Gene: Tgfbr1 (transforming growth factor, beta receptor 1) Rattus norvegicus
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Symbol: Tgfbr1
Name: transforming growth factor, beta receptor 1
Description: ENCODES a protein that exhibits ATP binding; protein heterodimerization activity; protein serine/threonine kinase activity; INVOLVED IN aging; animal organ regeneration; digestive tract development; PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; ASSOCIATED WITH Experimental Liver Cirrhosis; kidney disease; leiomyoma; FOUND IN apical plasma membrane; basolateral plasma membrane; caveola; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine
AGR Description: Exhibits several functions, including ATP binding activity, protein heterodimerization activity, and transforming growth factor beta binding activity; involved in several processes, including aging, animal organ development, and regulation of cellular biosynthetic process; localizes to several cellular components, including the apical plasma membrane, basolateral plasma membrane, and caveola; used to study leiomyoma, osteochondrodysplasia, and pulmonary hypertension; biomarker of kidney disease and myocardial infarction; orthologous to human TGFBR1 (transforming growth factor beta receptor 1).
Merged Description: Exhibits several functions, including ATP binding activity, protein heterodimerization activity, and transforming growth factor beta binding activity; involved in several processes, including aging, animal organ development, and regulation of cellular biosynthetic process; localizes to several cellular components, including the apical plasma membrane, basolateral plasma membrane, and caveola; used to study leiomyoma, osteochondrodysplasia, and pulmonary hypertension; biomarker of kidney disease and myocardial infarction; orthologous to human TGFBR1 (transforming growth factor beta receptor 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activin receptor-like kinase 5; Alk5; MGC93659; serine/threonine-protein kinase receptor R4; Skr4; tbetaR-I; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; Tgfr-1; transforming growth factor beta receptor I; transforming growth factor, beta receptor I; transforming growth factor-beta receptor type I
Orthologs:
Homo sapiens (human) : TGFBR1 (transforming growth factor beta receptor 1)  HGNC  Alliance
Mus musculus (house mouse) : Tgfbr1 (transforming growth factor, beta receptor I)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfbr1 (transforming growth factor beta receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFBR1 (transforming growth factor beta receptor 1)
Canis lupus familiaris (dog) : TGFBR1 (transforming growth factor beta receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfbr1 (transforming growth factor beta receptor 1)
Sus scrofa (pig) : TGFBR1 (transforming growth factor beta receptor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0563,056,071 - 63,119,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0569,079,391 - 69,097,816 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0567,575,578 - 67,643,666 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4563,976,868 - 64,034,058 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1563,981,949 - 64,034,967 (+)NCBI
Celera565,882,184 - 65,907,477 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tgfbr1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3852
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.