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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735832
Species: Homo sapiens
RGD Object: Gene
Symbol: LEPR
Name: leptin receptor
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LEPRdecreases expressionISOLepr (Mus musculus)6480464CTDFolic Acid results in decreased expression of LEPR mRNAPMID:25629700
LEPRmultiple interactionsISOLepr (Mus musculus)6480464CTD[Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of LEPR mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of LEPR mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LEPR mRNAPMID:20938992 PMID:29127188 PMID:33549593
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