Ecpas (Ecm29 proteasome adaptor and scaffold)

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Gene: Ecpas (Ecm29 proteasome adaptor and scaffold) Rattus norvegicus

Analyze

Symbol:

Ecpas

Name:

Ecm29 proteasome adaptor and scaffold

RGD ID:

1306148

Description:

Predicted to enable proteasome binding activity. Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be located in several cellular components, including centrosome; cytoplasmic vesicle; and nucleoplasm. Orthologous to human ECPAS (Ecm29 proteasome adaptor and scaffold); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; amiodarone.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC313196; proteasome adapter and scaffold protein ECM29; RGD1306148; similar to KIAA0368

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ECPAS (Ecm29 proteasome adaptor and scaffold)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Ecpas (Ecm29 proteasome adaptor and scaffold)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ecpas (Ecm29 proteasome adaptor and scaffold)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ECPAS (Ecm29 proteasome adaptor and scaffold)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ECPAS (Ecm29 proteasome adaptor and scaffold)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ecpas (Ecm29 proteasome adaptor and scaffold)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ECPAS (Ecm29 proteasome adaptor and scaffold)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ECPAS (Ecm29 proteasome adaptor and scaffold)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ecpas (Ecm29 proteasome adaptor and scaffold)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	POLD1 (DNA polymerase delta 1, catalytic subunit)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ECPAS (Ecm29 proteasome adaptor and scaffold)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ecpas (Ecm29 proteasome adaptor and scaffold)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ECM29	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8858	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	D2045.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ecpas	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ecps-2	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ecpas	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	73,601,745 - 73,714,026 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	73,604,533 - 73,713,860 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	75,928,510 - 76,040,771 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	75,931,293 - 76,039,760 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	80,073,657 - 80,184,763 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	76,827,647 - 76,942,881 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	72,425,077 - 72,537,191 (-)	NCBI		Celera
Cytogenetic Map	5	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amiodarone (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (EXP)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bortezomib (ISO)

butanal (ISO)

chloroprene (EXP)

chlorpyrifos (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diethylstilbestrol (EXP)

dorsomorphin (ISO)

entinostat (ISO)

enzyme inhibitor (ISO)

ethanol (EXP)

finasteride (EXP)

flutamide (EXP)

ivermectin (ISO)

leflunomide (EXP)

menadione (ISO)

methylmercury chloride (ISO)

nefazodone (EXP)

nimesulide (EXP)

oxaliplatin (EXP)

ozone (ISO)

panobinostat (ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

topotecan (EXP)

trichostatin A (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proteasome assembly (IEA)

ubiquitin-dependent ERAD pathway (IBA,ISO)

Cellular Component

centrosome (ISO)

COPII-coated ER to Golgi transport vesicle (ISO)

cytoplasm (IBA)

cytoplasmic vesicle (ISO)

early endosome (ISO)

endocytic vesicle (ISO)

endoplasmic reticulum (ISO)

late endosome (ISO)

multivesicular body (ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

trans-Golgi network (ISO)

Molecular Function

molecular adaptor activity (IBA,IEA)

proteasome binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15496406	PMID:19946888	PMID:20682791

Genomics

Comparative Map Data

Ecpas
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	73,601,745 - 73,714,026 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	73,604,533 - 73,713,860 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	5	75,928,510 - 76,040,771 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	75,931,293 - 76,039,760 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	80,073,657 - 80,184,763 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	76,827,647 - 76,942,881 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	72,425,077 - 72,537,191 (-)	NCBI		Celera
Cytogenetic Map	5	q24	NCBI

ECPAS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	111,360,685 - 111,484,383 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	111,360,685 - 111,484,745 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	114,122,965 - 114,246,663 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	113,162,794 - 113,286,846 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	84,622,093 - 84,746,150 (-)	NCBI		Celera
Cytogenetic Map	9	q31.3	NCBI
HuRef	9	83,721,967 - 83,846,182 (-)	NCBI		HuRef
CHM1_1	9	114,269,444 - 114,393,512 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	123,532,059 - 123,655,812 (-)	NCBI		T2T-CHM13v2.0

Ecpas
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	58,797,234 - 58,917,748 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	58,798,911 - 58,912,749 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	58,797,234 - 58,917,748 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	58,798,911 - 58,912,749 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	58,812,902 - 58,925,597 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	58,894,084 - 59,006,779 (-)	NCBI		MGSCv36	mm8
Celera	4	58,712,861 - 58,825,593 (-)	NCBI		Celera
Cytogenetic Map	4	B3	NCBI
cM Map	4	32.35	NCBI

Ecpas
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	15,782,453 - 15,890,022 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	15,775,208 - 15,886,101 (+)	NCBI	ChiLan1.0	ChiLan1.0

ECPAS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	9	27,939,978 - 28,064,059 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	82,499,075 - 82,623,007 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	110,662,590 - 110,774,511 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	110,662,590 - 110,786,472 (-)	Ensembl	panpan1.1		panPan2

ECPAS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	66,051,414 - 66,141,931 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	66,051,443 - 66,141,802 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	64,462,290 - 64,560,906 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	67,183,925 - 67,282,892 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	67,183,925 - 67,282,889 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	65,702,391 - 65,800,793 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	65,725,419 - 65,824,128 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	66,414,685 - 66,513,468 (-)	NCBI		UU_Cfam_GSD_1.0

Ecpas
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	181,345,187 - 181,460,324 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936559	1,807,753 - 1,921,423 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936559	1,807,768 - 1,918,529 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ECPAS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	252,218,819 - 252,324,928 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	252,221,687 - 252,325,068 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	283,049,989 - 283,120,665 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ECPAS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	28,076,607 - 28,201,556 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	28,087,447 - 28,203,848 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666035	14,575,484 - 14,701,030 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ecpas
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	67,650 - 195,122 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	67,558 - 194,653 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ecpas
377 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	49
Count of miRNA genes:	44
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000019959, ENSRNOT00000059529
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	31663789	131345958	Rat
1598807	Glom12	Glomerulus QTL 12	2.7		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	33215665	78215665	Rat
1298067	Scl15	Serum cholesterol level QTL 15	4.8	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	33215665	78215665	Rat
1302786	Kidm8	Kidney mass QTL 8	28.15		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	33215665	78215665	Rat
1576317	Eutr2	Estrogen induced uterine response QTL 2		0.01	uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	34730116	104251008	Rat
2316959	Gluco59	Glucose level QTL 59	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	34944474	113558310	Rat
1641912	Alcrsp18	Alcohol response QTL 18			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	35189153	141643988	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	40128307	148607290	Rat
1331773	Scl26	Serum cholesterol level QTL 26	3.065		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	43726656	86724018	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	43726656	129132602	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	46711509	161317411	Rat
1300115	Hrtrt7	Heart rate QTL 7	2.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	47869062	90099692	Rat
9589025	Epfw7	Epididymal fat weight QTL 7	20.66	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	5	49463600	94463600	Rat
7411561	Bw134	Body weight QTL 134	24	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	49463600	94463600	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	50328551	141643988	Rat
2303615	Vencon7	Ventilatory control QTL 7		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	5	50983895	95983895	Rat
2303574	Gluco42	Glucose level QTL 42	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	53496719	98496719	Rat
61359	Eaex	Experimental allergic encephalomyelitis QTL x	3		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	5	55715622	100715622	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55805606	132207589	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	58829236	128034027	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	59793399	143070159	Rat
2316954	Rf57	Renal function QTL 57	0		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	5	59793528	90450144	Rat
2316957	Pur21	Proteinuria QTL 21	6.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	5	59793528	113558156	Rat
61386	Bp49	Blood pressure QTL 49	16.6		cerebrum integrity trait (VT:0010549)	brain infarction volume (CMO:0001013)	5	60293434	98603051	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	60293434	161481680	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	64719390	109719390	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	66174080	124160948	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	68984307	104251008	Rat
61380	Edpm5	Estrogen-dependent pituitary mass QTL 5	4.5	0.92	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	5	68984307	104251008	Rat
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	68984307	104251008	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	68984307	104251008	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	69540295	151018848	Rat

Markers in Region

RH130692

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	73,603,501 - 73,603,684 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	75,930,267 - 75,930,449	NCBI	Rnor6.0
Rnor_5.0	5	80,075,404 - 80,075,586	UniSTS	Rnor5.0
RGSC_v3.4	5	76,828,309 - 76,828,491	UniSTS	RGSC3.4
Celera	5	72,426,834 - 72,427,016	UniSTS
RH 3.4 Map	5	504.5	UniSTS
Cytogenetic Map	5	q24	UniSTS

AI314180

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	73,604,541 - 73,604,671 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	75,931,307 - 75,931,436	NCBI	Rnor6.0
Rnor_5.0	5	80,076,444 - 80,076,573	UniSTS	Rnor5.0
RGSC_v3.4	5	76,829,349 - 76,829,478	UniSTS	RGSC3.4
Celera	5	72,427,874 - 72,428,003	UniSTS
Cytogenetic Map	5	q24	UniSTS

AW558785

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	73,603,633 - 73,603,716 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	75,930,399 - 75,930,481	NCBI	Rnor6.0
Rnor_5.0	5	80,075,536 - 80,075,618	UniSTS	Rnor5.0
RGSC_v3.4	5	76,828,441 - 76,828,523	UniSTS	RGSC3.4
Celera	5	72,426,966 - 72,427,048	UniSTS
Cytogenetic Map	5	q24	UniSTS

BB181316

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	73,642,009 - 73,642,110 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	75,968,776 - 75,968,876	NCBI	Rnor6.0
Rnor_5.0	5	80,113,913 - 80,114,013	UniSTS	Rnor5.0
RGSC_v3.4	5	76,866,821 - 76,866,921	UniSTS	RGSC3.4
Celera	5	72,465,337 - 72,465,437	UniSTS
Cytogenetic Map	5	q24	UniSTS

BE097667

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	73,628,761 - 73,628,911 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	75,955,529 - 75,955,678	NCBI	Rnor6.0
Rnor_5.0	5	80,100,666 - 80,100,815	UniSTS	Rnor5.0
RGSC_v3.4	5	76,853,574 - 76,853,723	UniSTS	RGSC3.4
Celera	5	72,452,090 - 72,452,239	UniSTS
RH 3.4 Map	5	505.8	UniSTS
Cytogenetic Map	5	q24	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_056985546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_056985547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_056985548	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_056985549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_056985550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_085838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_346529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_346530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_346531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC110824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474039	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000019959 ⟹ ENSRNOP00000019959

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	73,604,533 - 73,685,636 (-)	Ensembl
Rnor_6.0 Ensembl	5	75,931,293 - 76,039,760 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101784 ⟹ ENSRNOP00000077872

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	73,638,137 - 73,706,247 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105222 ⟹ ENSRNOP00000092109

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	73,604,533 - 73,713,860 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000112613 ⟹ ENSRNOP00000093368

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	73,604,533 - 73,713,860 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119027 ⟹ ENSRNOP00000085845

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	73,604,533 - 73,686,168 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000119799 ⟹ ENSRNOP00000080633

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	73,604,533 - 73,700,089 (-)	Ensembl

RefSeq Acc Id:

XM_056985546 ⟹ XP_056841526

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	73,601,745 - 73,713,305 (-)	NCBI

RefSeq Acc Id:

XM_056985547 ⟹ XP_056841527

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	73,604,665 - 73,713,306 (-)	NCBI

RefSeq Acc Id:

XM_056985548 ⟹ XP_056841528

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	73,604,665 - 73,714,026 (-)	NCBI

RefSeq Acc Id:

XM_056985549 ⟹ XP_056841529

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	73,604,665 - 73,714,026 (-)	NCBI

RefSeq Acc Id:

XM_056985550 ⟹ XP_056841530

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	73,601,745 - 73,713,306 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_056841526	(Get FASTA)	NCBI Sequence Viewer
	XP_056841527	(Get FASTA)	NCBI Sequence Viewer
	XP_056841528	(Get FASTA)	NCBI Sequence Viewer
	XP_056841529	(Get FASTA)	NCBI Sequence Viewer
	XP_056841530	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL91651	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000019959 ⟸ ENSRNOT00000019959

RefSeq Acc Id:

ENSRNOP00000077872 ⟸ ENSRNOT00000101784

RefSeq Acc Id:

ENSRNOP00000092109 ⟸ ENSRNOT00000105222

RefSeq Acc Id:

ENSRNOP00000085845 ⟸ ENSRNOT00000119027

RefSeq Acc Id:

ENSRNOP00000093368 ⟸ ENSRNOT00000112613

RefSeq Acc Id:

ENSRNOP00000080633 ⟸ ENSRNOT00000119799

RefSeq Acc Id:	XP_056841530 ⟸ XM_056985550
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I6A123 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_056841526 ⟸ XM_056985546
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AH81 (UniProtKB/TrEMBL), A0A8I6A123 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_056841529 ⟸ XM_056985549
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6A123 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_056841528 ⟸ XM_056985548
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A123 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_056841527 ⟸ XM_056985547
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6A123 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M446-F1-model_v2	AlphaFold	F1M446	1-1839	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306148	AgrOrtholog
BioCyc Gene	G2FUF-41169	BioCyc
Ensembl Genes	ENSRNOG00000025076	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000019959.7	UniProtKB/TrEMBL
	ENSRNOP00000077872.1	UniProtKB/TrEMBL
	ENSRNOP00000080633	ENTREZGENE
	ENSRNOP00000080633.1	UniProtKB/TrEMBL
	ENSRNOP00000085845.1	UniProtKB/TrEMBL
	ENSRNOP00000092109	ENTREZGENE
	ENSRNOP00000092109.1	UniProtKB/TrEMBL
	ENSRNOP00000093368	ENTREZGENE
	ENSRNOP00000093368.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019959.8	UniProtKB/TrEMBL
	ENSRNOT00000101784.1	UniProtKB/TrEMBL
	ENSRNOT00000105222	ENTREZGENE
	ENSRNOT00000105222.1	UniProtKB/TrEMBL
	ENSRNOT00000112613	ENTREZGENE
	ENSRNOT00000112613.1	UniProtKB/TrEMBL
	ENSRNOT00000119027.1	UniProtKB/TrEMBL
	ENSRNOT00000119799	ENTREZGENE
	ENSRNOT00000119799.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	Proteasome_stabil_ECM29	UniProtKB/TrEMBL
NCBI Gene	313196	ENTREZGENE
PANTHER	PTHR23346:SF19	UniProtKB/TrEMBL
	TRANSLATIONAL ACTIVATOR GCN1-RELATED	UniProtKB/TrEMBL
Pfam	Ecm29	UniProtKB/TrEMBL
PhenoGen	Ecpas	PhenoGen
Superfamily-SCOP	SSF48371	UniProtKB/TrEMBL
UniProt	A0A8I5Y6F9_RAT	UniProtKB/TrEMBL
	A0A8I5ZR65_RAT	UniProtKB/TrEMBL
	A0A8I6A123	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AH81	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AIV7_RAT	UniProtKB/TrEMBL
	F1M446_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-03-22	Ecpas	Ecm29 proteasome adaptor and scaffold	RGD1306148	similar to KIAA0368	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1306148	similar to KIAA0368	RGD1306148_predicted	similar to KIAA0368 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1306148_predicted	similar to KIAA0368 (predicted)	LOC313196_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC313196_predicted	similar to KIAA0368 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar