Gene: Lepr (leptin receptor) Rattus norvegicus
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Symbol: Lepr
Name: leptin receptor
Description: ENCODES a protein that exhibits peptide hormone binding; protein-hormone receptor activity; identical protein binding (ortholog); INVOLVED IN aging; angiogenesis; cellular response to organic substance; PARTICIPATES IN leptin system pathway; altered leptin system pathway; obesity pathway; ASSOCIATED WITH decreased survivor rate; glomerulosclerosis; hepatic steatosis; ASSOCIATED WITH Experimental Liver Cirrhosis; glucose intolerance; Insulin Resistance; FOUND IN extracellular space; plasma membrane; receptor complex (ortholog); INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol
AGR Description: Exhibits peptide hormone binding activity and protein-hormone receptor activity; involved in several processes, including aging, development of primary sexual characteristics, and positive regulation of cell communication; localizes to the extracellular space and plasma membrane; used to study glucose intolerance, obesity, pancreatitis, proteinuria, and type 2 diabetes mellitus; biomarker of pre-eclampsia and short bowel syndrome; orthologous to human LEPR (leptin receptor).
Merged Description: Exhibits peptide hormone binding activity and protein-hormone receptor activity; involved in several processes, including aging, development of primary sexual characteristics, and positive regulation of cell communication; localizes to the extracellular space and plasma membrane; used to study glucose intolerance, obesity, pancreatitis, proteinuria, and type 2 diabetes mellitus; biomarker of pre-eclampsia and short bowel syndrome; orthologous to human LEPR (leptin receptor); PARTICIPATES IN leptin system pathway; altered leptin system pathway; obesity pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Fa; LEP-R; Leptin receptor (fatty); OB receptor; OB-R
Orthologs:
Homo sapiens (human) : LEPR (leptin receptor)  HGNC  Alliance
Mus musculus (house mouse) : Lepr (leptin receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lepr (leptin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : LEPR (leptin receptor)
Canis lupus familiaris (dog) : LEPR (leptin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lepr (leptin receptor)
Sus scrofa (pig) : LEPR (leptin receptor)
more info ...
Allele / Splice: Lepr_v2   Lepr_v1   Leprem2Mcwi   Leprm1Rll   Leprcp   Leprem1   Leprem2   Leprem3   Leprfa  
Genetic Models: ZUC-Leprfa ZDF-Leprm1Rll WDF-Leprm1Rll SD-Leprem2 SD-Leprem1 SD-Leprem3 SS-Leprem2Mcwi
Is Marker For: Strains:   ZUC-LeprfaSte   ZUC-Lepr+Ste   KZ-LeprfaTky   F344.ZUC-Leprfa/Tj   ZDF-LeprfaCrlCrlj   ZDF-Leprfa/Crl   F344.ZUC-(Leprfa),OLETF-(D14Rat23-D14Rat12)/Tj   Slc:ZUC-Leprfa   Ho:ZDFM-Leprfa   ZDF-Leprfa/Drt   SS.ZUC-Leprfa-/+/Slc   SS.ZUC-Leprfa+/+/Slc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05120,503,475 - 120,682,281 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05124,380,327 - 124,525,200 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05124,555,678 - 124,556,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45122,320,075 - 122,503,449NCBIRGSC3.4rn4RGSC3.4
Celera5114,817,255 - 114,982,861 (+)NCBICelera
Cytogenetic Map5q33NCBI
RH 3.4 Map5 RGD
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
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Sequence

Nucleotide Sequences
Protein Sequences
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
RGD Curation Notes
 
More on Lepr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3001
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.