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Strain Registration

Strain: ZUC-LeprfaSte-/-

Symbol: ZUC-LeprfaSte-/-
Strain: ZUC-Leprfa-/-
Substrain: Ste
RGD ID: 629462
Citation ID: RRID:RRRC_00839
Ontology ID: RS:0001098
Alleles: Leprfa
Also Known As: Z(fa/fa); Z-Leprob/Ste; Z-Leprfa/Ste;ZUC-Leprfa/Ste; ZUC-LeprfaSte; Zucker rats; recessive fatty rats; ZUC-LeprfaSte; ZUC-Lepr^[faSte-/-]
Type: mutant
Available Source: Not Available
Origination: University of California Davis, Davis, CA
Description: This recessive fatty Zucker rat carries a mutation that occurred spontaneously in the 13M stock and was reported by Lois Zucker and Theodore Zucker in 1960. This was observed during genetic experiments related to coat color and body size.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85121,409,735 - 121,593,201RGD_MAPPER_PIPELINE
mRatBN7.25116,389,200 - 116,389,200RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05120,597,857 - 120,597,857RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05124,380,327 - 124,556,585RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.45122,320,075 - 122,503,449RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View
Hyperphagia  (IAGP)
obesity  (IAGP)
proteinuria  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Augmented insulinotropic action of arachidonic acid through the lipoxygenase pathway in the obese Zucker rat. Ahren B, etal., Obes Res 2000 Sep;8(6):475-80.
2. Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats. Kim K, etal., Physiol Genomics. 2010 Feb 16.
3. Association of fat cell size and paracrine growth factors in development of hyperplastic obesity. Marques BG, etal., Am J Physiol 1998 Dec;275(6 Pt 2):R1898-908.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Hyperphagia as a mediator of renal disease initiation in obese Zucker rats. Stevenson FT, etal., Obes Res 2001 Aug;9(8):492-9.
6. Leptin receptor interacts with rat chromosome 1 to regulate renal disease traits. Warden CH, etal., Physiol Genomics. 2012 Nov 1;44(21):1052-62. doi: 10.1152/physiolgenomics.00134.2011. Epub 2012 Sep 11.

Region

Strain QTL Data
Symbol Name Trait
Bw124 Body weight QTL 124 body mass   (VT:0001259)    
Bw125 Body weight QTL 125 retroperitoneal fat pad mass   (VT:0010430)    
Kidm42 Kidney mass QTL 42 kidney mass   (VT:0002707)    
Stl32 Serum triglyceride level QTL 32 blood triglyceride amount   (VT:0002644)    
Uae40 Urinary albumin excretion QTL 40 urine albumin amount   (VT:0002871)    
Uae41 Urinary albumin excretion QTL 41 urine albumin amount   (VT:0002871)    
Uae42 Urinary albumin excretion QTL 42 urine albumin amount   (VT:0002871)    
Uae43 Urinary albumin excretion QTL 43 urine albumin amount   (VT:0002871)    
Uae44 Urinary albumin excretion QTL 44 urine albumin amount   (VT:0002871)    
Uae45 Urinary albumin excretion QTL 45 urine albumin amount   (VT:0002871)    
Uae46 Urinary albumin excretion QTL 46 urine albumin amount   (VT:0002871)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy All bones are abnormally thick with severe reduction in the amount of hemopoietic bone marrow. The liver and spleen show an increase of extramedullary hemopoiesis. Female fatty rats have underdeveloped uterus and are uniformally sterile. 628581
strain_phys_biochem These have lactescence (milky appearance) of the blood serum.The total fatty acid level reaches ten times in obese rats as compared to the lean littermates. Blood lipid levels remain high even after 18-hours of fasting. Blood sugar stays in the normal range both in fed or fasted rats. Serum triglycerides were higher in obese rats. Metabolism of arachidonic acid alters the severe insulin resistance that is present in the obese rats. 628582
strain_phys_biochem These have three fold higher urinary albumin-to-creatinine ratios (ACR) as compared to ZUC.BN-(D1Rat42-D1Rat90)/Ste 7387321
strain_reproduction Breeding of this strain is very difficult mostly fatty males are bred with heterozygous females giving 50% fatty offsprings and 50% heterozygous. 628582

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-26 ZUC-LeprfaSte-/-    ZUC-LeprfaSte    Symbol and/or name change 68913 APPROVED
2011-09-29 ZUC-LeprfaSte    ZUC-LeprfaSte    Symbol updated 68687 APPROVED
2011-09-29 ZUC-LeprfaSte    ZUC-LeprfaSte    Name updated 68913 APPROVED
2011-09-29 ZUC-LeprfaSte    ZUC-LeprfaSte    Symbol updated 68687 APPROVED
2011-09-29 ZUC-LeprfaSte    ZUC-LeprfaSte    Name updated 68913 APPROVED
2011-09-29 ZUC-LeprfaSte    ZUC-LeprfaSte    Symbol updated 68687 APPROVED
2011-09-29 ZUC-LeprfaSte    ZUC-LeprfaSte    Name updated 68913 APPROVED
2011-09-29 ZUC-LeprfaSte    ZUC-LeprfaSte    Name updated 68913 APPROVED
2011-09-29 ZUC-LeprfaSte    ZUC-LeprfaSte    Symbol updated 68687 APPROVED
2010-06-08 ZUC-LeprfaSte    ZUC-Leprfa/Ste    Symbol updated 68687 APPROVED
2010-06-08 ZUC-LeprfaSte    ZUC-Leprfa/Ste    Name updated 68913 APPROVED
2010-06-08 ZUC-LeprfaSte    ZUC-Leprfa/Ste    Symbol updated 68687 APPROVED
2010-06-08 ZUC-LeprfaSte    ZUC-Leprfa/Ste    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00839 RGD