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Gene: Lepr (leptin receptor) Rattus norvegicus
Symbol: Lepr
Name: leptin receptor
Description: Exhibits peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of locomotor rhythm; and positive regulation of cell communication. Localizes to extracellular space and plasma membrane. Used to study glucose metabolism disease (multiple); hypertension; obesity; pancreatitis; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and osteoporosis. Orthologous to human LEPR (leptin receptor); PARTICIPATES IN leptin system pathway; altered leptin system pathway; obesity pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
Also known as: Fa; LEP-R; Leptin receptor (fatty); OB receptor; OB-R
Homo sapiens (human) : LEPR (leptin receptor)  HGNC  Alliance
Mus musculus (house mouse) : Lepr (leptin receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lepr (leptin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : LEPR (leptin receptor)
Canis lupus familiaris (dog) : LEPR (leptin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lepr (leptin receptor)
Sus scrofa (pig) : LEPR (leptin receptor)
Chlorocebus sabaeus (African green monkey) : LEPR (leptin receptor)
Heterocephalus glaber (naked mole-rat) : Lepr (leptin receptor)
more info ...
Allele / Splice: Lepr_v2   Lepr_v1   Leprem2Mcwi   Leprm1Rll   Leprcp   Leprem1   Leprem2   Leprem3   Leprfa   Leprem4Lizh  
Genetic Models: ZUC-Leprfa ZDF-Leprm1Rll WDF-Leprm1Rll SD-Leprem2 SD-Leprem1 SD-Leprem3 SS-Leprem2Mcwi
Is Marker For: Strains:   ZUC-LeprfaSte-/-   ZUC-Lepr+Ste   KZ-LeprfaTky   F344.ZUC-Leprfa/Tj   ZDF-LeprfaCrlCrlj   ZDF-Leprfa/Crl   F344.ZUC-(Leprfa),OLETF-(D14Rat23-D14Rat12)/Tj   Slc:ZUC-Leprfa   Ho:ZFDM-Leprfa   ZDF-Leprfa/Drt   SS.ZUC-Leprfa-/+/Slc   SS.ZUC-Leprfa+/+/Slc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05120,503,475 - 120,682,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5120,564,645 - 120,682,221 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05124,380,327 - 124,525,200 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05124,555,678 - 124,556,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45122,320,075 - 122,503,449NCBIRGSC3.4rn4RGSC3.4
Celera5114,817,255 - 114,982,861 (+)NCBICelera
Cytogenetic Map5q33NCBI
RH 3.4 Map5 RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lepr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3001
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.