Lepr<sup>cp</sup> (leptin receptor;corpulent) - Rat Genome Database

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Gene: Leprcp (leptin receptor;corpulent) Rattus norvegicus
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Symbol: Leprcp
Name: leptin receptor;corpulent
RGD ID: 11570565
Description: Nonsense mutation of leptin receptor gene identified in the obese spontaneously hypertensive Koletsky rat. The T to A transversion at 2289 results in premature stop at position 763.
ASSOCIATED WITH increased body mass index; increased circulating leptin level
Type: allele  of Lepr  
Previously known as: fak; Lepr^[cp]; Leprcp
Is Marker For: Strains:   SHR.Cg-Leprcp/NDmcr   SHROB/KolGmiCrl-Leprcp/Crl   SHHF-Leprcp/Crl   ZSF1-Leprfa/cp/Crl   SHR.Cg-Leprcp-Tg(APOB)110/Dmcr   LA-cp/NRll  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat. Takaya K, etal., Nat Genet. 1996 Oct;14(2):130-1.
2. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Wu-Peng XS, etal., Diabetes. 1997 Mar;46(3):513-8.

Genomics


Related Rat Strains
The following Strains have been annotated to Leprcp
LA-cp/NRll     SHHF-Leprcp/Crl     SHR.Cg-Leprcp-Tg(APOB)110/Dmcr     SHR.Cg-Leprcp/NDmcr     SHROB/KolGmiCrl-Leprcp/Crl     ZSF1-Leprfa/cp/Crl    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information