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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Leprdecreases expressionEXP 6480464CTDThioacetamide results in decreased expression of LEPR mRNA; Thioacetamide results in decreased expression of LEPR proteinPMID:17621560 PMID:23411599 PMID:34492290
Leprmultiple interactionsEXP 6480464CTDLEPR gene mutant form inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; LEPR protein affects the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; Lipopolysaccharides inhibits the reaction [Thioacetamide results in decreased expression of LEPR mRNA]PMID:11984526 PMID:17621560
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