Mcs12 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Mcs12 (Mammary carcinoma susceptibility QTL 12) Rattus norvegicus

Symbol: Mcs12
Name: Mammary carcinoma susceptibility QTL 12
RGD ID: 1598868
Also known as: Mcs5a
Trait: mammary gland integrity trait   (VT:0010552)    
Measurement Type: mammary tumor number   (CMO:0000343)    
LOD Score: Not Available
P Value: 1.0E-4
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2558,973,449 - 60,051,321RGD_MAPPER_PIPELINE
Rnor_6.0560,225,095 - 61,370,302RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0564,739,245 - 65,886,550RGDRnor5.0
RGSC_v3.4561,238,737 - 62,299,211RGDRGSC3.4
Cross Type: Not Available
Strains Crossed: WF.WKY-(D5Wox8-D5Uwm62)/Uwm WF.WKY-(D5Uwm63-D5Uwm64)/Uwm 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

Related QTLs

Related QTL Description Reference
Mcs23 sub_region RGD:1601189
Mcs24 sub_region RGD:1601189


Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
1310467Zcchc7zinc finger CCHC-type containing 756025054660430119Rat
11504104LOC10835096060S ribosomal protein L7a pseudogene56036801960375817Rat
1308851Grhprglyoxylate and hydroxypyruvate reductase56052898160538410Rat
1307367Zbtb5zinc finger and BTB domain containing 556053892660561487Rat
1565773Polr1eRNA polymerase I subunit E56057257360588097Rat
1305465Fbxo10F-box protein 1056058988160636551Rat
1596808Tomm5translocase of outer mitochondrial membrane 556065570860658568Rat
9330186LOC10369234660S ribosomal protein L24 pseudogene56065858760667063Rat
1305229Frmpd1FERM and PDZ domain containing 156073541360837773Rat
1310735Trmt10btRNA methyltransferase 10B56084151760866480Rat
1304739Exosc3exosome component 356086649860871734Rat
9455316LOC103690179phosphoglycerate mutase 1-like56088593360886593Rat
1586079LOC366365hypothetical LOC36636556089352060900239Rat
1304730Dcaf10DDB1 and CUL4 associated factor 1056090039060937547Rat
11429003LOC108350961uncharacterized LOC10835096156092315460926559Rat
1305190Mcart1mitochondrial carrier triple repeat 156094256660956135Rat
1565350ShbSH2 domain containing adaptor protein B56097065061077881Rat
6502452Slc25a51solute carrier family 25, member 5156112041961130053Rat
9246609LOC103692348uncharacterized LOC10369234856123095461235056Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
1581988D5Uwm6224556022509560225339Ratregion
5071174RH13493020656041434660414551Ratregion
5055731RH14397012256041731560417436Ratregion
5072780RH13704916056042938760429546Ratregion
5072540RH13690819656042976660429961Ratregion
5047210RH13219721156053900060539210Ratregion
5074606RH13811413156055900060559130Ratregion
5089451AU04916421856066997460670191Ratregion
66639D5Mco1526756068616560686414Ratregion
1640185D5Got31523256074120060741431Ratregion
5061094AW53223218256082556260825743Ratregion
5081290RH14207520656086493160865136Ratregion
5032359AI59350110756086662460866730Ratregion
5078086RH14013520656092154660921751Ratregion
5085728BQ20195021456093599160936204Ratregion
5054185RH14307911156093704060937150Ratregion
5076524RH13922518356093720060937382Ratregion
34322D5Mgh1014156108652561086653Ratregion
5046862RH13199719556122556061225754Ratregion
5506721G4477923156133387361334103Ratregion
1582038D5Uwm6427456137002961370302Ratregion
Position Markers

Flank 1: (D5Uwm62)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2558,973,449 - 58,973,694 (+)MAPPER
Rnor_6.0560,225,095 - 60,225,339NCBI
Rnor_5.0564,739,245 - 64,739,489UniSTS
RGSC_v3.4561,238,737 - 61,238,981UniSTS
Celera557,548,225 - 57,548,469UniSTS
Cytogenetic Map5 RGD
Flank 2: (D5Uwm64)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2560,051,047 - 60,051,321 (+)MAPPER
Rnor_6.0561,370,029 - 61,370,302NCBI
Rnor_5.0565,886,277 - 65,886,550UniSTS
RGSC_v3.4562,298,938 - 62,299,211UniSTS
Celera558,615,727 - 58,616,000UniSTS
Cytogenetic Map5 RGD


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5189432042Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5193273395Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51136640934Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5152509878720537Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5166658771552720Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)59514842103580403Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512651967117554267Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51884791363847913Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51884791376608178Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52190436366904363Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52907889974078899Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52907889974078899Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52964166174641661Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52964166174641661Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531926122136640934Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53440240979402409Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53440240979402409Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53440240979402409Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)535225432108092802Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)535661945117554267Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53578875670742105Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535788756147487820Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540777918154732375Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54440427689432042Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)544404276134502294Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54872203893587756Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)551418671147487820Rat
9589025Epfw7Epididymal fat weight QTL 720.660.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)55180442696804426Rat
7411561Bw134Body weight QTL 134240.001body mass (VT:0001259)body weight gain (CMO:0000420)55180442696804426Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55330956898309568Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)555903593100903593Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)556902367101902367Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)556991667137729065Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)560072951133313852Rat
1598868Mcs12Mammary carcinoma susceptibility QTL 120.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)56022509561370302Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)561086525149030144Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56108665393273130Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)561086653117554114Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general WF alleles associated with increased mammary tumor susceptibility in this region 1559294
qtl_statistics_details Kruskal-Wallis nonparametric test and ANOVA were used to analyze multiplicity data 1559294