Strain Report - Rat Genome Database

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Strain: F344.ZUC-Leprfa/Tj

Symbol: F344.ZUC-Leprfa/Tj
Strain: F344.ZUC-Leprfa
Substrain: Tj
RGD ID: 2304047
Citation ID: RRID:RGD_2304047
Ontology ID: RS:0001991
Alleles: Leprfa;   Lepr
Also Known As: F344.Z-Leprfa/Tj; F344.Z-Leprob/Tj; F.ZF-lepr; F.ZF-lepr; NBRP Rat No: 0178; F344-fa; F344.ZUC-Leprfa/Tj; F344.ZUC-Lepr^[fa]/Tj
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 2001. Afterwards, maintained by sib mating.
Inbred Generations: F4
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Diabetes Obesity


References - curated
# Reference Title Reference Citation
1. Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency. Kose H, etal., Exp Diabetes Res. 2012;2012:858121. doi: 10.1155/2012/858121. Epub 2012 Dec 5.
2. Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat. Kotoh J, etal., J Vet Med Sci. 2016 Aug 11.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats. Sasaki D, etal., Mamm Genome. 2015 Dec;26(11-12):619-29. doi: 10.1007/s00335-015-9597-4. Epub 2015 Aug 22.


Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Leprfa-var1 chr5 116389200 116389200 A C point_mutation mRatBN7.2
Leprfa-var1 chr5 120597857 120597857 A C point_mutation Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_reproduction Good breeding performance. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-10 F344.ZUC-Leprfa/Tj    F344.ZUC-Leprfa/Tj    Name updated 68913 APPROVED