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Gene: LEPR (leptin receptor) Homo sapiens
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Symbol: LEPR
Name: leptin receptor
Description: Exhibits identical protein binding activity. Involved in angiogenesis and negative regulation of autophagy. Localizes to the receptor complex. Implicated in several diseases, including chronic obstructive pulmonary disease; non-alcoholic fatty liver disease; obesity; obstructive sleep apnea; and osteoporosis. Biomarker of arteriosclerosis; chronic obstructive pulmonary disease; hepatocellular clear cell carcinoma; primary biliary cirrhosis; and sleep apnea.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD295; DKFZp686B1731; huB219; LEP-R; LEPRD; OB receptor; OB-R; OBR
Orthologs:
Mus musculus (house mouse) : Lepr (leptin receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lepr (leptin receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lepr (leptin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : LEPR (leptin receptor)
Canis lupus familiaris (dog) : LEPR (leptin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lepr (leptin receptor)
Sus scrofa (pig) : LEPR (leptin receptor)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   LDLPS20_H   LDLPS19_H   LDLPS21_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,420,652 - 65,637,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37165,886,335 - 66,103,176 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,658,906 - 65,875,410 (+)NCBINCBI36hg18NCBI36
Build 34165,598,338 - 65,814,843NCBI
Celera164,176,916 - 64,393,787 (+)NCBI
Cytogenetic Map1p31.3NCBI
HuRef163,995,123 - 64,212,195 (+)NCBIHuRef
CHM1_1166,002,606 - 66,219,234 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on LEPR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735832
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.