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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10865
Species: Mus musculus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: CHEBI:81584
Term: 2,2',4,4'-Tetrabromodiphenyl ether
Definition: An organobromine compound that has formula C12H6Br4O.
Chemical ID: MESH:C511295
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Leprincreases expressionEXP 6480464CTD2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LEPR mRNAPMID:29112739
Leprmultiple interactionsEXP 6480464CTDESR1 gene mutant form inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LEPR mRNA]PMID:29112739
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