Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Frmd3 | Rat | 1,2-dichloroethane | decreases expression | ISO | Frmd3 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of FRMD3 mRNA | CTD | PMID:28960355 | Frmd3 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Frmd3 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of FRMD3 mRNA | CTD | PMID:22206623 | Frmd3 | Rat | 17beta-estradiol | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Estradiol results in increased expression of FRMD3 mRNA | CTD | PMID:23019147 | Frmd3 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of FRMD3 mRNA | CTD | PMID:26496021 | Frmd3 | Rat | 17beta-estradiol | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of FRMD3 mRNA | CTD | PMID:20660070 | Frmd3 | Rat | 2,2',5,5'-tetrachlorobiphenyl | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:36804509 | Frmd3 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in decreased methylation of FRMD3 gene | CTD | PMID:31601247 | Frmd3 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of FRMD3 mRNA | CTD | PMID:28959563 | Frmd3 | Rat | acrylamide | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of FRMD3 mRNA | CTD | PMID:32763439 | Frmd3 | Rat | Aflatoxin B2 alpha | increases methylation | ISO | FRMD3 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of FRMD3 intron | CTD | PMID:30157460 | Frmd3 | Rat | aldehydo-D-glucose | multiple interactions | ISO | Frmd3 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of FRMD3 mRNA | CTD | PMID:37567420 | Frmd3 | Rat | all-trans-retinoic acid | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of FRMD3 mRNA | CTD | PMID:23724009 | Frmd3 | Rat | amiodarone | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Amiodarone results in increased expression of FRMD3 mRNA | CTD | PMID:19774075 | Frmd3 | Rat | aristolochic acid A | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of FRMD3 mRNA | CTD | PMID:33212167 | Frmd3 | Rat | arsenite(3-) | increases methylation | ISO | FRMD3 (Homo sapiens) | 6480464 | arsenite results in increased methylation of FRMD3 promoter | CTD | PMID:23974009 | Frmd3 | Rat | benzo[a]pyrene | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of FRMD3 mRNA | CTD | PMID:20106945 and PMID:21632981 | Frmd3 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20018196 | Frmd3 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of FRMD3 mRNA | CTD | PMID:26496021 | Frmd3 | Rat | bisphenol A | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of FRMD3 mRNA | CTD | PMID:31715268 | Frmd3 | Rat | bisphenol A | affects methylation | ISO | Frmd3 (Mus musculus) | 6480464 | bisphenol A affects the methylation of FRMD3 promoter | CTD | PMID:27334623 | Frmd3 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of FRMD3 mRNA | CTD | PMID:25181051 | Frmd3 | Rat | cadmium atom | multiple interactions | ISO | Frmd3 (Mus musculus) | 6480464 | [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of FRMD3 mRNA | CTD | PMID:31904401 | Frmd3 | Rat | cadmium atom | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FRMD3 mRNA | CTD | PMID:35301059 | Frmd3 | Rat | cadmium dichloride | multiple interactions | ISO | Frmd3 (Mus musculus) | 6480464 | [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of FRMD3 mRNA | CTD | PMID:31904401 | Frmd3 | Rat | cadmium dichloride | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FRMD3 mRNA | CTD | PMID:35301059 | Frmd3 | Rat | CGP 52608 | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to FRMD3 gene] | CTD | PMID:28238834 | Frmd3 | Rat | cisplatin | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of FRMD3 mRNA | CTD | PMID:27392435 | Frmd3 | Rat | cisplatin | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of FRMD3 mRNA | CTD | PMID:27392435 | Frmd3 | Rat | coumestrol | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of FRMD3 mRNA | CTD | PMID:19167446 | Frmd3 | Rat | cyclosporin A | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of FRMD3 mRNA | CTD | PMID:20106945 and PMID:21632981 | Frmd3 | Rat | D-glucose | multiple interactions | ISO | Frmd3 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of FRMD3 mRNA | CTD | PMID:37567420 | Frmd3 | Rat | DDE | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in decreased expression of FRMD3 mRNA | CTD | PMID:38568856 | Frmd3 | Rat | DDT | decreases expression | EXP | | 6480464 | DDT results in decreased expression of FRMD3 mRNA | CTD | PMID:30207508 | Frmd3 | Rat | dioxygen | increases expression | ISO | Frmd3 (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of FRMD3 mRNA | CTD | PMID:20880076 | Frmd3 | Rat | dioxygen | multiple interactions | EXP | | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in increased expression of FRMD3 mRNA | CTD | PMID:33729688 | Frmd3 | Rat | dorsomorphin | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Frmd3 | Rat | doxorubicin | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of FRMD3 mRNA | CTD | PMID:29803840 | Frmd3 | Rat | folic acid | decreases expression | ISO | Frmd3 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of FRMD3 mRNA | CTD | PMID:25629700 | Frmd3 | Rat | formaldehyde | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of FRMD3 mRNA | CTD | PMID:23649840 | Frmd3 | Rat | FR900359 | decreases phosphorylation | ISO | FRMD3 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of FRMD3 protein | CTD | PMID:37730182 | Frmd3 | Rat | fructose | multiple interactions | ISO | Frmd3 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of FRMD3 mRNA | CTD | PMID:37567420 | Frmd3 | Rat | fulvestrant | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [bisphenol S co-treated with Fulvestrant] results in decreased methylation of FRMD3 gene | CTD | PMID:31601247 | Frmd3 | Rat | fulvestrant | increases methylation | ISO | FRMD3 (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of FRMD3 gene | CTD | PMID:31601247 | Frmd3 | Rat | glucose | multiple interactions | ISO | Frmd3 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of FRMD3 mRNA | CTD | PMID:37567420 | Frmd3 | Rat | lead diacetate | decreases expression | ISO | Frmd3 (Mus musculus) | 6480464 | lead acetate results in decreased expression of FRMD3 mRNA | CTD | PMID:22613225 | Frmd3 | Rat | leflunomide | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | leflunomide results in increased expression of FRMD3 mRNA | CTD | PMID:28988120 | Frmd3 | Rat | mercury dibromide | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | mercuric bromide results in decreased expression of FRMD3 mRNA | CTD | PMID:26272509 | Frmd3 | Rat | mercury dibromide | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRMD3 mRNA | CTD | PMID:27188386 | Frmd3 | Rat | methylmercury chloride | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of FRMD3 mRNA | CTD | PMID:28001369 | Frmd3 | Rat | mono(2-ethylhexyl) phthalate | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of FRMD3 mRNA | CTD | PMID:36695872 | Frmd3 | Rat | nickel sulfate | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | nickel sulfate results in increased expression of FRMD3 mRNA | CTD | PMID:22714537 | Frmd3 | Rat | ochratoxin A | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | ochratoxin A results in increased expression of FRMD3 mRNA | CTD | PMID:30559759 | Frmd3 | Rat | ozone | multiple interactions | ISO | Frmd3 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of FRMD3 mRNA | CTD | PMID:27106289 | Frmd3 | Rat | p-chloromercuribenzoic acid | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of FRMD3 mRNA | CTD | PMID:26272509 | Frmd3 | Rat | p-chloromercuribenzoic acid | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRMD3 mRNA | CTD | PMID:27188386 | Frmd3 | Rat | phenylmercury acetate | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of FRMD3 mRNA | CTD | PMID:26272509 | Frmd3 | Rat | phenylmercury acetate | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FRMD3 mRNA | CTD | PMID:27188386 | Frmd3 | Rat | phorbol 13-acetate 12-myristate | multiple interactions | ISO | Frmd3 (Mus musculus) | 6480464 | [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of FRMD3 mRNA | CTD | PMID:31904401 | Frmd3 | Rat | pirinixic acid | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of FRMD3 mRNA | CTD | PMID:19710929 | Frmd3 | Rat | progesterone | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of FRMD3 mRNA | CTD | PMID:20660070 | Frmd3 | Rat | protein kinase inhibitor | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FRMD3 mRNA] | CTD | PMID:28003376 | Frmd3 | Rat | quercetin | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of FRMD3 mRNA | CTD | PMID:21632981 | Frmd3 | Rat | SB 431542 | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Frmd3 | Rat | silicon dioxide | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of FRMD3 mRNA | CTD | PMID:25895662 | Frmd3 | Rat | sodium arsenite | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of and affects the splicing of FRMD3 mRNA | CTD | PMID:25879800 | Frmd3 | Rat | sodium arsenite | affects expression | ISO | Frmd3 (Mus musculus) | 6480464 | sodium arsenite affects the expression of FRMD3 mRNA | CTD | PMID:26674514 | Frmd3 | Rat | sunitinib | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of FRMD3 mRNA | CTD | PMID:31533062 | Frmd3 | Rat | temozolomide | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of FRMD3 mRNA | CTD | PMID:31758290 | Frmd3 | Rat | testosterone | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Testosterone results in increased expression of FRMD3 mRNA | CTD | PMID:33359661 | Frmd3 | Rat | titanium dioxide | increases methylation | ISO | Frmd3 (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of FRMD3 gene | CTD | PMID:35295148 | Frmd3 | Rat | titanium dioxide | decreases methylation | ISO | Frmd3 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of FRMD3 gene | CTD | PMID:35295148 | Frmd3 | Rat | trichostatin A | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of FRMD3 mRNA | CTD | PMID:24935251 | Frmd3 | Rat | triclosan | decreases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of FRMD3 mRNA | CTD | PMID:30510588 | Frmd3 | Rat | triphenyl phosphate | affects expression | ISO | FRMD3 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of FRMD3 mRNA | CTD | PMID:37042841 | Frmd3 | Rat | valproic acid | affects expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of FRMD3 mRNA | CTD | PMID:25979313 | Frmd3 | Rat | valproic acid | decreases expression | ISO | Frmd3 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of FRMD3 mRNA | CTD | PMID:24896083 | Frmd3 | Rat | valproic acid | increases expression | ISO | FRMD3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of FRMD3 mRNA | CTD | PMID:23179753 more ... | Frmd3 | Rat | valproic acid | multiple interactions | ISO | FRMD3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRMD3 mRNA | CTD | PMID:27188386 | |