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GENE - TERM ANNOTATION REPORT

RGD ID: 735832
Species: Homo sapiens
RGD Object: Gene
Symbol: LEPR
Name: leptin receptor
Acc ID: DOID:9352
Term: type 2 diabetes mellitus
Definition: A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Diabetes "DO" "DO", http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LEPR IAGP 2311141RGDDNA:polymorphisms (human) 
LEPR IAGP 14696694RGDassociated with nonalcoholic fatty liver disease;DNA:intron:c.2673+1118C>T (rs6700896) (human) 
LEPRsusceptibilityIAGP 2311144RGDDNA:insertion:3' utr (human) 
LEPR ISOLepr (Rattus norvegicus)13432147RGD  
LEPRtreatmentISOLepr (Mus musculus)10412018RGD  
LEPR EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:20175764 PMID:22933112 PMID:24263156 PMID:26939912
LEPR ISSLepr (Mus musculus)13592920MouseDOOMIM:125853 | OMIM:601283 | OMIM:601407 | OMIM:603694 | OMIM:608036 
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