GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Lepr | affects abundance | ISO | Lepr (Mus musculus) | 6480464 | CTD | LEPR affects the abundance of Methionine | PMID:20567778 | Lepr | multiple interactions | ISO | Lepr (Mus musculus) | 6480464 | CTD | [Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of LEPR mRNA; [LEPR gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCB1A protein; [LEPR gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC3 mRNA; [LEPR gene mutant form co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC3 protein; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc] results in decreased expression of LEPR mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LEPR mRNA; LEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased activity of GPT protein]; LEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCB1A mRNA]; LEPR gene mutant form affects the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ABCC4 mRNA] | PMID:20938992 PMID:24384915 PMID:29127188 PMID:33549593 | | ||||||||||||||||||||||
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