Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - TERM ANNOTATION REPORT

21 Annotations Found.

An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Kanoski SE, etal., Am J Physiol Endocrinol Metab. 2012 Aug 15;303(4):E496-503. doi: 10.1152/ajpendo.00205.2012. Epub 2012 Jun 12.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IMP) inferred from mutant phenotype]
  • 2 additional annotations were made from Kanoski SE, etal., Am J Physiol Endocrinol Metab. 2012 Aug 15;303(4):E496-503. doi: 10.1152/ajpendo.00205.2012. Epub 2012 Jun 12.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from expression pattern (IEP)
    		•  
  • The annotation was made from Karlsson EA, etal., J Nutr. 2010 Sep;140(9):1691-7. Epub 2010 Jun 30.
  • 2 additional annotations were made from Karlsson EA, etal., J Nutr. 2010 Sep;140(9):1691-7. Epub 2010 Jun 30.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: mRNA:decreased expression:lung


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Popko K, etal., J Physiol Pharmacol. 2007 Nov;58 Suppl 5(Pt 2):551-61.
  • The annotation has been inferred from sequence orthology with LEPR (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 5 additional annotations were made from Popko K, etal., J Physiol Pharmacol. 2007 Nov;58 Suppl 5(Pt 2):551-61.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Qualifier: susceptibility
  • Curation Notes: DNA:polymorphism:exon:p.Q223R (human)


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Iida M, etal., Biochem Biophys Res Commun 1996 Jul 16;224(2):597-604.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IAGP) inferred by association of genotype and phenotype]
  • 2 additional annotations were made from Iida M, etal., Biochem Biophys Res Commun 1996 Jul 16;224(2):597-604.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: DNA:missense mutation: :p.Q269P (rat)


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Takaya K, etal., Nat Genet. 1996 Oct;14(2):130-1.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IAGP) inferred by association of genotype and phenotype]
  • 2 additional annotations were made from Takaya K, etal., Nat Genet. 1996 Oct;14(2):130-1.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from expression pattern (IEP)
    		•  
  • The annotation was made from Koga S, etal., Neurosci Lett. 2014 Jun 13;571:11-6. doi: 10.1016/j.neulet.2014.04.028. Epub 2014 Apr 28.
  • 2 additional annotations were made from Koga S, etal., Neurosci Lett. 2014 Jun 13;571:11-6. doi: 10.1016/j.neulet.2014.04.028. Epub 2014 Apr 28.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: protein:increased expression:hippocampus, astrocyte


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from mutant phenotype (IMP)
    		•  
  • The annotation was made from de Luca C, etal., J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.
  • 8 additional annotations were made from de Luca C, etal., J Clin Invest. 2005 Dec;115(12):3484-93. Epub 2005 Nov 10.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Qualifier: treatment


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
  • The annotation has been inferred from sequence orthology with LEPR (Homo sapiens) [(IEA) inferred from electronic annotation]
  • 619 additional annotations were made from Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Rolland V, etal., Obes Res. 1998 Mar;6(2):122-7.
  • The annotation has been inferred from sequence orthology with LEPR (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 2 additional annotations were made from Rolland V, etal., Obes Res. 1998 Mar;6(2):122-7.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Qualifier: no_association


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred by association of genotype and phenotype (IAGP)
    		•  
  • The annotation was made from RGD automated import pipeline for MGI gene-to-disease annotations
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: OMIM:601665


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Stevenson FT, etal., Obes Res 2001 Aug;9(8):492-9.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IAGP) inferred by association of genotype and phenotype]
  • 27 additional annotations were made from Stevenson FT, etal., Obes Res 2001 Aug;9(8):492-9.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: compared to heterozygous controls +/fa


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Chen Y, etal., Sci China Life Sci. 2017 Feb;60(2):152-157. doi: 10.1007/s11427-016-5049-y. Epub 2016 May 25.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IMP) inferred from mutant phenotype]
  • 24 additional annotations were made from Chen Y, etal., Sci China Life Sci. 2017 Feb;60(2):152-157. doi: 10.1007/s11427-016-5049-y. Epub 2016 May 25.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Marques BG, etal., Am J Physiol 1998 Dec;275(6 Pt 2):R1898-908.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IAGP) inferred by association of genotype and phenotype]
  • 29 additional annotations were made from Marques BG, etal., Am J Physiol 1998 Dec;275(6 Pt 2):R1898-908.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: compared to age-matched lean +/fa rats


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IMP) inferred from mutant phenotype]
  • 75 additional annotations were made from McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Qualifier: disease_progression


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Kim K, etal., Physiol Genomics. 2010 Feb 16.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IAGP) inferred by association of genotype and phenotype]
  • 119 additional annotations were made from Kim K, etal., Physiol Genomics. 2010 Feb 16.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Qualifier: sexual_dimorphism
  • Curation Notes: compared to BN


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IMP) inferred from mutant phenotype]
  • 75 additional annotations were made from McPherson KC, etal., Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Schauer A, etal., ESC Heart Fail. 2020 Oct;7(5):2123-2134. doi: 10.1002/ehf2.12915. Epub 2020 Jul 25.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IAGP) inferred by association of genotype and phenotype]
  • 39 additional annotations were made from Schauer A, etal., ESC Heart Fail. 2020 Oct;7(5):2123-2134. doi: 10.1002/ehf2.12915. Epub 2020 Jul 25.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: DNA:mutations:cds: : (rat)


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Dower K, etal., PLoS One. 2017 Jul 26;12(7):e0181861. doi: 10.1371/journal.pone.0181861. eCollection 2017.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IAGP) inferred by association of genotype and phenotype]
  • 42 additional annotations were made from Dower K, etal., PLoS One. 2017 Jul 26;12(7):e0181861. doi: 10.1371/journal.pone.0181861. eCollection 2017.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: DNA:mutations:cds: : (rat)


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for CTD gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with LEPR (Homo sapiens) [(EXP) inferred from experiment]
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: CTD Direct Evidence: marker/mechanism
  • Original References(s): PMID:3519326 PMID:17065336 PMID:17229951 PMID:19913045 PMID:20567778 PMID:22276206 PMID:23563609 PMID:24263156 PMID:25222487 PMID:29743445 PMID:30689673 PMID:30993381 PMID:35235096 PMID:35472412


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
  • The annotation has been inferred from sequence orthology with LEPR (Homo sapiens) [(IAGP) inferred by association of genotype and phenotype]
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: ClinVar Annotator: match by term: Monogenic Non-Syndromic Obesity | ClinVar Annotator: match by term: Obesity | ClinVar Annotator: match by term: Obesity disorder
  • Original References(s): PMID:11354636 PMID:11380591 PMID:11443193 PMID:12006639 PMID:17785359 PMID:18490929 PMID:21393862 PMID:21744741 PMID:22331430 PMID:25741868 PMID:26467025 PMID:28492532 PMID:8666155


    • An association has been curated linking Lepr and obesity in Mus musculus.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Tofovic SP, etal., Ren Fail. 2000;22(4):387-406. doi: 10.1081/jdi-100100882.
  • The annotation has been inferred from sequence orthology with Lepr (Rattus norvegicus) [(IAGP) inferred by association of genotype and phenotype]
  • 74 additional annotations were made from Tofovic SP, etal., Ren Fail. 2000;22(4):387-406. doi: 10.1081/jdi-100100882.
  • 635 RGD objects have been annotated to obesity  (DOID:9970)
  • 67 papers in RGD have been used to annotate Lepr
  • Curation Notes: DNA:mutations::cds: : (rat)


    • Go Back to source page   Continue to Ontology report