Lepr<sup>fa</sup> (leptin receptor; fa mutant) - Rat Genome Database

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Gene: Leprfa (leptin receptor; fa mutant) Rattus norvegicus
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Symbol: Leprfa
Name: leptin receptor; fa mutant
RGD ID: 13432153
Description: A missense mutation (an A to C conversion at nucleotide position 806) was found in the extracellular domain of all the isoforms in Zucker fatty (fa/fa) rats, which resulted in an amino acid change from Gln to Pro at + 269 (the Gln269Pro mutation).
ASSOCIATED WITH albuminuria; decreased survivor rate; hepatic steatosis; ASSOCIATED WITH Hyperphagia; Insulin Resistance; obesity
Type: allele  of Lepr  
Previously known as: Leprfa
Is Marker For: Strains:   ZUC-LeprfaSte-/-   ZUC-Leprfa   Crl:ZUC-Leprfa   F344.ZUC-Leprfa/Tj   Crlj:ZUC-Leprfa   Crl:ZUC(Orl)-Leprfa   HsdHlr:ZUC-Leprfa   Slc:ZUC-Leprfa-/-   Ho:ZFDM-Leprfa   SS.ZUC-Leprfa-/-/Slc   SS.ZUC-Leprfa-/+/Slc   BN.ZUC-Leprfa  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Lepr(fa)/Lepr(fa) rat. Hattori T, etal., Nutr Diabetes. 2011 Jan 31;1:e1. doi: 10.1038/nutd.2010.1.
2. Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats. Kim K, etal., Physiol Genomics. 2010 Feb 16.
3. Association of fat cell size and paracrine growth factors in development of hyperplastic obesity. Marques BG, etal., Am J Physiol 1998 Dec;275(6 Pt 2):R1898-908.
4. Hyperphagia as a mediator of renal disease initiation in obese Zucker rats. Stevenson FT, etal., Obes Res 2001 Aug;9(8):492-9.
5. Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats. Takaya K, etal., Biochem Biophys Res Commun. 1996 Aug 5;225(1):75-83.
6. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Wu-Peng XS, etal., Diabetes. 1997 Mar;46(3):513-8.

Genomics




Expression


Sequence

Nucleotide Sequences

Rat Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type
Leprfa-var1 chr5 116389200 116389200 A C point_mutation
Leprfa-var1 chr5 120597857 120597857 A C point_mutation

Additional Information