Mcs13 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Mcs13 (Mammary carcinoma susceptibility QTL 13) Rattus norvegicus

Symbol: Mcs13
Name: Mammary carcinoma susceptibility QTL 13
RGD ID: 1598814
Also known as: Mcs5b
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: mammary tumor number   (CMO:0000343)    
LOD Score: Not Available
P Value: 1.0E-4
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2563,190,890 - 69,927,503RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0568,395,096 - 71,941,113RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0572,838,045 - 76,105,732RGDRnor5.0
RGSC_v3.4565,553,185 - 73,080,336RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: WF.WKY-(D5Uwm66-D5Uwm67)/Uwm WF.WKY-(D5Uwm65-D5Uwm60)/Uwm 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
1. Samuelson DJ, etal., Cancer Res. 2005 Nov 1;65(21):9637-42.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
7712908LOC102546330uncharacterized LOC10254633056852552368541369Rat
1333384Olr848olfactory receptor 84856861915769134909Rat
1595535LOC678885similar to glyceraldehyde-3-phosphate dehydrogenase56867573568676746Rat
1305227Smc2structural maintenance of chromosomes 256871750968764080Rat
1309291RGD1309291similar to RIKEN cDNA 4930547C1056889781268911390Rat
7673458LOC10255084860S ribosomal protein L29-like56910672369107244Rat
1333279Olr843-psolfactory receptor pseudogene 84356915652969157144Rat
6487777LOC100912327olfactory receptor 13C3-like56917035869171413Rat
6487326LOC100912374olfactory receptor 13C3-like56921486469215914Rat
1333133Olr844olfactory receptor 84456921494869215901Rat
1332933Olr845olfactory receptor 84556924629269247760Rat
1333321Olr847olfactory receptor 84756927683069277783Rat
1334211Olr846-psolfactory receptor pseudogene 84656947729369478377Rat
1332612Olr850olfactory receptor 85056951632769517277Rat
1333398Olr851olfactory receptor 85156957749969578458Rat
1333551Olr852olfactory receptor 85256975136469752314Rat
1334138Olr853olfactory receptor 85356978480669785744Rat
1583223Nipsnap3anipsnap homolog 3A (C. elegans)56980949269820578Rat
1359688Nipsnap3bnipsnap homolog 3B56983320069849116Rat
631344Abca1ATP binding cassette subfamily A member 156985771769983042Rat
9340681LOC103692353uncharacterized LOC10369235357003179370040913Rat
11477247LOC108350972uncharacterized LOC10835097257006871270074254Rat
7625423LOC102551246uncharacterized LOC10255124657007474270093189Rat
11433694LOC10835097160S ribosomal protein L36a-like57013598970136466Rat
1597744LOC685138similar to ribosomal protein S2357018845870188955Rat
7499527LOC102551410uncharacterized LOC10255141057020264470212332Rat
621426Slc44a1solute carrier family 44 member 157024364370424115Rat
7555191LOC102551474uncharacterized LOC10255147457029732770326106Rat
1564809Fsd1lfibronectin type III and SPRY domain containing 1-like57044107570517131Rat
2322103LOC100360453chromobox homolog 3-like57046269270463994Rat
1310087Fktnfukutin57052200170578270Rat
1596467Tal2TAL bHLH transcription factor 257059287170599428Rat
11462383LOC108350973uncharacterized LOC10835097357061107670622615Rat
1305703Tmem38btransmembrane protein 38B57063915670675055Rat
7525226LOC102547886placenta-expressed transcript 1 protein-like57065376870656424Rat
1564956RGD1564956similar to calcium binding protein P2257074753470749967Rat
1595137LOC685311similar to Histidine triad nucleotide-binding protein 1 (Adenosine 5-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)57080944670809984Rat
11380844LOC108350974uncharacterized LOC10835097457097357670974468Rat
9227196LOC103692354uncharacterized LOC10369235457102786871050012Rat
2324157LOC100362701rCG31968-like57138717371387740Rat
11497680LOC108350975uncharacterized LOC10835097557140604371407876Rat
9092883LOC103692358glyceraldehyde-3-phosphate dehydrogenase pseudogene57141229471413006Rat
11361016LOC108350976uncharacterized LOC10835097657143344471476186Rat
1594562LOC298010similar to Carnitine acetyltransferase57154135371543296Rat
1562123Zfp462zinc finger protein 46257167984171824077Rat
2321090LOC100360970glutathione peroxidase 857185725571857923Rat
9223855LOC103692359glyceraldehyde-3-phosphate dehydrogenase pseudogene57186712671868188Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
34216D5Mgh614457115482871154967Ratregion
37440D5Rat8412957155256971552720Ratregion
36482D5Rat1215257003876570038916Ratregion
39402D5Rat13924657074186870742105Ratregion
41314D5Rat14116157025364270253776Ratregion
40790D5Rat13720956854514068545344Ratregion
43895D5Got618556995000369950187Ratregion
69560D5Uwm1716756867811968678301Ratregion
66643D5Mco1715457041021070410373Ratregion
1581996D5Uwm6527756839509668395372Ratregion
1582030D5Uwm6622057194089471941113Ratregion
5036619AU04861826756876673968766992Ratregion
5033971RH14080821157037659670376806Ratregion
5032181RH12625720157067348870673688Ratregion
5029423UniSTS:23812654557046297570463516Ratregion
5032797RH13533319757052130670521502Ratregion
5033713RH13984318257168237471682555Ratregion
5059766BE10319317957032177770321955Ratregion
5049844RH13371419157042385570424045Ratregion
5049748RH13365918857028558270285769Ratregion
5042664RH129571057057784870578053Ratregion
5041108RH12866720756984880469849010Ratregion
5075392RH13856712257024507270245193Ratregion
5077892RH14002018157057516970575349Ratregion
5073098RH13723621257067325970673470Ratregion
5071814RH13530020556985878169858985Ratregion
5073912RH13771024657032919970329444Ratregion
5074160RH13785619557169503771695231Ratregion
5062164BE11285821157100177571001985Ratregion
5062700BF40388321257070669470706905Ratregion
5065928BE11617616557067228770672451Ratregion
5060776BF38911915957176473971764897Ratregion
5084230AA84882920856985798469858191Ratregion
5086042BE10377819057051221270512401Ratregion
5087484PMC207565P114156998296569983105Ratregion
5087873Fin1613756876364368763779Ratregion
5083729AI10538221657051408870514303Ratregion
5085028AI00898720756985931469859520Ratregion
5090299AU04966822456977918569779408Ratregion
5084832AI17218917757067462970674808Ratregion
5083487BF39148914657018995970190104Ratregion
5085958AI13709622057037294270373159Ratregion
5503813CDW92_935072457037357870374301Ratregion
5504222RH7997520757037305470373260Ratregion
5501470D9S187E7157174472071744790Ratregion
Position Markers

Flank 1: (D5Uwm65)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2563,190,890 - 63,191,167 (-)MAPPER
Rnor_6.0568,395,096 - 68,395,372NCBI
Rnor_5.0572,838,045 - 72,838,321UniSTS
RGSC_v3.4565,553,185 - 65,553,461UniSTS
Celera564,405,381 - 64,405,657UniSTS
Cytogenetic Map5 RGD
Flank 2: (D5Uwm66)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2569,927,283 - 69,927,503 (+)MAPPER
Rnor_6.0571,940,894 - 71,941,113NCBI
Rnor_5.0576,105,513 - 76,105,732UniSTS
RGSC_v3.4573,080,117 - 73,080,336UniSTS
Celera568,790,675 - 68,790,894UniSTS
Cytogenetic Map5 RGD


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5189432042Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5193273395Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51136640934Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5152509878720537Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5166658771552720Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)59514842103580403Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512651967117554267Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51884791376608178Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52907889974078899Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52907889974078899Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52964166174641661Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52964166174641661Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531926122136640934Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53440240979402409Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53440240979402409Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53440240979402409Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)535225432108092802Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)535661945117554267Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53578875670742105Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535788756147487820Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540777918154732375Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54440427689432042Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)544404276134502294Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54872203893587756Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)551418671147487820Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)55180442696804426Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)55180442696804426Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55330956898309568Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)555903593100903593Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)556902367101902367Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)556991667137729065Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)560072951133313852Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)561086525149030144Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56108665393273130Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)561086653117554114Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)561612600102331727Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)565696672129038896Rat
1598814Mcs13Mammary carcinoma susceptibility QTL 130.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)56839509671941113Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)568838385113838385Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)571154828108092802Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)571154828108092802Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)571154828108092802Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)571154828108092802Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)571154828108092802Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)571552569157225114Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general WKY alleles associated with increased mammary tumor susceptibility in this QTL region 1559294
qtl_statistics_details Kruskal-Wallis nonparametric test and ANOVA were used to analyze multiplicity data 1559294