RGD Reference Report - 41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/faCP Rat Model. - Rat Genome Database

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41-Week Study of Progressive Diabetic Nephropathy in the ZSF1 fa/faCP Rat Model.

Authors: Homer, Bruce L  Dower, Ken 
Citation: Homer BL and Dower K, Toxicol Pathol. 2018 Dec;46(8):976-977. doi: 10.1177/0192623318803278. Epub 2018 Oct 3.
RGD ID: 401960095
Pubmed: PMID:30278832   (View Abstract at PubMed)
DOI: DOI:10.1177/0192623318803278   (Journal Full-text)

This symposium synopsis summarizes key results from a 41-week study of diabetic nephropathy (DN) in the type 2 diabetic ZSF1 fa/faCP rat model. During this study, we conducted longitudinal analysis of biomarkers, renal histopathology, ultrastructural assessment, renal quantitative image analysis, and transcriptome analysis of glomerular-enriched tissue. We concluded that there is translational value for using the ZSF1 rat model in mechanistic and therapeutic intervention efficacy studies for type 2 DN.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LeprRatexpanded mesangial matrix  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRatexpanded mesangial matrix  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
LeprRathypertension  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRathypertension  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
LeprRatincreased blood urea nitrogen level  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRatincreased blood urea nitrogen level  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
LeprRatincreased circulating cholesterol level  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRatincreased circulating cholesterol level  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
LeprRatincreased renal glomerulus basement membrane thickness  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRatincreased renal glomerulus basement membrane thickness  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
LeprRatincreased triglyceride level  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRatincreased triglyceride level  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
LeprRatincreased urine lipocalin 2 level  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRatincreased urine lipocalin 2 level  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
LeprRatincreased urine microalbumin level  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRatincreased urine microalbumin level  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
LeprRatrenal cast  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRatrenal cast  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
LeprRatrenal glomerulus hypertrophy  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRatrenal glomerulus hypertrophy  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
LeprRatrenal interstitial fibrosis  IAGP DNA:mutations:cds: : ratRGD 
ZSF1-Leprfa/cp/CrlRatrenal interstitial fibrosis  IAGP compared to lean leptin receptor sufficient littermates ZSF1-Leprlean/Crl RS:0005317RGD 
Objects Annotated

Genes (Rattus norvegicus)
Lepr  (leptin receptor)

Strains
ZSF1-Leprfa/cp/Crl  (NA)

Objects referenced in this article
Strain ZSF1-Leprfa, Leprcp/Crl null Rattus norvegicus
Strain ZSF1-Leprlean/Crl null Rattus norvegicus

Additional Information