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GENE - TERM ANNOTATION REPORT

RGD ID: 10865
Species: Mus musculus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: DOID:2018
Term: hyperinsulinism
Definition: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
Definition Source(s): MESH:D006946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lepr ISOLepr (Rattus norvegicus)12911216RGD  
Lepr ISOLEPR (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:3519326 PMID:15093691 PMID:22949526 PMID:24384915 PMID:25222487 PMID:29988851 PMID:30689673 PMID:33345901
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