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Gene: Lepr (leptin receptor) Mus musculus
Symbol: Lepr
Name: leptin receptor
Description: Exhibits leptin receptor activity. Involved in several processes, including energy homeostasis; negative regulation of gluconeogenesis; and positive regulation of cold-induced thermogenesis. Predicted to localize to the external side of plasma membrane; extracellular space; and receptor complex. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; non-alcoholic fatty liver disease; obesity; obstructive sleep apnea; and osteoporosis. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and musculoskeletal system. Orthologous to human LEPR (leptin receptor); PARTICIPATES IN altered leptin system pathway; leptin system pathway; obesity pathway; INTERACTS WITH (N(omega)-L-arginino)succinic acid; (R)-carnitine; (R)-pantothenic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B219; db; diabetes; LEP-R; Leprb; LEPROT; leptin receptor gene-related protein; MGC105189; Modb1; OB receptor; OB-RGRP; obese-like; obl; Obr
Homo sapiens (human) : LEPR (leptin receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lepr (leptin receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lepr (leptin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : LEPR (leptin receptor)
Canis lupus familiaris (dog) : LEPR (leptin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lepr (leptin receptor)
Sus scrofa (pig) : LEPR (leptin receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl4101,717,404 - 101,815,352 (+)Ensembl
GRCm384101,717,137 - 101,815,352 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374101,390,012 - 101,487,959 (+)NCBIGRCm37mm9NCBIm37
MGSCv364101,215,371 - 101,313,237 (+)NCBImm8
Celera4100,061,452 - 100,155,523 (+)NCBICelera
Cytogenetic Map4 C6NCBI
cM Map446.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lepr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10865
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.