Lepr<sup>em3</sup> (leptin receptor; TALEN induced mutant 3) - Rat Genome Database

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Gene: Leprem3 (leptin receptor; TALEN induced mutant 3) Rattus norvegicus
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Symbol: Leprem3
Name: leptin receptor; TALEN induced mutant 3
RGD ID: 12910546
Description: This allele was produced by injecting TALEN targeting the sequence of rat Lepr into SD embryos. The resulting mutation is a 18-bp insertion.
ASSOCIATED WITH impaired glucose tolerance; increased circulating alanine transaminase level; increased circulating aspartate transaminase level; ASSOCIATED WITH obesity
Type: allele  of Lepr  
Previously known as: Lepr^[em3]; Leprem3
Is Marker For: Strains:   SD-Leprem3  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
obesity  (IMP)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene. Chen Y, etal., Sci China Life Sci. 2017 Feb;60(2):152-157. doi: 10.1007/s11427-016-5049-y. Epub 2016 May 25.

Genomics


Related Rat Strains
The following Strains have been annotated to Leprem3
SD-Leprem3    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-19 Leprem3  leptin receptor; TALEN induced mutant 3  Leprem3    changed 629549 APPROVED