Strain Report - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Strain Registration

Strain: F344.ZUC-Leprfa/Tj

Symbol: F344.ZUC-Leprfa/Tj
Strain: F344.ZUC-Leprfa
Substrain: Tj
RGD ID: 2304047
Citation ID: RRID:RGD_2304047
Ontology ID: RS:0001991
Alleles: Leprfa;   Lepr
Previously known as: F344.Z-Leprfa/Tj; F344.Z-Leprob/Tj; F.ZF-lepr; F.ZF-lepr; NBRP Rat No: 0178; F344-fa; F344.ZUC-Leprfa/Tj
Type: congenic
Source: National BioResource Project for the Rat in Japan
Origin: Established as speed congenics (5 generations, microsatellite marker) at the University of Tokushima School of Medicine, Institute for Animal Experimentation in 2001. Afterwards, maintained by sib mating.
Inbred Generations: F4
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Diabetes Obesity





References

References - curated
# Reference Title Reference Citation
1. Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency. Kose H, etal., Exp Diabetes Res. 2012;2012:858121. doi: 10.1155/2012/858121. Epub 2012 Dec 5.
2. Plekhs1 and Prdx3 are candidate genes responsible for mild hyperglycemia associated with obesity in a new animal model of F344-fa-nidd6 rat. Kotoh J, etal., J Vet Med Sci. 2016 Aug 11.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats. Sasaki D, etal., Mamm Genome. 2015 Dec;26(11-12):619-29. doi: 10.1007/s00335-015-9597-4. Epub 2015 Aug 22.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Leprfa-var1 chr5 116389200 116389200 A C point_mutation mRatBN7.2
Leprfa-var1 chr5 120597857 120597857 A C point_mutation Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_reproduction Good breeding performance. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-10 F344.ZUC-Leprfa/Tj    F344.ZUC-Leprfa/Tj    Name updated 68913 APPROVED