RGD Reference Report - Attenuation of leptin and insulin signaling by SOCS proteins. - Rat Genome Database

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Attenuation of leptin and insulin signaling by SOCS proteins.

Authors: Howard, JK  Flier, JS 
Citation: Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28.
RGD ID: 1625125
Pubmed: PMID:17010638   (View Abstract at PubMed)
DOI: DOI:10.1016/j.tem.2006.09.007   (Journal Full-text)

Leptin and insulin are key hormones involved in the regulation of energy balance and glucose homeostasis. Development of resistance to the action of these hormones, which can occur with age, obesity and inflammation, appears to have a prime role in the pathogenesis of obesity and type 2 diabetes. Specific members of the suppressor of cytokine signaling (SOCS) family of proteins are now thought to have a role in the development of leptin and insulin resistance owing to their ability to inhibit leptin and insulin signaling pathways. In the case of leptin, current evidence suggests that SOCS3 appears to be of particular importance in the development of leptin resistance, whereas the ability to diminish insulin action has been described for several SOCS proteins (SOCS1, SOCS3, SOCS6 and SOCS7).



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LepMouseenergy homeostasis pathway  TAS  RGD 
LeprMouseenergy homeostasis pathway  TAS  RGD 
SOCS1Humaninsulin signaling pathway   ISOSocs1 (Mus musculus) RGD 
SOCS3Humaninsulin signaling pathway   ISOSocs3 (Mus musculus) RGD 
SOCS6Humaninsulin signaling pathway   ISOSocs6 (Mus musculus) RGD 
SOCS7Humaninsulin signaling pathway   ISOSocs7 (Mus musculus) RGD 
Socs1Ratinsulin signaling pathway   ISOSocs1 (Mus musculus) RGD 
Socs1Mouseinsulin signaling pathway   TAS  RGD 
Socs3Ratinsulin signaling pathway   ISOSocs3 (Mus musculus) RGD 
Socs3Mouseinsulin signaling pathway   TAS  RGD 
Socs6Ratinsulin signaling pathway   ISOSocs6 (Mus musculus) RGD 
Socs6Mouseinsulin signaling pathway   TAS  RGD 
Socs7Ratinsulin signaling pathway   ISOSocs7 (Mus musculus) RGD 
Socs7Mouseinsulin signaling pathway   TAS  RGD 
JAK2Humanleptin system pathway   TAS  RGD 
Jak2Ratleptin system pathway   ISO RGD 
Jak2Mouseleptin system pathway   ISO RGD 
LEPHumanleptin system pathway   ISOLep (Mus musculus) RGD 
LEPRHumanleptin system pathway   ISOLepr (Mus musculus) RGD 
LepRatleptin system pathway   ISOLep (Mus musculus) RGD 
LepMouseleptin system pathway   TAS  RGD 
LeprRatleptin system pathway   ISOLepr (Mus musculus) RGD 
LeprMouseleptin system pathway   TAS  RGD 
SOCS3Humanleptin system pathway   ISOSocs3 (Mus musculus) RGD 
STAT3Humanleptin system pathway   TAS  RGD 
Socs3Mouseleptin system pathway   TAS  RGD 
Socs3Ratleptin system pathway   ISOSocs3 (Mus musculus) RGD 
Stat3Ratleptin system pathway   ISOSTAT3 (Homo sapiens) RGD 
Stat3Mouseleptin system pathway   ISOSTAT3 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Jak2  (Janus kinase 2)
Lep  (leptin)
Lepr  (leptin receptor)
Socs1  (suppressor of cytokine signaling 1)
Socs3  (suppressor of cytokine signaling 3)
Socs6  (suppressor of cytokine signaling 6)
Socs7  (suppressor of cytokine signaling 7)
Stat3  (signal transducer and activator of transcription 3)

Genes (Mus musculus)
Jak2  (Janus kinase 2)
Lep  (leptin)
Lepr  (leptin receptor)
Socs1  (suppressor of cytokine signaling 1)
Socs3  (suppressor of cytokine signaling 3)
Socs6  (suppressor of cytokine signaling 6)
Socs7  (suppressor of cytokine signaling 7)
Stat3  (signal transducer and activator of transcription 3)

Genes (Homo sapiens)
JAK2  (Janus kinase 2)
LEP  (leptin)
LEPR  (leptin receptor)
SOCS1  (suppressor of cytokine signaling 1)
SOCS3  (suppressor of cytokine signaling 3)
SOCS6  (suppressor of cytokine signaling 6)
SOCS7  (suppressor of cytokine signaling 7)
STAT3  (signal transducer and activator of transcription 3)


Additional Information