc Gene G2FUF-25117 BioCyc
Ensembl Genes ENSRNOG00000026786 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000030704 ENTREZGENE
  ENSRNOP00000030704.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031762 ENTREZGENE
  ENSRNOT00000031762.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24495 UniProtKB/TrEMBL
NCBI Gene 24495 ENTREZGENE
Pfam IL3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il3 PhenoGen
PIRSF IL-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTERLEUKIN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LS41_RAT UniProtKB/TrEMBL
  IL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P97688_RAT UniProtKB/TrEMBL
UniProt Secondary P70513 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il3  interleukin 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in bone marrow cells 728966