MIR449B (microRNA 449b) - Rat Genome Database

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Gene: MIR449B (microRNA 449b) Homo sapiens
Analyze
Symbol: MIR449B
Name: microRNA 449b
RGD ID: 1603133
HGNC Page HGNC
Description: Predicted to be involved in several processes, including embryonic brain development; motile cilium assembly; and spermatogenesis.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-449b; MIRN449B
RGD Orthologs
Mouse
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl555,170,646 - 55,170,742 (-)EnsemblGRCh38hg38GRCh38
GRCh38555,170,646 - 55,170,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37554,466,474 - 54,466,570 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36554,502,230 - 54,502,326 (-)NCBINCBI36hg18NCBI36
Celera551,419,320 - 51,419,416 (-)NCBI
Cytogenetic Map5q11.2NCBI
HuRef551,439,647 - 51,439,743 (-)NCBIHuRef
CHM1_1554,469,967 - 54,470,063 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References
Additional References at PubMed
PMID:16381832   PMID:16505370   PMID:17604727   PMID:19144710   PMID:19960022   PMID:21037258   PMID:21321636   PMID:23674142   PMID:24086750   PMID:24120948   PMID:26055141   PMID:26242266  
PMID:27552335   PMID:28489914   PMID:29331413   PMID:30066926   PMID:30128865   PMID:30738779   PMID:31103631   PMID:31350893   PMID:31425497   PMID:31433128   PMID:32074771   PMID:32471413  
PMID:32495889  


Genomics

Comparative Map Data
MIR449B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl555,170,646 - 55,170,742 (-)EnsemblGRCh38hg38GRCh38
GRCh38555,170,646 - 55,170,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37554,466,474 - 54,466,570 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36554,502,230 - 54,502,326 (-)NCBINCBI36hg18NCBI36
Celera551,419,320 - 51,419,416 (-)NCBI
Cytogenetic Map5q11.2NCBI
HuRef551,439,647 - 51,439,743 (-)NCBIHuRef
CHM1_1554,469,967 - 54,470,063 (-)NCBICHM1_1
Mir449b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913113,173,953 - 113,174,032 (+)NCBIGRCm39mm39
GRCm39 Ensembl13113,173,953 - 113,174,032 (+)Ensembl
GRCm3813113,037,419 - 113,037,498 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13113,037,419 - 113,037,498 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713113,827,627 - 113,827,706 (+)NCBIGRCm37mm9NCBIm37
Celera13117,355,436 - 117,355,515 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
MIR449B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,542,049 - 42,542,177 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,542,049 - 42,542,177 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,587,625 - 39,587,753 (-)NCBI
ROS_Cfam_1.0243,004,082 - 43,004,210 (-)NCBI
UMICH_Zoey_3.1240,070,125 - 40,070,253 (-)NCBI
UNSW_CanFamBas_1.0240,884,685 - 40,884,813 (-)NCBI
UU_Cfam_GSD_1.0241,707,607 - 41,707,735 (-)NCBI

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
HDAC1hsa-miR-449b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21418558
CDK4hsa-miR-449b-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI19833767
CDC25Ahsa-miR-449b-5pMirtarbaseexternal_infoReporter assay;Western blotFunctional MTI19833767
CDK4hsa-miR-449b-5pTarbaseexternal_infoWesternblitNEGATIVE
CDK6hsa-miR-449b-5pTarbaseexternal_infoReporter GenePOSITIVE
CDK6hsa-miR-449b-5pTarbaseexternal_infoWesternblitPOSITIVE
HDAC1hsa-miR-449b-5pOncomiRDBexternal_infoNANA22078727
CDK6hsa-miR-449b-5pOncomiRDBexternal_infoNANA19833767

Predicted Targets
Summary Value
Count of predictions:55972
Count of gene targets:18689
Count of transcripts:43266
Interacting mature miRNAs:hsa-miR-449b-3p, hsa-miR-449b-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue appendage
High
Medium
Low 2 3 2 1 6 2 7 5 1 3
Below cutoff 4 5 2 1 3 1 6 8 6 2 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384995
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl555,170,646 - 55,170,742 (-)Ensembl
RefSeq Acc Id: NR_030387
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38555,170,646 - 55,170,742 (-)NCBI
GRCh37554,466,474 - 54,466,570 (-)RGD
Celera551,419,320 - 51,419,416 (-)RGD
HuRef551,439,647 - 51,439,743 (-)RGD
CHM1_1554,469,967 - 54,470,063 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q11.1-12.1(chr5:50288355-63149770)x1 copy number loss See cases [RCV000050797] Chr5:50288355..63149770 [GRCh38]
Chr5:49584189..62445597 [GRCh37]
Chr5:49619946..62481353 [NCBI36]
Chr5:5q11.1-12.1
pathogenic
GRCh38/hg38 5q11.1-11.2(chr5:50288355-56717370)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051838]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051838]|See cases [RCV000051838] Chr5:50288355..56717370 [GRCh38]
Chr5:49584189..56013197 [GRCh37]
Chr5:49619946..56048954 [NCBI36]
Chr5:5q11.1-11.2
pathogenic
GRCh38/hg38 5q11.2(chr5:53332485-57152396)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053283]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053283]|See cases [RCV000053283] Chr5:53332485..57152396 [GRCh38]
Chr5:52628315..56448223 [GRCh37]
Chr5:52664072..56483980 [NCBI36]
Chr5:5q11.2
uncertain significance
GRCh38/hg38 5q11.1-11.2(chr5:50462100-55862985)x1 copy number loss See cases [RCV000053451] Chr5:50462100..55862985 [GRCh38]
Chr5:49757934..55158813 [GRCh37]
Chr5:49793691..55194570 [NCBI36]
Chr5:5q11.1-11.2
pathogenic
GRCh38/hg38 5p13.2-q12.1(chr5:35201559-61903141)x3 copy number gain See cases [RCV000137302] Chr5:35201559..61903141 [GRCh38]
Chr5:35201661..61198968 [GRCh37]
Chr5:35237418..61234725 [NCBI36]
Chr5:5p13.2-q12.1
pathogenic
GRCh38/hg38 5p12-q11.2(chr5:45566861-56506493)x3 copy number gain See cases [RCV000138021] Chr5:45566861..56506493 [GRCh38]
Chr5:45566963..55802320 [GRCh37]
Chr5:45602720..55838077 [NCBI36]
Chr5:5p12-q11.2
uncertain significance
GRCh38/hg38 5p15.33-q13.3(chr5:22149-74412725)x3 copy number gain See cases [RCV000138780] Chr5:22149..74412725 [GRCh38]
Chr5:22149..73708550 [GRCh37]
Chr5:75149..73744306 [NCBI36]
Chr5:5p15.33-q13.3
pathogenic
GRCh38/hg38 5q11.2(chr5:55028257-55939697)x3 copy number gain See cases [RCV000139251] Chr5:55028257..55939697 [GRCh38]
Chr5:54324085..55235525 [GRCh37]
Chr5:54359842..55271282 [NCBI36]
Chr5:5q11.2
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q11.2(chr5:53784524-54985838) copy number loss Abnormality of esophagus morphology [RCV000416715] Chr5:53784524..54985838 [GRCh37]
Chr5:5q11.2
likely benign
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NC_000005.9:g.53180658_54552379dup duplication Neurodevelopmental disorder [RCV000787438] Chr5:53180658..54552379 [GRCh37]
Chr5:5q11.2
uncertain significance
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32794 AgrOrtholog
COSMIC MIR449B COSMIC
Ensembl Genes ENSG00000207728 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384995 ENTREZGENE
GTEx ENSG00000207728 GTEx
HGNC ID HGNC:32794 ENTREZGENE
Human Proteome Map MIR449B Human Proteome Map
miRBase MI0003673 ENTREZGENE
NCBI Gene 693123 ENTREZGENE
OMIM 613132 OMIM
PharmGKB PA164722719 PharmGKB
RNAcentral URS00003758F0 RNACentral
  URS0000490063 RNACentral
  URS000075B9B1 RNACentral