Tgfbr1 (transforming growth factor, beta receptor 1) - Rat Genome Database

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Gene: Tgfbr1 (transforming growth factor, beta receptor 1) Rattus norvegicus
Analyze
Symbol: Tgfbr1
Name: transforming growth factor, beta receptor 1
RGD ID: 3852
Description: Enables several functions, including ATP binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity, type I. Involved in several processes, including regulation of miRNA transcription; response to prostaglandin E; and transforming growth factor beta receptor signaling pathway. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of protein-containing complex. Used to study leiomyoma; osteochondrodysplasia; and pulmonary hypertension. Biomarker of kidney disease and myocardial infarction. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 1; Lynch syndrome; carcinoma (multiple); colorectal cancer; and urinary bladder cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activin receptor-like kinase 5; Alk5; LOC103690035; MGC93659; serine/threonine-protein kinase receptor R4; Skr4; tbetaR-I; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta receptor type-1-like; TGF-beta type I receptor; Tgfr-1; transforming growth factor beta receptor I; transforming growth factor, beta receptor I; transforming growth factor-beta receptor type I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Cia2
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8566,449,348 - 66,506,371 (+)NCBIGRCr8
mRatBN7.2561,653,773 - 61,710,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl561,653,233 - 61,710,777 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx563,625,637 - 63,682,716 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0565,444,934 - 65,502,017 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0565,414,409 - 65,471,481 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,056,071 - 63,119,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,050,758 - 63,119,635 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0567,575,578 - 67,643,666 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0569,079,391 - 69,097,816 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4563,976,868 - 64,034,058 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1563,981,949 - 64,034,967 (+)NCBI
Celera565,882,184 - 65,907,477 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Animal Disease Models  (ISO)
aortic aneurysm  (ISO)
aortic disease  (ISO)
Carotid Artery Injuries  (IEP)
Charlevoix-Saguenay spastic ataxia  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital disorder of glycosylation Ii  (ISO)
congenital disorder of glycosylation type II  (ISO)
congenital myasthenic syndrome 14  (ISO)
connective tissue disease  (ISO)
craniosynostosis  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
diffuse scleroderma  (ISO)
Disproportionate Tall Stature  (ISO)
Dissecting Aneurysm  (ISO)
Ehlers-Danlos syndrome  (ISO)
Ehlers-Danlos syndrome classic type 1  (ISO)
Experimental Liver Cirrhosis  (IEP,IMP)
Experimental Mammary Neoplasms  (ISO)
Familial Thoracic Aortic Aneurysm 6  (ISO)
Ferguson-Smith tumor  (ISO)
Hyperalgesia  (IMP)
intellectual disability  (ISO)
kidney disease  (IEP)
leiomyoma  (IMP)
liver cirrhosis  (ISO)
Loeys-Dietz syndrome  (ISO,ISS)
Loeys-Dietz syndrome 1  (ISO)
Lynch syndrome  (ISO)
Marfan syndrome  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency  (ISO)
myocardial infarction  (IEP)
myoepithelioma  (ISO)
Neoplasm Metastasis  (ISO)
nephronophthisis  (ISO)
osteoarthritis  (ISS)
osteochondrodysplasia  (IMP)
pancreatic ductal adenocarcinoma  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary hypertension  (IMP)
Skin Neoplasms  (ISO)
Spontaneous Abortions  (ISO)
systemic scleroderma  (ISS)
thoracic aortic aneurysm  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,3'-diindolylmethane  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acteoside  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allyl alcohol  (EXP)
alpha-pinene  (ISO)
AM-251  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthocyanin  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
bellidifolin  (EXP)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calciol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
chlorpyrifos  (ISO)
Cinobufagin  (ISO)
cisatracurium  (ISO)
cisplatin  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocin-1  (EXP)
Cuprizon  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diazepam  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
dimethylarsinic acid  (ISO)
enalapril  (EXP)
Enterolactone  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
furosemide  (EXP)
galangin  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
hexachlorobenzene  (ISO)
hydrogen cyanide  (ISO)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
Isoangustone A  (ISO)
ketamine  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
lenalidomide  (ISO)
leupeptin  (EXP)
lignan  (ISO)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
LY-2157299  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
nitrofen  (EXP)
Nutlin-3  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oxalic acid  (ISO)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
patulin  (EXP)
Pentoxifylline  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
Phyllanthin  (ISO)
piperine  (ISO)
potassium chromate  (ISO)
prostaglandin E2  (ISO)
quartz  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salvianolic acid B  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
Sinomenine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetramethylpyrazine  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
tolfenamic acid  (ISO)
tranilast  (EXP)
triadimefon  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activin receptor signaling pathway  (IBA,ISS)
angiogenesis  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (IEA,ISO)
animal organ regeneration  (IEP)
anterior/posterior pattern specification  (IEA,ISO)
apoptotic process  (IEA,ISO)
artery morphogenesis  (ISO)
blastocyst development  (IEA,ISO)
BMP signaling pathway  (IEA)
cardiac epithelial to mesenchymal transition  (ISS)
cell motility  (ISO)
cellular response to growth factor stimulus  (IBA)
cellular response to transforming growth factor beta stimulus  (ISO)
collagen fibril organization  (IEA,ISO)
coronary artery morphogenesis  (IEA,ISO)
digestive tract development  (IEP)
embryo implantation  (IEP)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
endothelial cell activation  (ISS)
endothelial cell migration  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO)
epicardium morphogenesis  (IEA,ISO)
epithelial to mesenchymal transition  (IEA,ISO)
filopodium assembly  (IEA,ISO)
germ cell migration  (IEA,ISO)
heart development  (IBA,ISO,ISS)
in utero embryonic development  (ISO)
intracellular signal transduction  (ISS)
kidney development  (IEA,ISO)
lens development in camera-type eye  (IEA,ISO)
lung development  (IEP)
male gonad development  (IEA,ISO)
mesenchymal cell differentiation  (ISS)
myofibroblast differentiation  (IEA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of chondrocyte differentiation  (IEA,ISO)
negative regulation of endothelial cell differentiation  (IMP)
negative regulation of endothelial cell proliferation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of miRNA transcription  (IMP)
nervous system development  (IBA)
neuron fate commitment  (IEA,ISO)
parathyroid gland development  (IEA,ISO)
peptidyl-serine phosphorylation  (ISO)
pharyngeal system development  (IEA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of endothelial cell proliferation  (ISS)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (IEA,ISO)
positive regulation of extracellular matrix assembly  (IEA,ISO)
positive regulation of filopodium assembly  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO,ISS)
positive regulation of mesenchymal stem cell proliferation  (IEA,ISO)
positive regulation of miRNA transcription  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of SMAD protein signal transduction  (IEA,ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of tight junction disassembly  (IEA,ISO)
positive regulation of vasculature development  (IEA,ISO)
post-embryonic development  (IEA,ISO)
proepicardium development  (ISO)
protein autophosphorylation  (IMP)
protein phosphorylation  (IMP)
regulation of cardiac muscle cell proliferation  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of epithelial to mesenchymal transition  (ISS)
regulation of gene expression  (ISO,ISS)
regulation of protein ubiquitination  (IEA,ISO)
response to cholesterol  (IEA,ISO)
response to electrical stimulus  (IEP)
response to estrogen  (IDA)
response to hypoxia  (IEP)
response to organic cyclic compound  (IEP)
response to prostaglandin E  (IEP)
response to toxic substance  (IEP)
roof of mouth development  (IEA,ISO)
signal transduction  (ISO)
skeletal system development  (ISO)
skeletal system morphogenesis  (ISO)
thymus development  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IBA,IEA,IMP,ISO,ISS)
vascular endothelial cell proliferation  (IBA)
ventricular compact myocardium morphogenesis  (IEA,ISO)
ventricular septum morphogenesis  (IEA,ISO)
ventricular trabecula myocardium morphogenesis  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular mechanisms of TGF beta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506. Akool el-S, etal., J Immunol. 2008 Aug 15;181(4):2831-45.
2. Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. Asano Y, etal., J Clin Invest. 2004 Jan;113(2):253-64.
3. A transforming growth factor beta type I receptor that signals to activate gene expression. Bassing CH, etal., Science 1994 Jan 7;263(5143):87-9.
4. Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis. Bonecini-Almeida MG, etal., Infect Immun. 2004 May;72(5):2628-34.
5. Regulation by gonadal steroids of the mRNA encoding for a type I receptor for TGF-beta in the female rat hypothalamus. Bouret S, etal., Neuroendocrinology 2002 Jul;76(1):1-7.
6. Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. Chen CL, etal., J Cell Sci. 2007 Oct 15;120(Pt 20):3509-21. Epub 2007 Sep 18.
7. Int7G24A variant of transforming growth factor-beta receptor type I is associated with invasive breast cancer. Chen T, etal., Clin Cancer Res. 2006 Jan 15;12(2):392-7.
8. An intronic variant of the TGFBR1 gene is associated with carcinomas of the kidney and bladder. Chen T, etal., Int J Cancer. 2004 Nov 10;112(3):420-5.
9. Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease. Chen Y, etal., Am J Pathol. 2005 Dec;167(6):1699-711.
10. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96
11. Ontogenic expression of TGFbeta 1, 2, and 3 and its receptors in the rat gastric mucosa. de Andrade Sa ER, etal., Dev Dyn. 2003 Jul;227(3):450-7.
12. Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis. de Gouville AC, etal., Br J Pharmacol. 2005 May;145(2):166-77.
13. Impact of PGE1 on cyclosporine A induced up-regulation of TGF-beta1, its receptors, and related matrix production in cultured mesangial cells. Dell K, etal., Cytokine. 2003 Jun 21;22(6):189-93.
14. miR-21 and miR-214 are consistently modulated during renal injury in rodent models. Denby L, etal., Am J Pathol. 2011 Aug;179(2):661-72. doi: 10.1016/j.ajpath.2011.04.021. Epub 2011 May 31.
15. Inhibition of ALK5 signaling induces physeal dysplasia in rats. Frazier K, etal., Toxicol Pathol. 2007;35(2):284-95.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Role of transforming growth factor-beta superfamily signaling pathways in human disease. Gordon KJ and Blobe GC, Biochim Biophys Acta. 2008 Apr;1782(4):197-228. Epub 2008 Feb 11.
19. [The expression of transforming growth factor beta1 and its I, II receptors in the development of rat embryo and embryonic lung] Guo Q, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Apr;23(4):317-9.
20. Elevation of expression of Smads 2, 3, and 4, decorin and TGF-beta in the chronic phase of myocardial infarct scar healing. Hao J, etal., J Mol Cell Cardiol. 1999 Mar;31(3):667-78.
21. Dynamic expression patterns of transforming growth factor-beta(2) and transforming growth factor-beta receptors in experimental glomerulonephritis. Hartner A, etal., J Mol Med. 2003 Jan;81(1):32-42. Epub 2002 Dec 14.
22. Transforming growth factor beta type I receptor acts as a potent tumor suppressor in rat bladder carcinoma. Hattori K, etal., Carcinogenesis. 1997 Oct;18(10):1867-70.
23. Developmental expression of four novel serine/threonine kinase receptors homologous to the activin/transforming growth factor-beta type II receptor family. He WW, etal., Dev Dyn 1993 Feb;196(2):133-42.
24. TGFBR1*6A polymorphism in sporadic and familial colorectal Carcinoma: a case-control study and systematic literature review. Ibrahim T, etal., J Gastrointest Cancer. 2014 Dec;45(4):441-7. doi: 10.1007/s12029-014-9625-8.
25. Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Jude EB, etal., Diabet Med. 2002 Jun;19(6):440-7.
26. Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: correlation with repair and fibrosis. Khalil N, etal., Exp Lung Res. 2002 Apr-May;28(3):233-50.
27. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Laping NJ, etal., Clin Cancer Res. 2007 May 15;13(10):3087-99.
28. Effects of hypoxia on expression of transforming growth factor-beta1 and its receptors I and II in the amoeboid microglial cells and murine BV-2 cells. Li JJ, etal., Neuroscience. 2008 Oct 15;156(3):662-72. Epub 2008 Aug 6.
29. Gene expression of transforming growth factor-beta receptors types I and II in rat endometrium during the estrous cycle and early pregnancy. Lin HY, etal., Life Sci. 2006 May 1;78(23):2669-75. Epub 2006 Jan 19.
30. Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis. Liu FY, etal., Am J Nephrol. 2007;27(2):176-83. Epub 2007 Mar 7.
31. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Loeys BL, etal., Nat Genet. 2005 Mar;37(3):275-81. Epub 2005 Jan 30.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition. Nishikawa Y, etal., J Cell Physiol. 1998 Sep;176(3):612-23.
35. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. Endothelial-to-mesenchymal transition in pulmonary hypertension. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.
38. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
39. GOA pipeline RGD automated data pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function. Schniewind B, etal., Oncogene. 2007 Jul 19;26(33):4850-62. doi: 10.1038/sj.onc.1210272. Epub 2007 Feb 12.
43. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
44. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Siegel PM, etal., Proc Natl Acad Sci U S A 2003 Jul 8;100(14):8430-5. Epub 2003 Jun 13.
45. Transforming growth factor beta (TGF-beta) signaling is regulated by electrical activity in skeletal muscle cells. TGF-beta type I receptor is transcriptionally regulated by myotube excitability. Ugarte G and Brandan E, J Biol Chem. 2006 Jul 7;281(27):18473-81. Epub 2006 May 8.
46. Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia. Vicencio AG, etal., J Appl Physiol 2002 Sep;93(3):1123-30.
47. [Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis] Wang XN, etal., Zhong Xi Yi Jie He Xue Bao. 2005 Jul;3(4):286-9.
48. Inhibitory effects of tranilast on expression of transforming growth factor-beta isoforms and receptors in injured arteries. Ward MR, etal., Atherosclerosis. 1998 Apr;137(2):267-75. doi: 10.1016/s0021-9150(97)00275-x.
49. Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89.
50. Expression of TGF beta1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin's lymphomas. Woszczyk D, etal., Med Sci Monit. 2004 Jan;10(1):CR33-7.
51. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13.
52. TGF-beta signaling alterations and susceptibility to colorectal cancer. Xu Y and Pasche B, Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R14-20.
53. Involvement of signaling of VEGF and TGF-beta in differentiation of sinusoidal endothelial cells during culture of fetal rat liver cells. Yoshida M, etal., Cell Tissue Res. 2007 Aug;329(2):273-82. Epub 2007 Apr 21.
54. Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension. Zaiman AL, etal., Am J Respir Crit Care Med. 2008 Apr 15;177(8):896-905. Epub 2008 Jan 17.
55. Localization of transforming growth factor-beta receptor types I, II, and III in the postnatal rat small intestine. Zhang MF, etal., Pediatr Res. 1999 Dec;46(6):657-65.
56. Acute Effects of Transforming Growth Factor-β1 on Neuronal Excitability and Involvement in the Pain of Rats with Chronic Pancreatitis. Zhang X, etal., J Neurogastroenterol Motil. 2016 Apr 30;22(2):333-43. doi: 10.5056/jnm15127.
57. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban Zhang Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Dec;27(12):1094-8.
58. Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate. Zhao H, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):482-91.
59. Transforming growth factor-beta(s) and their receptors in aging rat prostate. Zhao H, etal., Biochem Biophys Res Commun. 2002 Jun 7;294(2):464-9.
60. Ontogeny and localization of TGF-beta type I receptor expression during lung development. Zhao Y, etal., Am J Physiol Lung Cell Mol Physiol. 2000 Jun;278(6):L1231-9.
Additional References at PubMed
PMID:1326540   PMID:1333888   PMID:8752209   PMID:8774881   PMID:8889548   PMID:8980228   PMID:9311995   PMID:9389648   PMID:9921650   PMID:11157754   PMID:11278251   PMID:11285230  
PMID:11641223   PMID:12015308   PMID:12065756   PMID:12477932   PMID:12773577   PMID:12923327   PMID:14517293   PMID:14580334   PMID:14633705   PMID:14729481   PMID:15702480   PMID:15744664  
PMID:15761148   PMID:15820682   PMID:15993878   PMID:16344855   PMID:16601693   PMID:16806156   PMID:16806744   PMID:16845371   PMID:16897002   PMID:16980036   PMID:17078885   PMID:17972267  
PMID:18292396   PMID:18598696   PMID:18625725   PMID:18718461   PMID:18758450   PMID:18832104   PMID:19153267   PMID:19270180   PMID:19494318   PMID:19736306   PMID:20221422   PMID:20386537  
PMID:21266196   PMID:21358634   PMID:21832243   PMID:21859884   PMID:23342175   PMID:23486519   PMID:24088962   PMID:24386286   PMID:24835278   PMID:25065622   PMID:25424912   PMID:25893292  
PMID:26583432   PMID:26788514   PMID:27162619   PMID:27618520   PMID:27653860   PMID:27826032   PMID:27997889   PMID:28125630   PMID:28737766   PMID:30053527   PMID:31043581   PMID:31336100  
PMID:32109943   PMID:33955520   PMID:34181670   PMID:34678242   PMID:35122773   PMID:36293138   PMID:37676431   PMID:39025366  


Genomics

Comparative Map Data
Tgfbr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8566,449,348 - 66,506,371 (+)NCBIGRCr8
mRatBN7.2561,653,773 - 61,710,777 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl561,653,233 - 61,710,777 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx563,625,637 - 63,682,716 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0565,444,934 - 65,502,017 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0565,414,409 - 65,471,481 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0563,056,071 - 63,119,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl563,050,758 - 63,119,635 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0567,575,578 - 67,643,666 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0569,079,391 - 69,097,816 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4563,976,868 - 64,034,058 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1563,981,949 - 64,034,967 (+)NCBI
Celera565,882,184 - 65,907,477 (-)NCBICelera
Cytogenetic Map5q22NCBI
TGFBR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38999,103,647 - 99,154,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl999,104,038 - 99,154,192 (+)EnsemblGRCh38hg38GRCh38
GRCh379101,865,929 - 101,916,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369100,907,233 - 100,956,295 (+)NCBINCBI36Build 36hg18NCBI36
Build 34998,946,966 - 98,991,862NCBI
Celera972,381,280 - 72,430,335 (+)NCBICelera
Cytogenetic Map9q22.33NCBI
HuRef971,464,684 - 71,515,132 (+)NCBIHuRef
CHM1_19102,013,851 - 102,062,916 (+)NCBICHM1_1
T2T-CHM13v2.09111,275,348 - 111,325,904 (+)NCBIT2T-CHM13v2.0
Tgfbr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39447,353,258 - 47,414,926 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl447,353,222 - 47,414,931 (+)EnsemblGRCm39 Ensembl
GRCm38447,353,222 - 47,414,926 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl447,353,222 - 47,414,931 (+)EnsemblGRCm38mm10GRCm38
MGSCv37447,366,177 - 47,427,796 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36447,374,405 - 47,436,024 (+)NCBIMGSCv36mm8
Celera447,375,763 - 47,437,373 (+)NCBICelera
Cytogenetic Map4B1NCBI
cM Map426.02NCBI
Tgfbr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541926,490,899 - 26,547,017 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541926,490,899 - 26,546,349 (-)NCBIChiLan1.0ChiLan1.0
TGFBR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21140,304,045 - 40,352,561 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1940,306,377 - 40,354,930 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0970,195,007 - 70,243,514 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1998,337,417 - 98,362,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl998,332,739 - 98,362,748 (+)Ensemblpanpan1.1panPan2
TGFBR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11156,191,383 - 56,223,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1156,161,772 - 56,218,594 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1154,594,299 - 54,654,173 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01157,272,690 - 57,331,474 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1157,272,651 - 57,331,431 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11155,775,923 - 55,835,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01155,800,862 - 55,860,799 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01156,499,979 - 56,559,879 (+)NCBIUU_Cfam_GSD_1.0
Tgfbr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947171,109,141 - 171,133,324 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365247,655,847 - 7,681,097 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365247,656,523 - 7,680,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,860,156 - 240,918,528 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,842,735 - 240,918,267 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21269,090,577 - 269,149,183 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11240,272,507 - 40,321,740 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1240,276,916 - 40,297,372 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660352,236,283 - 2,258,310 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfbr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248251,839,178 - 1,899,156 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248251,773,158 - 1,899,120 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tgfbr1
391 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:733
Count of miRNA genes:309
Interacting mature miRNAs:432
Transcripts:ENSRNOT00000009452
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat

Markers in Region
D5Got230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2561,683,776 - 61,684,022 (+)MAPPERmRatBN7.2
Rnor_6.0564,565,215 - 64,565,460NCBIRnor6.0
Rnor_6.0563,092,898 - 63,093,141NCBIRnor6.0
Rnor_5.0567,612,457 - 67,612,700UniSTSRnor5.0
Rnor_5.0569,077,835 - 69,078,080UniSTSRnor5.0
RGSC_v3.4564,007,063 - 64,007,308UniSTSRGSC3.4
Celera565,908,831 - 65,909,355UniSTS
Cytogenetic Map5q22UniSTS
AU017191  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2561,685,518 - 61,685,640 (+)MAPPERmRatBN7.2
Rnor_6.0564,566,957 - 64,567,078NCBIRnor6.0
Rnor_6.0563,094,637 - 63,094,758NCBIRnor6.0
Rnor_5.0567,614,196 - 67,614,317UniSTSRnor5.0
Rnor_5.0569,079,577 - 69,079,698UniSTSRnor5.0
RGSC_v3.4564,008,805 - 64,008,926UniSTSRGSC3.4
Celera565,907,213 - 65,907,334UniSTS
Cytogenetic Map5q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009452   ⟹   ENSRNOP00000009452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl561,653,233 - 61,710,777 (+)Ensembl
Rnor_6.0 Ensembl563,050,758 - 63,119,635 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073192   ⟹   ENSRNOP00000066202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl564,566,804 - 64,584,309 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081090   ⟹   ENSRNOP00000071347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl563,056,089 - 63,115,701 (+)Ensembl
RefSeq Acc Id: NM_012775   ⟹   NP_036907
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8566,449,398 - 66,506,371 (+)NCBI
mRatBN7.2561,653,799 - 61,710,777 (+)NCBI
Rnor_6.0563,056,081 - 63,119,635 (+)NCBI
Rnor_5.0567,575,578 - 67,643,666 (+)NCBI
RGSC_v3.4563,976,868 - 64,034,058 (+)RGD
Celera565,882,184 - 65,907,477 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238030   ⟹   XP_006238092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8566,449,348 - 66,506,369 (+)NCBI
mRatBN7.2561,653,773 - 61,710,777 (+)NCBI
Rnor_6.0563,056,071 - 63,119,633 (+)NCBI
Rnor_5.0567,575,578 - 67,643,666 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001416585 (Get FASTA)   NCBI Sequence Viewer  
  NP_036907 (Get FASTA)   NCBI Sequence Viewer  
  XP_006238092 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA83216 (Get FASTA)   NCBI Sequence Viewer  
  AAH87035 (Get FASTA)   NCBI Sequence Viewer  
  EDL78209 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009452.5
GenBank Protein P80204 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036907   ⟸   NM_012775
- Peptide Label: precursor
- UniProtKB: Q5M9H3 (UniProtKB/TrEMBL),   A0A0H2UHE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238092   ⟸   XM_006238030
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000009452   ⟸   ENSRNOT00000009452
Ensembl Acc Id: ENSRNOP00000071347   ⟸   ENSRNOT00000081090
Ensembl Acc Id: ENSRNOP00000066202   ⟸   ENSRNOT00000073192
Protein Domains
GS   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R9M6-F1-model_v2 AlphaFold M0R9M6 1-431 view protein structure
AF-P80204-F1-model_v2 AlphaFold P80204 1-501 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693720
Promoter ID:EPDNEW_R4244
Type:initiation region
Name:Tgfbr1_1
Description:transforming growth factor, beta receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0563,056,109 - 63,056,169EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3852 AgrOrtholog
BioCyc Gene G2FUF-41383 BioCyc
Ensembl Genes ENSRNOG00000007036 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000050760 Ensembl
Ensembl Transcript ENSRNOT00000009452.7 UniProtKB/TrEMBL
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7098473 IMAGE-MGC_LOAD
InterPro Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29591 UniProtKB/TrEMBL
MGC_CLONE MGC:93659 IMAGE-MGC_LOAD
NCBI Gene 29591 ENTREZGENE
PANTHER PTHR23255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-BETA RECEPTOR TYPE-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_beta_GS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tgfbr1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS51256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007036 RatGTEx
  ENSRNOG00000050760 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57302 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHE8 ENTREZGENE, UniProtKB/TrEMBL
  A6KJH1_RAT UniProtKB/TrEMBL
  P80204 ENTREZGENE
  Q5M9H3 ENTREZGENE, UniProtKB/TrEMBL
  TGFR1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tgfbr1  transforming growth factor, beta receptor 1  LOC103690035  TGF-beta receptor type-1-like  Data merged from RGD:9435399 737654 PROVISIONAL
2014-08-25 LOC103690035  TGF-beta receptor type-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Tgfbr1  transforming growth factor, beta receptor 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression lacking in stroma of dorsal and ventral lobes of young prostates but present in the stroma of aging prostates 70812