Musk (muscle associated receptor tyrosine kinase) - Rat Genome Database

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Gene: Musk (muscle associated receptor tyrosine kinase) Rattus norvegicus
Analyze
Symbol: Musk
Name: muscle associated receptor tyrosine kinase
RGD ID: 3211
Description: Enables protein kinase binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of synaptic assembly at neuromuscular junction; and positive regulation of synaptic transmission. Located in cell projection; external side of plasma membrane; and neuromuscular junction. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 9 and fetal akinesia deformation sequence syndrome 1. Orthologous to human MUSK (muscle associated receptor tyrosine kinase); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH 1-naphthyl isothiocyanate; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: muscle specific kinase (neural fold/somite kinase 1); muscle, skeletal receptor tyrosine protein kinase; muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; muscle-specific tyrosine kinase receptor MuSK; muscle-specific tyrosine protein kinase receptor; Nsk1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2573,058,427 - 73,169,696 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl573,058,121 - 73,171,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx574,950,396 - 75,053,703 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0576,772,006 - 76,875,299 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0576,744,136 - 76,847,436 (+)NCBIRnor_WKY
Rnor_6.0575,392,790 - 75,498,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,392,790 - 75,498,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,542,952 - 79,649,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4576,273,430 - 76,388,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1576,278,542 - 76,393,727 (+)NCBI
Celera571,894,778 - 71,996,416 (+)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Bergamin E, etal., Mol Cell. 2010 Jul 9;39(1):100-9. doi: 10.1016/j.molcel.2010.06.007.
2. Localization and regulation of MuSK at the neuromuscular junction. Bowen DC, etal., Dev Biol. 1998 Jul 15;199(2):309-19.
3. Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Cheusova T, etal., Genes Dev. 2006 Jul 1;20(13):1800-16.
4. Identification of developmentally regulated expression of MuSK in astrocytes of the rodent retina. Cheusova T, etal., J Neurochem. 2006 Oct;99(2):450-7. Epub 2006 Aug 8.
5. Long-lasting treatment effect of rituximab in MuSK myasthenia. Díaz-Manera J, etal., Neurology. 2012 Jan 17;78(3):189-93. doi: 10.1212/WNL.0b013e3182407982. Epub 2012 Jan 4.
6. MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation. Garcia-Osta A, etal., J Neurosci. 2006 Jul 26;26(30):7919-32.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Herbst R, etal., Development 2002 Dec;129(23):5449-60.
10. Inhibition of synapse assembly in mammalian muscle in vivo by RNA interference. Kong XC, etal., EMBO Rep. 2004 Feb;5(2):183-8. Epub 2004 Jan 16.
11. Rapsyn carboxyl terminal domains mediate muscle specific kinase-induced phosphorylation of the muscle acetylcholine receptor. Lee Y, etal., Neuroscience. 2008 Jun 2;153(4):997-1007. Epub 2008 Mar 18.
12. Activity-dependent gene regulation in conditionally-immortalized muscle precursor cell lines. Macpherson PC, etal., J Cell Biochem. 2004 Mar 1;91(4):821-39.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Muscle-like nicotinic receptor accessory molecules in sensory hair cells of the inner ear. Osman AA, etal., Mol Cell Neurosci. 2008 Jun;38(2):153-69. Epub 2008 Mar 4.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK. Stiegler AL, etal., J Mol Biol. 2006 Dec 1;364(3):424-33. Epub 2006 Sep 12.
21. 14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse. Strochlic L, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18189-94. Epub 2004 Dec 16.
22. Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation. Till JH, etal., Structure. 2002 Sep;10(9):1187-96.
23. MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study. Tsonis AI, etal., J Neuroimmunol. 2015 Jul 15;284:10-7. doi: 10.1016/j.jneuroim.2015.04.015. Epub 2015 Apr 27.
24. Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury. Valenzuela DM, etal., Neuron 1995 Sep;15(3):573-84.
25. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
26. Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Woller B, etal., Biochim Biophys Acta. 2011 Jun;1813(6):1198-210. doi: 10.1016/j.bbamcr.2011.03.005. Epub 2011 Mar 17.
27. Delayed synapsing muscles are more severely affected in an experimental model of MuSK-induced myasthenia gravis. Xu K, etal., Neuroscience. 2006 Dec;143(3):655-9. Epub 2006 Nov 1.
Additional References at PubMed
PMID:8653786   PMID:10320756   PMID:11312299   PMID:11323662   PMID:11395002   PMID:12165471   PMID:14622576   PMID:14678832   PMID:16331983   PMID:16794080   PMID:17119023   PMID:17576800  
PMID:18848351   PMID:18957220   PMID:19038220   PMID:19664639   PMID:20053883   PMID:22210232   PMID:23382219   PMID:25537362   PMID:29604268  


Genomics

Comparative Map Data
Musk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2573,058,427 - 73,169,696 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl573,058,121 - 73,171,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx574,950,396 - 75,053,703 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0576,772,006 - 76,875,299 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0576,744,136 - 76,847,436 (+)NCBIRnor_WKY
Rnor_6.0575,392,790 - 75,498,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,392,790 - 75,498,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,542,952 - 79,649,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4576,273,430 - 76,388,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1576,278,542 - 76,393,727 (+)NCBI
Celera571,894,778 - 71,996,416 (+)NCBICelera
Cytogenetic Map5q24NCBI
MUSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389110,668,791 - 110,806,558 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9110,668,779 - 110,806,558 (+)EnsemblGRCh38hg38GRCh38
GRCh379113,431,071 - 113,568,838 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,470,960 - 112,603,099 (+)NCBINCBI36Build 36hg18NCBI36
Build 349110,510,693 - 110,642,833NCBI
Celera983,932,761 - 84,062,557 (+)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef983,032,852 - 83,161,644 (+)NCBIHuRef
CHM1_19113,577,505 - 113,709,694 (+)NCBICHM1_1
T2T-CHM13v2.09122,838,447 - 122,978,207 (+)NCBIT2T-CHM13v2.0
Musk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39458,285,742 - 58,377,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl458,285,960 - 58,374,303 (+)EnsemblGRCm39 Ensembl
GRCm38458,285,729 - 58,377,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl458,285,960 - 58,374,303 (+)EnsemblGRCm38mm10GRCm38
MGSCv37458,298,834 - 58,387,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36458,380,016 - 58,468,357 (+)NCBIMGSCv36mm8
Celera458,198,854 - 58,290,062 (+)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.87NCBI
Musk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541916,387,770 - 16,484,266 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541916,387,770 - 16,484,266 (-)NCBIChiLan1.0ChiLan1.0
MUSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19109,980,748 - 110,107,480 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9109,980,748 - 110,107,480 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0981,814,766 - 81,947,341 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MUSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11165,552,320 - 65,642,165 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1165,551,889 - 65,642,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1163,954,775 - 64,044,628 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01166,682,701 - 66,788,272 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1166,682,615 - 66,772,740 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11165,202,004 - 65,291,277 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01165,223,782 - 65,329,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01165,913,828 - 66,003,578 (+)NCBIUU_Cfam_GSD_1.0
Musk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947180,764,116 - 180,884,300 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365592,387,027 - 2,486,552 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365592,387,019 - 2,486,685 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,650,710 - 251,756,608 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,650,151 - 251,758,538 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21282,535,445 - 282,564,190 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MUSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11228,739,094 - 28,872,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603513,886,470 - 14,018,232 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Musk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624758733,919 - 829,075 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624758733,380 - 829,192 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Musk
537 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:29
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000048457
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat

Markers in Region
AW535152  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2573,101,390 - 73,101,543 (+)MAPPERmRatBN7.2
Rnor_6.0575,433,374 - 75,433,526NCBIRnor6.0
Rnor_5.0579,584,316 - 79,584,468UniSTSRnor5.0
RGSC_v3.4576,318,555 - 76,318,707UniSTSRGSC3.4
Celera571,935,703 - 71,935,855UniSTS
RH 3.4 Map5499.6UniSTS
Cytogenetic Map5q24UniSTS
AU048759  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2573,123,531 - 73,123,676 (+)MAPPERmRatBN7.2
Rnor_6.0575,456,078 - 75,456,220NCBIRnor6.0
Rnor_5.0579,607,020 - 79,607,162UniSTSRnor5.0
RGSC_v3.4576,340,856 - 76,340,998UniSTSRGSC3.4
Celera571,957,789 - 71,957,921UniSTS
Cytogenetic Map5q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 2 1
Low 3 11 2 2 11 2 7 9 2 22 22 9 7
Below cutoff 30 47 32 8 32 1 42 11 16 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000048457   ⟹   ENSRNOP00000041075
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl573,058,121 - 73,170,732 (+)Ensembl
Rnor_6.0 Ensembl575,392,790 - 75,498,694 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111211   ⟹   ENSRNOP00000085490
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl573,058,614 - 73,171,932 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118034   ⟹   ENSRNOP00000093853
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl573,058,614 - 73,171,932 (+)Ensembl
RefSeq Acc Id: NM_031061   ⟹   NP_112323
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,058,635 - 73,169,244 (+)NCBI
Rnor_6.0575,392,790 - 75,498,694 (+)NCBI
Rnor_5.0579,542,952 - 79,649,636 (+)NCBI
RGSC_v3.4576,273,430 - 76,388,614 (+)RGD
Celera571,894,778 - 71,996,416 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110838   ⟹   XP_038966766
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2573,058,427 - 73,169,696 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_112323   ⟸   NM_031061
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000041075   ⟸   ENSRNOT00000048457
RefSeq Acc Id: XP_038966766   ⟸   XM_039110838
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AL77 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085490   ⟸   ENSRNOT00000111211
RefSeq Acc Id: ENSRNOP00000093853   ⟸   ENSRNOT00000118034
Protein Domains
FZ   Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62838-F1-model_v2 AlphaFold Q62838 1-868 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3211 AgrOrtholog
BioCyc Gene G2FUF-41182 BioCyc
Ensembl Genes ENSRNOG00000033567 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000041075 ENTREZGENE
  ENSRNOP00000041075.6 UniProtKB/TrEMBL
  ENSRNOP00000085490.1 UniProtKB/TrEMBL
  ENSRNOP00000093853 ENTREZGENE
  ENSRNOP00000093853.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048457 ENTREZGENE
  ENSRNOT00000048457.6 UniProtKB/TrEMBL
  ENSRNOT00000111211.1 UniProtKB/TrEMBL
  ENSRNOT00000118034 ENTREZGENE
  ENSRNOT00000118034.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Frizzled_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81725 UniProtKB/Swiss-Prot
NCBI Gene 81725 ENTREZGENE
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF01392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MUSK RGD
PhenoGen Musk PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AL77 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GCY4_RAT UniProtKB/TrEMBL
  F1LMK4_RAT UniProtKB/TrEMBL
  MUSK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-27 Musk  muscle associated receptor tyrosine kinase  Musk  muscle, skeletal, receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Musk  muscle, skeletal, receptor tyrosine kinase      Symbol and Name updated 629477 APPROVED
2003-03-06 Musk  muscle, skeletal, receptor tyrosine kinase  Nsk1    Data Merged 628472 PROVISIONAL
2002-08-07 Nsk1        Symbol and Name status set to provisional 70820 PROVISIONAL
2001-11-29 Musk  muscle, skeletal, receptor tyrosine kinase      Symbol and Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog maps within the region of the Fukuyama muscular dystrophy locus 633425