RGD Reference Report - Leptin receptor signal transduction: OBRa and OBRb of fa type. - Rat Genome Database

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Leptin receptor signal transduction: OBRa and OBRb of fa type.

Authors: Yamashita, T  Murakami, T  Otani, S  Kuwajima, M  Shima, K 
Citation: Yamashita T, etal., Biochem Biophys Res Commun. 1998 May 29;246(3):752-9.
RGD ID: 2290294
Pubmed: PMID:9618284   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1998.8689   (Journal Full-text)

We report herein the characterization of activities of signal transduction for three types of leptin receptors (OBRs) from rats, the OBRa, OBRb, and OBRb with fa mutation (OBRb-fa), by measurement of the levels of tyrosine phosphorylation of STAT3 (signal transducers and activators of transcription 3) and MAPK (mitogen-activated protein kinase), which are induced by leptin stimulation of CHO cells stably expressing the OBR (CHO-OBRb, CHO-OBRa, or CHO-OBRb-fa cells). As the result of leptin stimulation, enhanced levels of tyrosine phosphorylation of STAT3 and MAPK were detected in CHO-OBRb cells. In CHO-OBRb-fa cells, enhancement levels for both were lower than those in CHO-OBRb cells. In CHO-OBRa cells, only the phosphorylation of MAPK was detected. These data suggest that these reduced signaling activities cause obesity in fa/fa rats and that OBRa, which has been generally thought to be inactive at signaling, actually transmits signals through the MAPK pathway.



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Biological Process

  

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LepRatleptin system pathway   IDA  RGD 
LeprRatleptin system pathway   IDA  RGD 
Lepr_v1Ratleptin system pathway   IDA  RGD 
Lepr_v2Ratleptin system pathway   IDA  RGD 
Objects Annotated

Genes (Rattus norvegicus)
Lep  (leptin)
Lepr  (leptin receptor)
Lepr_v1  (leptin receptor, variant 1)
Lepr_v2  (leptin receptor, variant 2)


Additional Information