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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1313128 | 6480464 | [potassium chromateVI co-treated with epigallocatechin gallate] results in decreased expression of SMC2 mRNA | CTD | PMID:22079256 | 1,1-dichloroethene | increases expression | ISO | RGD:1313129 | 6480464 | vinylidene chloride results in increased expression of SMC2 mRNA | CTD | PMID:26682919 | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of SMC2 mRNA | CTD | PMID:25380136, PMID:30723492 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1313129 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMC2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1313129 | 6480464 | Ethinyl Estradiol results in increased expression of SMC2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | ISO | RGD:1313128 | 6480464 | Estradiol results in increased expression of SMC2 mRNA | CTD | PMID:16474171, PMID:19167446 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:1313129 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:1313129 | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1313129 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SMC2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SMC2 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1313129 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SMC2 mRNA | CTD | PMID:21570461, PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1313128 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SMC2 mRNA | CTD | PMID:21802500 | 2,4,6-trinitrobenzenesulfonic acid | increases expression | ISO | RGD:1313129 | 6480464 | Trinitrobenzenesulfonic Acid results in increased expression of SMC2 mRNA | CTD | PMID:17982090 | 2-butoxyethanol | increases expression | ISO | RGD:1313129 | 6480464 | n-butoxyethanol results in increased expression of SMC2 mRNA | CTD | PMID:19812364 | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4, 4'-diaminodiphenylmethane results in increased expression of SMC2 mRNA | CTD | PMID:25380136 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:1313129 | 6480464 | 4, 4'-diaminodiphenylmethane results in increased expression of SMC2 mRNA | CTD | PMID:18648102 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:1313129 | 6480464 | Fenretinide results in increased expression of SMC2 mRNA | CTD | PMID:28973697 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SMC2 mRNA | CTD | PMID:31881176 | aflatoxin B1 | affects expression | ISO | RGD:1313128 | 6480464 | Aflatoxin B1 affects the expression of SMC2 protein | CTD | PMID:20106945 | aflatoxin M1 | decreases expression | ISO | RGD:1313128 | 6480464 | Aflatoxin M1 results in decreased expression of SMC2 mRNA | CTD | PMID:30928695 | azathioprine | decreases expression | ISO | RGD:1313128 | 6480464 | Azathioprine results in decreased expression of SMC2 mRNA | CTD | PMID:22623647 | benzene | decreases expression | ISO | RGD:1313129 | 6480464 | Benzene results in decreased expression of SMC2 mRNA | CTD | PMID:20018183 | benzo[a]pyrene | decreases expression | ISO | RGD:1313128 | 6480464 | Benzoapyrene results in decreased expression of SMC2 mRNA | CTD | PMID:21802500 | benzo[a]pyrene | increases expression | ISO | RGD:1313128 | 6480464 | Benzoapyrene results in increased expression of SMC2 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | RGD:1313128 | 6480464 | Benzoapyrene results in increased methylation of SMC2 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RGD:1313128 | 6480464 | 7 more ... | CTD | PMID:20382639 | benzo[b]fluoranthene | increases expression | ISO | RGD:1313129 | 6480464 | benzobfluoranthene results in increased expression of SMC2 mRNA | CTD | PMID:26377693 | bisphenol A | increases expression | ISO | RGD:1313128 | 6480464 | bisphenol A results in increased expression of SMC2 mRNA | CTD | PMID:16474171 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SMC2 mRNA | CTD | PMID:25181051 more ... | calcitriol | decreases expression | ISO | RGD:1313128 | 6480464 | Calcitriol results in decreased expression of SMC2 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:1313128 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of SMC2 mRNA | CTD | PMID:21592394 | carbon nanotube | increases expression | ISO | RGD:1313129 | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chromium(6+) | decreases expression | ISO | RGD:1313128 | 6480464 | chromium hexavalent ion results in decreased expression of SMC2 mRNA | CTD | PMID:27793765 | cisplatin | decreases expression | ISO | RGD:1313128 | 6480464 | Cisplatin results in decreased expression of SMC2 mRNA | CTD | PMID:27392435 | cobalt dichloride | decreases expression | ISO | RGD:1313128 | 6480464 | cobaltous chloride results in decreased expression of SMC2 mRNA | CTD | PMID:19376846 | copper atom | increases expression | ISO | RGD:1313129 | 6480464 | Copper results in increased expression of SMC2 mRNA | CTD | PMID:17205981 | copper atom | multiple interactions | ISO | RGD:1313129 | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of SMC2 mRNA | CTD | PMID:15467011 | copper(0) | increases expression | ISO | RGD:1313129 | 6480464 | Copper results in increased expression of SMC2 mRNA | CTD | PMID:17205981 | copper(0) | multiple interactions | ISO | RGD:1313129 | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of SMC2 mRNA | CTD | PMID:15467011 | coumestrol | increases expression | ISO | RGD:1313128 | 6480464 | Coumestrol results in increased expression of SMC2 mRNA | CTD | PMID:19167446 | coumestrol | multiple interactions | ISO | RGD:1313128 | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | RGD:1313128 | 6480464 | Cyclosporine results in decreased expression of SMC2 mRNA | CTD | PMID:20106945 more ... | dicrotophos | decreases expression | ISO | RGD:1313128 | 6480464 | dicrotophos results in decreased expression of SMC2 mRNA | CTD | PMID:28302478 | diethylstilbestrol | decreases expression | EXP | | 6480464 | Diethylstilbestrol results in decreased expression of SMC2 mRNA | CTD | PMID:21658437 | doxorubicin | decreases expression | ISO | RGD:1313128 | 6480464 | Doxorubicin results in decreased expression of SMC2 mRNA | CTD | PMID:29803840 | Enterolactone | multiple interactions | ISO | RGD:1313128 | 6480464 | [Coumestrol co-treated with 2, 3-bis3'-hydroxybenzylbutyrolactone] results in increased expression of SMC2 mRNA | CTD | PMID:19167446 | enzyme inhibitor | multiple interactions | ISO | RGD:1313128 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SMC2 protein | CTD | PMID:23301498 | folic acid | decreases expression | ISO | RGD:1313129 | 6480464 | Folic Acid results in decreased expression of SMC2 mRNA | CTD | PMID:25629700 | genistein | increases expression | ISO | RGD:1313128 | 6480464 | Genistein results in increased expression of SMC2 mRNA | CTD | PMID:16474171 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SMC2 mRNA | CTD | PMID:22061828 | levetiracetam | increases expression | EXP | | 6480464 | Levetiracetam results in increased expression of SMC2 mRNA | CTD | PMID:20345932 | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of SMC2 mRNA | CTD | PMID:22584684 | methyl methanesulfonate | increases expression | ISO | RGD:1313128 | 6480464 | Methyl Methanesulfonate results in increased expression of SMC2 mRNA | CTD | PMID:23649840 | N-nitrosodiethylamine | increases expression | ISO | RGD:1313129 | 6480464 | Diethylnitrosamine results in increased expression of SMC2 mRNA | CTD | PMID:17854601 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:1313129 | 6480464 | RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of SMC2 mRNA] | CTD | PMID:17854601 | N-nitrosodimethylamine | increases expression | EXP | | 6480464 | Dimethylnitrosamine results in increased expression of SMC2 mRNA | CTD | PMID:25380136 | N-Nitrosopyrrolidine | decreases expression | ISO | RGD:1313128 | 6480464 | N-Nitrosopyrrolidine results in decreased expression of SMC2 mRNA | CTD | PMID:32234424 | nickel atom | increases expression | ISO | RGD:1313128 | 6480464 | Nickel results in increased expression of SMC2 mRNA | CTD | PMID:25583101 | oxaliplatin | decreases expression | EXP | | 6480464 | oxaliplatin results in decreased expression of SMC2 mRNA | CTD | PMID:25729387 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SMC2 mRNA | CTD | PMID:25729387 | ozone | increases expression | ISO | RGD:1313129 | 6480464 | Ozone results in increased expression of SMC2 mRNA | CTD | PMID:12763052 | paracetamol | decreases expression | ISO | RGD:1313128 | 6480464 | Acetaminophen results in decreased expression of SMC2 mRNA | CTD | PMID:29067470 | paracetamol | increases expression | ISO | RGD:1313128 | 6480464 | Acetaminophen results in increased expression of SMC2 mRNA | CTD | PMID:22230336 | PCB138 | multiple interactions | ISO | RGD:1313129 | 6480464 | [2 more ... | CTD | PMID:25510870 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | RGD:1313128 | 6480464 | perfluorooctane sulfonic acid results in decreased expression of SMC2 mRNA | CTD | PMID:27153767 | perfluorooctanoic acid | decreases expression | ISO | RGD:1313128 | 6480464 | perfluorooctanoic acid results in decreased expression of SMC2 protein | CTD | PMID:26879310 | phenobarbital | affects expression | ISO | RGD:1313129 | 6480464 | Phenobarbital affects the expression of SMC2 mRNA | CTD | PMID:19136022, PMID:23091169 | phenytoin | increases expression | EXP | | 6480464 | Phenytoin results in increased expression of SMC2 mRNA | CTD | PMID:20345932 | pirinixic acid | affects expression | ISO | RGD:1313129 | 6480464 | pirinixic acid affects the expression of SMC2 mRNA | CTD | PMID:19136022 | pirinixic acid | increases expression | ISO | RGD:1313129 | 6480464 | pirinixic acid results in increased expression of SMC2 mRNA | CTD | PMID:17950772 more ... | pirinixic acid | decreases expression | ISO | RGD:1313129 | 6480464 | pirinixic acid results in decreased expression of SMC2 mRNA | CTD | PMID:17426115 | pirinixic acid | multiple interactions | ISO | RGD:1313129 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in increased expression of SMC2 mRNA] | CTD | PMID:17950772 | piroxicam | decreases expression | ISO | RGD:1313128 | 6480464 | Piroxicam results in decreased expression of SMC2 mRNA | CTD | PMID:21858171 | potassium chromate | decreases expression | ISO | RGD:1313128 | 6480464 | potassium chromateVI results in decreased expression of SMC2 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | RGD:1313128 | 6480464 | [potassium chromateVI co-treated with epigallocatechin gallate] results in decreased expression of SMC2 mRNA | CTD | PMID:22079256 | progesterone | increases expression | ISO | RGD:1313128 | 6480464 | Progesterone results in increased expression of SMC2 mRNA | CTD | PMID:18070364 | propanal | decreases expression | ISO | RGD:1313128 | 6480464 | propionaldehyde results in decreased expression of SMC2 mRNA | CTD | PMID:26079696 | quercetin | decreases expression | ISO | RGD:1313128 | 6480464 | Quercetin results in decreased expression of SMC2 mRNA | CTD | PMID:21632981 | resveratrol | multiple interactions | ISO | RGD:1313128 | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of SMC2 mRNA | CTD | PMID:19167446 | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of SMC2 mRNA | CTD | PMID:25905778 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of SMC2 mRNA | CTD | PMID:28374803 | senecionine | increases expression | EXP | | 6480464 | senecionine results in increased expression of SMC2 mRNA | CTD | PMID:32419051 | Senkirkine | increases expression | EXP | | 6480464 | senkirkine results in increased expression of SMC2 mRNA | CTD | PMID:32419051 | silicon dioxide | increases expression | ISO | RGD:1313129 | 6480464 | Silicon Dioxide results in increased expression of SMC2 mRNA | CTD | PMID:29341224 | sodium arsenate | increases expression | ISO | RGD:1313129 | 6480464 | sodium arsenate results in increased expression of SMC2 mRNA | CTD | PMID:30953684 | sodium arsenite | increases expression | ISO | RGD:1313129 | 6480464 | sodium arsenite results in increased expression of SMC2 mRNA | CTD | PMID:32068019 | succimer | multiple interactions | ISO | RGD:1313129 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SMC2 mRNA | CTD | PMID:21641980 | sunitinib | decreases expression | ISO | RGD:1313128 | 6480464 | Sunitinib results in decreased expression of SMC2 mRNA | CTD | PMID:31533062 | testosterone | multiple interactions | ISO | RGD:1313128 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of SMC2 mRNA | CTD | PMID:21592394 | testosterone | decreases expression | ISO | RGD:1313128 | 6480464 | Testosterone results in decreased expression of SMC2 mRNA | CTD | PMID:21592394 | testosterone enanthate | affects expression | ISO | RGD:1313128 | 6480464 | testosterone enanthate affects the expression of SMC2 mRNA | CTD | PMID:17440010 | tetrachloromethane | increases expression | ISO | RGD:1313129 | 6480464 | Carbon Tetrachloride results in increased expression of SMC2 mRNA | CTD | PMID:27339419, PMID:31919559 | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of SMC2 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SMC2 mRNA | CTD | PMID:25729387 | trimellitic anhydride | increases expression | ISO | RGD:1313129 | 6480464 | trimellitic anhydride results in increased expression of SMC2 mRNA | CTD | PMID:19042947 | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of SMC2 mRNA | CTD | PMID:30589522 | troglitazone | decreases expression | ISO | RGD:1313128 | 6480464 | troglitazone results in decreased expression of SMC2 mRNA | CTD | PMID:19140230 | tungsten | decreases expression | ISO | RGD:1313129 | 6480464 | Tungsten results in decreased expression of SMC2 mRNA | CTD | PMID:30912803 | valproic acid | increases expression | ISO | RGD:1313128 | 6480464 | Valproic Acid results in increased expression of SMC2 mRNA | CTD | PMID:29154799 | valproic acid | decreases methylation | ISO | RGD:1313128 | 6480464 | Valproic Acid results in decreased methylation of SMC2 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | RGD:1313128 | 6480464 | Valproic Acid affects the expression of SMC2 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | RGD:1313128 | 6480464 | Valproic Acid results in decreased expression of SMC2 mRNA | CTD | PMID:23179753, PMID:27188386 | |