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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: CHEBI:35932
Term: 3-methyl-2-oxovaleric acid
Definition: A 2-oxo monocarboxylic acid that is valeric acid carrying oxo- and methyl substituents at C-2 and C-3, respectively. An alpha-keto acid analogue and metabolite of isoleucine in man, animals and bacteria. Used as a clinical marker for maple syrup urine disease (MSUD).
Chemical ID: MESH:C016211
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepraffects abundanceISORGD:108656480464CTDLEPR affects the abundance of alpha-keto-beta-methylvaleric acid

PMID:20567778
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.