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Gene: Lepr (leptin receptor) Mus musculus
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Symbol: Lepr
Name: leptin receptor
Description: Exhibits leptin receptor activity. Involved in several processes, including energy homeostasis; negative regulation of gluconeogenesis; and positive regulation of cold-induced thermogenesis. Predicted to localize to the external side of plasma membrane; extracellular space; and receptor complex. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; non-alcoholic fatty liver disease; obesity; obstructive sleep apnea; and osteoporosis. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and musculoskeletal system. Orthologous to human LEPR (leptin receptor); PARTICIPATES IN altered leptin system pathway; leptin system pathway; obesity pathway; INTERACTS WITH (N(omega)-L-arginino)succinic acid; (R)-carnitine; (R)-pantothenic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B219; db; diabetes; LEP-R; Leprb; LEPROT; leptin receptor gene-related protein; MGC105189; Modb1; OB receptor; OB-RGRP; obese-like; obl; Obr
Orthologs:
Homo sapiens (human) : LEPR (leptin receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lepr (leptin receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lepr (leptin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : LEPR (leptin receptor)
Canis lupus familiaris (dog) : LEPR (leptin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lepr (leptin receptor)
Sus scrofa (pig) : LEPR (leptin receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl4101,717,404 - 101,815,352 (+)Ensembl
GRCm384101,717,137 - 101,815,352 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374101,390,012 - 101,487,959 (+)NCBIGRCm37mm9NCBIm37
MGSCv364101,215,371 - 101,313,237 (+)NCBImm8
Celera4100,061,452 - 100,155,523 (+)NCBICelera
Cytogenetic Map4 C6NCBI
cM Map446.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Lepr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10865
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.