Enables cytokine activity and interleukin-3 receptor binding activity. Involved in several processes, including hemopoiesis; positive regulation of cell population proliferation; and regulation of cell growth. Located in extracellular space. Used to study osteosarcoma. Biomarker of prostatic hypertrophy and pyelonephritis. Human ortholog(s) of this gene implicated in Graves ophthalmopathy; Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; interleukin-3 signaling pathway; apoptotic cell death pathway; INTERACTS WITH ammonium chloride; bisphenol A; Calcimycin.
Luteolin inhibits the reaction [Calcimycin results in increased expression of IL3 mRNA] and thunberginol B inhibits the reaction [Calcimycin results in increased expression of IL3 mRNA]
Cannabidiol inhibits the reaction [MOG protein modified form results in increased expression of IL3 mRNA] and Cannabidiol inhibits the reaction [MOG protein modified form results in increased secretion of IL3 protein]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein] and Naproxen inhibits the reaction [Capsaicin affects the expression of IL3 protein]
Sirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein]]
[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IL3 protein] and Sumatriptan inhibits the reaction [Capsaicin affects the expression of IL3 protein]
Sirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein]] and Tacrolimus inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL3 protein]
Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein] more ...
Cloning, biological characterization and high-level expression of rat interleukin-3 using recombinant adenovirus: description of a new splicing variant.
LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia.