RGD Reference Report - Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Lepr(fa)/Lepr(fa) rat. - Rat Genome Database

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Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Lepr(fa)/Lepr(fa) rat.

Authors: Hattori, T  Murase, T  Ohtake, M  Inoue, T  Tsukamoto, H  Takatsu, M  Kato, Y  Hashimoto, K  Murohara, T  Nagata, K 
Citation: Hattori T, etal., Nutr Diabetes. 2011 Jan 31;1:e1. doi: 10.1038/nutd.2010.1.
RGD ID: 13432147
Pubmed: (View Article at PubMed) PMID:23154293
DOI: Full-text: DOI:10.1038/nutd.2010.1

OBJECTIVE: The DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rat strain was established from a cross between Dahl salt-sensitive rats and Zucker fatty (fa/fa) rats, the latter of which harbor a missense mutation in the leptin receptor gene (Lepr). We examined whether DS/obese rats might be a suitable animal model of metabolic syndrome in humans.
METHODS: The systemic pathophysiological and metabolic characteristics of DS/obese rats were determined and compared with those of homozygous lean littermates, namely, DahlS.Z-Lepr(+)/Lepr(+) (DS/lean) rats.
RESULTS: Systolic blood pressure was higher in DS/obese rats fed a normal diet than in DS/lean rats at 11 weeks of age and thereafter. The survival rate of DS/obese rats was significantly lower than that of DS/lean rats at 18 weeks. Body weight, visceral and subcutaneous fat mass, as well as heart, kidney and liver weights, were increased in DS/obese rats at 18 weeks compared with DS/lean rats. Serum low-density lipoprotein (LDL)-cholesterol, triglyceride and insulin concentrations, as well as the ratio of LDL-cholesterol to high-density lipoprotein-cholesterol levels, were increased in DS/obese rats, whereas serum glucose concentration did not differ significantly between DS/obese and DS/lean rats. Creatinine clearance was decreased and urinary protein content was increased in DS/obese rats, which also manifested lipid accumulation in the liver and elevation of serum alanine aminotransferase levels.
CONCLUSION: These results show that the phenotype of DS/obese rats is similar to that of humans with metabolic syndrome, and that these animals may thus be an appropriate model for this condition.

Disease Annotations    

Phenotype Annotations    

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Strains with Phenominer Data Strains with phenominer data
SS.ZUC-Leprfa+/+/Slc SS.ZUC-Leprfa-/-/Slc

Objects Annotated

Genes (Rattus norvegicus)
Lepr  (leptin receptor)
Leprfa  (leptin receptor; fa mutant)

Genes (Mus musculus)
Lepr  (leptin receptor)

Genes (Homo sapiens)
LEPR  (leptin receptor)

SS.ZUC-Leprfa-/-/Slc  (NA)

Additional Information