Lepr (leptin receptor) - Rat Genome Database

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Gene: Lepr (leptin receptor) Rattus norvegicus
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Symbol: Lepr
Name: leptin receptor
RGD ID: 3001
Description: Exhibits peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of locomotor rhythm; and positive regulation of cell communication. Localizes to extracellular space and plasma membrane. Used to study several diseases, including chronic kidney disease; glucose metabolism disease (multiple); obesity; pancreatitis; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor); PARTICIPATES IN leptin system pathway; altered leptin system pathway; obesity pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Fa; LEP-R; Leptin receptor (fatty); OB receptor; OB-R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Lepr_v2   Lepr_v1   Leprem2Mcwi   Leprm1Rll   Leprcp   Leprem1   Leprem2   Leprem3   Leprfa   Leprem4Lizh  
Genetic Models: ZUC-Leprfa BN.ZUC-Leprfa LA-cp/NRll ZUC-LeprfaSte-/- WDF-Leprm1Rll ZDF-Leprm1Rll SD-Leprem3 SD-Leprem2 SD-Leprem1 SS-Leprem2Mcwi
Is Marker For: Strains:   ZUC-Lepr+Ste   KZ-LeprfaTky   F344.ZUC-Leprfa/Tj   ZDF-LeprfaCrlCrlj   ZDF-Leprfa/Crl   F344.ZUC-(Leprfa),OLETF-(D14Rat23-D14Rat12)/Tj   Slc:ZUC-Leprfa   Ho:ZFDM-Leprfa   ZDF-Leprfa/Drt   SS.ZUC-Leprfa-/+/Slc   SS.ZUC-Leprfa+/+/Slc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25116,294,409 - 116,477,904 (+)NCBI
Rnor_6.0 Ensembl5120,564,645 - 120,682,221 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05120,503,475 - 120,682,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05124,380,327 - 124,525,200 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05124,555,678 - 124,556,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45122,320,075 - 122,503,449NCBIRGSC3.4rn4RGSC3.4
Celera5114,817,255 - 114,982,861 (+)NCBICelera
RH 3.4 Map5 RGD
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Albuminuria  (ISO)
arteriosclerosis  (ISO)
bone disease  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic kidney disease  (IMP)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Delayed Puberty  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
dilated cardiomyopathy  (ISO)
Dyslipidemias  (IMP,ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
Female Infertility  (ISO)
Fibrosis  (ISO)
gestational diabetes  (ISO)
Gliosis  (ISO)
glucose intolerance  (IMP,ISO)
granulosa cell tumor  (ISO)
hepatocellular carcinoma  (ISO)
hepatocellular clear cell carcinoma  (ISO)
Hepatomegaly  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (IMP,ISO)
hyperinsulinism  (IMP,ISO)
Hyperphagia  (IAGP,IMP,ISO)
hypertension  (IMP,ISO)
hypogonadism  (ISO)
infertility  (ISO)
inherited metabolic disorder  (ISO)
Insulin Resistance  (IAGP,ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (IMP)
Leptin Receptor Deficiency  (ISO)
morbid obesity  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP)
Nasal Polyps  (ISO)
nephritis  (ISO)
non-alcoholic fatty liver disease  (ISO,ISS)
non-alcoholic steatohepatitis  (ISO)
obesity  (IAGP,IMP,ISO)
obstructive sleep apnea  (ISO)
osteoporosis  (ISO)
Overweight  (ISO)
pancreas disease  (ISO)
pancreatitis  (IAGP)
pituitary gland disease  (ISO)
Pneumococcal Pneumonia  (ISO)
pre-eclampsia  (IEP)
Precocious Puberty  (ISO)
primary biliary cholangitis  (ISO)
primary immunodeficiency disease  (ISO)
primary ovarian insufficiency  (ISO)
proteinuria  (IAGP,IMP)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal fibrosis  (IMP)
Respiratory Tract Infections  (ISO)
Right Ventricular Hypertrophy  (ISO)
short bowel syndrome  (IEP)
sleep apnea  (ISO)
Spinal Fractures  (ISO)
type 2 diabetes mellitus  (IAGP,ISO)
Varicose Ulcer  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(N(omega)-L-arginino)succinic acid  (ISO)
(R)-carnitine  (ISO)
(R)-pantothenic acid  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1-methylnicotinamide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxy-4-methylvaleric acid  (ISO)
2-hydroxyisobutyric acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-4-chlorophenoxybutyric acid  (EXP)
2-oxoadipic acid  (ISO)
3-methyl-2-oxobutanoic acid  (ISO)
3-methyl-2-oxovaleric acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetohydrazide  (ISO)
acetylcholine  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
allantoin  (ISO)
allopurinol  (EXP)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apocynin  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
astaxanthin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromodichloromethane  (ISO)
butanal  (ISO)
butyric acid  (ISO)
caffeine  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
captopril  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
citric acid  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
coumestrol  (ISO)
creatinine  (ISO)
crocidolite asbestos  (ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyromazine  (EXP)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dactolisib  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
estrone  (ISO)
ethanol  (EXP,ISO)
ethylmalonic acid  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formic acid  (ISO)
fructose  (EXP)
fumaric acid  (ISO)
furan  (EXP)
galactaric acid  (ISO)
gefitinib  (ISO)
genistein  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutaric acid  (ISO)
glutathione  (EXP)
glycidol  (EXP)
glycine betaine  (ISO)
glyphosate  (ISO)
harmine  (ISO)
hesperidin  (ISO)
hexanoic acid  (ISO)
high-density lipoprotein cholesterol  (ISO)
hydrazine  (EXP)
hydrochlorothiazide  (ISO)
hydrogen peroxide  (ISO)
indoxyl sulfate  (ISO)
isobutyric acid  (ISO)
isocaproic acid  (ISO)
isoprenaline  (EXP)
isovaleric acid  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (EXP)
LY294002  (ISO)
malonic acid  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methylmalonic acid  (ISO)
methylmercury chloride  (ISO)
metyrapone  (EXP)
mifepristone  (EXP)
MK-2206  (ISO)
morphine  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-6-pyridone-3-carboxamide  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (EXP,ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP)
Nicotinamide N-oxide  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
orotic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pioglitazone  (EXP)
pirimicarb  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propranolol  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
razoxane  (EXP)
resveratrol  (ISO)
riddelliine  (EXP)
rotenone  (EXP)
rutin  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (ISO)
succinic acid  (ISO)
sucrose  (ISO)
sulforaphane  (ISO)
superoxide  (ISO)
tacrine  (EXP)
taurine  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
urea  (ISO)
valeric acid  (ISO)
valproic acid  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal glomerular filtration barrier morphology  (IMP)
albuminuria  (IAGP)
decreased bone mineral density  (IMP)
decreased survivor rate  (IAGP)
decreased trabecular bone volume  (IMP)
expanded mesangial matrix  (IMP)
glomerulosclerosis  (IMP)
hepatic steatosis  (IAGP,IMP)
hyperlipidemia  (IAGP)
hypertension  (IMP)
impaired glucose tolerance  (IMP)
increased body mass index  (IAGP)
increased body weight  (IAGP,IMP)
increased bone trabecular spacing  (IMP)
increased circulating alanine transaminase level  (IAGP,IMP)
increased circulating aspartate transaminase level  (IMP)
increased circulating cholesterol level  (IAGP,IMP)
increased circulating creatinine level  (IMP)
increased circulating HDL cholesterol level  (IMP)
increased circulating insulin level  (IMP)
increased circulating LDL cholesterol level  (IMP)
increased circulating leptin level  (IAGP,IMP)
increased circulating triglyceride level  (IAGP,IMP)
increased epididymal fat pad weight  (IAGP)
increased fat cell size  (IMP)
increased food intake  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased retroperitoneal fat pad weight  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP,IMP)
increased urine protein level  (IMP)
increased white fat cell number  (IAGP)
insulin resistance  (IMP)
obese  (IAGP)
pancreas fibrosis  (IMP)
pancreas hyperplasia  (IMP)
podocyte foot process effacement  (IMP)
polyphagia  (IAGP)
renal glomerulus fibrosis  (IAGP)
renal interstitial fibrosis  (IMP)
References

References - curated
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94. Zain SM, etal., J Gastroenterol Hepatol. 2013 May;28(5):873-9. doi: 10.1111/jgh.12104.
Additional References at PubMed
PMID:8690163   PMID:8769097   PMID:8772180   PMID:9268737   PMID:9438411   PMID:9732873   PMID:10660043   PMID:11165038   PMID:11344130   PMID:11786145   PMID:12010881   PMID:12021059  
PMID:12594516   PMID:12606446   PMID:15995171   PMID:16116438   PMID:16328017   PMID:16962144   PMID:16964413   PMID:17038325   PMID:17218441   PMID:17391913   PMID:17611900   PMID:17951546  
PMID:18250539   PMID:18563836   PMID:18719678   PMID:18782535   PMID:19082917   PMID:19094094   PMID:19403617   PMID:19422379   PMID:19479985   PMID:19591986   PMID:19596404   PMID:19726710  
PMID:19726711   PMID:19747514   PMID:19877509   PMID:19996157   PMID:20171169   PMID:20347812   PMID:20501326   PMID:20600421   PMID:20691166   PMID:20963574   PMID:20977476   PMID:21109591  
PMID:21158112   PMID:21180167   PMID:21257164   PMID:21334312   PMID:21452040   PMID:21454707   PMID:21457721   PMID:21771332   PMID:21946196   PMID:22038286   PMID:22715380   PMID:22875962  
PMID:22968639   PMID:23028249   PMID:23304119   PMID:23382219   PMID:23549406   PMID:23576026   PMID:23669042   PMID:23782941   PMID:24007473   PMID:24013029   PMID:24051374   PMID:24291064  
PMID:24903921   PMID:24905621   PMID:24920667   PMID:25060689   PMID:25380550   PMID:25383904   PMID:26122392   PMID:26408544   PMID:26702900   PMID:27037668   PMID:28717967   PMID:28759941  
PMID:28973665   PMID:29568885   PMID:30133304   PMID:30269202   PMID:30339059   PMID:31702041  


Genomics

Candidate Gene Status
Lepr is a candidate Gene for QTL Bss4
Lepr is a candidate Gene for QTL Bw146
Comparative Map Data
Lepr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25116,294,409 - 116,477,904 (+)NCBI
Rnor_6.0 Ensembl5120,564,645 - 120,682,221 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05120,503,475 - 120,682,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05124,380,327 - 124,525,200 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05124,555,678 - 124,556,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45122,320,075 - 122,503,449NCBIRGSC3.4rn4RGSC3.4
Celera5114,817,255 - 114,982,861 (+)NCBICelera
RH 3.4 Map5 RGD
Cytogenetic Map5q33NCBI
LEPR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl165,420,652 - 65,641,559 (+)EnsemblGRCh38hg38GRCh38
GRCh38165,420,652 - 65,641,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37165,886,335 - 66,107,242 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,658,906 - 65,875,410 (+)NCBINCBI36hg18NCBI36
Build 34165,598,338 - 65,814,843NCBI
Celera164,176,916 - 64,393,787 (+)NCBI
Cytogenetic Map1p31.3NCBI
HuRef163,995,123 - 64,212,195 (+)NCBIHuRef
CHM1_1166,002,606 - 66,219,234 (+)NCBICHM1_1
Lepr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,574,393 - 101,676,375 (+)NCBIGRCm39mm39
GRCm39 Ensembl4101,574,601 - 101,672,549 (+)Ensembl
GRCm384101,717,137 - 101,815,352 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4101,717,404 - 101,815,352 (+)EnsemblGRCm38mm10GRCm38
MGSCv374101,390,012 - 101,487,959 (+)NCBIGRCm37mm9NCBIm37
MGSCv364101,215,371 - 101,313,237 (+)NCBImm8
Celera4100,061,452 - 100,155,523 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.96NCBI
Lepr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542325,111,266 - 25,185,407 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542325,108,897 - 25,185,315 (-)NCBIChiLan1.0ChiLan1.0
LEPR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1166,651,994 - 66,764,768 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl166,693,926 - 66,764,768 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0164,772,612 - 64,881,886 (+)NCBIMhudiblu_PPA_v0panPan3
LEPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1544,684,118 - 44,775,626 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl544,688,109 - 44,775,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha544,745,719 - 44,810,649 (-)NCBI
ROS_Cfam_1.0544,870,825 - 44,963,640 (-)NCBI
UMICH_Zoey_3.1544,840,852 - 44,906,048 (-)NCBI
UNSW_CanFamBas_1.0544,786,008 - 44,851,055 (-)NCBI
UU_Cfam_GSD_1.0545,029,763 - 45,094,688 (-)NCBI
Lepr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505878,634,973 - 78,718,201 (+)NCBI
SpeTri2.0NW_0049365915,771,371 - 5,846,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEPR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6146,798,979 - 146,896,108 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16146,802,297 - 146,896,152 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LEPR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12067,454,205 - 67,567,524 (-)NCBI
ChlSab1.1 Ensembl2067,454,334 - 67,524,229 (-)Ensembl
Vero_WHO_p1.0NW_02366603349,988,602 - 50,125,048 (+)NCBI
Lepr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474229,221,742 - 29,313,273 (-)NCBI

Position Markers
D5Wox38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,360,112 - 116,360,293 (+)MAPPER
Rnor_6.05120,569,168 - 120,569,348NCBIRnor6.0
Rnor_5.05124,446,252 - 124,446,432UniSTSRnor5.0
RGSC_v3.45122,386,495 - 122,386,675UniSTSRGSC3.4
Celera5114,882,835 - 114,883,015UniSTS
Cytogenetic Map5q33UniSTS
D5Wox37  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05120,566,555 - 120,566,842NCBIRnor6.0
Rnor_5.05124,443,639 - 124,443,926UniSTSRnor5.0
RGSC_v3.45122,383,882 - 122,384,169UniSTSRGSC3.4
Celera5114,880,222 - 114,880,509UniSTS
Cytogenetic Map5q33UniSTS
D5Wox39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,368,606 - 116,368,754 (+)MAPPER
Rnor_6.05120,577,662 - 120,577,809NCBIRnor6.0
Rnor_5.05124,454,745 - 124,454,892UniSTSRnor5.0
RGSC_v3.45122,394,986 - 122,395,133UniSTSRGSC3.4
Celera5114,891,327 - 114,891,474UniSTS
Cytogenetic Map5q33UniSTS
D5Rhw23  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,292,445 - 116,292,656 (+)MAPPER
Rnor_6.05120,501,513 - 120,501,723NCBIRnor6.0
Rnor_5.05124,378,365 - 124,378,575UniSTSRnor5.0
RGSC_v3.45122,318,113 - 122,318,323UniSTSRGSC3.4
Celera5114,815,293 - 114,815,503UniSTS
Cytogenetic Map5q33UniSTS
RH129126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,301,426 - 116,301,929 (+)MAPPER
Rnor_6.05120,510,487 - 120,510,989NCBIRnor6.0
Rnor_5.05124,387,687 - 124,388,189UniSTSRnor5.0
RGSC_v3.45122,327,396 - 122,327,898UniSTSRGSC3.4
Celera5114,824,241 - 114,824,743UniSTS
RH 3.4 Map5787.8UniSTS
Cytogenetic Map5q33UniSTS
RH94807  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,403,395 - 116,403,535 (+)MAPPER
Rnor_6.05120,612,273 - 120,612,412NCBIRnor6.0
Rnor_5.05124,488,768 - 124,488,907UniSTSRnor5.0
RGSC_v3.45122,433,750 - 122,433,889UniSTSRGSC3.4
Celera5114,926,233 - 114,926,372UniSTS
RH 3.4 Map5803.7UniSTS
Cytogenetic Map5q33UniSTS
AU048762  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera5114,903,630 - 114,903,747UniSTS
Cytogenetic Map5q33UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51136640934Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531926122136640934Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535788756147487820Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540777918154732375Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)544404276134502294Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)551418671147487820Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)556991667137729065Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)560072951133313852Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)561086525149030144Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)565696672129038896Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)571552569157225114Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)583424556128424556Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)583424556128424556Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)583424556128424556Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589502294134502294Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)591585539136585539Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)591585539136585539Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)591585539136585539Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)591884213136884213Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)593037304133313852Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)593037304133313852Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)593273130138273130Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)597921932149030144Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5100723739153577831Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5101265591141912026Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight as percentage of body weight (CMO:0000141)5102498468123852688Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5102945579154732228Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5107119214152119214Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111278451156278451Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112279412157279412Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112279412157279412Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112279412157279412Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112279412157279412Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112279412157279412Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5113059816120566842Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114140832159140832Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114140832159140832Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116767924161767924Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116767924161767924Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116767924161767924Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116767924161767924Rat




Genetic Models
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:96
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000044131, ENSRNOT00000050597
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 5 7 5 6 2 4 7
Low 3 14 32 16 12 16 8 10 46 17 22 4 8
Below cutoff 29 18 18 18 1 22 16 15

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB011006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC129815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF007818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF007819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF121333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF139208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF287268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF304191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U52966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U53144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U67207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000044131
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5120,577,975 - 120,682,221 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000050597   ⟹   ENSRNOP00000045398
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5120,568,242 - 120,652,220 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093171
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5120,646,516 - 120,680,609 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093218
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5120,567,822 - 120,581,390 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093574
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5120,568,020 - 120,652,253 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093648
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5120,564,645 - 120,585,228 (+)Ensembl
RefSeq Acc Id: NM_012596   ⟹   NP_036728
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25116,294,409 - 116,475,906 (+)NCBI
Rnor_6.05120,503,475 - 120,682,281 (+)NCBI
Rnor_5.05124,380,327 - 124,525,200 (+)NCBI
Rnor_5.05124,555,678 - 124,556,585 (+)NCBI
RGSC_v3.45122,320,075 - 122,503,449 (+)RGD
Celera5114,817,255 - 114,982,861 (+)RGD
Sequence:
RefSeq Acc Id: XM_039109264   ⟹   XP_038965192
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25116,358,875 - 116,477,904 (+)NCBI
RefSeq Acc Id: XM_039109265   ⟹   XP_038965193
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25116,358,603 - 116,477,904 (+)NCBI
RefSeq Acc Id: XM_039109266   ⟹   XP_038965194
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25116,358,879 - 116,451,540 (+)NCBI
RefSeq Acc Id: XM_039109267   ⟹   XP_038965195
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25116,358,879 - 116,474,232 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036728   ⟸   NM_012596
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000045398   ⟸   ENSRNOT00000050597
RefSeq Acc Id: XP_038965193   ⟸   XM_039109265
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965192   ⟸   XM_039109264
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965195   ⟸   XM_039109267
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038965194   ⟸   XM_039109266
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693869
Promoter ID:EPDNEW_R4386
Type:initiation region
Name:Lepr_2
Description:leptin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4387  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05120,567,819 - 120,567,879EPDNEW
RGD ID:13693862
Promoter ID:EPDNEW_R4387
Type:initiation region
Name:Lepr_1
Description:leptin receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R4386  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05120,568,306 - 120,568,366EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3001 AgrOrtholog
Ensembl Genes ENSRNOG00000023664 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000062308 ENTREZGENE
Ensembl Protein ENSRNOP00000045398 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050597 UniProtKB/TrEMBL
  ENSRNOT00000093560 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hematopoietin_rcpt_Gp130_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IgC2-like_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEP-R_IGD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lep_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24536 UniProtKB/Swiss-Prot
NCBI Gene 24536 ENTREZGENE
PANTHER PTHR23036:SF109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lep_receptor_Ig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ObR_Ig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB LEPR RGD
PhenoGen Lepr PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1M9F2_RAT UniProtKB/TrEMBL
  LEPR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O35772 UniProtKB/Swiss-Prot
  O35773 UniProtKB/Swiss-Prot
  O54805 UniProtKB/Swiss-Prot
  P70493 UniProtKB/Swiss-Prot
  P70494 UniProtKB/Swiss-Prot
  P70495 UniProtKB/Swiss-Prot
  P97589 UniProtKB/Swiss-Prot
  Q62960 UniProtKB/Swiss-Prot
  Q63007 UniProtKB/Swiss-Prot
  Q63385 UniProtKB/Swiss-Prot
  Q63386 UniProtKB/Swiss-Prot
  Q9ERI4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Lepr  leptin receptor    leptin receptor   Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Lepr  leptin receptor       Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the endothelial cells of the vascular wall 625675
gene_function receptor for obesity factor (leptin) 61790
gene_process protects nonadipocytes from the adverse consequences of lipid overaccumulation 62400
gene_product member of the gp130 family of cytokine receptors that stimulate gene transcription via activation of cytosolic STAT proteins 61790
gene_protein an isoform exists with a short intracellular domain 729196
gene_transcript two isoforms of the mRNA were detected 625675