Strain: ZUC-Lepr+Ste |
| Symbol: |
ZUC-Lepr+Ste |
| Strain: |
ZUC-Lepr+ |
| Substrain: |
Ste |
| RGD ID: |
629463 |
| Citation ID: |
RRID:RGD_629463 |
| Ontology ID: |
RS:0001095
|
| Alleles: |
Lepr |
| Also Known As: |
Z-Lepr+/Ste;ZUC-Lepr+/Ste; ZUC-Lepr+Ste; Z(Fa/Fa); Z-Lepr+/Ste; ZUC-Lepr^[+Ste] |
| Type: |
mutant |
| Available Source: |
Not Available |
| Origination: |
University of California Davis, Davis, CA |
| Description: |
This is the littermate of ZUC-LeprfaSte-/-. The fa mutation occurred spontaneously in the 13M stock and was reported by Lois Zucker and Theodore Zucker in 1960. This was observed during genetic experiments related to coat color and body size. These rats have lean phenotype. |
| Last Known Status: |
Unknown |
| Position |
| Rat Assembly | Chr | Position (strand) | Source | JBrowse |
|---|
| GRCr8 | 5 | 121,409,735 - 121,593,201 | RGD_MAPPER_PIPELINE | | | mRatBN7.2 | 5 | 116,294,409 - 116,477,904 | RGD_MAPPER_PIPELINE | mRatBN7.2 | | Rnor_6.0 | 5 | 120,503,475 - 120,682,281 | RGD_MAPPER_PIPELINE | Rnor6.0 | | Rnor_5.0 | 5 | 124,380,327 - 124,556,585 | RGD_MAPPER_PIPELINE | Rnor5.0 | | RGSC_v3.4 | 5 | 122,320,075 - 122,503,449 | RGD_MAPPER_PIPELINE | RGSC3.4 |
|
| 1. |
Augmented insulinotropic action of arachidonic acid through the lipoxygenase pathway in the obese Zucker rat. |
Ahren B, etal., Obes Res 2000 Sep;8(6):475-80.
|
| 2. |
Inbred Strains |
Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
|
| 3. |
Association of fat cell size and paracrine growth factors in development of hyperplastic obesity. |
Marques BG, etal., Am J Physiol 1998 Dec;275(6 Pt 2):R1898-908.
|
| 4. |
RGD Strain RSO annotation pipeline |
RGD Automated Pipelines
|
| 5. |
Hyperphagia as a mediator of renal disease initiation in obese Zucker rats. |
Stevenson FT, etal., Obes Res 2001 Aug;9(8):492-9.
|
| 6. |
Leptin receptor interacts with rat chromosome 1 to regulate renal disease traits. |
Warden CH, etal., Physiol Genomics. 2012 Nov 1;44(21):1052-62. doi: 10.1152/physiolgenomics.00134.2011. Epub 2012 Sep 11.
|
| Note Type |
Note |
Reference |
| strain_characteristics |
This is a good model for hyperphagia, obesity and hyperlipidemia. These die of renal failure due to glomerular disease. |
628581
|
| strain_characteristics |
This is a good model for hyperphagia, obesity and hyperlipidemia. These die of renal failure due to glomerular disease. |
628582
|
| strain_drgs_chems |
Esculetin inhibits the production of 12-hydroxyeicosatetraenoic acid (12-HETE) which inturn inhibits arachidonic acid stimulated insulin secretion in the islets. |
628581
|
| strain_drgs_chems |
Esculetin inhibits the production of 12-hydroxyeicosatetraenoic acid (12-HETE) which inturn inhibits arachidonic acid stimulated insulin secretion in the islets. |
628582
|
| strain_life_disease |
Surgical injury to the hypothalamus leads to serious kidney lesions which is noticed as these animals reach a year of age. These develop significant albuminuria by 6 weeks of age. Albuminuria was normailzed by the prevention of overeating. Prevention of hyperphagia showed an improvement in the end stage pathology associated with the disease. |
628581
|
| strain_life_disease |
Surgical injury to the hypothalamus leads to serious kidney lesions which is noticed as these animals reach a year of age. These develop significant albuminuria by 6 weeks of age. Albuminuria was normailzed by the prevention of overeating. Prevention of hyperphagia showed an improvement in the end stage pathology associated with the disease. |
628582
|
| strain_phys_biochem |
These have lactescence (milky appearance) of the blood serum.The total fatty acid level reaches ten times in obese rats as compared to the lean littermates. Blood lipid levels remain high even after 18-hours of fasting. Blood sugar stays in the normal range both in fed or fasted rats. Serum triglycerides were higher in obese rats. Metabolism of arachidonic acid alters the severe insulin resistance that is present in the obese rats. |
628581
|
| strain_phys_biochem |
These have lactescence (milky appearance) of the blood serum.The total fatty acid level reaches ten times in obese rats as compared to the lean littermates. Blood lipid levels remain high even after 18-hours of fasting. Blood sugar stays in the normal range both in fed or fasted rats. Serum triglycerides were higher in obese rats. Metabolism of arachidonic acid alters the severe insulin resistance that is present in the obese rats. |
628582
|
| strain_reproduction |
Breeding of this strain is very difficult mostly fatty males are bred with heterozygous females giving 50% fatty offsprings and 50% heterozygous |
628581
|
| strain_reproduction |
Breeding of this strain is very difficult mostly fatty males are bred with heterozygous females giving 50% fatty offsprings and 50% heterozygous |
628582
|
| Date |
Current Symbol |
Current Name |
Previous Symbol |
Previous Name |
Description |
Reference |
Status |
| 2010-06-08 |
ZUC-Lepr+Ste |
|
ZUC-Lepr+/Ste |
|
Symbol updated |
68687 |
APPROVED |
| 2010-06-08 |
ZUC-Lepr+Ste |
|
ZUC-Lepr+/Ste |
|
Name updated |
68913 |
APPROVED |
| 2010-06-08 |
ZUC-Lepr+Ste |
|
ZUC-Lepr+/Ste |
|
Symbol updated |
68687 |
APPROVED |
| 2010-06-08 |
ZUC-Lepr+Ste |
|
ZUC-Lepr+/Ste |
|
Name updated |
68913 |
APPROVED |
|
|
|
