Bp254 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Bp254 (Blood pressure QTL 254) Rattus norvegicus

Symbol: Bp254
Name: Blood pressure QTL 254
RGD ID: 1358895
Trait: arterial blood pressure trait   (VT:2000000)    
Measurement Type: mean arterial blood pressure   (CMO:0000009)    
LOD Score: 3.6
P Value: 3.0E-4
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8597,492,524 - 133,270,832RGD_MAPPER_PIPELINE
mRatBN7.2558,829,236 - 128,034,027RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0560,072,951 - 133,313,852RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0564,593,776 - 137,108,002RGDRnor5.0
RGSC_v3.4561,080,077 - 134,872,385RGDRGSC3.4
RGSC_v3.1561,080,322 - 134,877,312RGD
Cross Type: Not Available
Strains Crossed: LEW HTG 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp254Rathypertension  QTM 1303389 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp254Ratincreased systemic arterial blood pressure  QTM 1303389 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp254Ratmean arterial blood pressure  IDA 1303389 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp254Ratlosartan  IDA 1303389 RGD 
Bp254Ratpentolinium  IDA 1303389 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp254Ratvascular indwelling catheter method  IDA 1303389 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp254RatHTG  IEA 1303389 RGD 
Bp254RatLEW  IEA 1303389 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bp254Ratarterial blood pressure trait  IDA 1303389 RGD 


#
Reference Title
Reference Citation
1. Association of SLC6A9 gene variants with human essential hypertension. Ueno T, etal., J Atheroscler Thromb. 2009 Jun;16(3):201-6. Epub 2009 Jun 25.
2. Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems. Ueno T, etal., J Mol Med 2003 Jan;81(1):51-60. Epub 2002 Nov 21.


1 to 20 of 725 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1565236Pax5paired box 555876333458945719Rat
41144673LOC120102862uncharacterized LOC12010286255889677158899409Rat
1310467Zcchc7zinc finger CCHC-type containing 755899255859173308Rat
41206741LOC120102863uncharacterized LOC12010286355921362759226603Rat
1308851Grhprglyoxylate and hydroxypyruvate reductase55923417959243614Rat
1307367Zbtb5zinc finger and BTB domain containing 555924413259265461Rat
1565773Polr1eRNA polymerase I subunit E55927945659295346Rat
1305465Fbxo10F-box protein 1055929701659343429Rat
1596808Tomm5translocase of outer mitochondrial membrane 555936236059365191Rat
9330186LOC10369234660S ribosomal protein L24 pseudogene55937347759374019Rat
41380328LOC120103148uncharacterized LOC12010314855939229559395154Rat
1305229Frmpd1FERM and PDZ domain containing 155944307659545125Rat
41200968LOC120102864uncharacterized LOC12010286455947188159475003Rat
1310735Trmt10btRNA methyltransferase 10B55954884559572529Rat
1304739Exosc3exosome component 355957384959579065Rat
9455316Pgam1-ps8phosphoglycerate mutase 1, pseudogene 855959321759593995Rat
1586079Dcaf10lDDB1 and CUL4 associated factor 10 like55960217759607812Rat
1304730Dcaf10DDB1 and CUL4 associated factor 1055960779559647209Rat
1305190Slc25a51solute carrier family 25, member 5155964998059663454Rat
1565350ShbSH2 domain containing adaptor protein B55967806659785443Rat

1 to 20 of 725 rows
1 to 20 of 1049 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10262D5Rhm31335119564714119564847Ratregion
10263D5Rhm41455119592239119592384Ratregion
10321D5Lev171235103991975103992098Ratregion
10324D5Lev191835124411616124411799Ratregion
10826D5Mgh231285109897808109897936Ratregion
10827D5Lev152925109894810109895102Ratregion
10931D5Wox1322657516579275166041Ratregion
11090D5Rhm21685114659557114659726Ratregion
33804D5Mit62125117817033117817245Ratregion
33836D5Mit912156029343460293557Ratregion
33921D5Mit219456928513369285327Ratregion
33967D5Mit329658108229081082586Ratregion
33981D5Mit426659045014490450412Ratregion
33985D5Mit1113358361072983610862Ratregion
34041D5Mit51445104250862104251008Ratregion
34057D5Mit1713557196353371963668Ratregion
34144D5Mgh1114457425132074251464Ratregion
34170D5Mgh2412657830912778309253Ratregion
34216D5Mgh614056898430768984447Ratregion
34322D5Mgh1012955979339959793528Ratregion
1 to 20 of 1049 rows

Flank 1: (D5Rat9)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2558,829,236 - 58,829,371 (+)MAPPER
Rnor_6.0560,072,951 - 60,073,085NCBI
Rnor_5.0564,593,776 - 64,593,910UniSTS
RGSC_v3.4561,080,077 - 61,080,454RGD
RGSC_v3.4561,080,143 - 61,080,277UniSTS
RGSC_v3.1561,080,322 - 61,080,456RGD
Celera557,404,042 - 57,404,176UniSTS
RH 3.4 Map5378.7UniSTS
RH 3.4 Map5378.7RGD
SHRSP x BN Map536.1899UniSTS
SHRSP x BN Map536.1899RGD
Cytogenetic Map5q22UniSTS
Peak: (D5Rat156)
Rat AssemblyChrPosition (strand)Source
GRCr85115,381,593 - 115,381,763 (+)Marker Load Pipeline
mRatBN7.25110,265,888 - 110,266,058 (+)MAPPER
Rnor_6.05114,384,129 - 114,384,298NCBI
Rnor_5.05118,328,598 - 118,328,767UniSTS
RGSC_v3.45115,745,463 - 115,745,633RGD
RGSC_v3.45115,745,464 - 115,745,633UniSTS
RGSC_v3.15115,750,646 - 115,751,107RGD
Celera5108,877,950 - 108,878,119UniSTS
SHRSP x BN Map560.6499RGD
SHRSP x BN Map560.6499UniSTS
Flank 2: (D5Rat108)
Rat AssemblyChrPosition (strand)Source
GRCr85133,270,647 - 133,270,832 (+)Marker Load Pipeline
mRatBN7.25128,033,842 - 128,034,027 (+)MAPPER
Rnor_6.05133,313,668 - 133,313,852NCBI
Rnor_5.05137,107,818 - 137,108,002UniSTS
RGSC_v3.45134,871,897 - 134,872,385RGD
RGSC_v3.45134,871,902 - 134,872,086UniSTS
RGSC_v3.15134,877,128 - 134,877,312RGD
Celera5126,688,474 - 126,688,658UniSTS
RH 3.4 Map5828.8UniSTS
RH 3.4 Map5828.8RGD
RH 2.0 Map5776.9RGD
SHRSP x BN Map566.0999RGD
Cytogenetic Map5q35UniSTS


1 to 10 of 101 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat

1 to 10 of 101 rows


Note Type Note Reference
qtl_gene this region is syntenic to human chr 1 region that has 142 annotated genes including SLC6A9; the association of SNPs in the SLC6A9 region and hypertension is confirmed by case-control study in 758 patients 2316920
qtl_statistics_details QTL linkage only suggestive after renin-angiotensisin system block; QTL linkage is not detected after SNS or NOS block 1303389