Dhcr24 (24-dehydrocholesterol reductase) - Rat Genome Database

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Gene: Dhcr24 (24-dehydrocholesterol reductase) Rattus norvegicus
Analyze
Symbol: Dhcr24
Name: 24-dehydrocholesterol reductase
RGD ID: 1306529
Description: Predicted to enable enzyme binding activity; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; and peptide antigen binding activity. Involved in several processes, including Ras protein signal transduction; negative regulation of cell population proliferation; and steroid metabolic process. Predicted to be located in endoplasmic reticulum and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in lipid metabolism disorder. Orthologous to human DHCR24 (24-dehydrocholesterol reductase); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 3-beta-hydroxysterol delta-24-reductase; delta(24)-sterol reductase; LOC298298; seladin-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85126,573,366 - 126,599,940 (+)NCBIGRCr8
mRatBN7.25121,344,552 - 121,371,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5121,344,575 - 121,371,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5123,957,501 - 123,981,506 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05125,680,549 - 125,704,554 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05125,731,821 - 125,755,826 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05126,164,708 - 126,188,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,164,674 - 126,191,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05130,011,465 - 130,034,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45127,637,438 - 127,662,621 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15127,592,941 - 127,670,118 (+)NCBI
Celera5120,093,779 - 120,117,321 (+)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
amphetamine  (EXP)
Archazolid B  (ISO)
atrazine  (ISO)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfide  (ISO)
caffeine  (EXP)
calcitriol  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
cetrorelix  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dehydroepiandrosterone  (ISO)
desmosterol  (ISO)
desogestrel  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (ISO)
diclofenac  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dutasteride  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Febrifugine  (ISO)
fenthion  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gallic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycidyl methacrylate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
leflunomide  (EXP)
lucanthone  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
miconazole  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nebivolol  (ISO)
nickel dichloride  (EXP,ISO)
nicotine  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitexin  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Seladin-1 expression in rat adrenal gland: effect of adrenocorticotropic hormone treatment. Battista MC, etal., J Endocrinol. 2007 Jan;192(1):53-66.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. From integrative signalling to metabolic disorders. Otis M, etal., J Steroid Biochem Mol Biol. 2008 Apr;109(3-5):224-9. Epub 2008 Mar 8.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
15. Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis. Waterham HR, etal., Am J Hum Genet. 2001 Oct;69(4):685-94. Epub 2001 Aug 22.
16. Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Wu C, etal., Nature. 2004 Dec 2;432(7017):640-5.
Additional References at PubMed
PMID:11007892   PMID:12457401   PMID:12477932   PMID:14684813   PMID:15688385   PMID:16321981   PMID:16407971   PMID:16410790   PMID:16513830   PMID:19520779   PMID:19946888   PMID:24842139  
PMID:24916565   PMID:33450132   PMID:34338991  


Genomics

Comparative Map Data
Dhcr24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85126,573,366 - 126,599,940 (+)NCBIGRCr8
mRatBN7.25121,344,552 - 121,371,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5121,344,575 - 121,371,137 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5123,957,501 - 123,981,506 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05125,680,549 - 125,704,554 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05125,731,821 - 125,755,826 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05126,164,708 - 126,188,926 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5126,164,674 - 126,191,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05130,011,465 - 130,034,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45127,637,438 - 127,662,621 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15127,592,941 - 127,670,118 (+)NCBI
Celera5120,093,779 - 120,117,321 (+)NCBICelera
Cytogenetic Map5q34NCBI
DHCR24
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38154,849,627 - 54,887,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl154,849,627 - 54,887,195 (-)EnsemblGRCh38hg38GRCh38
GRCh37155,315,300 - 55,352,868 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36155,087,888 - 55,125,509 (-)NCBINCBI36Build 36hg18NCBI36
Build 34155,027,320 - 55,064,926NCBI
Celera153,602,965 - 53,640,513 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef153,429,205 - 53,466,807 (-)NCBIHuRef
CHM1_1155,431,045 - 55,468,571 (-)NCBICHM1_1
T2T-CHM13v2.0154,729,905 - 54,767,373 (-)NCBIT2T-CHM13v2.0
Dhcr24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394106,418,279 - 106,446,310 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4106,418,235 - 106,446,310 (+)EnsemblGRCm39 Ensembl
GRCm384106,561,038 - 106,589,113 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4106,561,038 - 106,589,113 (+)EnsemblGRCm38mm10GRCm38
MGSCv374106,233,643 - 106,261,718 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364106,059,082 - 106,084,718 (+)NCBIMGSCv36mm8
Celera4104,921,880 - 104,950,010 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map449.67NCBI
Dhcr24
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554644,533,928 - 4,558,133 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554644,533,928 - 4,557,893 (+)NCBIChiLan1.0ChiLan1.0
DHCR24
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21171,944,470 - 171,984,159 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11171,087,542 - 171,125,109 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0154,126,170 - 54,163,713 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1155,714,693 - 55,752,075 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl155,714,693 - 55,754,698 (-)Ensemblpanpan1.1panPan2
DHCR24
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1554,294,055 - 54,324,389 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl554,294,046 - 54,321,921 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha554,362,817 - 54,393,132 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0554,481,753 - 54,512,044 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl554,481,728 - 54,545,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1554,478,780 - 54,509,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0554,368,590 - 54,398,883 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0554,757,309 - 54,787,616 (+)NCBIUU_Cfam_GSD_1.0
Dhcr24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505868,968,931 - 68,992,733 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365226,423,561 - 6,444,814 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365226,423,561 - 6,447,363 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHCR24
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6157,483,783 - 157,519,061 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16157,483,794 - 157,519,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26145,547,688 - 145,582,947 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DHCR24
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12078,052,565 - 78,088,918 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2078,052,607 - 78,086,303 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603339,196,929 - 39,233,564 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhcr24
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248624,995,720 - 5,020,850 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248624,995,836 - 5,022,395 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dhcr24
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:79
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000009402
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
7794739Bp372Blood pressure QTL 3720.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5117913688125222967Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5119085612128034027Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat

Markers in Region
RH129237  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25121,370,904 - 121,371,123 (+)MAPPERmRatBN7.2
Rnor_6.05126,190,978 - 126,191,196NCBIRnor6.0
Rnor_5.05130,036,973 - 130,037,191UniSTSRnor5.0
RGSC_v3.45127,664,673 - 127,664,891UniSTSRGSC3.4
Celera5120,119,373 - 120,119,591UniSTS
RH 3.4 Map5806.2UniSTS
Cytogenetic Map5q34UniSTS
RH128821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25121,370,912 - 121,371,124 (+)MAPPERmRatBN7.2
Rnor_6.05126,190,986 - 126,191,197NCBIRnor6.0
Rnor_5.05130,036,981 - 130,037,192UniSTSRnor5.0
RGSC_v3.45127,664,681 - 127,664,892UniSTSRGSC3.4
Celera5120,119,381 - 120,119,592UniSTS
RH 3.4 Map5804.7UniSTS
Cytogenetic Map5q34UniSTS
RH129232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25121,370,904 - 121,371,121 (+)MAPPERmRatBN7.2
Rnor_6.05126,190,978 - 126,191,194NCBIRnor6.0
Rnor_5.05130,036,973 - 130,037,189UniSTSRnor5.0
RGSC_v3.45127,664,673 - 127,664,889UniSTSRGSC3.4
Celera5120,119,373 - 120,119,589UniSTS
RH 3.4 Map5804.5UniSTS
Cytogenetic Map5q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009402   ⟹   ENSRNOP00000009402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5121,344,575 - 121,371,137 (+)Ensembl
Rnor_6.0 Ensembl5126,164,674 - 126,191,206 (+)Ensembl
RefSeq Acc Id: NM_001080148   ⟹   NP_001073617
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85126,573,366 - 126,599,940 (+)NCBI
mRatBN7.25121,344,552 - 121,371,124 (+)NCBI
Rnor_6.05126,164,708 - 126,188,926 (+)NCBI
Rnor_5.05130,011,465 - 130,034,921 (+)NCBI
RGSC_v3.45127,637,438 - 127,662,621 (+)RGD
Celera5120,093,779 - 120,117,321 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001073617 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS66628 (Get FASTA)   NCBI Sequence Viewer  
  AAX29968 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009402.4
  ENSRNOP00055045511
  ENSRNOP00060028803
  ENSRNOP00065030985
GenBank Protein Q5BQE6 (Get FASTA)   NCBI Sequence Viewer  
  QST78217 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001073617   ⟸   NM_001080148
- Peptide Label: precursor
- UniProtKB: Q5BQE6 (UniProtKB/Swiss-Prot),   A1KXK4 (UniProtKB/TrEMBL),   A6JYN2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009402   ⟸   ENSRNOT00000009402
Protein Domains
FAD-binding PCMH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BQE6-F1-model_v2 AlphaFold Q5BQE6 1-516 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693879
Promoter ID:EPDNEW_R4404
Type:initiation region
Name:Dhcr24_1
Description:24-dehydrocholesterol reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05126,164,623 - 126,164,683EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306529 AgrOrtholog
BioCyc Gene G2FUF-40450 BioCyc
BioCyc Pathway PWY66-4 [cholesterol biosynthesis III (via desmosterol)] BioCyc
BioCyc Pathway Image PWY66-4 BioCyc
Ensembl Genes ENSRNOG00000006787 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055031818 UniProtKB/Swiss-Prot
  ENSRNOG00060020233 UniProtKB/Swiss-Prot
  ENSRNOG00065022441 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009402.7 UniProtKB/Swiss-Prot
  ENSRNOT00055055067 UniProtKB/Swiss-Prot
  ENSRNOT00060035053 UniProtKB/Swiss-Prot
  ENSRNOT00065038273 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.465.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Diminuto-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxid_FAD_bind_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:298298 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 298298 ENTREZGENE
PANTHER DELTA(24)-STEROL REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10801 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FAD_binding_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dhcr24 PhenoGen
PROSITE FAD_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006787 RatGTEx
  ENSRNOG00055031818 RatGTEx
  ENSRNOG00060020233 RatGTEx
  ENSRNOG00065022441 RatGTEx
Superfamily-SCOP SSF56176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8A1UCK8_RAT UniProtKB/TrEMBL
  A1KXK4 ENTREZGENE, UniProtKB/TrEMBL
  A6JYN2 ENTREZGENE, UniProtKB/TrEMBL
  DHC24_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Dhcr24  24-dehydrocholesterol reductase  Dhcr24_predicted  24-dehydrocholesterol reductase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dhcr24_predicted  24-dehydrocholesterol reductase (predicted)      Symbol and Name status set to approved 70820 APPROVED