Elavl4 (ELAV like RNA binding protein 4) - Rat Genome Database

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Gene: Elavl4 (ELAV like RNA binding protein 4) Rattus norvegicus
Analyze
Symbol: Elavl4
Name: ELAV like RNA binding protein 4
RGD ID: 1560027
Description: Enables mRNA 3'-UTR binding activity and translation regulator activity. Involved in several processes, including positive regulation of dendrite development; post-transcriptional regulation of gene expression; and response to cocaine. Located in several cellular components, including growth cone; neuronal cell body; and polysomal ribosome. Is active in glutamatergic synapse. Biomarker of hypothyroidism; learning disability; sciatic neuropathy; and status epilepticus. Orthologous to human ELAVL4 (ELAV like RNA binding protein 4); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4; ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); ELAV like neuron-specific RNA binding protein 4; ELAV-like protein 4; hu-antigen D; HuD; LOC298359; paraneoplastic encephalomyelitis antigen HuD; r-HuD; RGD1561943; similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25125,056,848 - 125,200,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5125,056,848 - 125,200,446 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5127,668,033 - 127,750,245 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05129,391,090 - 129,473,304 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05129,442,384 - 129,524,600 (-)NCBIRnor_WKY
Rnor_6.05130,001,387 - 130,144,557 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5130,001,372 - 130,085,838 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05133,837,537 - 133,979,844 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45131,672,012 - 131,767,950 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5123,783,448 - 123,864,325 (-)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Increased expression and localization of the RNA-binding protein HuD and GAP-43 mRNA to cytoplasmic granules in DRG neurons during nerve regeneration. Anderson KD, etal., Exp Neurol. 2003 Sep;183(1):100-8.
2. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells. Aranda-Abreu GE, etal., J Neurosci. 1999 Aug 15;19(16):6907-17.
3. Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity. Bolognani F, etal., Neurochem Res. 2007 Dec;32(12):2142-51. Epub 2007 Jun 19.
4. Dendritic localization of the RNA-binding protein HuD in hippocampal neurons: association with polysomes and upregulation during contextual learning. Bolognani F, etal., Neurosci Lett. 2004 Nov 23;371(2-3):152-7.
5. HuD distribution changes in response to heat shock but not neurotrophic stimulation. Burry RW and Smith CL, J Histochem Cytochem. 2006 Oct;54(10):1129-38. Epub 2006 Jun 26.
6. Expression of mRNA for the elav-like neural-specific RNA binding protein, HuD, during nervous system development. Clayton GH, etal., Brain Res Dev Brain Res. 1998 Aug 8;109(2):271-80.
7. Neuronal HuD gene encoding a mRNA stability regulator is transcriptionally repressed by thyroid hormone. Cuadrado A, etal., J Neurochem. 2003 Aug;86(3):763-73.
8. Expression of HuD protein is essential for initial phase of neuronal differentiation in rat pheochromocytoma PC12 cells. Dobashi Y, etal., Biochem Biophys Res Commun. 1998 Mar 6;244(1):226-9.
9. The survival of motor neuron (SMN) protein interacts with the mRNA-binding protein HuD and regulates localization of poly(A) mRNA in primary motor neuron axons. Fallini C, etal., J Neurosci. 2011 Mar 9;31(10):3914-25. doi: 10.1523/JNEUROSCI.3631-10.2011.
10. PKC activation during training restores mushroom spine synapses and memory in the aged rat. Hongpaisan J, etal., Neurobiol Dis. 2013 Jul;55:44-62. doi: 10.1016/j.nbd.2013.03.012. Epub 2013 Mar 29.
11. Protein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in culture. Lim CS and Alkon DL, Hippocampus. 2012 Dec;22(12):2303-19. doi: 10.1002/hipo.22048. Epub 2012 Jun 27.
12. Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory. Pascale A, etal., Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1217-22. Epub 2004 Jan 26.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. GAP-43 mRNA in growth cones is associated with HuD and ribosomes. Smith CL, etal., J Neurobiol. 2004 Nov;61(2):222-35.
17. Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. Tiruchinapalli DM, etal., J Neurochem. 2008 Dec;107(6):1529-43. doi: 10.1111/j.1471-4159.2008.05718.x. Epub 2008 Nov 6.
18. HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites. Vanevski F and Xu B, PLoS One. 2015 Feb 18;10(2):e0117264. doi: 10.1371/journal.pone.0117264. eCollection 2015.
19. A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3' untranslated region AU-rich regulatory element. Yoo S, etal., J Neurochem. 2013 Sep;126(6):792-804. doi: 10.1111/jnc.12266. Epub 2013 Apr 30.
20. Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells. Yoo YM J Pineal Res. 2013 Sep;55(2):207-20. doi: 10.1111/jpi.12064. Epub 2013 May 28.
Additional References at PubMed
PMID:8717365   PMID:10710437   PMID:12034726   PMID:12477932   PMID:16508003   PMID:17534028   PMID:18769135   PMID:19115409   PMID:21139978   PMID:22871113   PMID:23836929   PMID:24599466  
PMID:25944900   PMID:26152301   PMID:28849006   PMID:28871047   PMID:31173231  


Genomics

Comparative Map Data
Elavl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25125,056,848 - 125,200,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5125,056,848 - 125,200,446 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5127,668,033 - 127,750,245 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05129,391,090 - 129,473,304 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05129,442,384 - 129,524,600 (-)NCBIRnor_WKY
Rnor_6.05130,001,387 - 130,144,557 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5130,001,372 - 130,085,838 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05133,837,537 - 133,979,844 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45131,672,012 - 131,767,950 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5123,783,448 - 123,864,325 (-)NCBICelera
Cytogenetic Map5q35NCBI
ELAVL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38150,048,055 - 50,203,772 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl150,024,029 - 50,203,772 (+)EnsemblGRCh38hg38GRCh38
GRCh37150,513,727 - 50,669,444 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36150,347,225 - 50,439,648 (+)NCBINCBI36Build 36hg18NCBI36
Build 34150,286,657 - 50,379,074NCBI
Celera148,799,541 - 48,953,474 (+)NCBICelera
Cytogenetic Map1p33-p32.3NCBI
HuRef148,632,219 - 48,786,277 (+)NCBIHuRef
CHM1_1150,630,724 - 50,784,575 (+)NCBICHM1_1
T2T-CHM13v2.0149,927,008 - 50,082,746 (+)NCBIT2T-CHM13v2.0
Elavl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394110,060,934 - 110,209,145 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4110,060,919 - 110,209,106 (-)EnsemblGRCm39 Ensembl
GRCm384110,203,737 - 110,351,939 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4110,203,722 - 110,351,909 (-)EnsemblGRCm38mm10GRCm38
MGSCv374109,876,342 - 110,024,516 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364109,701,669 - 109,785,443 (-)NCBIMGSCv36mm8
Celera4108,542,389 - 108,690,370 (-)NCBICelera
Cytogenetic Map4C7NCBI
cM Map451.42NCBI
Elavl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554648,699,088 - 8,788,878 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554648,699,142 - 8,847,289 (-)NCBIChiLan1.0ChiLan1.0
ELAVL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1150,795,037 - 50,951,058 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl150,853,276 - 50,951,058 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0149,288,364 - 49,444,457 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ELAVL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11510,885,161 - 10,977,383 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1510,887,347 - 11,027,621 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1511,035,584 - 11,127,727 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01511,021,674 - 11,113,864 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1511,023,885 - 11,165,914 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11510,821,693 - 10,912,118 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01510,910,280 - 11,000,453 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01510,927,186 - 11,017,414 (-)NCBIUU_Cfam_GSD_1.0
Elavl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505864,929,747 - 65,066,032 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652210,349,571 - 10,486,427 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493652210,349,684 - 10,435,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELAVL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6161,785,770 - 161,928,910 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16161,784,146 - 161,928,953 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ELAVL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12082,712,987 - 82,869,013 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2082,712,944 - 82,806,387 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603334,379,488 - 34,475,682 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Elavl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248592,874,945 - 3,023,001 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248592,875,652 - 3,023,142 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Elavl4
480 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir141rno-miR-141-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20584986
Mir21rno-miR-21-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20584986

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:24
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000035252
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
7794739Bp372Blood pressure QTL 3720.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5117913688125222967Rat
1582230Bw78Body weight QTL 783.20.0016epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)5119085612128034027Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5120740824143608494Rat
2293642Bss37Bone structure and strength QTL 374.640.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5120740824151018848Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5124160767133749643Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat

Markers in Region
BB464020  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25125,057,610 - 125,057,695 (+)MAPPERmRatBN7.2
Rnor_6.05130,002,150 - 130,002,234NCBIRnor6.0
Rnor_5.05133,838,300 - 133,838,384UniSTSRnor5.0
RGSC_v3.45131,670,388 - 131,670,472UniSTSRGSC3.4
Celera5123,784,211 - 123,784,295UniSTS
Cytogenetic Map5q35UniSTS
RH131794  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25125,067,409 - 125,067,603 (+)MAPPERmRatBN7.2
Rnor_6.05130,011,948 - 130,012,141NCBIRnor6.0
Rnor_5.05133,848,098 - 133,848,291UniSTSRnor5.0
RGSC_v3.45131,680,186 - 131,680,379UniSTSRGSC3.4
Celera5123,794,010 - 123,794,203UniSTS
RH 3.4 Map5820.9UniSTS
Cytogenetic Map5q35UniSTS
PMC337033P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25125,059,245 - 125,059,374 (+)MAPPERmRatBN7.2
Rnor_6.05130,003,785 - 130,003,913NCBIRnor6.0
Rnor_5.05133,839,935 - 133,840,063UniSTSRnor5.0
RGSC_v3.45131,672,023 - 131,672,151UniSTSRGSC3.4
Celera5123,785,846 - 123,785,974UniSTS
Cytogenetic Map5q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 74 5
Low 3 22 20 14 14 16 22 2
Below cutoff 14 15 6 10 6 6 8 3 14 9 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000035252   ⟹   ENSRNOP00000037614
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5125,056,848 - 125,139,100 (-)Ensembl
Rnor_6.0 Ensembl5130,001,372 - 130,085,838 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098972   ⟹   ENSRNOP00000096475
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5125,058,877 - 125,145,091 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101036   ⟹   ENSRNOP00000076930
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5125,059,431 - 125,200,446 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101531   ⟹   ENSRNOP00000095267
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5125,056,848 - 125,140,002 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104896   ⟹   ENSRNOP00000079852
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5125,056,848 - 125,104,518 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108484   ⟹   ENSRNOP00000090516
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5125,058,877 - 125,142,708 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109917   ⟹   ENSRNOP00000086190
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5125,059,431 - 125,139,100 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110462   ⟹   ENSRNOP00000093173
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5125,058,877 - 125,104,799 (-)Ensembl
RefSeq Acc Id: NM_001077651   ⟹   NP_001071119
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25125,056,848 - 125,139,100 (-)NCBI
Rnor_6.05130,001,387 - 130,085,772 (-)NCBI
Rnor_5.05133,837,537 - 133,979,844 (-)NCBI
RGSC_v3.45131,672,012 - 131,767,950 (-)RGD
Celera5123,783,448 - 123,864,325 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238591   ⟹   XP_006238653
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25125,056,848 - 125,143,349 (-)NCBI
Rnor_6.05130,001,387 - 130,090,240 (-)NCBI
Rnor_5.05133,837,537 - 133,979,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238593   ⟹   XP_006238655
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25125,056,848 - 125,200,543 (-)NCBI
Rnor_6.05130,001,387 - 130,144,557 (-)NCBI
Rnor_5.05133,837,537 - 133,979,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006238594   ⟹   XP_006238656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25125,056,848 - 125,139,977 (-)NCBI
Rnor_6.05130,001,387 - 130,086,674 (-)NCBI
Rnor_5.05133,837,537 - 133,979,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110514   ⟹   XP_038966442
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25125,056,848 - 125,143,351 (-)NCBI
RefSeq Acc Id: XM_039110515   ⟹   XP_038966443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25125,056,848 - 125,143,348 (-)NCBI
RefSeq Acc Id: XM_039110516   ⟹   XP_038966444
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25125,056,848 - 125,143,350 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001071119   ⟸   NM_001077651
- UniProtKB: A0A140TAF2 (UniProtKB/TrEMBL),   B0BMT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238655   ⟸   XM_006238593
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006238653   ⟸   XM_006238591
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006238656   ⟸   XM_006238594
- Peptide Label: isoform X3
- UniProtKB: A0A8I6APY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000037614   ⟸   ENSRNOT00000035252
RefSeq Acc Id: XP_038966442   ⟸   XM_039110514
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038966444   ⟸   XM_039110516
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038966443   ⟸   XM_039110515
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000076930   ⟸   ENSRNOT00000101036
RefSeq Acc Id: ENSRNOP00000096475   ⟸   ENSRNOT00000098972
RefSeq Acc Id: ENSRNOP00000090516   ⟸   ENSRNOT00000108484
RefSeq Acc Id: ENSRNOP00000093173   ⟸   ENSRNOT00000110462
RefSeq Acc Id: ENSRNOP00000086190   ⟸   ENSRNOT00000109917
RefSeq Acc Id: ENSRNOP00000095267   ⟸   ENSRNOT00000101531
RefSeq Acc Id: ENSRNOP00000079852   ⟸   ENSRNOT00000104896
Protein Domains
RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09032-F1-model_v2 AlphaFold O09032 1-385 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560027 AgrOrtholog
BioCyc Gene G2FUF-40341 BioCyc
Ensembl Genes ENSRNOG00000023601 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000037614 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000076930.1 UniProtKB/TrEMBL
  ENSRNOP00000079852 ENTREZGENE
  ENSRNOP00000079852.1 UniProtKB/TrEMBL
  ENSRNOP00000086190 ENTREZGENE
  ENSRNOP00000086190.1 UniProtKB/TrEMBL
  ENSRNOP00000090516.1 UniProtKB/TrEMBL
  ENSRNOP00000093173.1 UniProtKB/TrEMBL
  ENSRNOP00000095267 ENTREZGENE
  ENSRNOP00000095267.1 UniProtKB/TrEMBL
  ENSRNOP00000096475 ENTREZGENE
  ENSRNOP00000096475.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035252 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000098972 ENTREZGENE
  ENSRNOT00000098972.1 UniProtKB/TrEMBL
  ENSRNOT00000101036.1 UniProtKB/TrEMBL
  ENSRNOT00000101531 ENTREZGENE
  ENSRNOT00000101531.1 UniProtKB/TrEMBL
  ENSRNOT00000104896 ENTREZGENE
  ENSRNOT00000104896.1 UniProtKB/TrEMBL
  ENSRNOT00000108484.1 UniProtKB/TrEMBL
  ENSRNOT00000109917 ENTREZGENE
  ENSRNOT00000109917.1 UniProtKB/TrEMBL
  ENSRNOT00000110462.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8371379 IMAGE-MGC_LOAD
InterPro ELAD_HU_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ELAV/Hu_RRM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HuD_RRM3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hud_Sxl_RNA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RRM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:432358 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187234 IMAGE-MGC_LOAD
NCBI Gene 432358 ENTREZGENE
Pfam RRM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Elavl4 PhenoGen
PRINTS HUDSXLRNA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs ELAV_HUD_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAF2 ENTREZGENE
  A0A8I5Y0H9_RAT UniProtKB/TrEMBL
  A0A8I5ZNE4_RAT UniProtKB/TrEMBL
  A0A8I6A344_RAT UniProtKB/TrEMBL
  A0A8I6ADY8_RAT UniProtKB/TrEMBL
  A0A8I6AI53_RAT UniProtKB/TrEMBL
  A0A8I6APY9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AV49_RAT UniProtKB/TrEMBL
  B0BMT8 ENTREZGENE, UniProtKB/TrEMBL
  ELAV4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A140TAF2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-09 Elavl4  ELAV like RNA binding protein 4  Elavl4  ELAV like neuron-specific RNA binding protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-11 Elavl4  ELAV like neuron-specific RNA binding protein 4  Elavl4  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Elavl4  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4  Elavl4  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 Elavl4  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)  RGD1561943_predicted  similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) (predicted)  Data Merged 1643240 APPROVED
2006-03-10 RGD1561943_predicted  similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) (predicted)      Name updated 1299863 APPROVED
2006-03-07 RGD1561943_predicted  similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) (predicted)  LOC298359  similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Elavl4  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-02-09 LOC298359  similar to ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)      Symbol and Name status set to provisional 70820 PROVISIONAL