Tyrp1 (tyrosinase-related protein 1) - Rat Genome Database

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Gene: Tyrp1 (tyrosinase-related protein 1) Rattus norvegicus
Symbol: Tyrp1
Name: tyrosinase-related protein 1
RGD ID: 1593266
Description: Predicted to enable protein homodimerization activity and tyrosinase activity. Predicted to be involved in melanocyte differentiation; melanosome organization; and positive regulation of melanin biosynthetic process. Predicted to act upstream of or within acetoacetic acid metabolic process; melanin metabolic process; and pigmentation. Predicted to be located in clathrin-coated endocytic vesicle membrane; endosome membrane; and melanosome membrane. Predicted to be active in melanosome. Human ortholog(s) of this gene implicated in oculocutaneous albinism; oculocutaneous albinism type III; and pigmentation disease. Orthologous to human TYRP1 (tyrosinase related protein 1); PARTICIPATES IN tyrosine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cocaine.
Type: protein-coding
Previously known as: 5,6-dihydroxyindole-2-carboxylic acid oxidase; B; tyrosinase-related protein 1 (mapped); tyrosine phosphatase 1, same as B (Brown); Tyrp1_mapped
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2595,280,982 - 95,299,516 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl595,280,982 - 95,299,516 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx597,659,552 - 97,678,085 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0599,480,692 - 99,499,221 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0599,470,354 - 99,488,887 (+)NCBIRnor_WKY
Rnor_6.0598,387,291 - 98,406,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl598,387,291 - 98,406,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05102,430,674 - 102,449,645 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4599,518,306 - 99,537,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera593,854,189 - 93,872,732 (+)NCBICelera
Cytogenetic Map5q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-tert-butylphenol  (ISO)
5-fluorouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
afzelin  (ISO)
all-trans-retinoic acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
chaetocin  (ISO)
chlorambucil  (ISO)
chlorogenic acid  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
decabromodiphenyl ether  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
etoposide  (ISO)
formaldehyde  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
isorhamnetin  (ISO)
kojic acid  (ISO)
lamivudine  (ISO)
Lasiocarpine  (ISO)
LY294002  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel sulfate  (ISO)
nonanedioic acid  (ISO)
O-methyleugenol  (ISO)
phytol  (ISO)
Pomiferin  (ISO)
puerarin  (ISO)
quercetin  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scoparone  (ISO)
Sweroside  (ISO)
taurine  (ISO)
testosterone enanthate  (ISO)
theophylline  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vorinostat  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3". Boissy RE, etal., Am J Hum Genet. 1996 Jun;58(6):1145-56.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Information Derived from GenBank Report RGD, Sept. 2003
10. Regulation of tyrosinase processing and trafficking by organellar pH and by proteasome activity. Watabe H, etal., J Biol Chem 2004 Feb 27;279(9):7971-81. Epub 2003 Nov 21.
Additional References at PubMed
PMID:2379821   PMID:7665913   PMID:9548375   PMID:9918801   PMID:13880466   PMID:17182842   PMID:17247639   PMID:19841138   PMID:21291857   PMID:21949658   PMID:21996312   PMID:22275436  
PMID:26620560   PMID:27390154  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2595,280,982 - 95,299,516 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl595,280,982 - 95,299,516 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx597,659,552 - 97,678,085 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0599,480,692 - 99,499,221 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0599,470,354 - 99,488,887 (+)NCBIRnor_WKY
Rnor_6.0598,387,291 - 98,406,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl598,387,291 - 98,406,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05102,430,674 - 102,449,645 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4599,518,306 - 99,537,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera593,854,189 - 93,872,732 (+)NCBICelera
Cytogenetic Map5q31NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38912,693,385 - 12,710,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl912,685,439 - 12,710,285 (+)EnsemblGRCh38hg38GRCh38
GRCh37912,693,385 - 12,710,285 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36912,683,449 - 12,700,258 (+)NCBINCBI36Build 36hg18NCBI36
Build 34912,683,448 - 12,700,258NCBI
Celera912,625,996 - 12,642,868 (+)NCBICelera
Cytogenetic Map9p23NCBI
HuRef912,658,087 - 12,674,962 (+)NCBIHuRef
CHM1_1912,693,770 - 12,710,634 (+)NCBICHM1_1
T2T-CHM13v2.0912,702,721 - 12,719,618 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39480,752,360 - 80,769,973 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl480,752,360 - 80,769,956 (+)EnsemblGRCm39 Ensembl
GRCm38480,834,123 - 80,851,736 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl480,834,123 - 80,851,719 (+)EnsemblGRCm38mm10GRCm38
MGSCv37480,480,134 - 80,497,622 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36480,305,461 - 80,322,949 (+)NCBIMGSCv36mm8
Celera479,387,103 - 79,404,579 (+)NCBICelera
Cytogenetic Map4C3NCBI
cM Map437.89NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543415,913,968 - 15,931,740 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543415,913,208 - 15,932,193 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan19111,831,122 - 113,001,599 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0912,502,610 - 12,550,203 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1912,950,831 - 12,996,808 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl912,950,831 - 12,996,799 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11133,317,084 - 33,336,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1133,317,121 - 33,335,498 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1132,027,482 - 32,045,312 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01134,222,689 - 34,240,515 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1134,222,689 - 34,240,515 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11132,928,733 - 32,946,547 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01132,713,987 - 32,731,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01133,376,152 - 33,394,014 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947148,084,995 - 148,102,753 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365396,537,509 - 6,556,513 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365396,537,448 - 6,555,440 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1209,725,638 - 209,745,705 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11209,725,698 - 209,745,141 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21233,661,356 - 233,680,103 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11266,841,867 - 66,861,730 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1266,842,926 - 66,859,842 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603855,076,959 - 55,095,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473617,011,115 - 17,029,322 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473617,011,092 - 17,028,689 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Tyrp1
82 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:333
Count of miRNA genes:198
Interacting mature miRNAs:229
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
2303615Vencon7Ventilatory control QTL 70.001respiration trait (VT:0001943)respiration rate (CMO:0000289)55098389595983895Rat
2303574Gluco42Glucose level QTL 422blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)55349671998496719Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)555715622100715622Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)58384059897059958Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,288,293 - 95,288,541 (+)MAPPERmRatBN7.2
Rnor_6.0598,394,603 - 98,394,850NCBIRnor6.0
Rnor_5.05102,437,986 - 102,438,233UniSTSRnor5.0
RGSC_v3.4599,525,263 - 99,525,679RGDRGSC3.4
RGSC_v3.4599,525,392 - 99,525,639UniSTSRGSC3.4
RGSC_v3.1599,530,489 - 99,530,905RGD
Celera593,861,504 - 93,861,751UniSTS
RH 3.4 Map5748.8RGD
RH 3.4 Map5748.8UniSTS
RH 2.0 Map5601.4RGD
SHRSP x BN Map553.5899RGD
Cytogenetic Map5q31UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2595,299,282 - 95,299,476 (+)MAPPERmRatBN7.2
Rnor_6.0598,405,850 - 98,406,043NCBIRnor6.0
Rnor_5.05102,449,412 - 102,449,605UniSTSRnor5.0
RGSC_v3.4599,537,056 - 99,537,249UniSTSRGSC3.4
Celera593,872,499 - 93,872,692UniSTS
RH 3.4 Map5749.49UniSTS
Cytogenetic Map5q31UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 6 3 16
Below cutoff 6 1 1 59 8 14 3 1


Reference Sequences
RefSeq Acc Id: ENSRNOT00000046503   ⟹   ENSRNOP00000041764
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl595,280,982 - 95,299,516 (+)Ensembl
Rnor_6.0 Ensembl598,387,291 - 98,406,083 (+)Ensembl
RefSeq Acc Id: NM_001106664   ⟹   NP_001100134
Rat AssemblyChrPosition (strand)Source
mRatBN7.2595,280,982 - 95,299,516 (+)NCBI
Rnor_6.0598,387,291 - 98,406,083 (+)NCBI
Rnor_5.05102,430,674 - 102,449,645 (+)NCBI
RGSC_v3.4599,518,306 - 99,537,289 (+)RGD
Celera593,854,189 - 93,872,732 (+)RGD
Protein Sequences
Protein RefSeqs NP_001100134 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10478 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100134   ⟸   NM_001106664
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: ENSRNOP00000041764   ⟸   ENSRNOT00000046503
Protein Domains
Tyrosinase copper-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZH71-F1-model_v2 AlphaFold D3ZH71 1-537 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593266 AgrOrtholog
BioCyc Gene G2FUF-40919 BioCyc
Ensembl Genes ENSRNOG00000029318 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000041764 ENTREZGENE
  ENSRNOP00000041764.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046503 ENTREZGENE
  ENSRNOT00000046503.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1280.10 UniProtKB/TrEMBL
InterPro Di-copper_centre UniProtKB/TrEMBL
  Tyrosinase UniProtKB/TrEMBL
Pfam Tyrosinase UniProtKB/TrEMBL
PhenoGen Tyrp1 PhenoGen
Superfamily-SCOP Di-copper_centre UniProtKB/TrEMBL
UniProt D3ZH71_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   tyrosinase-related protein 1  Tyrp1  tyrosinase-related protein 1 (mapped)  Name updated 737654 APPROVED
2007-02-12 Tyrp1  tyrosinase-related protein 1 (mapped)  Tyrp1_mapped  tyrosinase-related protein 1 (mapped)  Data Merged 737654 PROVISIONAL
2006-11-20 Tyrp1  tyrosinase-related protein 1 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Tyrp1_mapped  tyrosinase-related protein 1 (mapped)  Tyrp1  tyrosinase-related protein 1  Symbol and Name updated 1556543 APPROVED
2002-06-10 Tyrp1  Tyrosine phosphatase 1      Symbol and Name status set to approved 70586 APPROVED