Klf4 (KLF transcription factor 4) - Rat Genome Database

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Gene: Klf4 (KLF transcription factor 4) Rattus norvegicus
Symbol: Klf4
Name: KLF transcription factor 4
RGD ID: 621445
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and phosphatidylinositol 3-kinase regulator activity. Involved in several processes, including cellular response to cycloheximide; negative regulation of intracellular signal transduction; and regulation of DNA-templated transcription. Part of chromatin and transcription regulator complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (KLF transcription factor 4); INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
Previously known as: GKLF; Krueppel-like factor 4; Kruppel like factor 4; Kruppel-like factor 4 (gut); MGC93286
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Klf4m2Mcwi   Klf4m1Mcwi   Klf4m3Mcwi  
Genetic Models: SS-Klf4m3Mcwi SS-Klf4m2Mcwi SS-Klf4m1Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8575,074,107 - 75,079,182 (-)NCBIGRCr8
mRatBN7.2570,278,843 - 70,283,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl570,278,972 - 70,283,602 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx572,152,882 - 72,157,243 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0573,983,387 - 73,987,747 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0573,955,520 - 73,959,880 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0572,283,311 - 72,287,669 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl572,283,313 - 72,287,669 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0576,447,643 - 76,452,001 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4573,446,928 - 73,451,286 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1573,452,042 - 73,456,399 (-)NCBI
Celera569,133,658 - 69,138,016 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
angiotensin II  (ISO)
antirheumatic drug  (ISO)
Antrocin  (ISO)
aprepitant  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
captan  (ISO)
Carbaprostacyclin  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-penicillamine  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethylbenzene  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP)
furan  (EXP)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (ISO)
glutathione  (ISO)
glycidol  (EXP)
heparin  (EXP)
hydroquinone  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nimesulide  (ISO)
oxytocin  (ISO)
ozone  (EXP,ISO)
Paeonol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
procymidone  (ISO)
progesterone  (ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
taurocholic acid  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
wogonin  (ISO)
wortmannin  (EXP)
Xmu-MP-1  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
canonical Wnt signaling pathway  (ISO)
cellular response to cycloheximide  (IEP)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to laminar fluid shear stress  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to peptide  (IEP)
cellular response to retinoic acid  (IEP)
defense response to tumor cell  (ISO)
DNA-templated transcription  (ISO)
epidermal cell differentiation  (ISO)
epidermis development  (ISO)
epidermis morphogenesis  (ISO)
establishment of skin barrier  (ISO)
fat cell differentiation  (ISO)
gene expression  (ISO)
glandular epithelial cell differentiation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
negative regulation of DNA-templated transcription  (IMP,ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of heterotypic cell-cell adhesion  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of leukocyte adhesion to arterial endothelial cell  (ISO)
negative regulation of muscle hyperplasia  (IMP)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
negative regulation of response to cytokine stimulus  (ISO)
negative regulation of smooth muscle cell proliferation  (IDA,IMP)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hemoglobin biosynthetic process  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
post-embryonic camera-type eye development  (ISO)
post-embryonic hemopoiesis  (ISO)
regulation of axon regeneration  (ISO)
regulation of blastocyst development  (ISO)
regulation of cell differentiation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to retinoic acid  (ISO)
somatic stem cell population maintenance  (ISO)
stem cell population maintenance  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component
chromatin  (IDA,ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
euchromatin  (ISO)
microtubule cytoskeleton  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)
transcription regulator complex  (IDA,ISO)


References - curated
# Reference Title Reference Citation
1. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1. Higaki Y, etal., Nucleic Acids Res 2002 Jun 1;30(11):2270-9.
4. Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Li Q, etal., Gastroenterology. 2012 Sep;143(3):799-810.e2. doi: 10.1053/j.gastro.2012.05.043. Epub 2012 Jun 4.
5. Effects of flavonoids on MicroRNA 145 regulation through Klf4 and myocardin in neointimal formation in vitro and in vivo. Lin CM, etal., J Nutr Biochem. 2018 Feb;52:27-35. doi: 10.1016/j.jnutbio.2017.08.016. Epub 2017 Sep 14.
6. All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells. Meng F, etal., Biochem Biophys Res Commun. 2009 Sep 11;387(1):13-8. doi: 10.1016/j.bbrc.2009.05.112. Epub 2009 May 30.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation. Saifudeen Z, etal., Am J Physiol Renal Physiol. 2005 May;288(5):F899-909. Epub 2005 Jan 4.
11. Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells. Wassmann S, etal., J Mol Cell Cardiol. 2007 Sep;43(3):301-7. Epub 2007 Jun 16.
12. ATRA activates and PDGF-BB represses the SM22alpha promoter through KLF4 binding to, or dissociating from, its cis-DNA elements. Yu K, etal., Cardiovasc Res. 2011 Jun 1;90(3):464-74. doi: 10.1093/cvr/cvr017. Epub 2011 Jan 20.
13. Kruppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells. Zheng B, etal., J Biol Chem. 2009 Aug 21;284(34):22773-85. doi: 10.1074/jbc.M109.026989. Epub 2009 Jun 16.
Additional References at PubMed
PMID:8161377   PMID:8702718   PMID:8940147   PMID:9422764   PMID:10431239   PMID:12477932   PMID:12538588   PMID:12970361   PMID:15358627   PMID:15623517   PMID:16632465   PMID:16954384  
PMID:17060454   PMID:17130451   PMID:17671182   PMID:18396140   PMID:18400104   PMID:18511453   PMID:18768922   PMID:19041854   PMID:19168719   PMID:19618124   PMID:19796622   PMID:19816951  
PMID:20375011   PMID:20433848   PMID:20439489   PMID:20551324   PMID:20629177   PMID:20711222   PMID:21109779   PMID:21182892   PMID:21539536   PMID:22267480   PMID:22282354   PMID:22306741  
PMID:22337869   PMID:22405696   PMID:22430140   PMID:22491752   PMID:22679022   PMID:22723415   PMID:23013362   PMID:23287475   PMID:23372771   PMID:23726909   PMID:23828673   PMID:23867820  
PMID:23934449   PMID:24129709   PMID:24161396   PMID:24321547   PMID:25138274   PMID:25944743   PMID:26082460   PMID:26241060   PMID:26691508   PMID:26945917   PMID:27237094   PMID:27431648  
PMID:27740527   PMID:27907090   PMID:28262547   PMID:28720846   PMID:28851732   PMID:29593216   PMID:30076931   PMID:30520133   PMID:30939050   PMID:31030942   PMID:31486512   PMID:31829402  
PMID:32438059   PMID:32468029   PMID:32556726   PMID:33036290   PMID:33275236   PMID:33383116   PMID:33428060   PMID:34108361   PMID:35171385   PMID:37356737   PMID:37381993   PMID:37441941  
PMID:38084712   PMID:38085146   PMID:38866991  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8575,074,107 - 75,079,182 (-)NCBIGRCr8
mRatBN7.2570,278,843 - 70,283,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl570,278,972 - 70,283,602 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx572,152,882 - 72,157,243 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0573,983,387 - 73,987,747 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0573,955,520 - 73,959,880 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0572,283,311 - 72,287,669 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl572,283,313 - 72,287,669 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0576,447,643 - 76,452,001 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4573,446,928 - 73,451,286 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1573,452,042 - 73,456,399 (-)NCBI
Celera569,133,658 - 69,138,016 (-)NCBICelera
Cytogenetic Map5q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh389107,484,852 - 107,489,769 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9107,484,852 - 107,490,482 (-)EnsemblGRCh38hg38GRCh38
GRCh379110,247,133 - 110,252,050 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369109,286,956 - 109,291,576 (-)NCBINCBI36Build 36hg18NCBI36
Build 349107,326,689 - 107,331,310NCBI
Celera980,749,144 - 80,754,056 (-)NCBICelera
Cytogenetic Map9q31.2NCBI
HuRef979,848,720 - 79,853,633 (-)NCBIHuRef
CHM1_19110,393,822 - 110,398,611 (-)NCBICHM1_1
T2T-CHM13v2.09119,656,625 - 119,661,541 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39455,527,137 - 55,536,984 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl455,527,143 - 55,532,466 (-)EnsemblGRCm39 Ensembl
GRCm38455,527,137 - 55,532,475 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl455,527,143 - 55,532,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv37455,540,009 - 55,545,347 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36455,548,365 - 55,553,566 (-)NCBIMGSCv36mm8
Celera455,439,526 - 55,444,543 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map429.76NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541919,280,235 - 19,285,174 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541919,280,311 - 19,284,097 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21131,918,525 - 31,923,988 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1931,921,406 - 31,926,354 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0978,634,545 - 78,639,447 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19106,820,954 - 106,825,751 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9106,820,954 - 106,825,797 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11162,881,840 - 62,886,676 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1162,882,767 - 62,928,251 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1161,280,192 - 61,284,913 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01164,023,332 - 64,028,057 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1164,023,336 - 64,027,760 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11162,546,457 - 62,551,183 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01162,556,227 - 62,560,944 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01163,258,346 - 63,263,062 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947178,156,606 - 178,161,129 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365595,105,463 - 5,109,970 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365595,105,456 - 5,109,970 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1248,604,820 - 248,609,035 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11248,604,817 - 248,609,574 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21279,056,801 - 279,061,560 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q28-q29NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11232,045,690 - 32,050,531 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1232,045,609 - 32,050,703 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603510,633,003 - 10,637,951 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247584,047,219 - 4,051,983 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247584,047,217 - 4,052,257 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Klf4
9 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir146arno-miR-146a-5pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI21109779

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:101
Interacting mature miRNAs:121
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54372665686724018Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)54946360094463600Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)54946360094463600Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)55979352890450144Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2570,281,917 - 70,283,119 (+)MAPPERmRatBN7.2
mRatBN7.25155,921,461 - 155,922,013 (+)MAPPERmRatBN7.2
Rnor_6.0599,017,243 - 99,017,794NCBIRnor6.0
Rnor_6.0572,286,258 - 72,287,459NCBIRnor6.0
Rnor_5.0576,450,590 - 76,451,791UniSTSRnor5.0
Rnor_5.05103,050,485 - 103,051,036UniSTSRnor5.0
RGSC_v3.45162,463,654 - 162,464,205UniSTSRGSC3.4
RGSC_v3.4573,449,875 - 73,451,076UniSTSRGSC3.4
Celera569,136,605 - 69,137,806UniSTS
Celera5154,221,854 - 154,222,405UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map5q24UniSTS

Genetic Models
This gene Klf4 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 21 8 18 31 11
Low 22 57 41 11 41 8 11 74 17 10 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000022255   ⟹   ENSRNOP00000022255
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl570,278,972 - 70,283,329 (-)Ensembl
Rnor_6.0 Ensembl572,283,313 - 72,287,669 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095509   ⟹   ENSRNOP00000083640
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl570,278,972 - 70,283,602 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116294   ⟹   ENSRNOP00000095641
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl570,278,972 - 70,283,239 (-)Ensembl
RefSeq Acc Id: NM_053713   ⟹   NP_446165
Rat AssemblyChrPosition (strand)Source
GRCr8575,074,234 - 75,078,592 (-)NCBI
mRatBN7.2570,278,970 - 70,283,329 (-)NCBI
Rnor_6.0572,283,311 - 72,287,669 (-)NCBI
Rnor_5.0576,447,643 - 76,452,001 (-)NCBI
RGSC_v3.4573,446,928 - 73,451,286 (-)RGD
Celera569,133,658 - 69,138,016 (-)RGD
RefSeq Acc Id: XM_039109121   ⟹   XP_038965049
Rat AssemblyChrPosition (strand)Source
GRCr8575,074,107 - 75,079,182 (-)NCBI
mRatBN7.2570,278,843 - 70,283,751 (-)NCBI
RefSeq Acc Id: NP_446165   ⟸   NM_053713
- UniProtKB: Q923V7 (UniProtKB/TrEMBL),   F7F8L9 (UniProtKB/TrEMBL),   A0A8I6B336 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022255   ⟸   ENSRNOT00000022255
RefSeq Acc Id: XP_038965049   ⟸   XM_039109121
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B336 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095641   ⟸   ENSRNOT00000116294
RefSeq Acc Id: ENSRNOP00000083640   ⟸   ENSRNOT00000095509
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923V7-F1-model_v2 AlphaFold Q923V7 1-482 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621445 AgrOrtholog
BioCyc Gene G2FUF-41239 BioCyc
Ensembl Genes ENSRNOG00000016299 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022255 ENTREZGENE
  ENSRNOT00000022255.4 UniProtKB/TrEMBL
  ENSRNOT00000095509.1 UniProtKB/TrEMBL
  ENSRNOT00000116294.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:114505 UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Klf4 PhenoGen
RatGTEx ENSRNOG00000016299 RatGTEx
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8I5ZW83_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf4  KLF transcription factor 4  Klf4  Kruppel like factor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-08 Klf4  Kruppel like factor 4  Klf4  Kruppel-like factor 4 (gut)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Klf4  Kruppel-like factor 4 (gut)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Klf4  Kruppel-like factor 4 (gut)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds the bcn-1 element 619591