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Gene: Klf4 (Kruppel like factor 4) Rattus norvegicus
Symbol: Klf4
Name: Kruppel like factor 4
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and phosphatidylinositol 3-kinase regulator activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Localizes to chromatin; nucleus; and transcription regulator complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (Kruppel like factor 4); INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: GKLF; Krueppel-like factor 4; Kruppel-like factor 4 (gut); MGC93286
Homo sapiens (human) : KLF4 (Kruppel like factor 4)  HGNC  Alliance
Mus musculus (house mouse) : Klf4 (Kruppel-like factor 4 (gut))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klf4 (Kruppel like factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : KLF4 (Kruppel like factor 4)
Canis lupus familiaris (dog) : KLF4 (Kruppel like factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klf4 (Kruppel like factor 4)
Sus scrofa (pig) : KLF4 (Kruppel like factor 4)
Chlorocebus sabaeus (African green monkey) : KLF4 (Kruppel like factor 4)
Heterocephalus glaber (naked mole-rat) : Klf4 (Kruppel like factor 4)
more info ...
Allele / Splice: Klf4m2Mcwi   Klf4m1Mcwi   Klf4m3Mcwi  
Genetic Models: SS-Klf4m2Mcwi SS-Klf4m1Mcwi SS-Klf4m3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0572,283,311 - 72,287,669 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl572,283,313 - 72,287,669 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0576,447,643 - 76,452,001 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4573,446,928 - 73,451,286 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1573,452,042 - 73,456,399 (-)NCBI
Celera569,133,658 - 69,138,016 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Klf4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621445
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.