Symbol:
Hnrnpd
Name:
heterogeneous nuclear ribonucleoprotein D
Description:
Exhibits several functions, including chromatin binding activity; histone deacetylase binding activity; and nucleic acid binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to organonitrogen compound; and regulation of mRNA stability. Localizes to the cytosol and nucleus. Used to study uremia. Biomarker of hepatocellular carcinoma. Orthologous to human HNRNPD (heterogeneous nuclear ribonucleoprotein D); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane; 1,2,4-trimethylbenzene; adenine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AU-rich element RNA-binding factor 1; AU-rich element RNA-binding protein 1; Auf1; heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; Hnrpd; RNA binding protein p45AUF1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
HNRNPD (heterogeneous nuclear ribonucleoprotein D) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Hnrnpd (heterogeneous nuclear ribonucleoprotein D) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Hnrnpd (heterogeneous nuclear ribonucleoprotein D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
HNRNPD (heterogeneous nuclear ribonucleoprotein D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
HNRNPD (heterogeneous nuclear ribonucleoprotein D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Hnrnpd (heterogeneous nuclear ribonucleoprotein D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
HNRNPD (heterogeneous nuclear ribonucleoprotein D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
HNRNPD (heterogeneous nuclear ribonucleoprotein D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Hnrnpd (heterogeneous nuclear ribonucleoprotein D) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
HNRNPD (heterogeneous nuclear ribonucleoprotein D)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Hnrnpd (heterogeneous nuclear ribonucleoprotein D)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
hnrnpd (heterogeneous nuclear ribonucleoprotein D)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
HRP1
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, PANTHER)
Drosophila melanogaster (fruit fly):
sqd
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
sqd-1
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 14 11,256,163 - 11,274,684 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 14 11,256,268 - 11,274,578 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 14 11,200,186 - 11,218,696 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 14 10,917,674 - 10,935,989 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 14 10,917,909 - 10,935,760 (+) NCBI Celera 14 9,716,133 - 9,734,433 (+) NCBI Celera Cytogenetic Map 14 p22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(-)-demecolcine decreases expression ISO RGD:733451 6480464 Demecolcine results in decreased expression of HNRNPD mRNA CTD PMID:23649840 (Z)-3-butylidenephthalide increases expression ISO RGD:733451 6480464 butylidenephthalide results in increased expression of HNRNPD protein CTD PMID:23770345 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane increases expression EXP 6480464 2, 2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of HNRNPD protein CTD PMID:16683234 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane multiple interactions EXP 6480464 2 more ... CTD PMID:16683234 1,2,4-trimethylbenzene decreases expression EXP 6480464 pseudocumene results in decreased expression of HNRNPD protein CTD PMID:17337753 14-Deoxy-11,12-didehydroandrographolide decreases expression ISO RGD:733451 6480464 14-deoxy-11, 12-didehydroandrographolide results in decreased expression of HNRNPD mRNA CTD PMID:22101062 17beta-estradiol affects expression ISO RGD:733452 6480464 Estradiol affects the expression of HNRNPD mRNA CTD PMID:15598610 17beta-estradiol decreases expression ISO RGD:733452 6480464 Estradiol results in decreased expression of HNRNPD mRNA CTD PMID:30077407 17beta-estradiol multiple interactions ISO RGD:733452 6480464 [Polyphenols co-treated with Estradiol] results in decreased expression of HNRNPD mRNA CTD PMID:30077407 2,2',4,4'-Tetrabromodiphenyl ether increases expression ISO RGD:733451 6480464 2 more ... CTD PMID:19095052 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733452 6480464 Tetrachlorodibenzodioxin affects the expression of HNRNPD mRNA CTD PMID:21570461 2,6-di-tert-butyl-4-methylphenol affects localization ISO RGD:733452 6480464 Butylated Hydroxytoluene affects the localization of HNRNPD protein CTD PMID:10900464 4-hydroxyphenyl retinamide increases expression ISO RGD:733452 6480464 Fenretinide results in increased expression of HNRNPD mRNA CTD PMID:28973697 adenine multiple interactions EXP 6480464 [Adenine co-treated with Phosphorus] results in increased metabolism of HNRNPD protein more ... CTD PMID:16291838 , PMID:18583400 aflatoxin B1 increases expression ISO RGD:733452 6480464 Aflatoxin B1 results in increased expression of HNRNPD mRNA CTD PMID:19770486 all-trans-retinoic acid increases expression ISO RGD:733452 6480464 Tretinoin results in increased expression of HNRNPD protein alternative form CTD PMID:16514630 antirheumatic drug increases expression ISO RGD:733451 6480464 Antirheumatic Agents results in increased expression of HNRNPD mRNA CTD PMID:24449571 Aroclor 1254 decreases expression ISO RGD:733452 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of HNRNPD mRNA CTD PMID:23650126 atrazine decreases expression ISO RGD:733451 6480464 Atrazine results in decreased expression of HNRNPD mRNA CTD PMID:22378314 benzo[a]pyrene decreases expression ISO RGD:733451 6480464 Benzo(a)pyrene results in decreased expression of HNRNPD mRNA, Benzo(a)pyrene results in decreased expression of HNRNPD protein CTD PMID:20064835 more ... benzo[a]pyrene increases expression ISO RGD:733451 6480464 Benzo(a)pyrene results in increased expression of HNRNPD mRNA CTD PMID:22316170 benzo[a]pyrene diol epoxide I increases expression ISO RGD:733451 6480464 7 more ... CTD PMID:20382639 bisphenol A decreases expression ISO RGD:733451 6480464 bisphenol A results in decreased expression of HNRNPD mRNA CTD PMID:25047013 , PMID:29275510 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of HNRNPD mRNA CTD PMID:30903817 bisphenol A affects methylation ISO RGD:733452 6480464 bisphenol A affects the methylation of HNRNPD promoter CTD PMID:27334623 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HNRNPD mRNA CTD PMID:18180321 , PMID:30816183 Brodifacoum increases expression EXP 6480464 bromfenacoum results in increased expression of HNRNPD protein CTD PMID:28903499 butanal decreases expression ISO RGD:733451 6480464 butyraldehyde results in decreased expression of HNRNPD mRNA CTD PMID:26079696 cadmium sulfate multiple interactions ISO RGD:733451 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of HNRNPD mRNA CTD PMID:18654764 calcium atom multiple interactions EXP 6480464 Calcium deficiency promotes the reaction [HNRNPD protein binds to PTH 3' UTR] CTD PMID:18583400 calcium(0) multiple interactions EXP 6480464 Calcium deficiency promotes the reaction [HNRNPD protein binds to PTH 3' UTR] CTD PMID:18583400 carbamazepine affects expression ISO RGD:733451 6480464 Carbamazepine affects the expression of HNRNPD mRNA CTD PMID:24752500 carbon nanotube increases expression ISO RGD:733452 6480464 Nanotubes, Carbon analog results in increased expression of HNRNPD mRNA CTD PMID:25620056 chlorpyrifos decreases expression EXP 6480464 Chlorpyrifos results in decreased expression of HNRNPD mRNA CTD PMID:18668222 cisplatin multiple interactions ISO RGD:733451 6480464 Cisplatin affects the reaction [Piroxicam results in decreased expression of HNRNPD mRNA] CTD PMID:21858171 cisplatin decreases expression ISO RGD:733451 6480464 Cisplatin results in decreased expression of HNRNPD mRNA CTD PMID:27392435 cobalt dichloride multiple interactions ISO RGD:733451 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of HNRNPD mRNA CTD PMID:18654764 cobalt dichloride increases expression ISO RGD:733451 6480464 cobaltous chloride results in increased expression of HNRNPD mRNA CTD PMID:19376846 cobalt dichloride decreases expression ISO RGD:733451 6480464 cobaltous chloride results in decreased expression of HNRNPD mRNA CTD PMID:19320972 copper atom multiple interactions ISO RGD:733451 6480464 [NSC 689534 binds to Copper] which results in decreased expression of HNRNPD mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:733451 6480464 [NSC 689534 binds to Copper] which results in decreased expression of HNRNPD mRNA CTD PMID:20971185 curcumin decreases expression ISO RGD:733451 6480464 Curcumin results in decreased expression of HNRNPD mRNA CTD PMID:17999991 cyclosporin A decreases expression ISO RGD:733451 6480464 Cyclosporine results in decreased expression of HNRNPD mRNA CTD PMID:25562108 daunorubicin affects response to substance ISO RGD:733451 6480464 HNRNPD affects the susceptibility to Daunorubicin CTD PMID:18451141 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of HNRNPD mRNA CTD PMID:21804312 dibutyl phthalate decreases expression ISO RGD:733452 6480464 Dibutyl Phthalate results in decreased expression of HNRNPD mRNA CTD PMID:17361019 , PMID:21266533 diclofenac affects expression ISO RGD:733451 6480464 Diclofenac affects the expression of HNRNPD mRNA CTD PMID:24752500 dihydroartemisinin affects binding ISO RGD:733451 6480464 dihydroartemisinin analog binds to HNRNPD protein CTD PMID:26340163 disodium selenite increases expression ISO RGD:733451 6480464 Sodium Selenite results in increased expression of HNRNPD mRNA CTD PMID:18175754 diuron increases expression EXP 6480464 Diuron results in increased expression of HNRNPD mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:733451 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HNRNPD mRNA CTD PMID:27188386 doxorubicin decreases response to substance ISO RGD:733451 6480464 HNRNPD protein results in decreased susceptibility to Doxorubicin CTD PMID:24675091 elemental selenium increases expression ISO RGD:733451 6480464 Selenium results in increased expression of HNRNPD mRNA CTD PMID:19244175 enzyme inhibitor multiple interactions ISO RGD:733451 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HNRNPD protein CTD PMID:23301498 ethyl methanesulfonate decreases expression ISO RGD:733451 6480464 Ethyl Methanesulfonate results in decreased expression of HNRNPD mRNA CTD PMID:23649840 flutamide increases expression EXP 6480464 Flutamide results in increased expression of HNRNPD mRNA CTD PMID:24136188 formaldehyde decreases expression ISO RGD:733451 6480464 Formaldehyde results in decreased expression of HNRNPD mRNA CTD PMID:20655997 , PMID:23649840 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of HNRNPD mRNA CTD PMID:22061828 hydrogen peroxide affects expression ISO RGD:733451 6480464 Hydrogen Peroxide affects the expression of HNRNPD mRNA CTD PMID:20044591 hydrogen sulfide increases expression ISO RGD:733452 6480464 Hydrogen Sulfide results in increased expression of HNRNPD protein CTD PMID:29932956 irinotecan decreases expression ISO RGD:733451 6480464 Irinotecan analog results in decreased expression of HNRNPD mRNA CTD PMID:18927307 lead(0) affects splicing ISO RGD:733451 6480464 Lead affects the splicing of HNRNPD mRNA CTD PMID:28903495 lead(2+) affects splicing ISO RGD:733451 6480464 Lead affects the splicing of HNRNPD mRNA CTD PMID:28903495 lead(II) chloride multiple interactions ISO RGD:733451 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in decreased expression of HNRNPD mRNA CTD PMID:18654764 lipopolysaccharide multiple interactions ISO RGD:733451 6480464 HNRNPD protein inhibits the reaction [Lipopolysaccharides results in increased expression of CCL20 mRNA] more ... CTD PMID:21135123 lipopolysaccharide multiple interactions EXP 6480464 HNRNPD mutant form inhibits the reaction [2, 2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of MMP9 protein]] CTD PMID:16683234 methotrexate affects expression ISO RGD:733452 6480464 Methotrexate affects the expression of HNRNPD mRNA CTD PMID:18502557 methyl methanesulfonate decreases expression ISO RGD:733451 6480464 Methyl Methanesulfonate results in decreased expression of HNRNPD mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:733451 6480464 methylmercuric chloride results in decreased expression of HNRNPD mRNA CTD PMID:28001369 N-methyl-4-phenylpyridinium increases expression ISO RGD:733452 6480464 1-Methyl-4-phenylpyridinium results in increased expression of HNRNPD protein CTD PMID:26558463 N-methyl-4-phenylpyridinium increases expression ISO RGD:733451 6480464 1-Methyl-4-phenylpyridinium results in increased expression of HNRNPD mRNA CTD PMID:24810058 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of HNRNPD mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:733451 6480464 Acetaminophen affects the expression of HNRNPD mRNA CTD PMID:21420995 paracetamol decreases expression ISO RGD:733451 6480464 Acetaminophen results in decreased expression of HNRNPD mRNA CTD PMID:26497421 , PMID:29067470 paracetamol affects expression ISO RGD:733452 6480464 Acetaminophen affects the expression of HNRNPD mRNA CTD PMID:17562736 paraquat increases expression ISO RGD:733452 6480464 Paraquat results in increased expression of HNRNPD mRNA alternative form CTD PMID:17064354 pentachlorophenol increases expression ISO RGD:733452 6480464 Pentachlorophenol results in increased expression of HNRNPD mRNA CTD PMID:23892564 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of HNRNPD mRNA CTD PMID:19162173 phenylmercury acetate decreases expression ISO RGD:733451 6480464 Phenylmercuric Acetate results in decreased expression of HNRNPD mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:733451 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HNRNPD mRNA CTD PMID:27188386 phosphorus atom multiple interactions EXP 6480464 [Adenine co-treated with Phosphorus] results in increased metabolism of HNRNPD protein more ... CTD PMID:16291838 , PMID:18583400 phosphorus(.) multiple interactions EXP 6480464 [Adenine co-treated with Phosphorus] results in increased metabolism of HNRNPD protein more ... CTD PMID:16291838 , PMID:18583400 piroxicam decreases expression ISO RGD:733451 6480464 Piroxicam results in decreased expression of HNRNPD mRNA CTD PMID:21858171 piroxicam multiple interactions ISO RGD:733451 6480464 Cisplatin affects the reaction [Piroxicam results in decreased expression of HNRNPD mRNA] CTD PMID:21858171 putrescine multiple interactions EXP 6480464 Putrescine inhibits the reaction [Ornithine Decarboxylase Inhibitors inhibits the reaction [HNRNPD protein binds to JUND 3' UTR]] CTD PMID:20805360 quercetin decreases expression ISO RGD:733451 6480464 Quercetin results in decreased expression of HNRNPD mRNA CTD PMID:21632981 quinoline decreases expression ISO RGD:733451 6480464 quinoline analog results in decreased expression of HNRNPD protein CTD PMID:18645022 resveratrol decreases expression ISO RGD:733452 6480464 resveratrol results in decreased expression of HNRNPD protein CTD PMID:25505154 SB 431542 multiple interactions ISO RGD:733451 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HNRNPD mRNA CTD PMID:27188386 selenium atom increases expression ISO RGD:733451 6480464 Selenium results in increased expression of HNRNPD mRNA CTD PMID:19244175 sevoflurane affects expression EXP 6480464 sevoflurane affects the expression of HNRNPD mRNA CTD PMID:15967596 silver atom affects expression ISO RGD:733452 6480464 Silver affects the expression of HNRNPD mRNA CTD PMID:27131904 silver(0) affects expression ISO RGD:733452 6480464 Silver affects the expression of HNRNPD mRNA CTD PMID:27131904 sirolimus decreases expression ISO RGD:733451 6480464 Sirolimus results in decreased expression of HNRNPD protein CTD PMID:17603996 sirolimus increases expression EXP 6480464 Sirolimus results in increased expression of HNRNPD protein CTD PMID:17603996 sodium arsenite affects expression ISO RGD:733451 6480464 sodium arsenite affects the expression of HNRNPD mRNA CTD PMID:28595984 , PMID:29319823 Soman increases expression EXP 6480464 Soman results in increased expression of HNRNPD mRNA CTD PMID:19281266 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of HNRNPD mRNA CTD PMID:31150632 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of HNRNPD mRNA CTD PMID:25729387 Tributyltin oxide increases phosphorylation ISO RGD:733452 6480464 bis(tri-n-butyltin)oxide results in increased phosphorylation of HNRNPD protein CTD PMID:22174045 trichostatin A affects expression ISO RGD:733451 6480464 trichostatin A affects the expression of HNRNPD mRNA CTD PMID:28542535 trimellitic anhydride increases expression ISO RGD:733452 6480464 trimellitic anhydride results in increased expression of HNRNPD mRNA CTD PMID:19042947 troglitazone decreases expression ISO RGD:733452 6480464 troglitazone results in decreased expression of HNRNPD mRNA CTD PMID:28973697 urethane affects localization ISO RGD:733452 6480464 Urethane affects the localization of HNRNPD protein CTD PMID:10900464 urethane decreases expression ISO RGD:733451 6480464 Urethane results in decreased expression of HNRNPD mRNA CTD PMID:28818685 urethane increases expression ISO RGD:733452 6480464 Urethane results in increased expression of HNRNPD protein CTD PMID:10900464 valproic acid affects expression ISO RGD:733451 6480464 Valproic Acid affects the expression of HNRNPD mRNA CTD PMID:23179753 more ... valproic acid decreases expression ISO RGD:733451 6480464 Valproic Acid results in decreased expression of HNRNPD mRNA CTD PMID:28001369 vincristine decreases expression ISO RGD:733451 6480464 Vincristine results in decreased expression of HNRNPD mRNA CTD PMID:23649840 vorinostat decreases expression ISO RGD:733451 6480464 vorinostat results in decreased expression of HNRNPD mRNA CTD PMID:27188386 
Gene-Chemical Interaction Annotations
