Klf4 (Kruppel like factor 4) - Rat Genome Database

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Gene: Klf4 (Kruppel like factor 4) Rattus norvegicus
Analyze
Symbol: Klf4
Name: Kruppel like factor 4
RGD ID: 621445
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and phosphatidylinositol 3-kinase regulator activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Localizes to chromatin; nucleus; and transcription regulator complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (Kruppel like factor 4); INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GKLF; Krueppel-like factor 4; Kruppel-like factor 4 (gut); MGC93286
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Klf4m2Mcwi   Klf4m1Mcwi   Klf4m3Mcwi  
Genetic Models: SS-Klf4m2Mcwi SS-Klf4m1Mcwi SS-Klf4m3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2570,278,843 - 70,283,751 (-)NCBI
Rnor_6.0 Ensembl572,283,313 - 72,287,669 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0572,283,311 - 72,287,669 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0576,447,643 - 76,452,001 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4573,446,928 - 73,451,286 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1573,452,042 - 73,456,399 (-)NCBI
Celera569,133,658 - 69,138,016 (-)NCBICelera
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethylbenzene  (ISO)
fenamidone  (ISO)
ferric oxide  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP)
furan  (EXP)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (ISO)
glutathione  (ISO)
glycidol  (EXP)
heparin  (EXP)
indometacin  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (EXP)
LY294002  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nimesulide  (ISO)
oxytocin  (ISO)
ozone  (EXP)
Paeonol  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
taurocholic acid  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
tributylstannane  (ISO)
trichostatin A  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
canonical Wnt signaling pathway  (ISO)
cell differentiation  (ISO)
cellular response to cycloheximide  (IEP)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to laminar fluid shear stress  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to organic cyclic compound  (IEP)
cellular response to peptide  (IEP)
cellular response to retinoic acid  (IEP)
defense response to tumor cell  (IEA,ISO)
epidermal cell differentiation  (ISO)
epidermis morphogenesis  (ISO)
fat cell differentiation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of heterotypic cell-cell adhesion  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of leukocyte adhesion to arterial endothelial cell  (ISO)
negative regulation of muscle hyperplasia  (IMP)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of phosphatidylinositol 3-kinase signaling  (IMP)
negative regulation of protein kinase B signaling  (IMP)
negative regulation of response to cytokine stimulus  (ISO)
negative regulation of smooth muscle cell proliferation  (IDA,IMP)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (IMP,ISO,ISS)
positive regulation of cellular protein metabolic process  (ISO)
positive regulation of core promoter binding  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hemoglobin biosynthetic process  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of telomerase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
post-embryonic camera-type eye development  (ISO)
post-embryonic hemopoiesis  (ISO)
regulation of axon regeneration  (ISO)
regulation of blastocyst development  (ISO)
regulation of cell differentiation  (ISO)
regulation of cell population proliferation  (ISO)
regulation of phosphatidylinositol 3-kinase activity  (IEA)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to organic substance  (ISO)
response to retinoic acid  (ISO)
stem cell population maintenance  (ISO)
transcription, DNA-templated  (ISO)

Cellular Component
chromatin  (IDA,ISO)
cytoplasm  (ISO)
euchromatin  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,ISO)
transcription regulator complex  (IDA,ISO)

References

Additional References at PubMed
PMID:8161377   PMID:8702718   PMID:8940147   PMID:9422764   PMID:10431239   PMID:12477932   PMID:12538588   PMID:12970361   PMID:15358627   PMID:15623517   PMID:16632465   PMID:16954384  
PMID:17060454   PMID:17130451   PMID:17671182   PMID:18396140   PMID:18400104   PMID:18511453   PMID:18768922   PMID:19041854   PMID:19168719   PMID:19618124   PMID:19796622   PMID:19816951  
PMID:20375011   PMID:20433848   PMID:20439489   PMID:20551324   PMID:20629177   PMID:20711222   PMID:21109779   PMID:21182892   PMID:21539536   PMID:22267480   PMID:22282354   PMID:22306741  
PMID:22337869   PMID:22405696   PMID:22430140   PMID:22491752   PMID:22679022   PMID:22723415   PMID:23013362   PMID:23287475   PMID:23372771   PMID:23726909   PMID:23828673   PMID:23867820  
PMID:23934449   PMID:24129709   PMID:24161396   PMID:24321547   PMID:25138274   PMID:25944743   PMID:26082460   PMID:26241060   PMID:26691508   PMID:26945917   PMID:27237094   PMID:27431648  
PMID:27740527   PMID:27907090   PMID:28262547   PMID:28720846   PMID:28851732   PMID:29593216   PMID:30076931   PMID:30520133   PMID:30939050   PMID:31030942   PMID:31486512   PMID:31829402  
PMID:32438059   PMID:32468029   PMID:33036290   PMID:33383116  


Genomics

Comparative Map Data
Klf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2570,278,843 - 70,283,751 (-)NCBI
Rnor_6.0 Ensembl572,283,313 - 72,287,669 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0572,283,311 - 72,287,669 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0576,447,643 - 76,452,001 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4573,446,928 - 73,451,286 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1573,452,042 - 73,456,399 (-)NCBI
Celera569,133,658 - 69,138,016 (-)NCBICelera
Cytogenetic Map5q24NCBI
KLF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9107,484,852 - 107,490,482 (-)EnsemblGRCh38hg38GRCh38
GRCh389107,484,852 - 107,489,769 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379110,247,133 - 110,252,050 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369109,286,956 - 109,291,576 (-)NCBINCBI36hg18NCBI36
Build 349107,326,689 - 107,331,310NCBI
Celera980,749,144 - 80,754,056 (-)NCBI
Cytogenetic Map9q31.2NCBI
HuRef979,848,720 - 79,853,633 (-)NCBIHuRef
CHM1_19110,393,822 - 110,398,611 (-)NCBICHM1_1
Klf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39455,527,137 - 55,536,984 (-)NCBIGRCm39mm39
GRCm39 Ensembl455,527,143 - 55,532,466 (-)Ensembl
GRCm38455,527,137 - 55,532,475 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl455,527,143 - 55,532,466 (-)EnsemblGRCm38mm10GRCm38
MGSCv37455,540,009 - 55,545,347 (-)NCBIGRCm37mm9NCBIm37
MGSCv36455,548,365 - 55,553,566 (-)NCBImm8
Celera455,439,526 - 55,444,543 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map429.76NCBI
Klf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541919,280,235 - 19,285,174 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541919,280,311 - 19,284,097 (+)NCBIChiLan1.0ChiLan1.0
KLF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19106,820,954 - 106,825,751 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9106,820,954 - 106,825,797 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0978,634,545 - 78,639,447 (-)NCBIMhudiblu_PPA_v0panPan3
KLF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11162,881,840 - 62,886,676 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1162,882,767 - 62,928,251 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1161,280,192 - 61,284,913 (-)NCBI
ROS_Cfam_1.01164,023,332 - 64,028,057 (-)NCBI
UMICH_Zoey_3.11162,546,457 - 62,551,183 (-)NCBI
UNSW_CanFamBas_1.01162,556,227 - 62,560,944 (-)NCBI
UU_Cfam_GSD_1.01163,258,346 - 63,263,062 (-)NCBI
Klf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947178,156,606 - 178,161,129 (-)NCBI
SpeTri2.0NW_0049365595,105,456 - 5,109,970 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1248,604,820 - 248,609,574 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11248,604,817 - 248,609,574 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21279,056,801 - 279,061,560 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q28-q29NCBI
KLF4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11232,045,690 - 32,050,531 (+)NCBI
ChlSab1.1 Ensembl1232,045,609 - 32,050,703 (+)Ensembl
Vero_WHO_p1.0NW_02366603510,633,003 - 10,637,951 (-)NCBI
Klf4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247584,047,217 - 4,052,257 (+)NCBI

Position Markers
Klf4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2570,281,917 - 70,283,119 (+)MAPPER
mRatBN7.25155,921,461 - 155,922,013 (+)MAPPER
Rnor_6.0599,017,243 - 99,017,794NCBIRnor6.0
Rnor_6.0572,286,258 - 72,287,459NCBIRnor6.0
Rnor_5.0576,450,590 - 76,451,791UniSTSRnor5.0
Rnor_5.05103,050,485 - 103,051,036UniSTSRnor5.0
RGSC_v3.45162,463,654 - 162,464,205UniSTSRGSC3.4
RGSC_v3.4573,449,875 - 73,451,076UniSTSRGSC3.4
Celera569,136,605 - 69,137,806UniSTS
Celera5154,221,854 - 154,222,405UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map5q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5189432042Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5193273395Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51136640934Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5152509878720537Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)59514842103580403Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512651967117554267Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51884791376608178Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52907889974078899Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52907889974078899Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52964166174641661Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52964166174641661Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531926122136640934Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53440240979402409Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53440240979402409Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53440240979402409Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)535225432108092802Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)535661945117554267Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535788756147487820Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540777918154732375Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54440427689432042Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)544404276134502294Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54872203893587756Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)551418671147487820Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)55180442696804426Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)55180442696804426Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55330956898309568Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)555903593100903593Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)556902367101902367Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)556991667137729065Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)560072951133313852Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)561086525149030144Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56108665393273130Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)561086653117554114Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)561612600102331727Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)565696672129038896Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)568838385113838385Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)571154828108092802Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)571154828108092802Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)571154828108092802Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)571154828108092802Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)571154828108092802Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)571552569157225114Rat


Genetic Models
This gene Klf4 is modified in the following models/strains
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir146arno-miR-146a-5pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI21109779

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:101
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000022255
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 21 8 18 31 11
Low 22 57 41 11 41 8 11 74 17 10 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022255   ⟹   ENSRNOP00000022255
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl572,283,313 - 72,287,669 (-)Ensembl
RefSeq Acc Id: NM_053713   ⟹   NP_446165
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2570,278,970 - 70,283,329 (-)NCBI
Rnor_6.0572,283,311 - 72,287,669 (-)NCBI
Rnor_5.0576,447,643 - 76,452,001 (-)NCBI
RGSC_v3.4573,446,928 - 73,451,286 (-)RGD
Celera569,133,658 - 69,138,016 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109121   ⟹   XP_038965049
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2570,278,843 - 70,283,751 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446165 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965049 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85720 (Get FASTA)   NCBI Sequence Viewer  
  AAK73355 (Get FASTA)   NCBI Sequence Viewer  
  EDL91696 (Get FASTA)   NCBI Sequence Viewer  
  EDL91697 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446165   ⟸   NM_053713
- UniProtKB: Q923V7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022255   ⟸   ENSRNOT00000022255
RefSeq Acc Id: XP_038965049   ⟸   XM_039109121
- Peptide Label: isoform X1
Protein Domains
C2H2-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621445 AgrOrtholog
Ensembl Genes ENSRNOG00000016299 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022255 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022255 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190219 IMAGE-MGC_LOAD
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:114505 UniProtKB/TrEMBL
MGC_CLONE MGC:93286 IMAGE-MGC_LOAD
NCBI Gene 114505 ENTREZGENE
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Klf4 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt Q923V7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-08 Klf4  Kruppel like factor 4  Klf4  Kruppel-like factor 4 (gut)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Klf4  Kruppel-like factor 4 (gut)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Klf4  Kruppel-like factor 4 (gut)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds the bcn-1 element 619591