Lepr<sup>em2</sup> (leptin receptor; TALEN induced mutant 2) - Rat Genome Database

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Gene: Leprem2 (leptin receptor; TALEN induced mutant 2) Rattus norvegicus
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Symbol: Leprem2
Name: leptin receptor; TALEN induced mutant 2
RGD ID: 12910518
Description: This allele was produced by injecting TALEN targeting the sequence of rat Lepr into SD embryos. The resulting mutation is a 1-bp deletion.
ASSOCIATED WITH obesity
Type: allele  of Lepr  
Previously known as: Lepr^[em2]; Leprem2
Is Marker For: Strains:   SD-Leprem2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View
obesity  (IMP)

References

References - curated
# Reference Title Reference Citation
1. Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene. Chen Y, etal., Sci China Life Sci. 2017 Feb;60(2):152-157. doi: 10.1007/s11427-016-5049-y. Epub 2016 May 25.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Leprem2-var1 chr5 116372431 116372431 G - deletion mRatBN7.2
Leprem2-var1 chr5 120581486 120581486 G - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Leprem2
SD-Leprem2    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information