Gene: Orc1 (origin recognition complex, subunit 1) Rattus norvegicus
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Symbol: Orc1
Name: origin recognition complex, subunit 1
Description: ENCODES a protein that exhibits chromatin binding; INVOLVED IN positive regulation of G0 to G1 transition; positive regulation of smooth muscle cell proliferation; PARTICIPATES IN histone modification pathway; ASSOCIATED WITH Dwarfism (ortholog); Fetal Growth Retardation (ortholog); genetic disease (ortholog); FOUND IN nucleus; cytosol (ortholog); nuclear chromosome, telomeric region (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil
AGR Description: Exhibits chromatin binding activity; involved in positive regulation of G0 to G1 transition and positive regulation of smooth muscle cell proliferation; localizes to the nucleus; orthologous to human ORC1 (origin recognition complex subunit 1).
Merged Description: Exhibits chromatin binding activity; involved in positive regulation of G0 to G1 transition and positive regulation of smooth muscle cell proliferation; localizes to the nucleus; orthologous to human ORC1 (origin recognition complex subunit 1); PARTICIPATES IN histone modification pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Orc1l; origin recognition complex subunit 1; origin recognition complex, subunit 1-like; origin recognition complex, subunit 1-like (S.cereviaiae); origin recognition complex, subunit 1-like (yeast)
Orthologs:
Homo sapiens (human) : ORC1 (origin recognition complex subunit 1)  HGNC  Alliance
Mus musculus (house mouse) : Orc1 (origin recognition complex, subunit 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Orc1 (origin recognition complex subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ORC1 (origin recognition complex subunit 1)
Canis lupus familiaris (dog) : ORC1 (origin recognition complex subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Orc1 (origin recognition complex subunit 1)
Sus scrofa (pig) : ORC1 (origin recognition complex subunit 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05128,186,651 - 128,212,901 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05132,027,128 - 132,053,582 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45129,881,973 - 129,901,675 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15129,887,198 - 129,906,901 (+)NCBI
Celera5122,062,985 - 122,082,678 (+)NCBICelera
Cytogenetic Map5q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Orc1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 631435
Created: 2003-08-13
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.