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Strain: ZDF-Leprfa/Crl

Symbol: ZDF-Leprfa/Crl
Strain: ZDF-Leprfa
Substrain: Crl
RGD ID: 2311071
Citation ID: RRID:RGD_2311071
Ontology ID: RS:0002285
Alleles: Lepr
Previously known as: ZDF-Leprfa/Crl
Type: coisogenic
Source: Charles River Laboratories
Origin: A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974???75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001.
Genetic Markers: Hooded
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. Strains registered by Charles River Laboratories International, Inc. Personal communication with Charles River Laboratories
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Zucker Diabetic Fatty Rat as a Model for Non-insulin-dependent Diabetes Mellitus Richard G. Peterson, Walter N. Shaw, Mary-Ann Neel, Leah A. Little, J. Eichberg, ILAR news1990:32(3)16-19


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