Ifnb1 (interferon beta 1) - Rat Genome Database

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Gene: Ifnb1 (interferon beta 1) Rattus norvegicus
Symbol: Ifnb1
Name: interferon beta 1
RGD ID: 2865
Description: Predicted to enable chloramphenicol O-acetyltransferase activity; cytokine activity; and type I interferon receptor binding activity. Involved in macrophage activation involved in immune response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1); PARTICIPATES IN Chagas disease pathway; cytokine mediated signaling pathway; hepatitis C pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: If1da1; IFN-beta; Ifnb; interferon 1da1; interferon beta; Interferon beta 1 fibroblast; interferon beta 1, fibroblast; interferon, beta 1; Interferon, beta 1, fibroblast
RGD Orthologs
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25103,020,969 - 103,021,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5103,020,969 - 103,021,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5105,375,610 - 105,376,164 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05107,166,057 - 107,166,611 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05107,226,739 - 107,227,293 (-)NCBIRnor_WKY
Rnor_6.05106,865,192 - 106,865,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5106,865,192 - 106,865,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05110,843,902 - 110,844,456 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45107,837,628 - 107,838,182 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15107,842,853 - 107,843,408 (-)NCBI
Celera5100,095,218 - 100,095,772 (+)NCBICelera
RH 3.4 Map5746.3RGD
Cytogenetic Map5q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-aminopurine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetaldehyde  (ISO)
actinomycin D  (ISO)
alachlor  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-D-galactose  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amlexanox  (ISO)
ammonium chloride  (EXP)
apocynin  (ISO)
aripiprazole  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benomyl  (ISO)
bisphenol A  (EXP,ISO)
cannabidiol  (ISO)
carbaryl  (ISO)
chaetoglobosin A  (ISO)
chlordecone  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
Cirsimarin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cortisol  (ISO)
cudratricusxanthone A  (ISO)
curcumin  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dicofol  (ISO)
diethyl phthalate  (ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
ethanol  (EXP,ISO)
galactose  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
ifosfamide  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
malathion  (ISO)
mangiferin  (ISO)
mercury dichloride  (ISO)
metam  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
microcystin-LR  (ISO)
Mitotane  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
Nivalenol  (ISO)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
Octachlorostyrene  (ISO)
ozone  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
poly(I:C)  (EXP,ISO)
pravastatin  (ISO)
pristane  (EXP)
progesterone  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resiquimod  (ISO)
resveratrol  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
scoparone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
toluene 2,4-diisocyanate  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
Triptolide  (ISO)
wortmannin  (ISO)
zinc protoporphyrin  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection. Al-Khatib K, etal., Exp Eye Res. 2005 Feb;80(2):167-73. doi: 10.1016/j.exer.2004.08.026.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies. Hassan AO, etal., Cell. 2020 Jun 10. pii: S0092-8674(20)30742-X. doi: 10.1016/j.cell.2020.06.011.
5. Ubiquicidin, a novel murine microbicidal protein present in the cytosolic fraction of macrophages. Hiemstra PS, etal., J Leukoc Biol. 1999 Sep;66(3):423-8.
6. Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Hung IF, etal., Lancet. 2020 May 30;395(10238):1695-1704. doi: 10.1016/S0140-6736(20)31042-4. Epub 2020 May 10.
7. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity. Li XL, etal., Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20816-21. doi: 10.1073/pnas.0807265105. Epub 2008 Dec 15.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Isolation and expression of rat interferon beta gene and growth-inhibitory effect of its expression on rat glioma cells. Yokoyama S, etal., Biochem Biophys Res Commun 1997 Mar 27;232(3):698-701.
Additional References at PubMed
PMID:10918594   PMID:11337497   PMID:12932356   PMID:14597717   PMID:15240719   PMID:16984225   PMID:17277142   PMID:17442941   PMID:18035482   PMID:18596219   PMID:19008854   PMID:19176627  
PMID:19541371   PMID:20214528   PMID:20554961   PMID:21266579   PMID:21606371   PMID:23872679   PMID:24882218   PMID:26252165   PMID:27129230   PMID:33160814  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.25103,020,969 - 103,021,523 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5103,020,969 - 103,021,523 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5105,375,610 - 105,376,164 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05107,166,057 - 107,166,611 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05107,226,739 - 107,227,293 (-)NCBIRnor_WKY
Rnor_6.05106,865,192 - 106,865,746 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5106,865,192 - 106,865,746 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05110,843,902 - 110,844,456 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45107,837,628 - 107,838,182 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15107,842,853 - 107,843,408 (-)NCBI
Celera5100,095,218 - 100,095,772 (+)NCBICelera
RH 3.4 Map5746.3RGD
Cytogenetic Map5q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38921,077,104 - 21,077,942 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl921,077,104 - 21,077,942 (-)EnsemblGRCh38hg38GRCh38
GRCh37921,077,103 - 21,077,941 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,067,104 - 21,067,943 (-)NCBINCBI36Build 36hg18NCBI36
Build 34921,067,103 - 21,067,943NCBI
Celera921,015,373 - 21,016,212 (-)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef921,040,313 - 21,041,152 (-)NCBIHuRef
CHM1_1921,076,893 - 21,077,732 (-)NCBICHM1_1
T2T-CHM13v2.0921,090,986 - 21,091,824 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39488,440,253 - 88,441,083 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl488,440,262 - 88,441,011 (-)EnsemblGRCm39 Ensembl
GRCm38488,522,025 - 88,522,794 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl488,522,025 - 88,522,774 (-)EnsemblGRCm38mm10GRCm38
MGSCv37488,167,929 - 88,168,698 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36487,993,256 - 87,994,025 (-)NCBIMGSCv36mm8
Celera487,037,706 - 87,038,475 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map441.91NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495543423,301,623 - 23,302,304 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan19103,466,363 - 103,476,565 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0920,884,742 - 20,886,317 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1921,540,849 - 21,541,695 (-)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11140,668,295 - 40,668,855 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1140,668,295 - 40,668,855 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1139,330,806 - 39,331,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01141,610,249 - 41,610,809 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1141,610,249 - 41,610,809 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11140,302,366 - 40,302,926 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01140,090,657 - 40,091,217 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01140,726,193 - 40,726,753 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947155,066,763 - 155,067,326 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366522,736,270 - 2,736,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1201,850,935 - 201,851,495 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11201,850,935 - 201,851,495 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21225,469,554 - 225,470,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q23-q27NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462473625,099,061 - 25,099,746 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ifnb1
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:16
Interacting mature miRNAs:17
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)559793528113558156Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)564719390109719390Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)568984307104251008Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)568984307104251008Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599485997103690167Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)599753548113061097Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25103,020,870 - 103,020,967 (+)MAPPERmRatBN7.2
Rnor_6.05106,865,094 - 106,865,190NCBIRnor6.0
Rnor_5.05110,843,804 - 110,843,900UniSTSRnor5.0
RGSC_v3.45107,837,530 - 107,837,626UniSTSRGSC3.4
Celera5100,095,774 - 100,095,870UniSTS
RH 3.4 Map5746.3UniSTS
Cytogenetic Map5q31-q33UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25103,021,015 - 103,021,601 (+)MAPPERmRatBN7.2
Rnor_6.05106,865,239 - 106,865,824NCBIRnor6.0
Rnor_5.05110,843,949 - 110,844,534UniSTSRnor5.0
RGSC_v3.45107,837,675 - 107,838,260UniSTSRGSC3.4
Celera5100,095,140 - 100,095,725UniSTS
Cytogenetic Map5q31-q33UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system hemolymphoid system nervous system respiratory system
Low 1
Below cutoff 1 3 4 7 3


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008224   ⟹   ENSRNOP00000008225
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5103,020,969 - 103,021,523 (-)Ensembl
Rnor_6.0 Ensembl5106,865,192 - 106,865,746 (-)Ensembl
RefSeq Acc Id: NM_019127   ⟹   NP_062000
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.25103,020,969 - 103,021,523 (-)NCBI
Rnor_6.05106,865,192 - 106,865,746 (-)NCBI
Rnor_5.05110,843,902 - 110,844,456 (-)NCBI
RGSC_v3.45107,837,628 - 107,838,182 (-)RGD
Celera5100,095,218 - 100,095,772 (+)RGD
Protein Sequences
Protein RefSeqs NP_062000 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA13502 (Get FASTA)   NCBI Sequence Viewer  
  CAB0000194 (Get FASTA)   NCBI Sequence Viewer  
  EDL75998 (Get FASTA)   NCBI Sequence Viewer  
  P70499 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062000   ⟸   NM_019127
- Peptide Label: precursor
- UniProtKB: P70499 (UniProtKB/Swiss-Prot),   A0A7R8GV74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008225   ⟸   ENSRNOT00000008224

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70499-F1-model_v2 AlphaFold P70499 1-184 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2865 AgrOrtholog
BioCyc Gene G2FUF-40824 BioCyc
Ensembl Genes ENSRNOG00000006268 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000008225 ENTREZGENE
  ENSRNOP00000008225.1 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008224 ENTREZGENE
  ENSRNOT00000008224.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_alpha/beta/delta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24481 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11691 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Interferon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ifnb1 PhenoGen
SMART IFabd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Ifnb1  interferon beta 1  Ifnb1  interferon beta 1, fibroblast  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ifnb1  interferon beta 1, fibroblast    interferon, beta 1  Name updated 1299863 APPROVED
2002-11-06 Ifnb1  interferon, beta 1    Interferon, beta 1, fibroblast  Name updated 625702 APPROVED
2002-06-10 Ifnb1  Interferon, beta 1, fibroblast      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology 86.7 and 67.6% homologous to the mouse and human IFN beta 633076
gene_protein encodes a polypeptide 184 amino acids long 633076