Rasef (RAS and EF hand domain containing)

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Gene: Rasef (RAS and EF hand domain containing) Rattus norvegicus

Analyze

Symbol:

Rasef

Name:

RAS and EF hand domain containing

RGD ID:

1306418

Description:

Predicted to enable GDP binding activity; GTP binding activity; and identical protein binding activity. Predicted to be involved in vesicle-mediated transport. Predicted to be active in cytosol and perinuclear region of cytoplasm. Orthologous to human RASEF (RAS and EF-hand domain containing); INTERACTS WITH 17beta-estradiol; acetamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC298137; LOC298138; similar to RAS and EF hand domain containing

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RASEF (RAS and EF-hand domain containing)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Treefam
Mus musculus (house mouse):	Rasef (RAS and EF hand domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rasef (RAS and EF-hand domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RASEF (RAS and EF-hand domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RASEF (RAS and EF-hand domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rasef (RAS and EF-hand domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RASEF (RAS and EF-hand domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RASEF (RAS and EF-hand domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rasef (RAS and EF-hand domain containing)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	OMP (olfactory marker protein)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RASEF (RAS and EF-hand domain containing)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rasef (RAS and EF hand domain containing)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rasef (RAS and EF-hand domain containing)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rsef-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rasef	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	87,548,908 - 87,619,286 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	87,548,908 - 87,619,031 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	89,987,539 - 90,057,349 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	91,816,567 - 91,886,381 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	91,792,076 - 91,868,131 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	90,419,044 - 90,488,882 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	90,419,020 - 90,488,896 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	94,480,339 - 94,550,121 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	91,528,617 - 91,642,374 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	86,274,733 - 86,344,463 (-)	NCBI		Celera
Cytogenetic Map	5	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

belinostat (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

Benzo[ghi]perylene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

choline (ISO)

cisplatin (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

DDT (EXP)

dorsomorphin (ISO)

Enterolactone (ISO)

entinostat (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

fonofos (ISO)

formaldehyde (ISO)

L-methionine (ISO)

lead(0) (ISO)

mercury dibromide (ISO)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

panobinostat (ISO)

parathion (ISO)

phenylmercury acetate (ISO)

raloxifene (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

temozolomide (ISO)

terbufos (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

trichostatin A (ISO)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

vesicle-mediated transport (IBA)

Cellular Component

cytoplasm (IBA)

cytosol (IBA,ISO)

perinuclear region of cytoplasm (IBA,ISO)

Molecular Function

calcium ion binding (IEA)

GDP binding (IBA,ISO)

GTP binding (IBA,ISO)

GTPase activity (IEA)

identical protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17448446	PMID:22399288	PMID:30845941

Genomics

Comparative Map Data

Rasef
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	87,548,908 - 87,619,286 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	87,548,908 - 87,619,031 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	89,987,539 - 90,057,349 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	91,816,567 - 91,886,381 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	91,792,076 - 91,868,131 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	90,419,044 - 90,488,882 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	90,419,020 - 90,488,896 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	94,480,339 - 94,550,121 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	91,528,617 - 91,642,374 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	86,274,733 - 86,344,463 (-)	NCBI		Celera
Cytogenetic Map	5	q31	NCBI

RASEF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	82,979,590 - 83,219,224 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	82,979,590 - 83,063,177 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	85,594,505 - 85,678,057 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	84,787,135 - 84,867,863 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	82,826,877 - 82,907,597	NCBI
Celera	9	56,167,301 - 56,247,219 (-)	NCBI		Celera
Cytogenetic Map	9	q21.32	NCBI
HuRef	9	55,419,509 - 55,502,961 (-)	NCBI		HuRef
CHM1_1	9	85,741,051 - 85,824,644 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	95,129,181 - 95,212,707 (-)	NCBI		T2T-CHM13v2.0

Rasef
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	73,632,814 - 73,709,382 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	73,632,816 - 73,709,231 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	73,714,577 - 73,791,236 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	73,714,579 - 73,790,994 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	73,360,483 - 73,436,506 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	73,185,810 - 73,261,833 (-)	NCBI		MGSCv36	mm8
Celera	4	72,287,509 - 72,364,841 (-)	NCBI		Celera
Cytogenetic Map	4	C3	NCBI
cM Map	4	36.06	NCBI

Rasef
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955530	690,748 - 747,415 (+)	NCBI	ChiLan1.0	ChiLan1.0

RASEF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	9	82,150,182 - 82,227,478 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	41,815,989 - 41,893,302 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	81,923,829 - 82,000,739 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	81,923,834 - 82,001,272 (-)	Ensembl	panpan1.1		panPan2

RASEF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	76,257,108 - 76,468,515 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	76,391,186 - 76,466,651 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	76,909,496 - 77,120,665 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	76,565,886 - 76,777,693 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	76,700,215 - 76,775,828 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	76,379,667 - 76,592,170 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	76,275,069 - 76,351,612 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	76,840,803 - 77,053,408 (+)	NCBI		UU_Cfam_GSD_1.0

Rasef
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	123,293,536 - 123,360,592 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936632	115,008 - 181,990 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936632	114,969 - 179,642 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RASEF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	10	31,929,121 - 32,012,183 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	36,103,563 - 36,158,619 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RASEF
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	93,799,064 - 93,876,163 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	93,802,158 - 93,875,908 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	82,209,533 - 82,288,832 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rasef
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624811	10,848,490 - 10,926,493 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624811	10,844,717 - 10,926,558 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rasef
420 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	83
Count of miRNA genes:	80
Interacting mature miRNAs:	81
Transcripts:	ENSRNOT00000058893
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	47869062	90099692	Rat
9589025	Epfw7	Epididymal fat weight QTL 7	20.66	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	49463600	94463600	Rat
7411561	Bw134	Body weight QTL 134	24	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	49463600	94463600	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
2303615	Vencon7	Ventilatory control QTL 7		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	5	50983895	95983895	Rat
2303574	Gluco42	Glucose level QTL 42	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	53496719	98496719	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	55715622	100715622	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
2316954	Rf57	Renal function QTL 57	0		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	59793528	90450144	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	59793528	113558156	Rat
61386	Bp49	Blood pressure QTL 49	16.6		cerebrum integrity trait (VT:0010549)	brain infarction volume (CMO:0001013)	5	60293434	98603051	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	64719390	109719390	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	66174080	124160948	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	68984307	104251008	Rat
61380	Edpm5	Estrogen-dependent pituitary mass QTL 5	4.5	0.92	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	5	68984307	104251008	Rat
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	68984307	104251008	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	79584860	124584860	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	79584860	124584860	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	79584860	124584860	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	82394392	166664054	Rat
1331782	Rf36	Renal function QTL 36	3.296		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	83840598	97059958	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84132602	129132602	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	87468046	132468046	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	87468046	132468046	Rat

Markers in Region

AU047638

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	87,558,268 - 87,558,398 (-)	MAPPER	mRatBN7.2
Rnor_6.0	5	90,479,393 - 90,479,522	NCBI	Rnor6.0
Rnor_5.0	5	94,540,632 - 94,540,761	UniSTS	Rnor5.0
RGSC_v3.4	5	91,513,332 - 91,513,461	UniSTS	RGSC3.4
Celera	5	86,284,094 - 86,284,223	UniSTS
Cytogenetic Map	5	q31	UniSTS

AU047631

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	87,558,182 - 87,558,405 (-)	MAPPER	mRatBN7.2
Rnor_6.0	5	90,479,386 - 90,479,608	NCBI	Rnor6.0
Rnor_5.0	5	94,540,625 - 94,540,847	UniSTS	Rnor5.0
RGSC_v3.4	5	91,513,246 - 91,513,468	UniSTS	RGSC3.4
Celera	5	86,284,008 - 86,284,230	UniSTS
Cytogenetic Map	5	q31	UniSTS

RH138327

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	87,619,060 - 87,619,248 (-)	MAPPER	mRatBN7.2
Rnor_6.0	5	90,418,555 - 90,418,742	NCBI	Rnor6.0
Rnor_5.0	5	94,479,850 - 94,480,037	UniSTS	Rnor5.0
RGSC_v3.4	5	91,528,491 - 91,528,678	UniSTS	RGSC3.4
Celera	5	86,344,765 - 86,344,952	UniSTS
RH 3.4 Map	5	687.7	UniSTS
Cytogenetic Map	5	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2										13	8
Low	1	16	18	2	16	2	7	7	23	35	27	3	7
Below cutoff		23	20	20	3	20	1	2	49		1		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001277334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109488	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039109491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005504390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CB799643	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK598987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000058893 ⟹ ENSRNOP00000055680

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	87,548,908 - 87,619,031 (-)	Ensembl
Rnor_6.0 Ensembl	5	90,419,020 - 90,488,896 (+)	Ensembl

RefSeq Acc Id:

NM_001277334 ⟹ NP_001264263

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	87,548,908 - 87,618,759 (-)	NCBI
Rnor_6.0	5	90,419,044 - 90,488,882 (+)	NCBI
Celera	5	86,274,733 - 86,344,463 (-)	NCBI

Sequence:

show sequence

ATGGAGGCGGACGCGGACCCCGAGGAACTTGCGCGGCTGCGCTCCGTCTTCACAACCTATGACA
CGAACTGCTCCGGGCGCCTAGAACGTGCGGAGTTCCGCACGCTGTGCGCGGAGCTGCACGTGGC
CGAAGCCGAAGCAGAGGCAGTGTTCCTGGGGCTCGACACGGACCGCGATGGCGCAATCACCTTC
CCGGAGTTCGCGCGTGGCTTCCGCGGAGCGCTCGGCCAGGACAGCGGAGAGGCCCAAGGCCTCT
GGGACGCGGTAGAGCCTGAGAGCCCCGGCCCCGCCTGGCGGGACTTCCACACGCGCCTCGGAGA
GGAGGCCCAGCTCATTCCCAGAAAAGAACAAGTTAGTACCCTGTATCAGAACATTAACCTTGTG
GAACCAAGACTAATCCAGCCATATGAACATGTGATAAGGAACTTTCTCCGTGAGATCAGACTCC
AGAGCACAGAAATGGAAAACTTGGCCATTGCAGTGAAAAGAGCCCAGGACAAGGCGGCCATTCA
GCTAAGTGAGCTGGAAGAGGAAATGGATCAGAGGATTCAAGCTGTGGAAAATGAGACCCGAAAA
GATGAAAAACGCAAAGCTGAGGAAGCTCTCACTGACCTCAGACGTCAGTATGAAACAGAAGTAG
GAGATTTACAAGTGACCATTAAAAGGTTAAAAAAGCTTGAAGAGCAGTCAAGAAAAATAAGTCA
AAAGCAAGATGTGACTTCATTAAAGAAACAAATTTATGATTTAACAACGGAAAATCAAAAACTC
AAAAAAGATCTTTTGGAGACACAGACAAATTTAGCCTTTCTTCAGAGTGAACTAGATGCTTTGA
AAAGTGATTATGCTGACCAGACTATGAATTCTGAACGGGATCTGGAACTAATCCGAGAGTTCAA
TGAAGATCGAAGTAATCTTGAGAGGCAAATTGAAGTCCTCCAAACAGCTAACCGGAAGCTTCAT
GATAGTAATGACGGCCTTAGAAGTGCCCTTGAAAACACTTACAGCAAGCTCACCAAATCCTTGC
GTATGAATAACATATCACCAGGGAATACAATTTCTAGCAGCAGTCCCAAGTTTAATCATCATTC
TTCTCAACCACTGGGCTACGATAGGTCATCCCATTCTTCATATGCAGATGAGGATTGTGACTGT
TTGGCTCTCTGTGACCCTCTGCAGAAGATGAATTATGAAGTTGACAGCCTCCCCGAAAGCTGTT
TTGACAGTGGCCTGTCTACTCTGAGAGATTCTAATGAGTGTGATTCTGAGGTGGACTACAAGCC
CCAGGAAGGATTTCAGAGTTTGCACAGAACAGAGGAGAGCCTTGAGGGAGATACGTCAGACACA
GATGTTCCTGATATGAGGGATGAAGAAACATTCGATTGTGAAAGCGTGGCCTCTGTCTTACACG
GGCATCCCCAGGGGTCTGCTGGTGAGGGCAGCACTGTTAGTTCCTCCAGAAAGACCATCTCAGC
TCTTTCACCTGAAACAGACATGGTGAATAACACCTTGAAGTCCACATCTCAGAAGGCTTACAAG
ATTGTGCTGGCCGGTGATGCTGCAGTGGGAAAGTCCAGCTTCCTCATGCGACTCTGCAAGAATG
AGTTTCAGGGAAACACAAGTGCAACCCTAGGAGTTGATTTCCAAATGAAAACTCTGATGGTAGA
TGGTGAACCAACAGTCCTTCAGCTCTGGGATACAGCTGGACAAGAAAGATTTAGAAGTATCGCC
AAGTCTTACTTCCGAAAAGCAGATGGTGTCTTACTGCTGTACGATGTTACTTGTGAGAAAAGCT
TTCTTAATGTACGAGAATGGGTAGCTATGGTTGAGGATGGAACCCACAGATCCGTTCCTATCAT
GTTAGTAGGAAACAAGGCTGATCTTCGTGATGCTGCTACTGCAGAGAATCAAAAGTGTATCTCA
TCACATCTTGGAGAAAAACTGGCCATGACCTATGGGGCATTATTCTGTGAAACAAGCGCGAAAG
ATGGCTCCAATGTGGTGGAAGCTGTTCTCCATCTTGCTCGGGAAGTAAAGAAAAGGGCAGAGAA
TGATGACAGCAAATCCATCACCAGTCTGGCCACTTCTACTTCCAGAAAGTCACTGCAGATGAAG
AACTGTTGCAATGGCTAAAGCCCAGCTGTCCATTGTTCGTAAACTCTTTGCTTCCAGGTTACTG
ATTGTGGGACACTGACTCTCAAAGAAACAGTGCATCATAATGACATTGGCCTCTGAAGAATCAT
AGCCTGGCAAAATGTACTGCTCTTCCCTCTTCACAGCAACCGCAGGCTTGCTTTGTTCTATCTC
AGTGAGCTATTTGGGACGTCTGGCCTTACAGTTCACTGAGAGAAAATGTGTTAATGTTTTTAAT
GTGATATAGTAAAATAAAATAACATTCTCAGATCAAA

hide sequence

RefSeq Acc Id:

XM_039109486 ⟹ XP_038965414

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	87,548,908 - 87,618,518 (-)	NCBI

RefSeq Acc Id:

XM_039109487 ⟹ XP_038965415

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	87,548,908 - 87,599,033 (-)	NCBI

RefSeq Acc Id:

XM_039109488 ⟹ XP_038965416

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	87,548,908 - 87,599,033 (-)	NCBI

RefSeq Acc Id:

XM_039109490 ⟹ XP_038965418

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	87,567,422 - 87,619,273 (-)	NCBI

RefSeq Acc Id:

XM_039109491 ⟹ XP_038965419

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	87,548,908 - 87,575,461 (-)	NCBI

RefSeq Acc Id:

XR_005504390

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	87,563,716 - 87,619,286 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001264263	(Get FASTA)	NCBI Sequence Viewer
	XP_038965414	(Get FASTA)	NCBI Sequence Viewer
	XP_038965415	(Get FASTA)	NCBI Sequence Viewer
	XP_038965416	(Get FASTA)	NCBI Sequence Viewer
	XP_038965418	(Get FASTA)	NCBI Sequence Viewer
	XP_038965419	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001264263 ⟸ NM_001277334

- UniProtKB:

F1LVA5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEADADPEELARLRSVFTTYDTNCSGRLERAEFRTLCAELHVAEAEAEAVFLGLDTDRDGAITF
PEFARGFRGALGQDSGEAQGLWDAVEPESPGPAWRDFHTRLGEEAQLIPRKEQVSTLYQNINLV
EPRLIQPYEHVIRNFLREIRLQSTEMENLAIAVKRAQDKAAIQLSELEEEMDQRIQAVENETRK
DEKRKAEEALTDLRRQYETEVGDLQVTIKRLKKLEEQSRKISQKQDVTSLKKQIYDLTTENQKL
KKDLLETQTNLAFLQSELDALKSDYADQTMNSERDLELIREFNEDRSNLERQIEVLQTANRKLH
DSNDGLRSALENTYSKLTKSLRMNNISPGNTISSSSPKFNHHSSQPLGYDRSSHSSYADEDCDC
LALCDPLQKMNYEVDSLPESCFDSGLSTLRDSNECDSEVDYKPQEGFQSLHRTEESLEGDTSDT
DVPDMRDEETFDCESVASVLHGHPQGSAGEGSTVSSSRKTISALSPETDMVNNTLKSTSQKAYK
IVLAGDAAVGKSSFLMRLCKNEFQGNTSATLGVDFQMKTLMVDGEPTVLQLWDTAGQERFRSIA
KSYFRKADGVLLLYDVTCEKSFLNVREWVAMVEDGTHRSVPIMLVGNKADLRDAATAENQKCIS
SHLGEKLAMTYGALFCETSAKDGSNVVEAVLHLAREVKKRAENDDSKSITSLATSTSRKSLQMK
NCCNG

hide sequence

RefSeq Acc Id:

ENSRNOP00000055680 ⟸ ENSRNOT00000058893

RefSeq Acc Id:	XP_038965414 ⟸ XM_039109486
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038965416 ⟸ XM_039109488
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038965415 ⟸ XM_039109487
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038965419 ⟸ XM_039109491
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038965418 ⟸ XM_039109490
- Peptide Label:	isoform X3

Protein Domains

EF-hand

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LVA5-F1-model_v2	AlphaFold	F1LVA5	1-709	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306418	AgrOrtholog
BioCyc Gene	G2FUF-40973	BioCyc
Ensembl Genes	ENSRNOG00000024190	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000055680	ENTREZGENE
	ENSRNOP00000055680.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000058893	ENTREZGENE
	ENSRNOT00000058893.5	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.1490	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	EF-hand	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/TrEMBL
KEGG Report	rno:298138	UniProtKB/TrEMBL
NCBI Gene	Rasef	ENTREZGENE
PANTHER	RAS AND EF-HAND DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	RAS-RELATED PROTEIN RAB	UniProtKB/TrEMBL
Pfam	EF-hand_7	UniProtKB/TrEMBL
	Ras	UniProtKB/TrEMBL
PhenoGen	Rasef	PhenoGen
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	EF_HAND_1	UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/TrEMBL
	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
SMART	ARF	UniProtKB/TrEMBL
	EFh	UniProtKB/TrEMBL
	RAB	UniProtKB/TrEMBL
	RAN	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	F1LVA5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-07-08	Rasef	RAS and EF hand domain containing	LOC298138	similar to RAS and EF hand domain containing	Data Merged	737654	APPROVED
2008-04-30	Rasef	RAS and EF hand domain containing	Rasef_predicted	RAS and EF hand domain containing (predicted)	'predicted' is removed	2292626	APPROVED
2006-11-20	LOC298138	similar to RAS and EF hand domain containing			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Rasef_predicted	RAS and EF hand domain containing (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar